P Baluk

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airways
    P Baluk
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Pathol 152:1463-76. 1998
  2. pmc Neurogenic plasma leakage in mouse airways
    P Baluk
    Cardiovascular Research Institute, Department of Anatomy, University of California, San Francisco 94143 0130, USA
    Br J Pharmacol 126:522-8. 1999
  3. ncbi request reprint Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004
  4. pmc Angiogenesis in mice with chronic airway inflammation: strain-dependent differences
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
    Am J Pathol 153:1099-112. 1998
  5. ncbi request reprint Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P
    M L Kwan
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Am J Physiol Lung Cell Mol Physiol 280:L286-97. 2001
  6. pmc Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Clin Invest 101:1401-13. 1998
  7. ncbi request reprint Glucocorticoid-induced apoptosis of dendritic cells in the rat tracheal mucosa
    J J Brokaw
    Department of Anatomy, Indiana University School of Medicine, Evansville, Indiana, USA
    Am J Respir Cell Mol Biol 19:598-605. 1998
  8. ncbi request reprint Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation
    P Baluk
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130
    J Comp Neurol 319:586-98. 1992
  9. pmc Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice
    P J Wolters
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0911, USA
    Clin Exp Allergy 35:82-8. 2005
  10. doi request reprint Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008

Collaborators

Detail Information

Publications30

  1. pmc Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airways
    P Baluk
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Pathol 152:1463-76. 1998
    ..We conclude that endothelial gaps contribute to both early and late phases of plasma leakage induced by antigen, but most leakage occurs upstream to sites of leukocyte adhesion...
  2. pmc Neurogenic plasma leakage in mouse airways
    P Baluk
    Cardiovascular Research Institute, Department of Anatomy, University of California, San Francisco 94143 0130, USA
    Br J Pharmacol 126:522-8. 1999
    ..Neurogenic inflammation does not involve the pulmonary microvasculature...
  3. ncbi request reprint Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004
    ..We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. pulmonis-induced chronic airway inflammation...
  4. pmc Angiogenesis in mice with chronic airway inflammation: strain-dependent differences
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
    Am J Pathol 153:1099-112. 1998
    ..Endothelial cells proliferate in both cases, but in one case new capillaries form whereas in the other capillaries convert to venules...
  5. ncbi request reprint Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P
    M L Kwan
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Am J Physiol Lung Cell Mol Physiol 280:L286-97. 2001
    ..This leakage is accompanied by an abnormal sensitivity to substance P but not to platelet-activating factor or 5-hydroxytryptamine and can be reduced by beta2-agonists...
  6. pmc Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Clin Invest 101:1401-13. 1998
    ..This preferential uptake raises the possibility of using cationic liposomes to target diagnostic or therapeutic agents selectively to angiogenic blood vessels in tumors and sites of chronic inflammation...
  7. ncbi request reprint Glucocorticoid-induced apoptosis of dendritic cells in the rat tracheal mucosa
    J J Brokaw
    Department of Anatomy, Indiana University School of Medicine, Evansville, Indiana, USA
    Am J Respir Cell Mol Biol 19:598-605. 1998
    ..The location of TUNEL+ bodies closely corresponded to that of Ia+ cells stained in adjacent histologic sections. We conclude that apoptosis contributes to the rapid decrease in airway dendritic cells after glucocorticoid treatment...
  8. ncbi request reprint Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation
    P Baluk
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130
    J Comp Neurol 319:586-98. 1992
    ..Therefore, the mechanism by which sensory axons evoke plasma extravasation from these venules is likely to involve the diffusion of the peptide or a secondary mediator from the epithelium or from the arterioles upstream...
  9. pmc Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice
    P J Wolters
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0911, USA
    Clin Exp Allergy 35:82-8. 2005
    ..However, because they are compound heterozygotes in a mixed genetic background and are infertile, they cannot be crossed easily with other mice...
  10. doi request reprint Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
    ..Other markers, including CD31, junctional proteins, and receptors, such as VEGF-2, are shared by lymphatic and blood vessels...
  11. ncbi request reprint Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection
    Arin B Aurora
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 175:6319-26. 2005
    ..The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology...
  12. ncbi request reprint Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Chest 128:602S-608S. 2005
  13. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases...
  14. ncbi request reprint In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin
    Kyung Eun Kim
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Arterioscler Thromb Vasc Biol 27:564-70. 2007
    ..We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature with that during wound healing...
  15. pmc Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    Tetsuichiro Inai
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 165:35-52. 2004
    ..Early loss of endothelial fenestrations in RIP-Tag2 tumors is a clue that vessel phenotype may be predictive of exceptional sensitivity to these inhibitors...
  16. ncbi request reprint Significance of blood vessel leakiness in cancer
    Donald M McDonald
    Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Res 62:5381-5. 2002
    ..New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding...
  17. ncbi request reprint The biologic basis of in vivo angiogenesis imaging
    Iclal Ocak
    Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
    Front Biosci 12:3601-16. 2007
    ..Serial analysis of gene expression or in vivo phage display may help identify new, more selective, markers that can be utilized for the targeted imaging and treatment of angiogenesis...
  18. pmc Functionally specialized junctions between endothelial cells of lymphatic vessels
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2349-62. 2007
    ..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
  19. pmc Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401 B, New Haven, CT 06520 8057, USA
    Proc Natl Acad Sci U S A 103:11021-6. 2006
    ..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling...
  20. pmc Disease-specific gene expression profiling in multiple models of lung disease
    Christina C Lewis
    Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
    Am J Respir Crit Care Med 177:376-87. 2008
    ..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis...
  21. pmc Mast cells protect mice from Mycoplasma pneumonia
    Xiang Xu
    Pulmonary and Critical Care Medicine, Mailstop 111 D, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121
    Am J Respir Crit Care Med 173:219-25. 2006
    ..Mice infected with Mycoplasma pulmonis can develop localized, life-long airway infection accompanied by persistent inflammation and remodeling...
  22. pmc Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors
    Patricia Parsons-Wingerter
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Pathol 167:193-211. 2005
    ..This strategy of injecting antibodies revealed the uniform overexpression and rapid accessibility of alpha5beta1 integrin on tumor vessels and may prove useful in assessing other potential therapeutic targets in cancer...
  23. ncbi request reprint Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Circ Res 97:86-94. 2005
    ..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow...
  24. ncbi request reprint Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels
    Anette Magnussen
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
    Cancer Res 65:2712-21. 2005
    ..Together, these findings indicate that the rapid accessibility of alpha(5)beta(1) integrin in RIP-Tag2 tumors results from overexpression of the integrin on the luminal surface of tumor vessels...
  25. ncbi request reprint Cellular abnormalities of blood vessels as targets in cancer
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Curr Opin Genet Dev 15:102-11. 2005
    ..Rapid vascular regrowth reflects the ongoing drive for angiogenesis and bizarre microenvironment in tumors that promote vascular abnormalities and thereby create therapeutic targets...
  26. pmc Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    Shunichi Morikawa
    Department of Anatomy and Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California 94143 0130, USA
    Am J Pathol 160:985-1000. 2002
    ..The association of pericytes with endothelial sprouts raises the possibility of an involvement in sprout growth or retraction in tumors...
  27. pmc Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143 0130, USA
    Am J Pathol 165:1071-85. 2004
    ..Blood vessels can respond to VEGF by sprouting angiogenesis within a few days, but regress more slowly after VEGF withdrawal, and leave a historical record of their previous extent in the form of empty basement membrane sleeves...
  28. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    ..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders...
  29. pmc Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 163:1801-15. 2003
    ..These findings indicate that basement membrane covers most tumor vessels but has profound structural abnormalities, consistent with the dynamic nature of endothelial cells and pericytes in tumors...
  30. ncbi request reprint Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung
    Cecile J Favre
    Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 285:H1917-38. 2003
    ..This approach can readily be used to profile genes expressed in blood vessels in tumors, chronic inflammation, and other sites in which endothelial cells avidly take up cationic liposomes...