Lihua Bao

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice
    Lihua Bao
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:3601-7. 2002
  2. doi Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury
    Lihua Bao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 80:524-34. 2011
  3. pmc Complement factor H deficiency accelerates development of lupus nephritis
    Lihua Bao
    Section of Nephrology, The University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 22:285-95. 2011
  4. pmc Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis
    Lihua Bao
    The University of Chicago, Chicago, IL 60637, USA
    Immunology 128:e895-904. 2009
  5. pmc Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells
    Lihua Bao
    University of Chicago, Illinois, 60637, USA
    J Clin Invest 119:1264-74. 2009
  6. ncbi Complement in lupus nephritis: the good, the bad, and the unknown
    Lihua Bao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Semin Nephrol 27:69-80. 2007
  7. ncbi Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, IL 60637, USA
    Lab Invest 87:357-64. 2007
  8. ncbi C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, IL, USA
    Eur J Immunol 35:2496-506. 2005
  9. ncbi Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis
    Lihua Bao
    Section of Nephrology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 175:1947-55. 2005
  10. ncbi Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failure
    Lihua Bao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 18:811-22. 2007

Collaborators

Detail Information

Publications21

  1. ncbi Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice
    Lihua Bao
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 168:3601-7. 2002
    ..Thus, long-term complement inhibition reduces renal disease in MRL/lpr mice, which translates into improved survival. MRL/lpr mice in which complement is inhibited still have spontaneous mortality, yet this is not from renal disease...
  2. doi Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury
    Lihua Bao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 80:524-34. 2011
    ..Thus, blockade of C3a receptor signaling is a possible treatment to reduce renal inflammation and preserve renal function associated with complement activation...
  3. pmc Complement factor H deficiency accelerates development of lupus nephritis
    Lihua Bao
    Section of Nephrology, The University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 22:285-95. 2011
    ..This illustrates the critical role of complement regulation and metabolism of immune complexes in the pathogenesis of lupus nephritis...
  4. pmc Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis
    Lihua Bao
    The University of Chicago, Chicago, IL 60637, USA
    Immunology 128:e895-904. 2009
    ..Thus, our data indicate that mesangial cell Crry limits complement activation and subsequent neutrophil recruitment in the setting of local immune complex deposition...
  5. pmc Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells
    Lihua Bao
    University of Chicago, Illinois, 60637, USA
    J Clin Invest 119:1264-74. 2009
    ..These findings add to growing evidence that complement-derived signals shape T cell responses, since T cells that recognize sheep Abs bound to podocytes can lead to cellular injury and development of FSGS...
  6. ncbi Complement in lupus nephritis: the good, the bad, and the unknown
    Lihua Bao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Semin Nephrol 27:69-80. 2007
    ..Although these and others earlier in their clinical development hold promise to be used therapeutically in lupus nephritis, this optimism must be tempered by the fact that the clinical trials to prove this remain fraught with obstacles...
  7. ncbi Decay-accelerating factor but not CD59 limits experimental immune-complex glomerulonephritis
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, IL 60637, USA
    Lab Invest 87:357-64. 2007
    ..Our findings suggest that activation of C3 is strongly associated with experimental ICGN while downstream formation of C5b-9 is of lesser pathogenic importance in this model...
  8. ncbi C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, IL, USA
    Eur J Immunol 35:2496-506. 2005
    ..These data support an important role for the C5a anaphylatoxin in lupus nephritis, and that blockade of C5aR represents a potentially viable treatment for human lupus nephritis...
  9. ncbi Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis
    Lihua Bao
    Section of Nephrology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 175:1947-55. 2005
    ..These data illustrate that C3aR is relevant in experimental lupus nephritis and may be a target for therapeutic intervention in the human disease...
  10. ncbi Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failure
    Lihua Bao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, MC5100, Chicago, IL 60637, USA
    J Am Soc Nephrol 18:811-22. 2007
    ....
  11. ncbi Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice
    Lihua Bao
    Section of Nephrology, The University of Chicago, Illinois 60637, USA
    J Am Soc Nephrol 14:670-9. 2003
    ..Thus, inhibition of complement activation with Crry-Ig significantly reduces renal disease in MRL/lpr lupus mice. The data support the strategy of using recombinant complement C3 inhibitors to treat human lupus nephritis...
  12. pmc Renal FcRn reclaims albumin but facilitates elimination of IgG
    Menaka Sarav
    Section of Nephrology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Am Soc Nephrol 20:1941-52. 2009
    ..7 h). Taken together, these data suggest that renal FcRn reclaims albumin, thereby maintaining the serum concentration of albumin, but facilitates the loss of IgG from plasma protein pools...
  13. ncbi Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis
    Jessy J Alexander
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, IL 60637, USA
    Biochim Biophys Acta 1639:169-76. 2003
    ..It is conceivable that increased AQ4 expression results in cerebral edema and hence complement inhibition may provide a new therapeutic option in inflammatory cerebral disorders such as lupus cerebritis...
  14. ncbi Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis
    Jessy J Alexander
    Section of Nephrology, Department of Medicine, University of Chicago, IL 60637, USA
    J Immunol 175:8312-9. 2005
    ..These findings present the exciting possibility that complement inhibition is a therapeutic option for lupus cerebritis...
  15. ncbi Injury in renal ischemia-reperfusion is independent from immunoglobulins and T lymphocytes
    Pierce Park
    Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Renal Physiol 282:F352-7. 2002
    ..Thus Igs and mature T lymphocytes do not appear to play a significant role in the pathogenesis of IRI in the kidney...
  16. ncbi Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes
    Lihua Bao
    Section of Nephrology, The University of Chicago, Chicago, Illinois 60637, USA
    Kidney Int 62:2010-21. 2002
    ..DAF is present in human glomeruli and on cultured human glomerular visceral epithelial cells (GEC). We studied the distribution and function of rat DAF...
  17. ncbi Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation
    Lihua Bao
    Section of Nephrology, University of Chicago, Chicago, Illinois 60637, USA
    J Am Soc Nephrol 14:2516-25. 2003
    ..Thus, complement inhibition with Crry has a prominent effect on matrix-related genes and proteins, which translates into improvement in functional renal disease...
  18. ncbi Prominent renal expression of a murine leukemia retrovirus in experimental systemic lupus erythematosus
    Jessy J Alexander
    Section of Nephrology, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Am Soc Nephrol 13:2869-77. 2002
    ..The remarkable upregulation of the EDV transcript only in the setting of active disease suggests this transcript is involved in inflammatory disease...
  19. pmc Pirfenidone suppressed the development of glomerulosclerosis in the FGS/Kist mouse
    Ho Sun Park
    Department of Microbiology, College of Medicine, Yeungnam University, Daegu, Korea
    J Korean Med Sci 18:527-33. 2003
    ..These results suggested that long-term administration of PFD suppressed the progression of glomerulosclerosis and improved renal function of the FGS/Kist mice...
  20. ncbi CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE
    Susan A Boackle
    Department of Medicine and Immunology, Division of Rheumatology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Autoimmunity 37:111-23. 2004
    ..Together these data support the concept that alterations in CR1/CR2 expression or function affect the regulation of autoantibody production and/or clearance and may have clinical consequences...
  21. ncbi Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis
    Anja S Mühlfeld
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 65:1214-23. 2004
    ....