GREG BASHAW

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    G J Bashaw
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 155:1117-22. 2001
  2. pmc Signaling from axon guidance receptors
    Greg J Bashaw
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cold Spring Harb Perspect Biol 2:a001941. 2010
  3. ncbi request reprint Semaphorin directs axon traffic in the fly olfactory system
    Greg J Bashaw
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuron 53:157-9. 2007
  4. pmc The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline
    Hope A Coleman
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 137:2417-26. 2010
  5. ncbi request reprint Semaphorin signaling unplugged; a nervy AKAP cAMP(s) out on plexin
    Greg J Bashaw
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 42:363-6. 2004
  6. pmc Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion
    Hailan Hu
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:4613-8. 2005
  7. ncbi request reprint Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity
    Tanja A Godenschwege
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 22:3117-29. 2002
  8. ncbi request reprint Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:4325-34. 2007
  9. ncbi request reprint Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:3584-92. 2007
  10. ncbi request reprint Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline
    Xueping Fan
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuron 40:113-27. 2003

Research Grants

Collaborators

  • Rudiger Klein
  • E C Lai
  • RONALD DUBREUIL
  • H Hu
  • R K Murphey
  • David S Garbe
  • Juan Pablo Labrador
  • Hope A Coleman
  • Long Yang
  • Xueping Fan
  • Tanja A Godenschwege
  • Rebecca K Chance
  • Mike O'Donnell
  • Amlan Das
  • Shingo Yoshikawa
  • Randall D McKinnon
  • John B Thomas
  • David O'keefe
  • Huey Hing
  • Xiaoliang Shan
  • Julie H Simpson
  • Corey S Goodman

Detail Information

Publications14

  1. pmc A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion
    G J Bashaw
    Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 155:1117-22. 2001
    ..Surprisingly, evidence from genetic, biochemical, and cell culture experiments suggests that the promotion of axon attraction by GEF64C is dependent on the activation of Rho, but not Rac or Cdc42...
  2. pmc Signaling from axon guidance receptors
    Greg J Bashaw
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cold Spring Harb Perspect Biol 2:a001941. 2010
    ..Here, we review recent insights into how specific receptors for each of these guidance cues engage downstream regulators of the growth cone cytoskeleton to control axon guidance...
  3. ncbi request reprint Semaphorin directs axon traffic in the fly olfactory system
    Greg J Bashaw
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuron 53:157-9. 2007
    ..In this issue of Neuron, two beautiful studies in Drosophila by Lattemann et al. and Sweeney et al. show that Semaphorin repulsion regulates interactions between olfactory receptor neurons to help axons find their correct targets...
  4. pmc The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline
    Hope A Coleman
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 137:2417-26. 2010
    ..Finally, Kuz activity is required for Robo to recruit its downstream signaling partner, Son of sevenless (Sos). These observations support the model that Kuz-directed cleavage is important for Robo receptor activation...
  5. ncbi request reprint Semaphorin signaling unplugged; a nervy AKAP cAMP(s) out on plexin
    Greg J Bashaw
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 42:363-6. 2004
  6. pmc Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion
    Hailan Hu
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:4613-8. 2005
    ..Dosage-sensitive genetic interactions among CrGAP, Robo, and Rac support a model in which CrGAP transduces signals downstream of Robo receptor to regulate Rac-dependent cytoskeletal changes...
  7. ncbi request reprint Ectopic expression in the giant fiber system of Drosophila reveals distinct roles for roundabout (Robo), Robo2, and Robo3 in dendritic guidance and synaptic connectivity
    Tanja A Godenschwege
    Department of Biology, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Neurosci 22:3117-29. 2002
    ..We conclude that axon guidance, dendritic guidance, and synaptogenesis are separable processes and that the different Robo family members affect them distinctly...
  8. ncbi request reprint Cytoplasmic domain requirements for Frazzled-mediated attractive axon turning at the Drosophila midline
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, 1113 BRB2 3, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:4325-34. 2007
    ....
  9. ncbi request reprint Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:3584-92. 2007
    ..Our results are not consistent with the proposal based on genetic analysis in Drosophila that the sole function of Slit and Robo during midline guidance is to repress Netrin attraction...
  10. ncbi request reprint Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline
    Xueping Fan
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Neuron 40:113-27. 2003
    ..These results provide a direct physical link between the Robo receptor and an important cytoskeletal regulatory protein complex and suggest that Rac can function in both attractive and repulsive axon guidance...
  11. ncbi request reprint beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS
    David S Garbe
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Development 134:273-84. 2007
    ....
  12. ncbi request reprint The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila
    Juan Pablo Labrador
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Curr Biol 15:1413-9. 2005
    ..Our results support a functional link between the expression of distinct Netrin receptor combinations and the transcriptional control of dorsal motor-axon guidance...
  13. ncbi request reprint Son of sevenless directly links the Robo receptor to rac activation to control axon repulsion at the midline
    Long Yang
    Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Neuron 52:595-607. 2006
    ..These results provide in vivo evidence that the Ras and RhoGEF domains of Sos are separable signaling modules and support a model in which Robo recruits Sos to the membrane via Dock to activate Rac during midline repulsion...
  14. ncbi request reprint Axon guidance at the midline: from mutants to mechanisms
    David S Garbe
    Department of Neuroscience, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Crit Rev Biochem Mol Biol 39:319-41. 2004
    ..Here we review recent advances in understanding the regulation of midline axon guidance, with a particular emphasis on the contributions made from molecular genetic studies of invertebrate model systems...

Research Grants1

  1. Mechanisms of Slit-Roundabout Mediated Axon Repulsion
    GREG BASHAW; Fiscal Year: 2008
    ..abstract_text> ..