R Arsenescu

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation
    Razvan Arsenescu
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40515, USA
    J Immunol 174:3906-11. 2005
  2. doi request reprint Signature biomarkers in Crohn's disease: toward a molecular classification
    R Arsenescu
    Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Mucosal Immunol 1:399-411. 2008
  3. ncbi request reprint Substance P regulates Th1-type colitis in IL-10 knockout mice
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:3762-7. 2003
  4. ncbi request reprint Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity
    Houssam E Mardini
    Department of Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536, USA
    Dig Dis Sci 50:2316-22. 2005
  5. pmc Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis
    Erik R M Eckhardt
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    BMC Gastroenterol 10:133. 2010
  6. ncbi request reprint IL-18 and IL-12 signal through the NF-kappa B pathway to induce NK-1R expression on T cells
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:5003-7. 2003

Collaborators

  • David Elliott
  • J V Weinstock
  • Erik R M Eckhardt
  • Willem J S de Villiers
  • Houssam E Mardini
  • Sarbani Ghoshal
  • Jassir Witta
  • Yu Wang
  • Violeta Arsenescu
  • Marcielle C de Beer
  • Frederick C de Beer
  • Jian Zhong
  • Kalvin J Gregory
  • Trevor A Winter
  • Munira Nasser
  • Lisbeth Selby

Detail Information

Publications6

  1. ncbi request reprint IL-12 induction of mRNA encoding substance P in murine macrophages from the spleen and sites of inflammation
    Razvan Arsenescu
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40515, USA
    J Immunol 174:3906-11. 2005
    ..Thus, macrophages are a source for SP at these sites of chronic inflammation, and IL-12 and STAT4 are regulators of macrophage SP mRNA expression...
  2. doi request reprint Signature biomarkers in Crohn's disease: toward a molecular classification
    R Arsenescu
    Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Mucosal Immunol 1:399-411. 2008
    ..Classification of CD patients by these biomarkers may predict disease behavior and responses to therapy...
  3. ncbi request reprint Substance P regulates Th1-type colitis in IL-10 knockout mice
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 171:3762-7. 2003
    ..NK-1R antagonist reverses ongoing intestinal inflammation attesting to the importance of SP and its receptor in mucosal inflammation...
  4. ncbi request reprint Gastroduodenal Crohn's disease is associated with NOD2/CARD15 gene polymorphisms, particularly L1007P homozygosity
    Houssam E Mardini
    Department of Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536, USA
    Dig Dis Sci 50:2316-22. 2005
    ..There is evidence of specific variant-phenotype associations. G908R heterozygosity is associated with ileal involvement and smoking, whereas L1007P homozygosity is strongly associated with GDCD and younger age at diagnosis...
  5. pmc Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis
    Erik R M Eckhardt
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    BMC Gastroenterol 10:133. 2010
    ....
  6. ncbi request reprint IL-18 and IL-12 signal through the NF-kappa B pathway to induce NK-1R expression on T cells
    Joel V Weinstock
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 170:5003-7. 2003
    ..IL-10, a regulator of the Th1 response, blocks this activation. These data further suggest that SP and NK-1R, which promote IFN-gamma synthesis, are part of the Th1 pathway of immunity...