Anthony Azakie

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Anatomic repair of anomalous left coronary artery from the pulmonary artery by aortic reimplantation: early survival, patterns of ventricular recovery and late outcome
    Anthony Azakie
    Department of Surgery, Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Ann Thorac Surg 75:1535-41. 2003
  2. ncbi request reprint Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo
    Anthony Azakie
    Department of Surgery, Univ of California, San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Heart Circ Physiol 291:H600-11. 2006
  3. ncbi request reprint Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo
    Anthony Azakie
    University of California, San Francisco, Department of Surgery, San Francisco, Calif 94143, USA
    J Thorac Cardiovasc Surg 132:1262-71. 2006
  4. ncbi request reprint Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs
    Peter Oishi
    Department of Pediatrics, University of California, San Francisco, 505 Parnassus Avenue, Box 0106, San Francisco, CA 94143 0106, USA
    Pediatr Pulmonol 42:1057-71. 2007
  5. ncbi request reprint B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery
    Omar Chikovani
    Department of Pediatrics, University of California, San Francisco, Calif 94143 0106, USA
    J Thorac Cardiovasc Surg 134:1179-87. 2007
  6. ncbi request reprint Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs
    Peter Oishi
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143 0106, USA
    Am J Physiol Heart Circ Physiol 290:H1922-32. 2006
  7. ncbi request reprint Pulmonary valve cusp augmentation with autologous pericardium may improve early outcome for tetralogy of Fallot
    Petros Anagnostopoulos
    Division of Pediatric Cardiac Surgery, Pediatric Heart Center, University of California at San Francisco Children s Hospital, San Francisco, Calif, USA
    J Thorac Cardiovasc Surg 133:640-7. 2007
  8. ncbi request reprint Anomalous coronary artery from the wrong sinus of Valsalva: a physiologic repair strategy
    Nelson Alphonso
    Pediatric Heart Center, UCSF Children s Hospital, University of California San Francisco, San Francisco, California 94143, USA
    Ann Thorac Surg 83:1472-6. 2007
  9. pmc Early results of the "clamp and sew" Fontan procedure without the use of circulatory support
    Takeshi Shinkawa
    Division of Pediatric Cardiothoracic Surgery, Department of Surgery, UCSF Benioff Children s Hospital, University of California, San Francisco, California 94143 0117, USA
    Ann Thorac Surg 91:1453-9. 2011
  10. doi request reprint Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection
    Jong Hau Hsu
    Department of Pediatrics, University of California, San Francisco, Calif 94143, USA
    J Thorac Cardiovasc Surg 135:746-53. 2008

Research Grants

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Anatomic repair of anomalous left coronary artery from the pulmonary artery by aortic reimplantation: early survival, patterns of ventricular recovery and late outcome
    Anthony Azakie
    Department of Surgery, Division of Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Ann Thorac Surg 75:1535-41. 2003
    ..To determine the early and late outcomes of patients presenting with anomalous left coronary artery from the pulmonary artery who had repair by aortic reimplantation...
  2. ncbi request reprint Sp3 inhibits Sp1-mediated activation of the cardiac troponin T promoter and is downregulated during pathological cardiac hypertrophy in vivo
    Anthony Azakie
    Department of Surgery, Univ of California, San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Heart Circ Physiol 291:H600-11. 2006
    ..This observation is consistent with the in vitro activating function of Sp1 and inhibitory effects of Sp3 on activity of cTnT promoter constructs. Sp factor levels are modulated during the hypertrophic cardiac program in vivo...
  3. ncbi request reprint Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo
    Anthony Azakie
    University of California, San Francisco, Department of Surgery, San Francisco, Calif 94143, USA
    J Thorac Cardiovasc Surg 132:1262-71. 2006
    ..The cardiac troponin T promoter is used as a model gene...
  4. ncbi request reprint Alterations in cGMP, soluble guanylate cyclase, phosphodiesterase 5, and B-type natriuretic peptide induced by chronic increased pulmonary blood flow in lambs
    Peter Oishi
    Department of Pediatrics, University of California, San Francisco, 505 Parnassus Avenue, Box 0106, San Francisco, CA 94143 0106, USA
    Pediatr Pulmonol 42:1057-71. 2007
    ....
  5. ncbi request reprint B-type natriuretic peptide levels predict outcomes for children on extracorporeal life support after cardiac surgery
    Omar Chikovani
    Department of Pediatrics, University of California, San Francisco, Calif 94143 0106, USA
    J Thorac Cardiovasc Surg 134:1179-87. 2007
    ..The objective of this study was to investigate potential associations between changes in B-type natriuretic peptide during trials off extracorporeal life support and clinical outcome...
  6. ncbi request reprint Nitric oxide-endothelin-1 interactions after surgically induced acute increases in pulmonary blood flow in intact lambs
    Peter Oishi
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143 0106, USA
    Am J Physiol Heart Circ Physiol 290:H1922-32. 2006
    ..Thus NO appears to be important in maintaining a reduction in PVR after acutely increased PBF...
  7. ncbi request reprint Pulmonary valve cusp augmentation with autologous pericardium may improve early outcome for tetralogy of Fallot
    Petros Anagnostopoulos
    Division of Pediatric Cardiac Surgery, Pediatric Heart Center, University of California at San Francisco Children s Hospital, San Francisco, Calif, USA
    J Thorac Cardiovasc Surg 133:640-7. 2007
    ..We hypothesized that pulmonary valve cusp augmentation with pericardium would decrease pulmonary insufficiency and improve the early outcome for transatrial-transpulmonary tetralogy of Fallot repair requiring transannular patch...
  8. ncbi request reprint Anomalous coronary artery from the wrong sinus of Valsalva: a physiologic repair strategy
    Nelson Alphonso
    Pediatric Heart Center, UCSF Children s Hospital, University of California San Francisco, San Francisco, California 94143, USA
    Ann Thorac Surg 83:1472-6. 2007
    ..A coronary artery arising from the wrong aortic sinus, with or without a proximal course between the aorta and the pulmonary artery, may predispose to myocardial ischemia, myocardial infarction, or sudden death...
  9. pmc Early results of the "clamp and sew" Fontan procedure without the use of circulatory support
    Takeshi Shinkawa
    Division of Pediatric Cardiothoracic Surgery, Department of Surgery, UCSF Benioff Children s Hospital, University of California, San Francisco, California 94143 0117, USA
    Ann Thorac Surg 91:1453-9. 2011
    ..The objective of this study is to assess the outcomes of this novel off-pump "clamp and sew" Fontan procedure...
  10. doi request reprint Perioperative B-type natriuretic peptide levels predict outcome after bidirectional cavopulmonary anastomosis and total cavopulmonary connection
    Jong Hau Hsu
    Department of Pediatrics, University of California, San Francisco, Calif 94143, USA
    J Thorac Cardiovasc Surg 135:746-53. 2008
    ....
  11. doi request reprint Differential responses of the right ventricle to abnormal loading conditions in vivo: possible pathophysiologic mechanisms
    Anthony Azakie
    Department of Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    J Thorac Cardiovasc Surg 145:1335-44. 2013
    ..The purpose of this study is to elucidate possible transcriptional mechanisms of the RV response to pressure versus volume loading in vivo...
  12. doi request reprint Size of the right ventricle-to-pulmonary artery conduit impacts mid-term outcome after the Norwood procedure in patients weighing less than 3 kg
    Naruhito Watanabe
    Division of Pediatric Cardiothoracic Surgery, University of California San Francisco, San Francisco, CA, USA
    J Thorac Cardiovasc Surg 144:1091-4. 2012
    ..The optimal shunt size for patients who have the Norwood operation with a right ventricle-to-pulmonary artery conduit is controversial. The goal of this study is to compare outcomes of 2 shunt sizes in this population...
  13. pmc Preoperative B-type natriuretic peptide levels are associated with outcome after total cavopulmonary connection (Fontan)
    Monique Radman
    Department of Pediatrics, University of California, San Francisco, Calif Cardiovascular Research Institute, University of California, San Francisco, Calif
    J Thorac Cardiovasc Surg 148:212-9. 2014
    ..Although outcomes have improved, there remains an unpredictable risk of early total cavopulmonary connection takedown. The prediction of adverse postoperative outcomes is imprecise, despite an extensive preoperative evaluation...
  14. pmc Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow
    Peter E Oishi
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA
    Pediatr Res 73:54-61. 2013
    ..Pulmonary vascular function is impaired with increased pulmonary blood flow (PBF). We hypothesized that a peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist would mitigate this effect...
  15. ncbi request reprint Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter
    Anthony Azakie
    Department of Surgery, Univ of California San Francisco, San Francisco, CA 94143, USA
    Am J Physiol Cell Physiol 289:C1522-34. 2005
    ....
  16. ncbi request reprint B-type natriuretic peptide levels predict outcome after neonatal cardiac surgery
    Jong Hau Hsu
    Department of Pediatrics, University of California, San Francisco, Calif, USA
    J Thorac Cardiovasc Surg 134:939-45. 2007
    ..Therefore, the objective of this study was to determine the predictive value of perioperative B-type natriuretic peptide levels for postoperative outcomes in neonates undergoing cardiac surgery...
  17. ncbi request reprint Abnormal brain development in newborns with congenital heart disease
    Steven P Miller
    Department of Neurology, University of California at San Francisco, San Francisco, USA
    N Engl J Med 357:1928-38. 2007
    ..We characterized brain metabolism and microstructure, as measures of brain maturation, in newborns with congenital heart disease before they underwent heart surgery...
  18. ncbi request reprint The Lecompte maneuver for relief of airway compression in absent pulmonary valve syndrome
    Lars Nolke
    Pediatric Heart Center, UCSF Children s Hospital, San Francisco, California, USA
    Ann Thorac Surg 81:1802-7. 2006
    ..Surgical mortality rates as high as 16% to 56% have been reported. Here, we describe the surgical results using the Lecompte maneuver, reduction pulmonary arterioplasty, and a valved right ventricle to pulmonary artery (RV-PA) conduit...
  19. doi request reprint Surgical management of left ventricular outflow tract obstruction
    Petros V Anagnostopoulos
    Department of Surgery, University of California, San Francisco, San Francisco, California, USA
    J Card Surg 27:103-11. 2012
    ..Left ventricular outflow tract obstruction (LVOTO) is caused by a spectrum of lesions. This study was performed to determine the outcomes of surgical management of LVOTO...
  20. ncbi request reprint Neonatal mitral and tricuspid valve repair for in utero papillary muscle rupture
    Petros V Anagnostopoulos
    Pediatric Heart Center, University of California San Francisco Children s Hospital, San Francisco, California 94143, USA
    Ann Thorac Surg 83:1458-62. 2007
    ..We undertook surgical repair of this lesion in the neonatal period and report on our midterm results...
  21. pmc The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR)
    Monique Radman
    Pediatrics, University of California, San Francisco, Calif Cardiovascular Research Institute, University of California, San Francisco, Calif
    J Thorac Cardiovasc Surg 147:442-50. 2014
    ..The objective of this study was to determine the association between preoperative nutritional status and postoperative outcomes in children undergoing surgery for congenital heart defects (CHD)...
  22. ncbi request reprint Endothelial alterations during inhaled NO in lambs with pulmonary hypertension: implications for rebound hypertension
    Gregory A Ross
    Department of Pediatrics, University of California, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 288:L27-35. 2005
    ..These data suggest that the endothelial response to iNO and the potential mechanisms of rebound pulmonary hypertension are dependent upon the underlying pulmonary vasculature...
  23. ncbi request reprint Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects
    Patrick S McQuillen
    Pediatric Heart Center, University of California at San Francisco, San Francisco, CA, USA
    Stroke 38:736-41. 2007
    ..The purpose of this study is to define the risk factors for preoperative and postoperative brain injuries and their association with functional cardiac anatomic groups...
  24. pmc Stage II palliation of hypoplastic left heart syndrome without cardiopulmonary bypass
    Anthony Azakie
    UCSF Benioff Children s Hospital, Department of Surgery, University of California, San Francisco, CA 94143, USA
    J Thorac Cardiovasc Surg 141:400-6. 2011
    ..The purpose of this study is to determine the early outcomes for stage II palliation of hypoplastic left heart syndrome without cardiopulmonary bypass...
  25. doi request reprint Early outcomes of primary sutureless repair of the pulmonary veins
    Anthony Azakie
    UCSF Benioff Children s Hospital, Department of Surgery, University of California San Francisco, San Francisco, California 94143, USA
    Ann Thorac Surg 92:666-71; discussion 671-2. 2011
    ..The purpose of this study is to determine the early outcomes of primary sutureless repair of pulmonary venoocclusive disease in infants with congenital PV stenosis-hypoplasia or PVs at high risk for progressive stenosis...
  26. doi request reprint Prenatal diagnosis of hypoplastic left heart syndrome in current era
    Alaina K Kipps
    Department of Pediatrics, Division of Cardiology, University of California, San Francisco, Benioff Children s Hospital, USA
    Am J Cardiol 108:421-7. 2011
    ..Improved preoperative status was observed in the preDx patients; however, they were born earlier with a lower birthweight. What effect these factors might have on longer term morbidity remains unknown...
  27. ncbi request reprint Undiagnosed coronary fistula causing low cardiac output syndrome after pediatric heart surgery
    Nelson Alphonso
    Pediatric Heart Center, UCSF Children s Hospital, Division of Pediatric Cardiothoracic Surgery, 513 Parnassus Avenue, Suite S 549, Box 0117, San Francisco, CA 94143 0117, USA
    Eur J Cardiothorac Surg 30:397-9. 2006
    ..Following recovery, a fistulous connection between the right coronary artery and main pulmonary artery was demonstrated. Implications and management strategies of unsuspected coronary fistula in pediatric heart surgery are discussed...
  28. ncbi request reprint Increased pulmonary blood flow does not alter surfactant protein gene expression in lambs within the first week of life
    Jae W Lee
    Department of Anesthesiology, University of California, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1237-43. 2004
    ....
  29. doi request reprint Cardiac surgery in low birth weight infants: current outcomes
    Anthony Azakie
    UCSF Benioff Children s Hospital, San Francisco, CA, USA
    Interact Cardiovasc Thorac Surg 12:409-13, discussion 414. 2011
    ..Cardiac surgery in LBW infants can be performed with low early and mid-term mortality. LBW infants with chromosomal/genetic anomalies have a higher risk...
  30. pmc Single-ventricle anatomy predicts delayed microstructural brain development
    Viyeka Sethi
    Department of Pediatrics and Neurology, University of California, San Francisco Benioff Children s Hospital, San Francisco, California, USA
    Pediatr Res 73:661-7. 2013
    ....
  31. pmc Ross-Konno and endocardial fibroelastosis resection after hybrid stage I palliation in infancy: successful staged left-ventricular rehabilitation and conversion to biventricular circulation after fetal diagnosis of aortic stenosis
    Anita J Moon-Grady
    Pediatric Heart Center, UCSF Benioff Children s Hospital, University of California San Francisco, San Francisco, CA 94143 0117, USA
    Pediatr Cardiol 32:211-4. 2011
    ....
  32. pmc Prenatal diagnosis of atrial restriction in hypoplastic left heart syndrome is associated with decreased 2-year survival
    Alexander Lowenthal
    Division of Pediatric Cardiology, University of California, San Francisco, San Francisco, CA, USA
    Prenat Diagn 32:485-90. 2012
    ..To compare the course of hypoplastic left heart syndrome (HLHS) patients diagnosed prenatally with any degree of atrial restriction with those without evidence of atrial restriction...
  33. ncbi request reprint Regional and central venous oxygen saturation monitoring following pediatric cardiac surgery: concordance and association with clinical variables
    Patrick S McQuillen
    Pediatric Heart Center, University of California, San Francisco, USA
    Pediatr Crit Care Med 8:154-60. 2007
    ..To compare changes in regional cerebral or flank oxygen saturation measured by near-infrared spectroscopy with changes in central venous oxygen saturation (ScvO2) and to determine clinical variables associated with these changes...
  34. ncbi request reprint Alterations in plasma B-type natriuretic peptide levels after repair of congenital heart defects: a potential perioperative marker
    Chie Youn Shih
    Department of Pediatrics, University of California, San Francisco, Calif, USA
    J Thorac Cardiovasc Surg 131:632-8. 2006
    ....
  35. doi request reprint Course, predictors of diaphragm recovery after phrenic nerve injury during pediatric cardiac surgery
    Brendan M Smith
    Pediatric Division of Cardiology, University of California, San Francisco, San Francisco, California 94143, USA
    Ann Thorac Surg 96:938-42. 2013
    ..To describe return of function, we reviewed fluoroscopy and ultrasonography in all diagnosed cases of diaphragmatic paralysis...
  36. doi request reprint Aortic stenosis in a patient with Hurler's syndrome after bone marrow transplantation
    Naruhito Watanabe
    Department of Surgery, Division of Pediatric Cardiac Surgery, UCSF Benioff Children s Hospital, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cardiol Young 21:349-50. 2011
    ..This is the first case report of aortic valve replacement in a patient with Hurler's syndrome treated with bone marrow transplantation that demonstrates progression of the aortic valve disease despite treatment...
  37. ncbi request reprint Outcomes of mitral valve replacement in children: a competing-risks analysis
    Fatemeh Kojori
    Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    J Thorac Cardiovasc Surg 128:703-9. 2004
    ..We sought to define patient characteristics, outcomes, and associated factors after mitral valve replacement in children...
  38. pmc Performance of bovine pericardial valves in the pulmonary position
    Takeshi Shinkawa
    Division of Pediatric Cardiothoracic Surgery, Department of Surgery, University of California, San Francisco, San Francisco, California, USA
    Ann Thorac Surg 90:1295-300. 2010
    ..The purpose of this study is to determine the outcome and performance of bovine pericardial valves in the pulmonary position...
  39. pmc Pulmonary interstitial glycogenosis: an unrecognized etiology of persistent pulmonary hypertension of the newborn in congenital heart disease?
    Monique R Radman
    Department of Pediatrics, University of California, 513 Parnassus Avenue, Box 1346, San Francisco, CA 94143 1346, USA
    Pediatr Cardiol 34:1254-7. 2013
    ..Pulmonary interstitial glycogenosis (PIG) arises from a developmental disorder of the pulmonary mesenchyme and presents clinically with reversible neonatal respiratory distress and/or persistent pulmonary hypertension of the newborn (PPHN)...
  40. ncbi request reprint Outcomes of tricuspid atresia in the Fontan era
    Rekwan Sittiwangkul
    Departments of Pediatrics and Surgery, Divisions of Cardiology and Cardiovascular Surgery, The Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Ontario, Canada
    Ann Thorac Surg 77:889-94. 2004
    ..Whereas indications expand and results improve with increasing refinements to the Fontan procedure the overall impact on outcomes related to tricuspid atresia remains suboptimally defined...
  41. ncbi request reprint Perioperative antibiotic prophylaxis in paediatric cardiac surgery
    Nelson Alphonso
    Paediatric Heart Center, University of California San Francisco Children s Hospital, San Francisco, California 94143 0117, USA
    Cardiol Young 17:12-25. 2007
  42. ncbi request reprint Associated factors and trends in outcomes of interrupted aortic arch
    Thomas Oosterhof
    Department of Pediatrics, Division of Cardiology, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 78:1696-702. 2004
    ..We sought to determine trends in presentation, management, outcomes and associated factors...
  43. ncbi request reprint Cerebral oxygen balance is impaired during repair of aortic coarctation in infants and children
    Anthony Azakie
    Department of Surgery, University of California, San Francisco, Calif, USA
    J Thorac Cardiovasc Surg 130:830-6. 2005
    ..The study objective is to determine whether aortic occlusion impairs left hemispheric cerebral oxygen balance measured by near-infrared spectroscopy...
  44. ncbi request reprint Invited commentary
    Anthony Azakie
    Pediatric Heart Center, University of California San Francisco, Department of Surgery, University of California Medical Center, 513 Paranassus Ave, San Francisco, CA94143
    Ann Thorac Surg 82:956-7. 2006
  45. pmc Infection and white matter injury in infants with congenital cardiac disease
    Hannah C Glass
    Department of Neurology, University of California, San Francisco, United States of America
    Cardiol Young 21:562-71. 2011
    ..Infection prevention may have the potential to mitigate long-term neurologic impairment as a consequence of white matter injury, which underscores the importance of attention to infection control for these patients...
  46. ncbi request reprint Late pulmonary valve implantation after repair of tetralogy of Fallot
    Shengli Yin
    Division of Pediatric Cardiothoracic Surgery, University of California, San Francisco, CA 94143 0117, USA
    Asian Cardiovasc Thorac Ann 13:139-42. 2005
    ..It was concluded that late pulmonary valve implantation after tetralogy of Fallot repair had significant benefits and carried low operative risk...
  47. ncbi request reprint Immature intrapericardial teratoma in a newborn with elevated alpha-fetoprotein
    Nathalie Roy
    Division of Pediatric Cardiothoracic Surgery, Children s Hospital, University of California, San Francisco, San Francisco, California 94143 0118, USA
    Ann Thorac Surg 78:e6-8. 2004
    ..The pathologic analysis demonstrated a grade I immature teratoma with foci of hepatoid tissue. The patient had an uneventful postoperative recovery. A review of the literature and pathologic implications are discussed...
  48. ncbi request reprint Impact of right ventricle to pulmonary artery conduit on outcome of the modified Norwood procedure
    Anthony Azakie
    Department of Surgery, University of Claifornia, San Francisco, CA 94143, USA
    Ann Thorac Surg 77:1727-33. 2004
    ..To determine and compare outcome of the modified Norwood procedure using either a systemic to pulmonary artery (SPA) shunt or right ventricle to pulmonary artery (RV-PA) conduit in a consecutive series of neonates at a single institution...
  49. ncbi request reprint Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow
    Boaz Ovadia
    Department of Pediatrics, University of California, San Francisco, 94143, USA
    Am J Physiol Heart Circ Physiol 284:H480-90. 2003
    ..These data demonstrate that increased pulmonary blood flow induces alterations in ET-1 signaling before NO signaling and suggest an early role for ET-1 in the altered vascular reactivity associated with increased pulmonary blood flow...
  50. ncbi request reprint Preoperative brain injury in newborns with transposition of the great arteries
    Steven P Miller
    Department of Pediatrics, University of California, San Francisco, CA 94143 0663, USA
    Ann Thorac Surg 77:1698-706. 2004
    ....
  51. ncbi request reprint Lung antioxidant enzymes are regulated by development and increased pulmonary blood flow
    Shruti Sharma
    Vascular Biology Center, Medical College of Georgia, CB3210B, 1459 Laney Walker Blvd, Augusta, GA 30912, USA
    Am J Physiol Lung Cell Mol Physiol 293:L960-71. 2007
    ..An increased understanding of these alterations may have important therapeutic implications for the treatment of pulmonary hypertension secondary to increased pulmonary blood flow...
  52. ncbi request reprint Chronic endothelin A receptor blockade in lambs with increased pulmonary blood flow and pressure
    Sohrab Fratz
    Dept of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum Munchen, Klinik an der Technischen Universität München, Lazarettstr 36, 80636 Munich, Germany
    Am J Physiol Lung Cell Mol Physiol 287:L592-7. 2004
    ..We conclude that chronic endothelin A receptor blockade attenuates the progression of pulmonary hypertension and augments alveolar growth in lambs with increased pulmonary blood flow...
  53. ncbi request reprint The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, Children s Hospital and Regional Medical Center, Seattle, Wash 98105, USA
    Am Heart J 148:393-8. 2004
    ..A double-blind, randomized, placebo-controlled trial is needed to define clinical safety and efficacy of triiodothyronine supplementation in infants...
  54. ncbi request reprint Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase
    Albert C Grobe
    Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59802, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1069-77. 2006
    ..Rather, the observed increase in oxidative stress is due, at least in part, to increased expression and activity of the NADPH oxidase complex and uncoupled eNOS due to elevated levels of BH(2)...
  55. ncbi request reprint Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension
    Stephen Wedgwood
    Department of Pediatrics, Northwestern University, Chicago, Illinois 60611, USA
    Pediatr Res 61:32-6. 2007
    ..Elevated FGF-2 signaling by PASMC and PAEC exposed to increased pulmonary blood flow may play a role in the pulmonary vascular remodeling associated with the shunt model of pulmonary hypertension secondary to congenital heart disease...
  56. ncbi request reprint Effect of chamber capacitance on Doppler flow pattern across restrictive defects in obligatory atrial-level shunts
    Alessandro Giardini
    Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Italy
    J Am Soc Echocardiogr 17:1286-91. 2004
    ..0; range, 2.8-20). Because atrial capacitance affects mean PG and Doppler flow pattern across the ASD, we propose that the assessment of ASD adequacy in RAVVA should not rely on Doppler findings...

Research Grants1

  1. Developmental regulation of cardiac gene expression
    Anthony Azakie; Fiscal Year: 2007
    ..An understanding of the transcriptional mechanisms that control cardiogenesis may also elucidate the molecular pathogenesis of various congenital heart defects and cardiomyopathies. ..