Mitchel S Berger

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Astrocytic gliomas WHO grades II and III
    Mitchel S Berger
    Department of Neurological Surgery, University of California, San Francisco, CA, USA Electronic address
    Handb Clin Neurol 134:345-60. 2016
  2. doi Surgery of intrinsic cerebral tumors
    Mitchel S Berger
    Department of Neurosurgery, University of California at San Francisco, 505 Parnassus Avenue, Room M787, San Francisco, California 94143, USA
    Neurosurgery 61:279-304; discussion 304-5. 2007
  3. pmc The use of convection-enhanced delivery with liposomal toxins in neurooncology
    Massimo S Fiandaca
    Molecular Therapeutics Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, Mission Center Building, Rm 226, San Francisco, CA 94103, USA
    Toxins (Basel) 3:369-97. 2011
  4. pmc Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM
    Forrest W Crawford
    Department of Radiology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94143 2532, USA
    J Neurooncol 91:337-51. 2009
  5. pmc Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma
    Andrea Pirzkall
    Department of Radiology and Margaret Hart Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 11:842-52. 2009
  6. ncbi 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, California 94158 2532, USA
    J Magn Reson Imaging 26:23-30. 2007
  7. pmc Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update
    Kavita K Mishra
    Department of Radiation Oncology, University of California, San Francisco, 1600 Divisadero, San Francisco, CA 94143, USA
    J Neurooncol 100:121-7. 2010
  8. ncbi Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy
    Charles O Noble
    Division of Hematology Oncology, University of California at San Francisco, California 94115, USA
    Cancer Res 66:2801-6. 2006
  9. pmc Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates
    Dali Yin
    Department of Neurosurgery, University of California San Francisco, 1855 Folsom Street, MCB 226, San Francisco, CA 94103, USA
    Neuroimage 54:S196-203. 2011
  10. pmc Magnetoencephalographic imaging of resting-state functional connectivity predicts postsurgical neurological outcome in brain gliomas
    Phiroz E Tarapore
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0628, USA
    Neurosurgery 71:1012-22. 2012

Detail Information

Publications149 found, 100 shown here

  1. doi Astrocytic gliomas WHO grades II and III
    Mitchel S Berger
    Department of Neurological Surgery, University of California, San Francisco, CA, USA Electronic address
    Handb Clin Neurol 134:345-60. 2016
    ....
  2. doi Surgery of intrinsic cerebral tumors
    Mitchel S Berger
    Department of Neurosurgery, University of California at San Francisco, 505 Parnassus Avenue, Room M787, San Francisco, California 94143, USA
    Neurosurgery 61:279-304; discussion 304-5. 2007
    ..This would be a paradigm shift away from stimulation mapping, which currently deactivates the cortex, as opposed to identifying an activation function which identifies functional cortex...
  3. pmc The use of convection-enhanced delivery with liposomal toxins in neurooncology
    Massimo S Fiandaca
    Molecular Therapeutics Laboratory, Department of Neurological Surgery, University of California San Francisco, 1855 Folsom Street, Mission Center Building, Rm 226, San Francisco, CA 94103, USA
    Toxins (Basel) 3:369-97. 2011
    ..How CED and liposomal technologies may influence future neurooncologic treatments are also considered...
  4. pmc Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM
    Forrest W Crawford
    Department of Radiology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94143 2532, USA
    J Neurooncol 91:337-51. 2009
    ..These parameters may provide useful information for predicting outcome and for the stratification of patients into high or low risk groups for clinical trials...
  5. pmc Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma
    Andrea Pirzkall
    Department of Radiology and Margaret Hart Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 11:842-52. 2009
    ..The acquisition of metabolic and physiologic imaging data prior to adjuvant therapy may also be valuable in assessing regions of new CE and nonenhancing tumor...
  6. ncbi 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, California 94158 2532, USA
    J Magn Reson Imaging 26:23-30. 2007
    ..To implement proton magnetic resonance spectroscopic imaging (1H MRSI) at 3 Tesla (3T) using an eight-channel phased-array head coil in a population of brain-tumor patients...
  7. pmc Phase II TPDCV protocol for pediatric low-grade hypothalamic/chiasmatic gliomas: 15-year update
    Kavita K Mishra
    Department of Radiation Oncology, University of California, San Francisco, 1600 Divisadero, San Francisco, CA 94143, USA
    J Neurooncol 100:121-7. 2010
    ..2% and 15-year PFS of 23.4%. No survival benefit is demonstrated for greater extent of resection. Age is a significant prognostic factor for progression and survival...
  8. ncbi Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy
    Charles O Noble
    Division of Hematology Oncology, University of California at San Francisco, California 94115, USA
    Cancer Res 66:2801-6. 2006
    ..5 days; P = 0.011). We conclude that CED of nanoliposomal CPT-11 greatly prolonged tissue residence while also substantially reducing toxicity, resulting in a highly effective treatment strategy in preclinical brain tumor models...
  9. pmc Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates
    Dali Yin
    Department of Neurosurgery, University of California San Francisco, 1855 Folsom Street, MCB 226, San Francisco, CA 94103, USA
    Neuroimage 54:S196-203. 2011
    ....
  10. pmc Magnetoencephalographic imaging of resting-state functional connectivity predicts postsurgical neurological outcome in brain gliomas
    Phiroz E Tarapore
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0628, USA
    Neurosurgery 71:1012-22. 2012
    ..The removal of brain tumors in perieloquent or eloquent cortex risks causing new neurological deficits in patients. The assessment of the functionality of perilesional tissue is essential to avoid postoperative neurological morbidity...
  11. pmc Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts
    Pin Yuan Chen
    Department of Neurological Surgery, University of California San Francisco, 1450 Third Street, Room HD 283, San Francisco, CA 94158, USA
    Neuro Oncol 15:189-97. 2013
    ....
  12. doi Neurosurgical management and prognosis of patients with glioblastoma that progresses during bevacizumab treatment
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurosurgery 70:361-70. 2012
    ..The management and prognosis of glioblastoma patients after Stupp protocol treatment and progression during bevacizumab (BV) treatment remain undefined...
  13. ncbi Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
    Daphne A Haas-Kogan
    Department of Neurosurgery, Brain Tumor Research Center, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143, USA
    J Natl Cancer Inst 97:880-7. 2005
    ....
  14. pmc Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model
    Ryuta Saito
    Department of Neurological Surgery, University of California at San Francisco, 1855 Folsom Street, Mission Center Building Room 226, San Francisco, CA 94103, USA
    Neuro Oncol 8:205-14. 2006
    ..0005 versus control). We conclude that the combination of a novel nanoparticle Ls-TPT and CED administration was very effective in treating experimental brain tumors...
  15. ncbi Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group
    Sandeep Kunwar
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94143 0350, USA
    J Clin Oncol 25:837-44. 2007
    ..We assessed the use of intracerebral CED to deliver CB in patients with recurrent malignant glioma (MG)...
  16. pmc Functional mapping-guided resection of low-grade gliomas in eloquent areas of the brain: improvement of long-term survival. Clinical article
    Edward F Chang
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:566-73. 2011
    ..Given the lack of long-term survival data, the prognostic significance of eloquent brain tumor location and the role of functional mapping during resective surgery in presumed eloquent brain regions are unknown...
  17. doi Results with judicious modern neurosurgical management of parasagittal and falcine meningiomas. Clinical article
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:731-7. 2011
    ..The present study aims to address surgical outcomes in a focused cohort of these patients for which there is not clinical equipoise between radiosurgery and transcranial resection...
  18. ncbi Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery
    Ryuta Saito
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, Mission Center Building, 94103, USA
    J Neurosci Methods 154:225-32. 2006
    ..Thus, an increased and more predictable tissue distribution can be achieved by reducing the tissue affinity of the infusate using appropriately engineered liposomes or other nanoparticles...
  19. pmc Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity
    Sarang S Dalal
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Neuroimage 40:1686-700. 2008
    ..This method enables the ultimate promise of MEG and EEG for five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics during cognition...
  20. pmc Language mapping with navigated repetitive TMS: proof of technique and validation
    Phiroz E Tarapore
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Neuroimage 82:260-72. 2013
    ..Although not lesion-based, magnetoencephalographic imaging (MEGI) is another noninvasive modality for language mapping. In this study, we compare the accuracy of nTMS and MEGI with DCS...
  21. ncbi Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain
    Ryuta Saito
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
    Exp Neurol 196:381-9. 2005
    ..Our ability to directly monitor and to control local delivery of liposomal drugs will most likely result in greater clinical efficacy when using CED in management of patients...
  22. pmc Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients
    Michael Safaee
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 8:e62765. 2013
    ..This phenotype may explain the discrepancy in survival between high and low CD97-expressing tumors. This data provides impetus for further studies to determine its viability as a therapeutic target in the treatment of GBM...
  23. doi Impact of extent of resection for recurrent glioblastoma on overall survival: clinical article
    Orin Bloch
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 117:1032-8. 2012
    ..In this study the authors investigate the impact of EOR at initial and repeat resection of GBM on overall survival...
  24. pmc Preoperative multimodal motor mapping: a comparison of magnetoencephalography imaging, navigated transcranial magnetic stimulation, and direct cortical stimulation
    Phiroz E Tarapore
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 117:354-62. 2012
    ..While MEG imaging has already been extensively validated as an accurate modality of noninvasive motor mapping, TMS is less well studied. In this study, the authors compared the accuracy of TMS to both DCS and MEG imaging...
  25. pmc Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging
    Ramon F Barajas
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2330, USA
    Neuro Oncol 14:942-54. 2012
    ..Image-guided tissue acquisition and assessment of residual tumor from treatment-naive GBM should be guided by DSC in CE regions and by DWI in NE regions...
  26. doi Preoperative prognostic classification system for hemispheric low-grade gliomas in adults
    Edward F Chang
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 109:817-24. 2008
    ..As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs...
  27. doi Gamma Knife radiosurgery for brain metastases from primary breast cancer
    Norbert Kased
    Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 75:1132-40. 2009
    ..The relative roles of stereotactic radiosurgery (SRS) vs. whole brain radiotherapy (WBRT) in the treatment of patients with brain metastases from breast cancer remain undefined. In this study, we reviewed our experience with these patients...
  28. pmc Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging
    Ramon F Barajas
    Department of Radiology, Neuroradiology Section, University of California, San Francisco, CA 94143, USA
    Radiology 253:486-96. 2009
    ....
  29. doi Secondary gliosarcoma after diagnosis of glioblastoma: clinical experience with 30 consecutive patients
    Seunggu J Han
    Department of Neurological Surgery, University of California, San Francisco, California 94117, USA
    J Neurosurg 112:990-6. 2010
    ..The authors present a large series of histologically confirmed SGSs, with follow-up to describe the clinical and radiological presentation, pathological diagnosis, and treatment outcomes...
  30. doi Intraoperative stimulation techniques for functional pathway preservation and glioma resection
    Nader Sanai
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Neurosurg Focus 28:E1. 2010
    ..Collectively, these surgical strategies represent the cornerstone for operating on gliomas in and around functional pathways...
  31. doi Intraoperative mapping during repeat awake craniotomy reveals the functional plasticity of adult cortex
    Derek G Southwell
    Department of Neurological Surgery, University of California, San Francisco, California
    J Neurosurg 124:1460-9. 2016
    ..The insight gained from this subset of patients has implications for our understanding of brain plasticity in clinical settings. ..
  32. ncbi Repeated operations for infiltrative low-grade gliomas without intervening therapy
    Meic H Schmidt
    Department of Neurological Surgery, University of California at San Francisco, California, USA
    J Neurosurg 98:1165-9. 2003
    ..The authors examined factors that may be associated with tumor progression...
  33. ncbi Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas
    Tracy R McKnight
    Department of Radiology, University of California, San Francisco 94107, USA
    J Neurosurg 106:660-6. 2007
    ....
  34. doi Seizure characteristics and control following resection in 332 patients with low-grade gliomas
    Edward F Chang
    Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, California 94143, USA
    J Neurosurg 108:227-35. 2008
    ..The aim of this study was to identify factors that influenced perioperative seizure characteristics and postoperative seizure control...
  35. pmc Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology
    Terri Rice
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94107, USA
    Neuro Oncol 15:535-41. 2013
    ..Because the inherited variant in 11q23 has been associated with risk of lower grade glioma and not with glioblastomas, we hypothesized that this variant increases susceptibility to IDH-mutated gliomas, but not to IDH-wild-type gliomas...
  36. pmc Na⁺/K⁺-ATPase β2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells
    Matthew Z Sun
    Corresponding Author Andrew T Parsa, MD, PhD, Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94117
    Neuro Oncol 15:1518-31. 2013
    ....
  37. doi Disseminated progression of glioblastoma after treatment with bevacizumab
    Orin Bloch
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, CA 94143 0112, USA
    Clin Neurol Neurosurg 115:1795-801. 2013
    ..We have reviewed our institutional experience with bevacizumab for GBM to evaluate the prognostic factors and outcomes of patients with disseminated progression...
  38. pmc Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents
    Michal T Krauze
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, California 94103, USA
    J Neurosurg 103:923-9. 2005
    ..This step-design cannula may allow reflux-free distribution and shorten the duration of infusion in future clinical applications of CED in humans...
  39. doi T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery
    R Mark Richardson
    Laboratory of Molecular Therapeutics, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Neurosurgery 69:154-63; discussion 163. 2011
    ..The use of T2 MRI in RCD is less developed. In addition, the effect of flushing a dead-space volume on subsequent distribution of a therapeutic agent is not known...
  40. doi Intracranial hemangiopericytoma: clinical experience and treatment considerations in a modern series of 40 adult patients
    Martin J Rutkowski
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
    Cancer 118:1628-36. 2012
    ..Intracranial hemangiopericytoma (HPC) is a malignant meningothelial tumor. Because of its rarity, few guidelines exist for optimal management...
  41. doi Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas
    Justin S Smith
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave, Room M 779, San Francisco, CA 94143 0112, USA
    J Clin Oncol 26:1338-45. 2008
    ..The prognostic role of extent of resection (EOR) of low-grade gliomas (LGGs) is a major controversy. We designed a retrospective study to assess the influence of EOR on long-term outcomes of LGGs...
  42. pmc Glioblastoma multiforme regional genetic and cellular expression patterns: influence on anatomic and physiologic MR imaging
    Ramon F Barajas
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Long L200B, Box 0628, San Francisco, CA 94143, USA
    Radiology 254:564-76. 2010
    ..To determine whether magnetic resonance (MR) imaging is influenced by genetic and cellular features of glioblastoma multiforme (GBM) aggressiveness...
  43. doi Supratentorial cavernous malformations in eloquent and deep locations: surgical approaches and outcomes. Clinical article
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:814-27. 2011
    ..We hypothesized that an organized system of approaches can guide operative planning and lead to acceptable neurological outcomes in surgical patients...
  44. doi Homotopic organization of essential language sites in right and bilateral cerebral hemispheric dominance
    Edward F Chang
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 114:893-902. 2011
    ..Language dominance in the right hemisphere is rare. Therefore, the organization of essential language sites in the dominant right hemisphere is unclear, especially compared with cases involving the more prevalent left dominant hemisphere...
  45. pmc Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide
    Gautam Prasad
    Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA
    Neuro Oncol 13:384-92. 2011
    ..05) with a trend toward improvement in median survival (logrank p = 0.09) compared with TMZ alone. XL765 shows activity as monotherapy and in combination with conventional therapeutics in a range of genetically diverse GBM xenografts...
  46. doi The relevance of Simpson Grade I and II resection in modern neurosurgical treatment of World Health Organization Grade I meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 113:1029-35. 2010
    ....
  47. ncbi Intraoperative subcortical stimulation mapping for hemispherical perirolandic gliomas located within or adjacent to the descending motor pathways: evaluation of morbidity and assessment of functional outcome in 294 patients
    G Evren Keles
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 100:369-75. 2004
    ..The purpose of this retrospective analysis was to assess the morbidity and functional outcome associated with this method, thus allowing the surgeon to predict the likelihood of causing a temporary or permanent motor deficit...
  48. pmc mTOR-independent translational control of the extrinsic cell death pathway by RalA
    Amith Panner
    UCSF Cancer Center, 2340 Sutter St, Rm N219, San Francisco, CA 94115 0875, USA
    Mol Cell Biol 26:7345-57. 2006
    ....
  49. doi Management of recurrent intracranial hemangiopericytoma
    Martin J Rutkowski
    Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    J Clin Neurosci 18:1500-4. 2011
    ..This multimodality approach also appears to outperform GKS in extending time to second recurrence. Accordingly, when safe and feasible, surgical resection of recurrent HPC with adjuvant EBRT should be the first steps in management...
  50. ncbi Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery
    Christoph Mamot
    Division of Hematology Oncology, University of California at San Francisco, San Francisco, CA, USA
    J Neurooncol 68:1-9. 2004
    ..To our knowledge, this is the first report of CED infusion of liposomes into the CNS. We conclude that CED of liposomes in the CNS is a feasible approach, and offers a promising strategy for targeting therapeutic agents to brain tumors...
  51. ncbi Cooperative function of Chk1 and p38 pathways in activating G2 arrest following exposure to temozolomide
    Yuichi Hirose
    Brain Tumor Research Center, Department of Neurological Surgery, San Francisco, California, USA
    J Neurosurg 100:1060-5. 2004
    ..Although inhibition of either pathway sensitizes glioma cells to TMZ-induced cytotoxicity, the relative contributions of these pathways to TMZ-induced G2 arrest and to TMZ resistance conferred by G2 arrest have not been defined...
  52. ncbi Serial diffusion-weighted magnetic resonance imaging in cases of glioma: distinguishing tumor recurrence from postresection injury
    Justin S Smith
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco School of Medicine, San Francisco, California 94143 0112, USA
    J Neurosurg 103:428-38. 2005
    ..The purpose of this study was to investigate prospectively the incidence, time course, and ultimate outcome of these abnormalities...
  53. ncbi Volumetric extent of resection and residual contrast enhancement on initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytoma
    G Evren Keles
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 105:34-40. 2006
    ....
  54. doi Outcome and survival following primary and repeat surgery for World Health Organization Grade III meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, California 94143, USA
    J Neurosurg 113:202-9. 2010
    ..The authors present the largest case series to date dealing with these tumors, providing analysis of 63 patients...
  55. doi Postoperative seizures following the resection of convexity meningiomas: are prophylactic anticonvulsants indicated? Clinical article
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:705-9. 2011
    ..Given the paucity of tumor-type and site-specific data, the authors evaluated the incidence of postoperative seizures in patients with convexity meningiomas and no prior seizures...
  56. doi Risk factors for the development of serious medical complications after resection of meningiomas. Clinical article
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:697-704. 2011
    ..The authors performed a review of 834 patients who underwent craniotomy for meningioma at their institution and analyzed the rate of major cardiac, pulmonary, renal, and hepatic complications...
  57. doi Incidence, risk factors, and outcome of venous infarction after meningioma surgery in 705 patients
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, P O Box 0112, San Francisco, California 94143, USA
    J Clin Neurosci 18:628-32. 2011
    ..9%, χ(2)p<0.05). We demonstrated that the most important factor determining the risk of venous infarction is the approach used to access the tumor...
  58. pmc Survival advantage combining a BRAF inhibitor and radiation in BRAF V600E-mutant glioma
    Tina Dasgupta
    Valley Radiotherapy Associates, 1500 Rosecrans Avenue, Manhattan Beach, CA, 90266, USA
    J Neurooncol 126:385-93. 2016
    ..These studies provide the pre-clinical rationale for clinical trials of concurrent radiotherapy and BRAF V600E inhibitors...
  59. pmc Permanent iodine 125 brachytherapy in patients with progressive or recurrent glioblastoma multiforme
    David A Larson
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 6:119-26. 2004
    ..We conclude that permanent 125I brachytherapy for recurrent or progressive GM is well tolerated. Survival time was comparable to that of a similar group of patients treated with temporary brachytherapy...
  60. pmc PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome
    Sabine Mueller
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Neuro Oncol 14:1146-52. 2012
    ..0475). Tumors with no PTEN expression had a higher MIB labeling index (P= .007). The majority of pediatric gliomas show activation of the PI3K/Akt/mTOR pathway, with methylation of the PTEN promoter occurring commonly in these tumors...
  61. pmc Subcortical pathways serving cortical language sites: initial experience with diffusion tensor imaging fiber tracking combined with intraoperative language mapping
    Roland G Henry
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuroimage 21:616-22. 2004
    ..The combined techniques may provide improved preservation of eloquent regions during neurological surgery, and may provide access to direct connectivity information between functional regions of the brain...
  62. pmc The role of up-front radiation therapy for incompletely resected pediatric WHO grade II low-grade gliomas
    Kavita K Mishra
    Brain Tumor Research Center and Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 8:166-74. 2006
    ..We were unable to demonstrate a benefit for administering radiation as part of initial treatment. An outcome benefit was seen with greater extent of resection...
  63. pmc Categorical speech representation in human superior temporal gyrus
    Edward F Chang
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
    Nat Neurosci 13:1428-32. 2010
    ..Our results provide direct evidence for acoustic-to-higher order phonetic level encoding of speech sounds in human language receptive cortex...
  64. doi Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics
    Dali Yin
    Department of Neurosurgery, University of California, San Francisco, California 94103, USA
    J Neurosurg 113:240-8. 2010
    ....
  65. pmc Expression of miR-124 inhibits growth of medulloblastoma cells
    Joachim Silber
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Neuro Oncol 15:83-90. 2013
    ..Further testing of miR-124 will help define the ultimate therapeutic potential of preclinical models of medulloblastoma in conjunction with various delivery strategies for treatment...
  66. doi Modern surgical outcomes following surgery for sphenoid wing meningiomas
    Michael E Sughrue
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg 119:86-93. 2013
    ..The authors review their experience with resection of sphenoid wing meningiomas at a single center, to examine whether this classification predicts clinical presentation and postsurgical outcome...
  67. doi Pediatric intracranial ependymoma: the roles of surgery, radiation and chemotherapy
    Sunanda Pejavar
    Department of Radiation Oncology, University of California, San Francisco and UCSF Benioff Children s Hospital, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94115 1708, USA
    J Neurooncol 106:367-75. 2012
    ..Our findings suggest the benefit of RT even in the presence of GTR. Future prospective studies with larger sample number are needed to validate our findings...
  68. ncbi Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence
    Yuchi Hirose
    Department of Neurological Surgery and The Brain Tumor Research Center, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 65:4861-9. 2005
    ..The Akt pathway therefore represents a new target for the sensitization of gliomas to chemotherapeutic methylating agents such as temozolomide...
  69. pmc mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells
    Amith Panner
    Brain Tumor Research Center, Department of Neurological Surgery, University of California San Francisco, 94143 0875, USA
    Mol Cell Biol 25:8809-23. 2005
    ....
  70. pmc Mapping functional connectivity in patients with brain lesions
    Adrian G Guggisberg
    Biomagnetic Imaging Lab, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Ann Neurol 63:193-203. 2008
    ..Based on the rationale that damaged brain tissue is disconnected from the physiological interactions among healthy areas, this study aimed to map the functionality of brain areas according to their connectivity with other areas...
  71. doi Radiation is an important component of multimodality therapy for pediatric non-pineal supratentorial primitive neuroectodermal tumors
    Sean M McBride
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA
    Int J Radiat Oncol Biol Phys 72:1319-23. 2008
    ..To review a historical cohort of pediatric patients with supratentorial primitive neuroectodermal tumors (sPNET), to clarify the role of radiation in the treatment of these tumors...
  72. doi Seizure control outcomes after resection of dysembryoplastic neuroepithelial tumor in 50 patients
    Edward F Chang
    Northern California Comprehensive Epilepsy Center, Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg Pediatr 5:123-30. 2010
    ..The authors' aim was to identify factors that predict seizure control following excision...
  73. pmc Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing
    Rintaro Hashizume
    Brain Tumor Research Center, Department of Neurological Surgery, University ofCalifornia, San Diego, CA, USA
    Neuro Oncol 12:366-76. 2010
    ....
  74. doi Impact of bevacizumab chemotherapy on craniotomy wound healing
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California 94143 0112, USA
    J Neurosurg 114:1609-16. 2011
    ..Phase II trials reported 4%-6% impaired wound healing for bevacizumab initiated postoperatively. The effect of preoperative bevacizumab on subsequent craniotomy healing has not been addressed...
  75. pmc Asymmetry-defective oligodendrocyte progenitors are glioma precursors
    Sista Sugiarto
    Department of Neurological Surgery, University of California San Francisco, USA
    Cancer Cell 20:328-40. 2011
    ..Regulators of asymmetric cell division are misexpressed in low-grade oligodendrogliomas. Our results identify loss of asymmetric division associated with the neoplastic transformation of OPC...
  76. doi Surgical outcomes in choroid plexus papillomas: an institutional experience
    Michael Safaee
    Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, CA 94117, USA
    J Neurooncol 113:117-25. 2013
    ..This modern experience at a tertiary care center performed exclusively during the MRI-era demonstrates that CPPs can be safely removed with minimal morbidity and good tumor control...
  77. ncbi Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model
    Ryuta Saito
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94103, USA
    Cancer Res 64:6858-62. 2004
    ..However, the combination of these two treatments was significantly more effective than either treatment alone. CED of TRAIL in conjunction with systemic TMZ treatment is a promising strategy for the treatment of malignant gliomas...
  78. ncbi Diffusion-tensor imaging-guided tracking of fibers of the pyramidal tract combined with intraoperative cortical stimulation mapping in patients with gliomas
    Jeffrey I Berman
    Department of Radiology, University of California at San Francisco, California 94143 0946, USA
    J Neurosurg 101:66-72. 2004
    ..Subcortical localization of motor pathways in relation to a glioma may provide critical information to guide tumor resection and prevent surgical morbidity...
  79. pmc Patterns of recurrence analysis in newly diagnosed glioblastoma multiforme after three-dimensional conformal radiation therapy with respect to pre-radiation therapy magnetic resonance spectroscopic findings
    Ilwoo Park
    Surbeck Laboratory of Advanced Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Int J Radiat Oncol Biol Phys 69:381-9. 2007
    ....
  80. pmc Signal transduction molecules in gliomas of all grades
    Ralph P Ermoian
    Department of Radiation Oncology, The University of California, San Francisco, 1600 Divisadero St Suite H1031, San Francisco, CA, 94143 1708, USA
    J Neurooncol 91:19-26. 2009
    ..To address the multiple comparisons, first an overall analysis was done comparing the four groups using Spearman's Correlation Coefficient. Only if this analysis was statistically significant were individual pairwise comparisons done...
  81. pmc Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
    Michael D Prados
    University of California, San Francisco, CA 94143, USA
    J Clin Oncol 27:579-84. 2009
    ..The objectives were to determine efficacy of this treatment as measured by survival and to explore the relationship between molecular markers and treatment response...
  82. ncbi Pre-operative factors affecting resectability of giant intracranial meningiomas
    Alfredo Quinones-Hinojosa
    Johns Hopkins Hospital, Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21231, USA
    Can J Neurol Sci 36:623-30. 2009
    ..As a group, it remains largely unknown whether these relatively rare lesions are amenable to radical resection, and what factors influence their resectability...
  83. doi Assessment of morbidity following resection of cingulate gyrus gliomas. Clinical article
    Matthew C Tate
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    J Neurosurg 114:640-7. 2011
    ..The goal of the present study is to define the short- and long-term morbidity profile associated with resection of gliomas within this region...
  84. doi Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomas
    Aaron J Clark
    Department of Neurological Surgery, University of California, San Francisco, California, USA
    World Neurosurg 74:200-5. 2010
    ..Although benign, their highly vascular nature makes resection challenging. A major difficulty involves intraoperative differentiation of vessels supplying the tumor from those supplying the spinal cord...
  85. pmc Anatomic location is a risk factor for atypical and malignant meningiomas
    Ari J Kane
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer 117:1272-8. 2011
    ..Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location...
  86. doi An extent of resection threshold for newly diagnosed glioblastomas
    Nader Sanai
    Brain Tumor Research Center, University of California, San Francisco, California, USA
    J Neurosurg 115:3-8. 2011
    ..The authors attempt to define these values for the patient with newly diagnosed GBM in the modern neurosurgical era...
  87. pmc Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma
    Tracy R McKnight
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Magn Reson Imaging 33:808-16. 2011
    ..PC and glycerophosphocholine (GPC) are involved in phospholipid metabolism that accompanies mitosis. PC is the predominant peak in Grade 4 astrocytoma (GBM) while GPC dominates in AS2...
  88. doi Surgical resection and permanent iodine-125 brachytherapy for brain metastases
    Kim Huang
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, Room L 08, San Francisco, CA, 94143 0226, USA
    J Neurooncol 91:83-93. 2009
    ..To evaluate the efficacy and toxicity of surgical resection and permanent iodine-125 brachytherapy without adjuvant whole brain radiation therapy (WBRT) for brain metastases...
  89. pmc p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts
    Eduard B Dinca
    Brain Tumor Research Center, University of California San Francisco, San Francisco, California 94143, USA
    Cancer Res 68:10034-9. 2008
    ..In total, our results indicate that the p53 active and precursor inhibitor pair enhances TMZ cytotoxicity in vitro and in vivo, respectively, and do so in a p53-dependent manner...
  90. ncbi Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy
    Michael S Bobola
    Department of Neurological Surgery, University of Washington, 1959 N E Pacific Street, Seattle, WA 98195 6470, USA
    Clin Cancer Res 10:7875-83. 2004
    ..Clin Cancer Res 2002;8:3008.). Here we examine the association of glioma Ap endo activity with clinical response after alkylating agent-based chemotherapy or after radiotherapy...
  91. ncbi Preoperative correlation of intraoperative cortical mapping with magnetic resonance imaging landmarks to predict localization of the Broca area
    Alfredo Quinones-Hinojosa
    Department of Neurosurgery, The Brain Tumor Research Center, University of California at San Francisco, California 94143 0112, USA
    J Neurosurg 99:311-8. 2003
    ..These landmarks demonstrate novel structural-functional relationships that can be used preoperatively to predict the location of the Broca area...
  92. ncbi Invasive phenotype observed in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant sublines of 9L rat glioma cells: a tumor model mimicking a recurrent malignant glioma
    Ryuta Saito
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, California 94103, USA
    J Neurosurg 101:826-31. 2004
    ..The authors investigated phenotypical changes in invasion observed in 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-resistant sublines of the 9L rat gliosarcoma...
  93. ncbi Patterns of care for adults with newly diagnosed malignant glioma
    Susan M Chang
    Department of Neurological Surgery, University of California, San Francisco, CA 94143 0350, USA
    JAMA 293:557-64. 2005
    ..Patients with malignant glioma (grade III or IV) face a poor prognosis, and few evidence-based treatment guidelines are available. There is a dearth of prospective data on patterns of care for these patients...
  94. ncbi Prognostic significance of intracranial dissemination of glioblastoma multiforme in adults
    Andrew T Parsa
    Department of Neurological Surgery, School of Medicine, University of California at San Francisco, California 94143, USA
    J Neurosurg 102:622-8. 2005
    ..The objective in the present study was to assess the prognostic significance of disseminated intracranial GBM in adults at presentation and at the time of tumor progression...
  95. ncbi Neural stem cells and the origin of gliomas
    Nader Sanai
    Department of Neurological Surgery, Brain Tumor Research Center, and the Developmental Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
    N Engl J Med 353:811-22. 2005
  96. ncbi Biomarkers to predict response to epidermal growth factor receptor inhibitors
    Daphne A Haas-Kogan
    Department of Radiation Oncology, University of California San Francisco, USA
    Cell Cycle 4:1369-72. 2005
    ..Ultimately the goal of these studies is to allow selection of patients who will preferentially respond to EGFR inhibitors...
  97. ncbi Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging
    Michal T Krauze
    Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
    Brain Res Brain Res Protoc 16:20-6. 2005
    ..Findings presented in this manuscript may allow for modeling of parameters used for direct delivery of therapeutics into various regions of the brain...
  98. ncbi Intracranial microenvironment reveals independent opposing functions of host alphaVbeta3 expression on glioma growth and angiogenesis
    Masayuki Kanamori
    Department of Neurological Surgery and The Brain Tumor Research Center, University of California, San Francisco, California 94115 0875, USA
    J Biol Chem 281:37256-64. 2006
    ..Appropriate management of these functions could lead to enhanced efficacy of anti-integrin based therapies for glioma...
  99. ncbi Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T
    Yan Li
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94720, USA
    Magn Reson Imaging 24:1295-302. 2006
    ..5 T with a quadrature head coil. This is expected to be critical for clinical applications of MRSI in patients with brain tumors because it can be used to either decrease acquisition time or improve spatial resolution...
  100. pmc Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
    John K Wiencke
    Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 9:271-9. 2007
    ....
  101. doi Functional outcome after language mapping for glioma resection
    Nader Sanai
    Department of Neurological Surgery and The Brain Tumor Research Center, University of California at San Francisco, San Francisco, CA 94143 0112, USA
    N Engl J Med 358:18-27. 2008
    ..Language sites in the cortex of the brain vary among patients. Language mapping while the patient is awake is an intraoperative technique designed to minimize language deficits associated with brain-tumor resection...