Alisa P Alker

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
    Alisa P Alker
    Department of Epidemiology, UNC School of Public Health, Chapel Hill, North Carolina 27599, USA
    Am J Trop Med Hyg 76:641-7. 2007
  2. pmc Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi
    Alisa P Alker
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
    Antimicrob Agents Chemother 49:3919-21. 2005
  3. pmc Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia
    Naman K Shah
    University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
    Emerg Infect Dis 14:1637-40. 2008
  4. pmc dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo
    Alisa P Alker
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Trop Med Int Health 13:1384-91. 2008
  5. pmc Rapid real-time PCR genotyping of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum
    Alisa P Alker
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Antimicrob Agents Chemother 48:2924-9. 2004
  6. ncbi request reprint Rare Congolese Plasmodium falciparum DHFR alleles
    Paul E Wilson
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Biochem Parasitol 144:227-9. 2005
  7. pmc Socio-demographic characteristics associated with HIV and syphilis seroreactivity among pregnant women in Blantyre, Malawi, 2000-2004
    Jesse J Kwiek
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Malawi Med J 20:80-5. 2008
  8. pmc Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections
    Jesse J Kwiek
    University of North Carolina at Chapel Hill School of Public Health, Department of Epidemiology, CB 7435, Chapel Hill, NC 27599 7435, USA
    Antimicrob Agents Chemother 51:521-7. 2007
  9. pmc A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women
    Linda Kalilani
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 2:e1166. 2007
  10. pmc Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi
    Jesse J Kwiek
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS Med 3:e10. 2006

Detail Information

Publications12

  1. ncbi request reprint Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
    Alisa P Alker
    Department of Epidemiology, UNC School of Public Health, Chapel Hill, North Carolina 27599, USA
    Am J Trop Med Hyg 76:641-7. 2007
    ..040). pfmdr1 copy number should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia...
  2. pmc Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi
    Alisa P Alker
    Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC 27599 7435, USA
    Antimicrob Agents Chemother 49:3919-21. 2005
    ..The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found...
  3. pmc Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia
    Naman K Shah
    University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
    Emerg Infect Dis 14:1637-40. 2008
    ....
  4. pmc dhfr and dhps genotype and sulfadoxine-pyrimethamine treatment failure in children with falciparum malaria in the Democratic Republic of Congo
    Alisa P Alker
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Trop Med Int Health 13:1384-91. 2008
    ..To determine the relationship between mutations in dhfr and dhps and SP treatment failure in Plasmodium falciparum malaria in the Democratic Republic of the Congo (DRC)...
  5. pmc Rapid real-time PCR genotyping of mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum
    Alisa P Alker
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Antimicrob Agents Chemother 48:2924-9. 2004
    ..This assay is rapid and sensitive, with a detection limit of 10 copies in most cases. This assay is amenable to large-scale studies of drug resistance...
  6. ncbi request reprint Rare Congolese Plasmodium falciparum DHFR alleles
    Paul E Wilson
    Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Mol Biochem Parasitol 144:227-9. 2005
  7. pmc Socio-demographic characteristics associated with HIV and syphilis seroreactivity among pregnant women in Blantyre, Malawi, 2000-2004
    Jesse J Kwiek
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Malawi Med J 20:80-5. 2008
    ..We aimed to evaluate socio-demographic factors associated with HIV and syphilis seroreactivity in pregnant Malawians presenting for antenatal care in late third trimester of pregnancy...
  8. pmc Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections
    Jesse J Kwiek
    University of North Carolina at Chapel Hill School of Public Health, Department of Epidemiology, CB 7435, Chapel Hill, NC 27599 7435, USA
    Antimicrob Agents Chemother 51:521-7. 2007
    ..By summing these probabilities, treatment efficacy was estimated...
  9. pmc A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women
    Linda Kalilani
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 2:e1166. 2007
    ..We investigated the safety and efficacy of azithromycin or artesunate combined with sulfadoxine-pyrimethamine used for treatment of malaria in pregnant women in Blantyre, Malawi...
  10. pmc Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi
    Jesse J Kwiek
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS Med 3:e10. 2006
    ..Between 25% and 35% of infants born to HIV-infected mothers become HIV-1 infected. One potential route of mother-to-child transmission (MTCT) could be through a breakdown in the placental barrier (i.e., maternal-fetal microtransfusions)...
  11. ncbi request reprint Real-time PCR methods for monitoring antimalarial drug resistance
    Paul E Wilson
    University of North Carolina School of Medicine, Department of Microbiology and Immunology, CB 7290, Chapel Hill, NC 27599, USA
    Trends Parasitol 21:278-83. 2005
    ..In this article, we describe newer high-throughput methods for detecting these molecular markers. One method, 5' nuclease real-time polymerase chain reaction, is discussed in detail...
  12. ncbi request reprint Amodiaquine and combination chemotherapy for malaria
    Steven R Meshnick
    Am J Trop Med Hyg 73:821-3. 2005