Karen C Arden

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint FoxO: linking new signaling pathways
    Karen C Arden
    Ludwig Institute for Cancer Research and University of California San Diego School of Medicine, San Diego, CA, USA
    Mol Cell 14:416-8. 2004
  2. ncbi request reprint Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
    Karen C Arden
    Ludwig Institute for Cancer Research, Departments of Medicine and Cancer Center, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0669, USA
    Exp Gerontol 41:709-17. 2006
  3. ncbi request reprint FOXO animal models reveal a variety of diverse roles for FOXO transcription factors
    K C Arden
    Department of Medicine, Ludwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093 0660, USA
    Oncogene 27:2345-50. 2008
  4. ncbi request reprint Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling
    Karen C Arden
    The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
    Arch Biochem Biophys 403:292-8. 2002
  5. ncbi request reprint FoxOs in tumor suppression and stem cell maintenance
    Karen C Arden
    Ludwig Institute for Cancer Research and Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Cell 128:235-7. 2007
  6. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
  7. ncbi request reprint The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    Jun Nakae
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Cell 4:119-29. 2003
  8. pmc Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    Hart S Dengler
    Program of Inflammatory Disease Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Nat Immunol 9:1388-98. 2008
  9. ncbi request reprint Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    W H Biggs
    Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, California 92093 0660, USA
    Mamm Genome 12:416-25. 2001
  10. pmc Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    Taisuke Hosaka
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 101:2975-80. 2004

Collaborators

Detail Information

Publications29

  1. ncbi request reprint FoxO: linking new signaling pathways
    Karen C Arden
    Ludwig Institute for Cancer Research and University of California San Diego School of Medicine, San Diego, CA, USA
    Mol Cell 14:416-8. 2004
    ..The second report identifies IkappaB kinase as a negative regulator of FoxO proteins, suggesting a mechanism for relieving negative regulation of cell cycle and promoting tumor cell proliferation...
  2. ncbi request reprint Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
    Karen C Arden
    Ludwig Institute for Cancer Research, Departments of Medicine and Cancer Center, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0669, USA
    Exp Gerontol 41:709-17. 2006
    ..FOXO proteins may represent new therapeutic targets for a broad spectrum of cancers...
  3. ncbi request reprint FOXO animal models reveal a variety of diverse roles for FOXO transcription factors
    K C Arden
    Department of Medicine, Ludwig Institute for Cancer Research, University of California San Diego School of Medicine, La Jolla, CA 92093 0660, USA
    Oncogene 27:2345-50. 2008
    ..Many roles are conserved among the different model organisms. Several Foxo-related animal model systems are reviewed here along with the knowledge gleaned to date from each model system...
  4. ncbi request reprint Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling
    Karen C Arden
    The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
    Arch Biochem Biophys 403:292-8. 2002
  5. ncbi request reprint FoxOs in tumor suppression and stem cell maintenance
    Karen C Arden
    Ludwig Institute for Cancer Research and Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Cell 128:235-7. 2007
    ..Demonstrate that FoxOs are critical for the long-term maintenance of hematopoietic stem cells, and show that FoxOs suppress the formation of hemangiomas and lymphomas in mice...
  6. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
    ..We propose that insulin/IGFs regulate beta cell proliferation by relieving Foxo1 inhibition of Pdx1 expression in a subset of cells embedded within pancreatic ducts...
  7. ncbi request reprint The forkhead transcription factor Foxo1 regulates adipocyte differentiation
    Jun Nakae
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Cell 4:119-29. 2003
    ..We propose that Foxo1 plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes adipocyte differentiation...
  8. pmc Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    Hart S Dengler
    Program of Inflammatory Disease Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Nat Immunol 9:1388-98. 2008
    ..Thus, Foxo1 regulates a transcriptional program that is essential for early B cell development and peripheral B cell function...
  9. ncbi request reprint Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    W H Biggs
    Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, California 92093 0660, USA
    Mamm Genome 12:416-25. 2001
    ..Further characterization will provide insight into the roles of members of the FKHR subfamily of forkhead-related genes during both normal and neoplastic development...
  10. pmc Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    Taisuke Hosaka
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 101:2975-80. 2004
    ..In contrast, histological analyses of Foxo4-null mice did not identify any consistent abnormalities. These results demonstrate that the physiological roles of Foxo genes are functionally diverse in mammals...
  11. pmc FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue
    Jane J Kim
    Department of Pediatrics, University of California at San Diego, La Jolla, California, USA
    Diabetes 58:1275-82. 2009
    ..Although the FoxO1 isoform is known to play a key role in adipogenesis, its physiological role in differentiated adipose tissue remains unclear...
  12. ncbi request reprint Guilt by association: PAX3-FOXO1 regulates gene expression through selective destabilization of the EGR1 transcription factor
    Wendy Roeb
    The Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California, USA
    Cell Cycle 7:837-41. 2008
    ..These results yield new insight into how tumor-associated genetic alterations increase the likelihood of cancer formation and may lead to new therapeutic approaches...
  13. pmc Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells
    Anne S Dejean
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, San Diego, California, USA
    Nat Immunol 10:504-13. 2009
    ..Thus, Foxo3 acts to constrain the production of key inflammatory cytokines by dendritic cells and to control T cell survival...
  14. pmc Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs
    Leah O Barrera
    Ludwig Institute for Cancer Research, UCSD School of Medicine, La Jolla, California 92093 0653, USA
    Genome Res 18:46-59. 2008
    ..Our results provide a resource for exploring promoter Polr2a binding and epigenetic states across pluripotent and differentiated cell types in mammals...
  15. ncbi request reprint Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
    M J Anderson
    Ludwig Institute for Cancer Research, San Diego Branch, California, USA
    Genomics 47:187-99. 1998
    ..These results suggest that these four genes represent an FKHR-like gene subfamily within the larger human forkhead gene family...
  16. pmc Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    W H Biggs
    The Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 96:7421-6. 1999
    ..These results indicate that phosphorylation by PKB/Akt negatively regulates FKHR1 by promoting export from the nucleus...
  17. ncbi request reprint CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis
    A O Gure
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Int J Cancer 85:726-32. 2000
    ..CT10 mRNA is expressed in testis and in 20 to 30% of various human cancers. A serological survey identified 2 melanoma patients with anti-CT10 antibody, demonstrating the immunogenicity of CT10 in humans...
  18. ncbi request reprint cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes
    R V Stan
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0651, USA
    Genomics 72:304-13. 2001
    ..Radiation hybrid panel mapping has localized the human and mouse PLVAP genes to chromosomes 19p13.2 and 8B3-C1, respectively...
  19. pmc Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3
    M J Anderson
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 98:1589-94. 2001
    ..These data suggest that the tumor-associated PAX3-FKHR fusion protein interferes with normal Pax3 developmental functions as a prelude to transformation...
  20. pmc PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1
    Wendy Roeb
    Ludwig Institute for Cancer Research, Biomedical Sciences Graduate Program, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0660, USA
    Proc Natl Acad Sci U S A 104:18085-90. 2007
    ..Thus, the breakage and fusion of the genes encoding these transcription factors creates a unique chimeric protein that controls a key cell-cycle and -differentiation regulator...
  21. ncbi request reprint Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    Jun Nakae
    Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Genet 32:245-53. 2002
    ..This has been corrected in the full-text online version of the article. The name will appear correctly in the print version...
  22. ncbi request reprint Isoforms of the human PDZ-73 protein exhibit differential tissue expression
    M J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1445:39-52. 1999
    ..The existence of multiple PDZ-73 isoforms with variations in tissue distribution, PDZ domains, protein degradation sequences and carboxyl terminal structure indicate that these isoforms have distinct tissue-specific functions...
  23. ncbi request reprint Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes
    H Y Wang
    Department of Medicine, Department of Pathology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California, 92093 0651, USA
    Genomics 57:310-5. 1999
    ..1 (a region of conserved synteny to mouse Chromosome 5). In addition, we also found multiple SRPK-related sequences on other human chromosomes, one of which appears to correspond to a SRPK2 pseudogene on human chromosome 8...
  24. ncbi request reprint ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family
    M E Clark
    Department of Molecular Biology, Neurocrine Biosciences Inc, San Diego, California 92121, USA
    Genomics 67:343-50. 2000
    ..Using FISH and radiation hybrid analysis, we have localized ADAMTS9 to chromosome 3p14.2-p14.3, an area known to be lost in hereditary renal tumors...
  25. ncbi request reprint Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination
    D X Tishkoff
    Ludwig Institute for Cancer Research, Cancer Center, University of California School of Medicine at San Diego, La Jolla 92093, USA
    Cancer Res 58:5027-31. 1998
    ..2-qter. Northern blot analysis demonstrates that hEXO1 is expressed in high levels in testis; elevated expression was also observed in thymus and colon and to a lesser extent in small intestine, placenta, spleen, and ovary...
  26. pmc Molecular cloning of the human leukotriene C4 synthase gene and assignment to chromosome 5q35
    T D Bigby
    Department of Medicine, University of California, San Diego, USA
    Mol Med 2:637-46. 1996
    ..Cysteinyl leukotrienes (LT) are mediators involved in inflammatory and allergic disorders LTC4 synthase catalyzes the first committed step in the synthesis of these inflammatory mediators, and its cellular distribution appears to be unique...
  27. ncbi request reprint Localization of the human B-type natriuretic peptide precursor (NPPB) gene to chromosome 1p36
    K C Arden
    Ludwig Institute for Cancer Research, University of California San Diego 92093 0660, USA
    Genomics 26:385-9. 1995
    ....
  28. ncbi request reprint FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    Domenico Accili
    College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell 117:421-6. 2004
    ..The gamut of phenotypes runs from protection against diabetes and predisposition to neoplasia, conferred by FoxO loss of function, to increased cellular survival and a marked catabolic response associated with gain of function...
  29. ncbi request reprint Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression
    Cameron N Johnstone
    Ludwig Institute for Cancer Research, Melbourne Branch, Post Office Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Biol Chem 277:34531-9. 2002
    ..Taken together, our data lead us to propose that the activity of CDX1 is pivotal in mediating the exquisite, intestine-specific expression pattern of the A33 antigen gene...