N M Ampel

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Combating opportunistic infections: coccidioidomycosis
    Neil M Ampel
    University of Arizona, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Expert Opin Pharmacother 5:255-61. 2004
  2. pmc In vitro whole-blood analysis of cellular immunity in patients with active coccidioidomycosis by using the antigen preparation T27K
    Neil M Ampel
    Medicine and Primary Care Service, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
    Clin Diagn Lab Immunol 9:1039-43. 2002
  3. pmc Preliminary evaluation of whole-blood gamma interferon release for clinical assessment of cellular immunity in patients with active coccidioidomycosis
    Neil M Ampel
    Medicine and Primary Care 1 111, Southern Arizona Veterans Affairs Health Care System, 3601 S Sixth Avenue, Tucson, AZ 85723, USA
    Clin Diagn Lab Immunol 12:700-4. 2005
  4. ncbi request reprint Assessment of the human cellular immune response to T27K, a coccidioidal antigen preparation, by flow cytometry of whole blood
    N M Ampel
    University of Arizona, Tucson, USA
    Med Mycol 39:315-20. 2001
  5. ncbi request reprint Flow cytometric assessment of human peripheral blood mononuclear cells in response to a coccidioidal antigen
    N M Ampel
    University of Arizona and the Medical and Research Services of the Tucson Veterans Affairs Medical Center, 85723, USA
    Med Mycol 38:127-32. 2000
  6. ncbi request reprint In vitro modulation of cytokine production by lymphocytes in human coccidioidomycosis
    Neil M Ampel
    Medicine and Primary Care 1 111, Southern Arizona Veterans Affairs Medical Center, 3601 S Sixth Avenue, Tucson, AZ, USA
    Cell Immunol 221:115-21. 2003
  7. ncbi request reprint Delayed-type hypersensitivity, in vitro T-cell responsiveness and risk of active coccidioidomycosis among HIV-infected patients living in the coccidioidal endemic area
    N M Ampel
    Medical and Research Services of the Tucson Veterans Affairs Medical Center, Department of Medicine of the University of Arizona College of Medicine 85723, USA
    Med Mycol 37:245-50. 1999
  8. pmc In vitro modulation of proliferation and cytokine production by human peripheral blood mononuclear cells from subjects with various forms of coccidioidomycosis
    N M Ampel
    Department of Medicine, University of Arizona College of Medicine, Tucson Veterans Affairs Medical Center, 85723, USA
    Infect Immun 65:4483-7. 1997
  9. ncbi request reprint Measurement of cellular immunity in human coccidioidomycosis
    Neil M Ampel
    University of Arizona, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
    Mycopathologia 156:247-62. 2003
  10. ncbi request reprint Coccidioidomycosis among persons with human immunodeficiency virus infection in the era of highly active antiretroviral therapy (HAART)
    N M Ampel
    University of Arizona College of Medicine, Tucson, AZ, USA
    Semin Respir Infect 16:257-62. 2001

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Combating opportunistic infections: coccidioidomycosis
    Neil M Ampel
    University of Arizona, Southern Arizona Veterans Affairs Medical Center, Tucson, AZ 85723, USA
    Expert Opin Pharmacother 5:255-61. 2004
    ..Intrathecal amphotericin B is required for those cases that fail. Prevention of coccidioidomycosis by environmental control is difficult. In the future, immunisation or immune modulation may offer protection...
  2. pmc In vitro whole-blood analysis of cellular immunity in patients with active coccidioidomycosis by using the antigen preparation T27K
    Neil M Ampel
    Medicine and Primary Care Service, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
    Clin Diagn Lab Immunol 9:1039-43. 2002
    ..001), but not for IL-4, IL-5, or IL-10. These data indicate that in vitro assessment of CD69 expression on T lymphocytes by using T27K may be a useful measure of cellular immune response among subjects with active coccidioidomycosis...
  3. pmc Preliminary evaluation of whole-blood gamma interferon release for clinical assessment of cellular immunity in patients with active coccidioidomycosis
    Neil M Ampel
    Medicine and Primary Care 1 111, Southern Arizona Veterans Affairs Health Care System, 3601 S Sixth Avenue, Tucson, AZ 85723, USA
    Clin Diagn Lab Immunol 12:700-4. 2005
    ..59; P < 0.01). These results suggest that the IFN-gamma release assay with T27K as the antigen may be a useful clinical test for assessing cellular immunity in patients with active coccidioidomycosis...
  4. ncbi request reprint Assessment of the human cellular immune response to T27K, a coccidioidal antigen preparation, by flow cytometry of whole blood
    N M Ampel
    University of Arizona, Tucson, USA
    Med Mycol 39:315-20. 2001
    ..005). These data indicate that there is a specific human cellular immune response to T27K as a coccidioidal antigen and that this response can be categorized based on the clinical status of the coccidioidally infected patient...
  5. ncbi request reprint Flow cytometric assessment of human peripheral blood mononuclear cells in response to a coccidioidal antigen
    N M Ampel
    University of Arizona and the Medical and Research Services of the Tucson Veterans Affairs Medical Center, 85723, USA
    Med Mycol 38:127-32. 2000
    ..Addition of IL-12 leads to a significant recruitment of cells producing IFN-gamma among immune donors...
  6. ncbi request reprint In vitro modulation of cytokine production by lymphocytes in human coccidioidomycosis
    Neil M Ampel
    Medicine and Primary Care 1 111, Southern Arizona Veterans Affairs Medical Center, 3601 S Sixth Avenue, Tucson, AZ, USA
    Cell Immunol 221:115-21. 2003
    ..These data demonstrate a differential response to stimulation with the coccidioidal antigen T27K among donors with coccidioidomycosis that can be manipulated by cell type and cytokine environment...
  7. ncbi request reprint Delayed-type hypersensitivity, in vitro T-cell responsiveness and risk of active coccidioidomycosis among HIV-infected patients living in the coccidioidal endemic area
    N M Ampel
    Medical and Research Services of the Tucson Veterans Affairs Medical Center, Department of Medicine of the University of Arizona College of Medicine 85723, USA
    Med Mycol 37:245-50. 1999
    ....
  8. pmc In vitro modulation of proliferation and cytokine production by human peripheral blood mononuclear cells from subjects with various forms of coccidioidomycosis
    N M Ampel
    Department of Medicine, University of Arizona College of Medicine, Tucson Veterans Affairs Medical Center, 85723, USA
    Infect Immun 65:4483-7. 1997
    ..On the other hand, PBMC from DTH-negative individuals do not respond in vitro to TSL and their response is not modulable, suggesting a lack of antigen response...
  9. ncbi request reprint Measurement of cellular immunity in human coccidioidomycosis
    Neil M Ampel
    University of Arizona, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
    Mycopathologia 156:247-62. 2003
    ..Despite this, a study of a coccidioidal vaccine failed to demonstrate efficacy. Current and future studies are focused on modulating the coccidioidal immune response in vitro and in vivo and on developing an improved vaccine...
  10. ncbi request reprint Coccidioidomycosis among persons with human immunodeficiency virus infection in the era of highly active antiretroviral therapy (HAART)
    N M Ampel
    University of Arizona College of Medicine, Tucson, AZ, USA
    Semin Respir Infect 16:257-62. 2001
    ..Future studies should indicate whether this is necessary if immune function has been reconstituted through appropriate therapy for the HIV infection...
  11. ncbi request reprint Extraction of serologic and delayed hypersensitivity antigens from spherules of Coccidioides immitis
    J N Galgiani
    Medical Service, VA Medical Center, Tucson, AZ 85723
    Diagn Microbiol Infect Dis 11:65-80. 1988
    ....
  12. ncbi request reprint An archived lot of coccidioidin induces specific coccidioidal delayed-type hypersensitivity and correlates with in vitro assays of coccidioidal cellular immune response
    Neil M Ampel
    Department of Medicine, University of Arizona, Tucson, AZ, USA
    Mycopathologia 161:67-72. 2006
    ..01 for both). These data suggest that archived coccidioidin retains its potency and specificity and that in vitro test of coccidioidal immunity may have utility in the measurement of coccidioidal cellular immunity...
  13. ncbi request reprint Dendritic cells pulsed with Coccidioides immitis lysate induce antigen-specific naive T cell activation
    J O Richards
    Department of Microbiology and Immunology, University of Arizona, Tucson, AZ 85724, USA
    J Infect Dis 184:1220-4. 2001
    ..immitis can specifically prime lymphocytes for coccidioidal antigens and that the response generated by the lymphocytes is characteristic of a cellular immune response...
  14. doi request reprint Coccidioidomycosis in patients with HIV-1 infection in the era of potent antiretroviral therapy
    Fares Y Masannat
    Division of Infectious Diseases, Department of Medicine, and Valley Fever Center for Excellence, University of Arizona, and Southern Arizona Veterans Affairs Health Care System, Tucson, USA
    Clin Infect Dis 50:1-7. 2010
    ..However, there have been no studies on its incidence or clinical expression during the era of potent antiretroviral therapy...
  15. ncbi request reprint Coccidioidomycosis in persons infected with HIV-1
    Neil M Ampel
    Medical Service 1 111, SAVAHCS, 3601 S Sixth Avenue, Tucson, Arizona 85723, USA
    Ann N Y Acad Sci 1111:336-42. 2007
    ..The duration of treatment of coccidioidomycosis in those with HIV-1 infection is not established and in many patients it is either prolonged or life-long. Adherence to antiretroviral therapy is important in preventing recurrence...
  16. ncbi request reprint The complex immunology of human coccidioidomycosis
    Neil M Ampel
    Medical Service, 1 111, SAVAHCS, 3601 S Sixth Avenue, Tucson, AZ 85723, USA
    Ann N Y Acad Sci 1111:245-58. 2007
    ..These observations could be useful in the development of a human vaccine against coccidiodomycosis...
  17. doi request reprint Factors and outcomes associated with the decision to treat primary pulmonary coccidioidomycosis
    Neil M Ampel
    Department of Medicine, Section of Infectious Diseases, University of Arizona, Tucson, AZ, USA
    Clin Infect Dis 48:172-8. 2009
    ..Studies that assess the value of initiating oral antifungal therapy to treat primary pulmonary coccidioidomycosis have not been published previously...
  18. doi request reprint Mannose-binding lectin serum levels are low in persons with clinically active coccidioidomycosis
    Neil M Ampel
    The Valley Fever Center for Excellence, The University of Arizona College of Medicine, Tucson, AZ 85723, USA
    Mycopathologia 167:173-80. 2009
    ..Mannose-binding lectin (MBL) is a circulating collectin that is part of the innate immune response. We explored the serum levels of MBL in persons with different forms of coccidioidomycosis...
  19. doi request reprint Coccidioidomycosis: a review of recent advances
    Neil M Ampel
    College of Medicine, University of Arizona, Medical Service 1 111, SAVAHCS, Tucson, AZ 85723, USA
    Clin Chest Med 30:241-51, v. 2009
    ..With this increase in incidence have come new observations and insights and re-examination of past issues. This article explores some of these areas by focusing principally on recent publications that are of importance...
  20. doi request reprint New perspectives on coccidioidomycosis
    Neil M Ampel
    Division of Infectious Diseases, Department of Medicine, and the Valley Fever Center for Excellence, University of Arizona, Tucson, AZ, USA
    Proc Am Thorac Soc 7:181-5. 2010
    ..However, a recent study suggests that, at least for those with primary pulmonary disease, antifungal therapy may lead to subsequent complications once this therapy is discontinued compared with those who receive no therapy at all...
  21. ncbi request reprint Coccidioidomycosis
    John N Galgiani
    Valley Fever Center for Excellence, Tucson, AZ 85723, USA
    Clin Infect Dis 41:1217-23. 2005
  22. ncbi request reprint Coccidioidomycosis in persons infected with HIV type 1
    Neil M Ampel
    Department of Medicine, University of Arizona College of Medicine and Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA
    Clin Infect Dis 41:1174-8. 2005
    ..Other manifestations of coccidioidomycosis require prolonged therapy, and life-long treatment is recommended for persons with meningitis...
  23. ncbi request reprint Reversal of coccidioidal anergy in vitro by dendritic cells from patients with disseminated coccidioidomycosis
    John O Richards
    Department of Microbiology and Immunology, Arizona Health Sciences Center, Tucson, AZ 85724, USA
    J Immunol 169:2020-5. 2002
    ....
  24. ncbi request reprint What's Behind the Increasing Rates of Coccidioidomycosis in Arizona and California?
    Neil M Ampel
    Medical Service 1 111, Southern Arizona Veterans Affairs Health Care System, 3601 South Sixth Avenue, Tucson, AZ, 85723, USA
    Curr Infect Dis Rep 12:211-6. 2010
    ..None of these factors are mutually exclusive and none has been clearly established as the etiology for the increase...
  25. ncbi request reprint Increased risk of coccidioidomycosis in patients treated with tumor necrosis factor alpha antagonists
    Laurie Bergstrom
    University of Arizona, Tucson, 85724, USA
    Arthritis Rheum 50:1959-66. 2004
    ....
  26. pmc The mannose receptor mediates the cellular immune response in human coccidioidomycosis
    Neil M Ampel
    Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona, USA
    Infect Immun 73:2554-5. 2005
    ..These data suggest that MR mediates IL-2 release by T27K...
  27. ncbi request reprint Barriers to use of electronic adherence monitoring in an HIV clinic
    C S Wendel
    Health Services Research Center, Southern Arizona Veterans Affairs Health Care System, Tucson, 85723 0001, USA
    Ann Pharmacother 35:1010-5. 2001
    ..To evaluate barriers to Medication Event Monitoring System (MEMS) measurement of adherence to combination antiretroviral therapy in an HIV clinic...
  28. ncbi request reprint Practice guideline for the treatment of coccidioidomycosis. Infectious Diseases Society of America
    J N Galgiani
    Valley Fever Center for Excellence, Southern Arizona Veterans Affairs Health Care System, and University of Arizona, Tucson, 85723, USA
    Clin Infect Dis 30:658-61. 2000
    ..Duration of therapy often ranges from many months to years, and, for some patients, chronic suppressive therapy is needed to prevent relapses...
  29. pmc Coccidioidomycosis as a common cause of community-acquired pneumonia
    Lisa Valdivia
    University of Arizona College of Medicine, Tucson, Arizona 85723, USA
    Emerg Infect Dis 12:958-62. 2006
    ..If CAP develops in persons who travel or reside in Coccidioides-endemic regions, diagnostic evaluation should routinely include laboratory evaluation for this organism...
  30. pmc Polyfunctional T lymphocytes are in the peripheral blood of donors naturally immune to coccidioidomycosis and are not induced by dendritic cells
    Lance Nesbit
    Department of Immunobiology, University of Arizona, Tucson, Arizona, USA
    Infect Immun 78:309-15. 2010
    ..03). These data demonstrate the presence of polyfunctional T lymphocytes in the peripheral blood of individuals with coccidioidal immunity and suggest a model for the in vitro testing of vaccine candidates for coccidioidomycosis...
  31. pmc Emerging disease issues and fungal pathogens associated with HIV infection
    N M Ampel
    University of Arizona College of Medicine, Tuscon Veterans Affairs Medical Center, Tucson, Arizona 85713, USA
    Emerg Infect Dis 2:109-16. 1996
    ....
  32. ncbi request reprint Fatigue in coccidioidomycosis. Quantification and correlation with clinical, immunological, and nutritional factors
    Jennifer Muir Bowers
    Valley Fever Center for Excellence and the Department of Medicine of the University of Arizona, and the Southern Arizona Veterans Affairs Health Center System, Tucson, Arizona, USA
    Med Mycol 44:585-90. 2006
    ..078, P=0.261) or serum TNF-alpha (r2=0.028, P=0.504) concentrations. Severe fatigue is a common condition among patients with active coccidioidomycosis and is associated with a declining BMI...
  33. pmc Spherules derived from Coccidioides posadasii promote human dendritic cell maturation and activation
    Sara O Dionne
    Valley Fever Center for Excellence, Tuscon, AZ, USA
    Infect Immun 74:2415-22. 2006
    ....
  34. pmc Cellular immune suppressor activity resides in lymphocyte cell clusters adjacent to granulomata in human coccidioidomycosis
    Lijin Li
    Department of Microbiology and Immunology, University of Arizona, Tucson, Arizona, USA
    Infect Immun 73:3923-8. 2005
    ....
  35. ncbi request reprint The solitary pulmonary nodule
    Neil M Ampel
    N Engl J Med 349:1575; author reply 1575. 2003