Shanjana Awasthi

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Lung dendritic cell developmental programming, environmental stimuli, and asthma in early periods of life
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA
    J Allergy (Cairo) 2012:176468. 2012
  2. pmc A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-α release from mouse JAWS II dendritic cells
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    J Pharmacol Exp Ther 336:672-81. 2011
  3. pmc Surfactant protein-A and toll-like receptor-4 modulate immune functions of preterm baboon lung dendritic cell precursor cells
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK 73117, USA
    Cell Immunol 268:87-96. 2011
  4. doi request reprint Susceptibility of TLR4-defective C3H/HeJ mice to Coccidioides posadasii infection
    Shanjana Awasthi
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, Texas, USA
    Med Mycol 48:470-5. 2010
  5. ncbi request reprint Surfactant protein (SP)-A and SP-D as antimicrobial and immunotherapeutic agents
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Recent Pat Antiinfect Drug Discov 5:115-23. 2010
  6. pmc Ontogeny and phagocytic function of baboon lung dendritic cells
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Immunol Cell Biol 87:419-27. 2009
  7. doi request reprint Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, 1110 N Stonewall Avenue, Oklahoma City, OK 73117, USA
    Dev Comp Immunol 32:1088-98. 2008
  8. ncbi request reprint Dendritic cell-based vaccine against coccidioides infection
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA
    Ann N Y Acad Sci 1111:269-74. 2007
  9. ncbi request reprint Efficacy of antigen 2/proline-rich antigen cDNA-transfected dendritic cells in immunization of mice against Coccidioides posadasii
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Immunol 175:3900-6. 2005
  10. ncbi request reprint Immunophenotype and functions of fetal baboon bone-marrow derived dendritic cells
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Cell Immunol 240:31-40. 2006

Collaborators

Detail Information

Publications26

  1. pmc Lung dendritic cell developmental programming, environmental stimuli, and asthma in early periods of life
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA
    J Allergy (Cairo) 2012:176468. 2012
    ..This knowledge can eventually help in designing novel pharmacological modulators to skew the DC characteristics and immune responses to benefit the host across a lifetime...
  2. pmc A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-α release from mouse JAWS II dendritic cells
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    J Pharmacol Exp Ther 336:672-81. 2011
    ..In conclusion, we identify a human SP-A-derived peptide (SPA4 peptide) that interacts with TLR4-MD2 protein and inhibits the LPS-stimulated release of TNF-α in JAWS II dendritic cells...
  3. pmc Surfactant protein-A and toll-like receptor-4 modulate immune functions of preterm baboon lung dendritic cell precursor cells
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK 73117, USA
    Cell Immunol 268:87-96. 2011
    ..In conclusion, our results indicate that an exogenous administration of SP-A can potentially induce phagocytic activity and anti-inflammatory effect in preterm babies, and help control infection and inflammation...
  4. doi request reprint Susceptibility of TLR4-defective C3H/HeJ mice to Coccidioides posadasii infection
    Shanjana Awasthi
    Department of Microbiology and Immunology, University of Texas Health Science Center, San Antonio, Texas, USA
    Med Mycol 48:470-5. 2010
    ..05). Our results suggest that the TLR4 may not be involved in inducing protective host defense against C. posadasii, but it appears to be critical for fungal dissemination...
  5. ncbi request reprint Surfactant protein (SP)-A and SP-D as antimicrobial and immunotherapeutic agents
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Recent Pat Antiinfect Drug Discov 5:115-23. 2010
    ....
  6. pmc Ontogeny and phagocytic function of baboon lung dendritic cells
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Immunol Cell Biol 87:419-27. 2009
    ..The fetal lung DCs were also less capable of phagocytosing E. coli as compared to the adult lung DCs (P<0.05). In conclusion, the fetal lung DCs are not only phenotypically immature, but also less efficient in phagocytosing E. coli...
  7. doi request reprint Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, 1110 N Stonewall Avenue, Oklahoma City, OK 73117, USA
    Dev Comp Immunol 32:1088-98. 2008
    ..The protein expression of both TLRs was found increased in naturally infected baboons. Our results suggest that the lung TLR expression is developmentally regulated and altered during respiratory infection in preterm babies...
  8. ncbi request reprint Dendritic cell-based vaccine against coccidioides infection
    Shanjana Awasthi
    Department of Pharmaceutical Sciences, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA
    Ann N Y Acad Sci 1111:269-74. 2007
    ..posadasii). Our results suggest that DCs act as a potent adjuvant and activate protective responses in mice against C. posadasii...
  9. ncbi request reprint Efficacy of antigen 2/proline-rich antigen cDNA-transfected dendritic cells in immunization of mice against Coccidioides posadasii
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Immunol 175:3900-6. 2005
    ..The results suggest that the DCs have a potent immunostimulatory activity, and immunization with DCs transfected with Ag2/proline-rich Ag-cDNA induces protective immunity against C. posadasii in C57BL6 mice...
  10. ncbi request reprint Immunophenotype and functions of fetal baboon bone-marrow derived dendritic cells
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Cell Immunol 240:31-40. 2006
    ..These results suggest that compared to adult BMDCs, fetal baboon BMDCs are less efficient in mounting immune response against Gram-negative bacterial stimuli...
  11. pmc In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine
    Prachi Vilekar
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, OK 73117, USA
    BMC Immunol 11:60. 2010
    ..Based on the PET-probe accumulation in vaccinated mice, selected tissues were studied for antigen-specific response and T cell phenotypes using ELISPOT and flow cytometry, respectively...
  12. pmc EF24 suppresses maturation and inflammatory response in dendritic cells
    Prachi Vilekar
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, 73117, USA
    Int Immunol 24:455-64. 2012
    ..These results suggest that EF24 modulates DCs by suppressing their maturation and reducing the secretion of inflammatory cytokines. Further, it appears that EF24 acts at or upstream of MyD88 in the LPS-TLR4/MyD88/NF-κB pathway...
  13. ncbi request reprint Differences in expression of cell surface co-stimulatory molecules, Toll-like receptor genes and secretion of IL-12 by bone marrow-derived dendritic cells from susceptible and resistant mouse strains in response to Coccidioides posadasii
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Cell Immunol 231:49-55. 2004
    ..The data suggest that the differences in the activation status of DC in DBA/2 and BALB/c mice may be responsible for the discrepancy in their susceptibility to C. posadasii...
  14. doi request reprint A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation
    Vijay Ramani
    1Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Innate Immun 19:596-610. 2013
    ..Our results suggest that the anti-inflammatory activity of the SPA4 peptide through its binding to TLR4 can be of therapeutic benefit. ..
  15. pmc Role of CD14 in responses to clinical isolates of Escherichia coli: effects of K1 capsule expression
    Shalaka Metkar
    Department of Microbiology and Immunology, CUNY Medical School, and Sophie Davis School for Biomedical Sciences, City College of New York, New York, New York, USA
    Infect Immun 75:5415-24. 2007
    ..These studies show that different bacterial isolates can use distinctly different mechanisms to cause disease and suggest that new, nonantibiotic therapeutics need to be directed against multiple targets...
  16. pmc Coccidioides posadasii infection alters the expression of pulmonary surfactant proteins (SP)-A and SP-D
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Respir Res 5:28. 2004
    ..Pulmonary surfactant proteins (SP)-A and SP-D have been recognized to play an important role in binding and phagocytosis of various microorganisms, but their roles in Coccidioides infection are not known...
  17. pmc Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock
    Geeta Rao
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma and
    Am J Physiol Gastrointest Liver Physiol 311:G180-91. 2016
    ..On the other hand, saline-resuscitated animals showed a decoupling of oxidative stress and cellular protective mechanisms. ..
  18. doi request reprint Antibacterial activity of synthetic curcumin derivatives: 3,5-bis(benzylidene)-4-piperidone (EF24) and EF24-dimer linked via diethylenetriaminepentacetic acid (EF2DTPA)
    Prachi Vilekar
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, 1110 N Stonewall Avenue, Oklahoma City, OK, 73117, USA
    Appl Biochem Biotechnol 172:3363-73. 2014
    ..Our results demonstrate that treatment with EF24 and EF2DTPA directly suppresses the bacterial growth. However, these compounds do not affect the bacterial uptake or localization in the DCs. ..
  19. pmc Biofilm and planktonic Enterococcus faecalis elicit different responses from host phagocytes in vitro
    Kasturee Daw
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73126, USA
    FEMS Immunol Med Microbiol 65:270-82. 2012
    ..Macrophages infected with biofilm cells also secreted lower levels of proinflammatory cytokines studied. Overall, these results suggest that biofilm E. faecalis may be better adapted to overcome host defenses in vivo...
  20. pmc Toll-like receptor 4-interacting SPA4 peptide suppresses the NLRP3 inflammasome in response to LPS and ATP stimuli
    Vijay Ramani
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Leukoc Biol 98:1037-48. 2015
    ..Together our results suggest that the SPA4 peptide exerts its anti-inflammatory activity by suppressing Toll-like receptor-4-priming of the NLRP3 inflammasome. ..
  21. pmc Nanovesicular liposome-encapsulated hemoglobin (LEH) prevents multi-organ injuries in a rat model of hemorrhagic shock
    Vivek R Yadav
    Department of Pharmaceutical Sciences, University of Oklahoma Health Science Center, 1110 N Stonewall Avenue, Oklahoma City, OK 73117, USA
    Eur J Pharm Sci 93:97-106. 2016
    ..These results indicate that resuscitation with nanoparticulate LEH creates a pro-survival phenotype in hemorrhaged rats, and because of its oxygen-carrying capacity, LEH performs significantly better than saline in hemorrhagic shock. ..
  22. pmc Hemorrhage-induced interleukin-1 receptor pathway in lung is suppressed by 3,5-bis(2-fluorobenzylidene)-4-piperidone in a rat model of hypovolemic shock
    Vivek R Yadav
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Artif Organs 38:675-83. 2014
    ....
  23. pmc Distinct compartmentalization of NF-κB activity in crypt and crypt-denuded lamina propria precedes and accompanies hyperplasia and/or colitis following bacterial infection
    Parthasarathy Chandrakesan
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Infect Immun 80:753-67. 2012
    ..rodentium-induced pathogenesis...
  24. pmc Improved formulation of liposome-encapsulated hemoglobin with an anionic non-phospholipid
    Hrushikesh Agashe
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA
    Colloids Surf B Biointerfaces 75:573-83. 2010
    ..The LEH formulation with novel anionic lipid and high hemoglobin content reported in this article is an improvement from the past preparations...
  25. ncbi request reprint Transfection of murine dendritic cell line (JAWS II) by a nonviral transfection reagent
    Shanjana Awasthi
    Department of Pathology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Biotechniques 35:600-2, 604. 2003
    ..In addition, the flexibility of this agent for expressing multiple antigens (GFP and C. immitis Ag2) offers an advantage of delivering multiple immunogens...