T Mark Beasley
Affiliation: University of Alabama at Birmingham
- Validity and power of missing data imputation for extreme sampling and terminal measures designs in mediation analysisRobert Makowsky
Department of Biostatistics, University of Alabama at Birmingham Birmingham, AL, USA
Front Genet 2:75. 2011..Yet, the use of extreme sampling designs and methods to handle the resultant missing data presents a viable research strategy...
- Rank-based inverse normal transformations are increasingly used, but are they merited?T Mark Beasley
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Ryals Public Health Building, Suite 327, Birmingham, AL, 35294, USA
Behav Genet 39:580-95. 2009..Rigorous research evaluating the utility of INTs seems warranted...
- Joint tests for quantitative trait loci in experimental crossesT Mark Beasley
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
Genet Sel Evol 36:601-19. 2004..Joint tests were generally more powerful for one-tailed selection under both backcross and F2 intercross situations. However, joint tests cannot be recommended for one-tailed selective genotyping if segregation distortion is suspected...
- Warfarin dosing in patients with impaired kidney functionNita A Limdi
Department of Neurology, University of Alabama at Birmingham, AL 35294 0021, USA
Am J Kidney Dis 56:823-31. 2010..Unfortunately, few data exist to guide dose adjustment in patients with decreased kidney function. Here, we determine the degree of warfarin dose reduction associated with kidney impairment and make recommendations for warfarin dosing...
- Body fat and racial genetic admixture are associated with aerobic fitness levels in a multiethnic pediatric populationAmanda L Willig
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 19:2222-7. 2011..01). In conclusion, aerobic fitness levels differ by percent body fat and genetic admixture irrespective of BMI classification, and such differences should be taken into account when evaluating outcomes of health interventions...
- VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-AmericansNita A Limdi
Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, Birmingham AL 35294 0021, USA
Pharmacogenomics 9:1445-58. 2008..However, the inadequate representation of African-Americans and the assessment of a few VKORC1 polymorphisms have hindered this effort...
- Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of childrenYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Hum Genomics 5:79-89. 2011..Importantly, we have implicated this region in the early development of diabetes-related phenotypes, and in the genetic aetiology of population differences in these phenotypes...
- Parental feeding practices and socioeconomic status are associated with child adiposity in a multi-ethnic sample of childrenMichelle Cardel
Department of Nutrition Sciences, Clinical Nutrition Research Center, University of Alabama at Birmingham, 1675 University Blvd, WEBB 415, Birmingham, AL 35294 3360, USA
Appetite 58:347-53. 2012..Thus, parental feeding practices differ across racial/ethnic groups and SES and may contribute to population differences in child adiposity...
- Empirical bayes method for incorporating data from multiple genome scansT Mark Beasley
Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
Hum Hered 60:36-42. 2005..This EB method for incorporating data from multiple studies into genome scan analyses seems promising...
- Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear modelDavid T Redden
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS Genet 2:e137. 2006....
- Intramyocellular lipid and insulin resistance: differential relationships in European and African AmericansKatherine H Ingram
Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
Obesity (Silver Spring) 19:1469-75. 2011..These results highlight ethnic differences in the determinants of insulin sensitivity and in the pathogenesis of the metabolic syndrome trait cluster...
- A proposed metric for assessing the measurement quality of individual microarraysKyoungmi Kim
Department of Biostatistics, University of Alabama, Birmingham, Alabama, USA
BMC Bioinformatics 7:35. 2006..In some cases this may be manifested as systematic spatial variation on the surface of microarray in which expression measurements within an individual array may vary as a function of geographic position on the array surface...
- Kidney function influences warfarin responsiveness and hemorrhagic complicationsNita A Limdi
Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 312, Birmingham, Alabama 35294 0021, USA
J Am Soc Nephrol 20:912-21. 2009..Diminished renal function may have implications for a larger proportion of warfarin users than previously estimated...
- New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random samplingHemant K Tiwari
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Genet Epidemiol 28:48-57. 2005..Both random sampling and extreme sampling schemes were investigated. A multinomial logistic joint test provides the highest overall power irrespective of sample size, allele frequency, heritability, and modes of inheritance...
- Association of African genetic admixture with resting metabolic rate and obesity among womenJose R Fernandez
Department of Nutrition Sciences and the Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Obes Res 11:904-11. 2003....
- Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populationsKrista Casazza
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
Am J Phys Anthropol 145:181-91. 2011..Interactive effects of genetic and non-genetic factors alter metabolic pathways and underlie some of the present population-based differences in fat storage...
- Canaries in the coal mine: a cross-species analysis of the plurality of obesity epidemicsYann C Klimentidis
Department of Biostatistics, University of Alabama, Birmingham, AL, USA
Proc Biol Sci 278:1626-32. 2011..g. viral pathogens, epigenetic factors). This finding may eventually enhance the discovery and fuller elucidation of other factors that have contributed to the recent rise in obesity rates...
- Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing biasDavid B Allison
Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, 35294 0022, USA
Am J Hum Genet 70:575-85. 2002..Finally, limitations of the MOM approach are noted, and we discuss some alternative procedures that may also reduce bias...
- Randomized controlled trial of chewing gum for weight lossJames M Shikany
Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 20:547-52. 2012..Analyses including completers only produced essentially the same results. We conclude that chewing gum on a regular schedule for 8 weeks did not facilitate weight loss in these overweight and obese adults...
- Associations among calcium intake, resting energy expenditure, and body fat in a multiethnic sample of childrenLynae J Hanks
Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
J Pediatr 157:473-8. 2010..The objective was to determine if calcium intake was associated with resting energy expenditure (REE) and body fat in children after accounting for ancestral genetic background...
- A pilot assessment of parental practices and attitudes regarding risk disclosure and clinical research involving children in Huntington disease familiesLeon S Dure
Department of Pediatrics, The University of Alabama at Birmingham School of Medicine, Alabama, USA
Genet Med 10:811-9. 2008..To characterize parental practices of informing children of risk for Huntington disease (HD), and to understand the attitudes of parents concerning childhood participation in HD research...
- Improving the power of sib pair quantitative trait loci detection by phenotype winsorizationJose R Fernandez
Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, 35294 3360, USA
Hum Hered 53:59-67. 2002..We evaluated the robustness and power of reducing the influence of subjects with extreme phenotypic values by Winsorizing non-normal distributions in three versions of Haseman-Elston regression-based methods of QTL linkage analysis...
- Influence of kidney function on risk of supratherapeutic international normalized ratio-related hemorrhage in warfarin users: a prospective cohort studyNita A Limdi
Neurology, University of Alabama at Birmingham, Birmingham, AL Electronic address
Am J Kidney Dis 65:701-9. 2015..We evaluated whether the interaction of INR and lower estimated glomerular filtration rate (eGFR) increases hemorrhage risk and whether patients with lower eGFRs experience slower anticoagulation reversal...
- Using genetic admixture to explain racial differences in insulin-related phenotypesBarbara A Gower
Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, Alabama 35294 3360, USA
Diabetes 52:1047-51. 2003....
- Comparison of linear weighting schemes for perfect match and mismatch gene expression levels from microarray dataT Mark Beasley
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Pharmacogenomics 5:197-205. 2005....
- Race-Specific Influence of CYP4F2 on Dose and Risk of Hemorrhage Among Warfarin UsersAditi Shendre
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama
Pharmacotherapy 36:263-72. 2016....
- Predictors of Thromboembolic Events in Patients with Ventricular Assist DeviceAmelia K Boehme
From the Department of Epidemiology, School of Public Health, Department of Neurology, School of Medicine, Division of Cardiovascular Diseases, Department of Medicine, Division of Cardiothoracic Surgery, Department of Surgery, and Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama
ASAIO J 61:640-7. 2015..This study details the increased risk of thromboembolism with early LDH elevation and the importance of maintaining time in therapeutic INR range. ..
- Common scientific and statistical errors in obesity researchBrandon J George
Office of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obesity (Silver Spring) 24:781-90. 2016..It is hoped that discussion of these errors can improve the quality of obesity research by helping researchers to implement proper statistical practice and to know when to seek the help of a statistician. ..
- Psychometric evaluation of an online and paper accidental bowel leakage questionnaire: The ICIQ-B questionnaireAlayne D Markland
Birmingham Atlanta Geriatric Research, Education, and Clinical Center, Birmingham Department of Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama
Neurourol Urodyn 36:166-170. 2017..To evaluate the psychometric properties of an online versus paper US-English version of the International Consultation on Incontinence Questionnaire-Bowel (ICIQ-B)...
- The effect of gender and respirator brand on the association of respirator fit with facial dimensionsR Kent Oestenstad
Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
J Occup Environ Hyg 4:923-30. 2007....
- Effectiveness evaluation of the N-O-T smoking cessation program for adolescentsConnie L Kohler
Department of Health Behavior, University of Alabama at Birmingham, 1530 3rd Avenue South, RPHB 227, Birmingham, AL 35294 0022, USA
Am J Health Behav 32:368-79. 2008..To evaluate the effectiveness of the Not-On-Tobacco Program...
- Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-AmericansNita A Limdi
University of Alabama at Birmingham, Department of Neurology, 1719 6th Avenue South, CIRC 312, Birmingham, AL 35294 0021, USA
Pharmacogenomics 9:511-26. 2008....
- Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpzBrandon F Keele
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nature 460:515-9. 2009..These findings challenge the prevailing view that all natural SIV infections are non-pathogenic and suggest that SIVcpz has a substantial negative impact on the health, reproduction and lifespan of chimpanzees in the wild...
- Effect of winsorization on power and type 1 error of variance components and related methods of QTL detectionSanjay Shete
Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Behav Genet 34:153-9. 2004..A robust version of the LRT that adjusts for sample kurtosis showed the best power for nonnormal data. Finally, phenotype winsorization of nonnormal data reduces the bias in estimation of the major gene variance component...
- Tympanometry in rhesus monkeys: effects of aging and caloric restrictionCynthia G Fowler
Department of Communicative Disorders, University of Wisconsin Madison, WI 53706, USA
Int J Audiol 47:209-14. 2008..These results parallel many findings in middle-ear function in aging humans. Longitudinal studies are planned...
- Attenuation of sarcopenia by dietary restriction in rhesus monkeysRicki J Colman
Wisconsin National Primate Research Center, University of Wisconsin Madison, 1220 Capitol Ct, Madison, WI 53715, USA
J Gerontol A Biol Sci Med Sci 63:556-9. 2008..Body weight-adjusted skeletal muscle mass declined somewhat in both groups but was far more rapid in the control group. We have shown that moderate, adult-onset DR can attenuate sarcopenia in a nonhuman primate model...