Aroumougame Asaithamby

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Unrepaired clustered DNA lesions induce chromosome breakage in human cells
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8293-8. 2011
  2. pmc Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Centre, Dallas, TX 75390, USA
    Nucleic Acids Res 39:5474-88. 2011
  3. doi request reprint Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 169:437-46. 2008
  4. pmc Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, United States
    Mutat Res 711:87-99. 2011
  5. pmc Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway
    Fengtao Su
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Oncotarget 7:46-65. 2016
  6. pmc Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress
    Fengtao Su
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Rep 9:1387-401. 2014
  7. pmc Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity
    J Jefferson P Perry
    Division of Molecular Radiation Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:25699-707. 2010
  8. pmc Ku recruits XLF to DNA double-strand breaks
    Ken ichi Yano
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 5801 Forest Park Road, Dallas, TX 75390 9187, USA
    EMBO Rep 9:91-6. 2008
  9. pmc Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nucleic Acids Res 37:3912-23. 2009
  10. ncbi request reprint Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
    Benjamin P C Chen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    J Biol Chem 280:14709-15. 2005

Collaborators

Detail Information

Publications13

  1. pmc Unrepaired clustered DNA lesions induce chromosome breakage in human cells
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 108:8293-8. 2011
    ..Difficulties associated with clustered DNA damage repair and checkpoint release before the completion of clustered DNA damage repair appear to promote genome instability that may lead to carcinogenesis...
  2. pmc Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas, Southwestern Medical Centre, Dallas, TX 75390, USA
    Nucleic Acids Res 39:5474-88. 2011
    ..Our data suggest that downregulation of multiple DNA repair pathway genes in differentiated cells renders them vulnerable to DSBs, promoting genome instability that may lead to carcinogenesis...
  3. doi request reprint Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 169:437-46. 2008
    ..Collectively, these data demonstrate that the inability of cells to rejoin DSBs within clustered DNA lesions likely contributes to the greater biological effectiveness of HZE particles...
  4. pmc Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, United States
    Mutat Res 711:87-99. 2011
    ..Understanding the mechanism underlying the repair of DNA damage induced by HZE particles will have important implications for estimating the risks to human health associated with HZE particle exposure...
  5. pmc Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway
    Fengtao Su
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Oncotarget 7:46-65. 2016
    ..These findings reveal a unique role for WRN as a modulator of DNA repair, replication, and recombination, and link ATR-WRN signaling to the maintenance of genome stability. ..
  6. pmc Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress
    Fengtao Su
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Rep 9:1387-401. 2014
    ..Thus, this previously unrecognized nonenzymatic function of WRN in the stabilization of nascent DNA strands sheds light on the molecular reason for the origin of genome instability in WS individuals. ..
  7. pmc Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity
    J Jefferson P Perry
    Division of Molecular Radiation Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 285:25699-707. 2010
    ....
  8. pmc Ku recruits XLF to DNA double-strand breaks
    Ken ichi Yano
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, 5801 Forest Park Road, Dallas, TX 75390 9187, USA
    EMBO Rep 9:91-6. 2008
    ..Our observations showed the direct involvement of XLF in the dynamic assembly of the NHEJ machinery and provide mechanistic insights into DSB recognition...
  9. pmc Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation
    Aroumougame Asaithamby
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nucleic Acids Res 37:3912-23. 2009
    ..These findings have important implications for estimating the risk associated with low-dose radiation exposure on human health...
  10. ncbi request reprint Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks
    Benjamin P C Chen
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9187, USA
    J Biol Chem 280:14709-15. 2005
    ..These results indicate that although IR-induced DNA-PKcs phosphorylation is attenuated in the S phase, DNA-PKcs is preferentially activated by the physiologically relevant DNA replication-associated DSBs at the sites of DNA synthesis...
  11. pmc Human ventricular unloading induces cardiomyocyte proliferation
    Diana C Canseco
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
    J Am Coll Cardiol 65:892-900. 2015
    ..We reasoned that the postnatal physiological increase in mechanical load contributes to the increase in mitochondrial content, with subsequent activation of DNA damage response (DDR) and permanent cell cycle arrest of cardiomyocytes...
  12. pmc Transcriptional elongation requires DNA break-induced signalling
    Heeyoun Bunch
    Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Commun 6:10191. 2015
    ..Our findings propose that DDR signalling is required for effective Pol II pause release and transcriptional elongation through a novel mechanism involving TRIM28, DNA-PK and topoisomerase II. ..
  13. pmc Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior
    Shibani Mukherjee
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Biol Psychiatry 68:503-11. 2010
    ..Previously, we reported that mice with a mutation in the Clock gene (ClockDelta19) display a behavioral profile that is strikingly similar to bipolar patients in the manic state...