Affiliation: University of California
- Distribution and surfactant association of carcinoembryonic cell adhesion molecule 6 in human lungCheryl Chapin
Department of Pediatrics, University of California San Francisco, San Francisco, California, USA
Am J Physiol Lung Cell Mol Physiol 302:L216-25. 2012..Production appears to be upregulated during neonatal lung disease, perhaps related to roles of CEACAM6 in surfactant function, cell proliferation, and innate immune defense...
- Regulated gene expression in cultured type II cells of adult human lungPhilip L Ballard
Department of Pediatrics, University of California San Francisco, San Francisco, USA
Am J Physiol Lung Cell Mol Physiol 299:L36-50. 2010..Our results further define the adult human type II cell molecular phenotype and demonstrate that a subset of genes remains hormone responsive in cultured adult cells...
- Plasma biomarkers of oxidative stress: relationship to lung disease and inhaled nitric oxide therapy in premature infantsPhilip L Ballard
Department of Pediatrics, University of California, San Francisco, California 94118, USA
Pediatrics 121:555-61. 2008..However, there has been no information regarding possible effects of this therapy on oxidative stress. We hypothesized that inhaled nitric oxide therapy would not influence concentrations of plasma biomarkers of oxidative stress...
- Surfactant function and composition in premature infants treated with inhaled nitric oxidePhilip L Ballard
Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94118, USA
Pediatrics 120:346-53. 2007..We hypothesized that inhaled nitric oxide treatment of premature infants at risk for bronchopulmonary dysplasia would not adversely affect endogenous surfactant function or composition...
- Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthmaNathan Rabinovitch
Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
J Allergy Clin Immunol 126:545-51.e1-4. 2010..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
- Differentiation of human pulmonary type II cells in vitro by glucocorticoid plus cAMPLinda W Gonzales
Division of Neonatology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
Am J Physiol Lung Cell Mol Physiol 283:L940-51. 2002....
- Inflammatory markers and mediators in tracheal fluid of premature infants treated with inhaled nitric oxideWilliam E Truog
Department of Pediatrics, Section of Neonatology, Children s Mercy Hospitals and Clinics, University of Missouri Kansas City School of Medicine, 2401 Gillham Rd, Kansas City, MO 64108, USA
Pediatrics 119:670-8. 2007..We investigated relationships between respiratory severity scores and airway concentrations of inflammatory markers/mediators...
- Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiationTheresa M McDevitt
Division of Neonatology, Department of Pediatrics, University of California San Francisco, 3333 California St, Suite 150, San Francisco, CA 94118 1981, USA
Am J Physiol Lung Cell Mol Physiol 292:L249-57. 2007..Surfactant production during fetal development is likely influenced by relative levels of TGF-beta and glucocorticoids...
- Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell proteinVenkatadri Kolla
Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Physiol Lung Cell Mol Physiol 296:L1019-30. 2009..Because CEACAM6 acts as an antiapoptotic factor and stabilizes surfactant function, in addition to a putative role in innate defense against bacteria, we propose that it is a multifunctional alveolar protein...
- Gene induction during differentiation of human pulmonary type II cells in vitroKelly C Wade
Department of Pediatrics, Division of Neonatology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Respir Cell Mol Biol 34:727-37. 2006..Hormone-induced differentiation of human type II cells is associated with genome-wide increased expression of genes with diverse functions...
- Thyroid transcription factor in differentiating type II cells: regulation, isoforms, and target genesVenkatadri Kolla
Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
Am J Respir Cell Mol Biol 36:213-25. 2007..In addition, knockdown of TTF-1 inhibited 72 of 274 other genes induced by hormones. We conclude that 42-kD TTF-1 is required for induction of a subset of regulated genes during type II cell differentiation...
- Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxidePhilip L Ballard
Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA
Pediatr Res 59:157-62. 2006..NO treatment improves the apparent ability of hydrophobic SP to promote low surface tension, perhaps secondary to less protein inactivation of surfactant, and improves lung volume by a process unrelated to surfactant function...
- One-year respiratory outcomes of preterm infants enrolled in the Nitric Oxide (to prevent) Chronic Lung Disease trialAnna Maria Hibbs
Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106 6010, USA
J Pediatr 153:525-9. 2008..To identify whether inhaled nitric oxide treatment decreased indicators of long-term pulmonary morbidities after discharge from the neonatal intensive care unit...
- Expression of nitric oxide synthases and endogenous NO metabolism in bronchopulmonary dysplasiaChristiana W Davis
Department of Pediatrics, Division of Neonatology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
Pediatr Pulmonol 43:703-9. 2008..This study demonstrates a strong correlation between products of NO reactivity and NOS localization in BPD...
- Low levels of tissue inhibitors of metalloproteinases with a high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio are present in tracheal aspirate fluids of infants who develop chronic lung diseaseIkechukwu I Ekekezie
Children s Mercy Hospitals and Clinics, University of Missouri Kansas City, School of Medicine, Department of Pediatrics, Section of Neonatal Perinatal Medicine, Kansas City, Missouri, USA
Pediatrics 113:1709-14. 2004....
- Multiple courses of antenatal corticosteroids are associated with early severe lung disease in preterm neonatesBeverly A Banks
Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Division of Neonatology, Philadelphia, PA 19104, USA
J Perinatol 22:101-7. 2002....
- Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezingKatherine Rivera-Spoljaric
Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
J Pediatr 154:877-81.e4. 2009..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...
- Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasiaDonald C McCurnin
Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Am J Respir Crit Care Med 179:492-500. 2009..Fetal estradiol levels increase during late gestation and estradiol up-regulates NOS, suggesting that after preterm birth estradiol deprivation causes attenuated lung NOS resulting in impaired pulmonary function...
- Dysfunction of pulmonary surfactant in chronically ventilated premature infantsJeffrey D Merrill
Neonatology, Department of Pediatrics, University of Pennsylvania School of Medicine, USA
Pediatr Res 56:918-26. 2004..We conclude that most premature infants requiring continued respiratory support after 7 d of age experience transient episodes of dysfunctional surfactant that are associated with a deficiency of SP-B and SP-C...
- Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apneaGerard T Berry
Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:18297-302. 2003..This model demonstrates the critical importance of SMIT1 in the developing nervous system. The high affinity SMIT1 transporter is responsible for the Ins concentration gradient in the murine fetal-placental unit...
- HTII-280, a biomarker specific to the apical plasma membrane of human lung alveolar type II cellsRobert F Gonzalez
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94118, USA
J Histochem Cytochem 58:891-901. 2010..HTII-280 is likely to be a useful morphological and biochemical marker of human TII cells that may help to advance our understanding of various lung pathological conditions, including the origin and development of various lung tumors...
- Surfactant protein profile of pulmonary surfactant in premature infantsPhilip L Ballard
Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Respir Crit Care Med 168:1123-8. 2003..Despite continuing lung disease, some infants who are more than 1 week of age have surfactant with normal in vitro function that contains SPs at levels comparable to adult surfactant...
- Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factorsChanggong Li
Department of Pediatrics, Women s and Children s Hospital, University of Southern California School of Medicine, Los Angeles, California 90033, USA
J Biol Chem 277:38399-408. 2002..1 was not affected. We conclude that SMAD3 interactions with the positive regulators NKX2.1 and HNF-3 underlie the molecular basis for TGF-beta-induced repression of Sp-B gene transcription...
- Regulation and role of CEACAM6 in the lung alveolusPhilip L Ballard; Fiscal Year: 2011..The studies of this project will examine expression and function of the protein in normal lung and its role in response to lung injury and infection. ..