Affiliation: University of Washington
- Role of oestrogen in the treatment and prevention of Alzheimer's diseaseS Asthana
Geriatric Research, Education and Clinical Center GRECC 182 B, Veterans Affairs Puget Sound Health Care System, Seattle Tacoma, WA, USA
Expert Opin Investig Drugs 6:1203-9. 1997..However, findings of preliminary studies, although promising, need to be confirmed in larger, controlled clinical trials before the role of oestrogen in the treatment and prevention of AD can be firmly established...
- Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot studyS Asthana
Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, American Lake Division, Tacoma, WA 98493, USA
Psychoneuroendocrinology 24:657-77. 1999....
- High-dose estradiol improves cognition for women with AD: results of a randomized studyS Asthana
Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Tacoma, Tacoma, WA 98493, USA
Neurology 57:605-12. 2001..To characterize the cognitive and neuroendocrine response to treatment with a high dose of estrogen for postmenopausal women with AD...
- Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucoseS Craft
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Wash 98108, USA
Arch Gen Psychiatry 56:1135-40. 1999..We address this question by examining memory and counterregulatory hormone response during hyperglycemia when endogenous insulin was suppressed by concomitant infusion of the somatostatin analogue octreotide (Sandostatin)...
- Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotypeS Craft
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Ann N Y Acad Sci 903:222-8. 2000....
- Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer diseaseJ J Kulstad
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Neurology 66:1506-10. 2006..Insulin regulates levels of the amyloid beta-peptide (Abeta) in vitro in neuronal cultures and in vivo in the CSF of normal older adults...
- Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairmentM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
Neurology 64:2063-8. 2005..To determine the efficacy of testosterone (T) supplementation on cognition in a sample of men with Alzheimer disease (AD) or mild cognitive impairment (MCI)...
- Insulin increases CSF Abeta42 levels in normal older adultsG S Watson
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
Neurology 60:1899-903. 2003..In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden...
- Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older menM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 1959 NE Pacific, Box 356560, Seattle, WA 98195, USA
Psychoneuroendocrinology 29:65-82. 2004..This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning...
- Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparationC E Gleason
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave, Suite 106, Madison, WI 53705, USA
Neurology 67:2039-41. 2006..These preliminary findings emphasize the need to characterize differential neural effects of various HTs...
- Activation of brain regions vulnerable to Alzheimer's disease: the effect of mild cognitive impairmentS C Johnson
Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, 2500 Overlook Terrace 11G, GRECC, Madison, WI 53705, USA
Neurobiol Aging 27:1604-12. 2006..Our results suggest that a change in function in the PC may account, in part, for memory recollection failure in AD...
- Neuroprotective effects of female sex steroids in humans: current controversies and future directionsC E Gleason
Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
Cell Mol Life Sci 62:299-312. 2005..Further, the paper briefly discusses variables that may account for the unexpected findings of WHIMS, and offers suggestions for future research...
- Prevalence and risk factors for development of lymphedema following breast cancer treatmentS V S Deo
Department of Surgical Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110 029, India
Indian J Cancer 41:8-12. 2004..This study was conducted to evaluate the prevalence and risk factors for development of lymphedema...
- Plasma amyloid beta protein is elevated in late-onset Alzheimer disease familiesN Ertekin-Taner
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA
Neurology 70:596-606. 2008..Plasma A beta levels are elevated in early-onset Alzheimer disease (AD) caused by autosomal dominant mutations. Our objective was to determine whether similar genetic elevations exist in late-onset AD (LOAD)...