Karim A Alkadhi

Summary

Affiliation: University of Houston
Country: USA

Publications

  1. doi request reprint Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX, USA Electronic address
    Mol Cell Neurosci 71:125-31. 2016
  2. doi request reprint Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer's Disease
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77204, USA
    Mol Neurobiol 52:93-100. 2015
  3. doi request reprint Chronic psychosocial stress impairs early LTP but not late LTP in the dentate gyrus of at-risk rat model of Alzheimer's disease
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA Electronic address
    Brain Res 1588:150-8. 2014
  4. pmc Chronic stress and Alzheimer's disease-like pathogenesis in a rat model: prevention by nicotine
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Curr Neuropharmacol 9:587-97. 2011
  5. doi request reprint Elevation of BACE in an Aβ rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    Int J Neuropsychopharmacol 15:223-33. 2012
  6. ncbi request reprint Chronic psychosocial stress exposes Alzheimer's disease phenotype in a novel at-risk model
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Front Biosci (Elite Ed) 4:214-29. 2012
  7. doi request reprint Long-term depression in the superior cervical ganglion of the rat
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX 77204 5515, USA
    Brain Res 1234:25-31. 2008
  8. ncbi request reprint Chronic psychosocial stress exacerbates impairment of synaptic plasticity in β-amyloid rat model of Alzheimer's disease: prevention by nicotine
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Curr Alzheimer Res 8:718-31. 2011
  9. doi request reprint Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5037, USA
    Mol Cell Neurosci 45:289-96. 2010
  10. doi request reprint Rhythmic discharge induced by temperature variation and drugs in isolated sympathetic ganglia
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, Houston, Texas 77204 5515, USA
    Clin Exp Hypertens 30:497-510. 2008

Collaborators

  • Karem Alzoubi
  • Samina Salim
  • Mohammad Asghar
  • David M Diamond
  • JANET STRINGER
  • An T Dao
  • Trinh T Tran
  • Ibrahim A Alhaider
  • N Z Gerges
  • Munder A Zagaar
  • A M Aleisa
  • Marisa Srivareerat
  • Abdulaziz M Aleisa
  • Nashaat Z Gerges
  • Gaurav Patki
  • Amber T Levine
  • Jason L Eriksen
  • Farida Allam
  • Gaurav Chugh
  • Faizan Jafri
  • Ritu Bohat
  • L A Schwarz
  • Fatin Atrooz
  • Farida H Allam
  • Naimesh Solanki
  • Christopher Mowrey
  • Collin R Park
  • A A Alhaider

Detail Information

Publications57

  1. doi request reprint Caffeine and REM sleep deprivation: Effect on basal levels of signaling molecules in area CA1
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX, USA Electronic address
    Mol Cell Neurosci 71:125-31. 2016
    ..All these changes were completely prevented in rats that chronically consumed caffeine. The present findings suggest an important neuroprotective property of caffeine in sleep deprivation. ..
  2. doi request reprint Chronic Stress Decreases Basal Levels of Memory-Related Signaling Molecules in Area CA1 of At-Risk (Subclinical) Model of Alzheimer's Disease
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77204, USA
    Mol Neurobiol 52:93-100. 2015
    ....
  3. doi request reprint Chronic psychosocial stress impairs early LTP but not late LTP in the dentate gyrus of at-risk rat model of Alzheimer's disease
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA Electronic address
    Brain Res 1588:150-8. 2014
    ....
  4. pmc Chronic stress and Alzheimer's disease-like pathogenesis in a rat model: prevention by nicotine
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Curr Neuropharmacol 9:587-97. 2011
    ..Chronic treatment with nicotine was highly efficient in preventing the effects of Aβ infusion and the exacerbating impact of chronic stress. Possible mechanisms for the effect of chronic stress are discussed...
  5. doi request reprint Elevation of BACE in an Aβ rat model of Alzheimer's disease: exacerbation by chronic stress and prevention by nicotine
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    Int J Neuropsychopharmacol 15:223-33. 2012
    ..The increased BACE levels and decreased nAChR levels, which are established hallmarks of AD, provide additional support for the validity of the Aβ i.c.v.-infused rat as a model of AD...
  6. ncbi request reprint Chronic psychosocial stress exposes Alzheimer's disease phenotype in a novel at-risk model
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Front Biosci (Elite Ed) 4:214-29. 2012
    ..Behavioral (learning and memory tests), electrophysiological and molecular findings indicated that even mild chronic psychosocial stress clearly transforms this seemingly normal rat model to a full-fledge AD phenotype...
  7. doi request reprint Long-term depression in the superior cervical ganglion of the rat
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX 77204 5515, USA
    Brain Res 1234:25-31. 2008
    ..These results indicate the presence of LTD in the rat SCG and suggest that expression of gLTD involves activation of 5-HT(3) receptor...
  8. ncbi request reprint Chronic psychosocial stress exacerbates impairment of synaptic plasticity in β-amyloid rat model of Alzheimer's disease: prevention by nicotine
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Curr Alzheimer Res 8:718-31. 2011
    ..These effects were not seen in Aβ- infused rats chronically treated with nicotine. The changes in synaptic plasticity-related molecules may explain the effects of stress and/or chronic nicotine on L-LTP in Aβ animals...
  9. doi request reprint Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5037, USA
    Mol Cell Neurosci 45:289-96. 2010
    ..These disturbances in signaling pathways, which may be the underlying mechanisms of impairment of long-term memory in these rats, were totally prevented by chronic nicotine treatment...
  10. doi request reprint Rhythmic discharge induced by temperature variation and drugs in isolated sympathetic ganglia
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, Houston, Texas 77204 5515, USA
    Clin Exp Hypertens 30:497-510. 2008
    ..The spontaneous rhythmic discharge may be important as a support mechanism for the cardiovascular system in victims of exposure to extreme cold temperature...
  11. ncbi request reprint Psychosocial stress-induced hypertension results from in vivo expression of long-term potentiation in rat sympathetic ganglia
    Karim A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5515, USA
    Neurobiol Dis 20:849-57. 2005
    ....
  12. ncbi request reprint Plasticity of synaptic transmission in autonomic ganglia
    K A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5515, USA
    Prog Neurobiol 75:83-108. 2005
    ..These new advances will be discussed in depth in this review...
  13. ncbi request reprint Inhibition of ganglionic long-term potentiation decreases blood pressure in spontaneously hypertensive rats
    K A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5515, USA
    Exp Biol Med (Maywood) 226:1024-30. 2001
    ..This contrasts with the absence of gLTP in ganglia from normotensive rats. The results support contribution of gLTP to the expression of neurogenic hypertension...
  14. ncbi request reprint Retrograde carbon monoxide is required for induction of long-term potentiation in rat superior cervical ganglion
    K A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Neurosci 21:3515-20. 2001
    ..These results suggest that activation of 5-HT(3) receptors may be involved in the production of CO. The results also suggest that CO, probably originating outside the presynaptic nerve terminal, is involved in the induction of LTP...
  15. pmc Induction and maintenance of ganglionic long-term potentiation require activation of 5-hydroxytryptamine (5-HT3) receptors
    K A Alkadhi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, TX 77204 5515, USA
    J Physiol 496:479-89. 1996
    ..9. We conclude that tetanus-induced LTP of the SCG of the rat requires activation of 5-HT3 receptors both for induction and maintenance...
  16. ncbi request reprint Nitric oxide mediates long-term potentiation in rat superior cervical ganglion
    K A Alkadhi
    Department of Pharmacological and Pharmaceutical Science, College of Pharmacy, University of Houston, TX 77204 5515, USA
    Brain Res 753:315-7. 1997
    ..We investigated a similar possible involvement of NO in the LTP of the SCG of the rat. Treatment of ganglia with the NO-synthase inhibitor N(G)-nitro-L-arginine (L-NOARG, 10 microM) blocked LTP at the maintenance phase...
  17. pmc Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity
    Ibrahim A Alhaider
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5515, USA
    Sleep 33:437-44. 2010
    ..This study was undertaken to provide a detailed account of the effect of chronic treatment with a small dose of caffeine on the deleterious effects of sleep loss on brain function in rats...
  18. doi request reprint Chronic psychosocial stress exacerbates impairment of cognition and long-term potentiation in beta-amyloid rat model of Alzheimer's disease
    Marisa Srivareerat
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204 5037, USA
    Biol Psychiatry 65:918-26. 2009
    ..Individuals suffering from chronic stress are at an increased risk for developing AD. This study investigated the effect of chronic psychosocial stress in Abeta rat model of AD...
  19. pmc Grape powder intake prevents ovariectomy-induced anxiety-like behavior, memory impairment and high blood pressure in female Wistar rats
    Gaurav Patki
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas, United States of America
    PLoS ONE 8:e74522. 2013
    ..Our study is the first to examine behavioral, biochemical, physiological and electrophysiological outcome of estrogen depletion in rats and to test protective role of grape powder, all in the same study. ..
  20. doi request reprint Chronic psychosocial stress triggers cognitive impairment in a novel at-risk model of Alzheimer's disease
    Trinh T Tran
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA
    Neurobiol Dis 37:756-63. 2010
    ..These findings suggest that the stress-induced alterations may accelerate the impairment of cognition and synaptic plasticity in individuals "at-risk" for AD...
  21. doi request reprint Caffeine prevents sleep loss-induced deficits in long-term potentiation and related signaling molecules in the dentate gyrus
    Ibrahim A Alhaider
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    Eur J Neurosci 31:1368-76. 2010
    ..The results suggest that chronic use of caffeine prevented anomalous changes in the basal levels of P-CaMKII and BDNF associated with sleep deprivation and as a result contributes to the revival of LTP in the DG region...
  22. doi request reprint Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease
    Marisa Srivareerat
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, United States
    Neurobiol Aging 32:834-44. 2011
    ..Furthermore, chronic nicotine treatment prevented the Aβ-induced reduction of α(7)- and α(4)-nAChR. These effects of nicotine may be due, at least in part, to upregulation of brain derived neurotropic factor (BDNF)...
  23. ncbi request reprint Nicotine blocks stress-induced impairment of spatial memory and long-term potentiation of the hippocampal CA1 region
    Abdulaziz M Aleisa
    University of Houston, College of Pharmacy, Department of Pharmacological and Pharmaceutical Sciences, Houston, TX 77204, USA
    Int J Neuropsychopharmacol 9:417-26. 2006
    ..Nicotine had no effect on LTP in control animals. These results showed that chronic nicotine treatment improved hippocampus-dependent spatial memory and LTP only when impaired by stress...
  24. pmc Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology
    An T Dao
    Department of PPS, College of Pharmacy, University of Houston, Houston, TX 77204 5037, USA
    Curr Alzheimer Res 10:507-15. 2013
    ..We conclude that treadmill exercise maybe able to prevent cognitive impairment associated with AD pathology...
  25. doi request reprint Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine
    Ibrahim A Alhaider
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    Mol Cell Neurosci 46:742-51. 2011
    ..The results suggest that chronic caffeine treatment may protect the sleep-deprived brain probably by preserving the levels of P-CREB and BDNF...
  26. doi request reprint Chronic psychosocial stress enhances long-term depression in a subthreshold amyloid-beta rat model of Alzheimer's disease
    Trinh T Tran
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas, USA
    J Neurochem 119:408-16. 2011
    ..These findings suggest that chronic stress may accelerate the impairment of synaptic plasticity and consequently cognition in individuals 'at-risk' for AD...
  27. ncbi request reprint Adverse effect of the combination of hypothyroidism and chronic psychosocial stress on hippocampus-dependent memory in rats
    Nashaat Z Gerges
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5515, USA
    Behav Brain Res 155:77-84. 2004
    ..The data indicated that the combination of stress and hypothyroidism produced more deleterious effects on hippocampal function than either chronic stress or hypothyroidism alone...
  28. ncbi request reprint Impairment of long-term potentiation in the CA1, but not dentate gyrus, of the hippocampus in Obese Zucker rats: role of calcineurin and phosphorylated CaMKII
    Korem H Alzoubi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA
    J Mol Neurosci 27:337-46. 2005
    ..These findings suggest that the DG might possess a compensatory mechanism whereby calcineurin levels are reduced to allow sufficient P-CaMKII to produce an apparently normal LTP in the DG area of OZR hippocampus...
  29. doi request reprint Chronic psychosocial stress accelerates impairment of long-term memory and late-phase long-term potentiation in an at-risk model of Alzheimer's disease
    Trinh T Tran
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, College of Pharmacy, Texas
    Hippocampus 21:724-32. 2011
    ..These findings suggest that the chronic stress-induced molecular alteration may accelerate the impairment of cognition and synaptic plasticity in individuals "at-risk" for AD...
  30. ncbi request reprint Hypothyroidism impairs late LTP in CA1 region but not in dentate gyrus of the intact rat hippocampus: MAPK involvement
    Nashaat Z Gerges
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204 5515, USA
    Hippocampus 14:40-5. 2004
    ..The correlation between the effect of hypothyroidism on L-LTP and enzyme levels suggests that hypothyroidism-induced impairment of L-LTP in CA1 may be due to decreased levels of phosphorylated ERK1 and ERK2...
  31. ncbi request reprint Reduction of elevated arterial blood pressure in obese Zucker rats by inhibition of ganglionic long-term potentiation
    N Z Gerges
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, TX, Houston 77204 5515, USA
    Neuropharmacology 43:1070-6. 2002
    ....
  32. pmc Regular exercise prevents non-cognitive disturbances in a rat model of Alzheimer's disease
    An T Dao
    University of Houston, College of Pharmacy, Houston, TX, USA
    Int J Neuropsychopharmacol 17:593-602. 2014
    ..We conclude that regular exercise may exert beneficial effects on both cognitive and non-cognitive functions in this AD model...
  33. ncbi request reprint Comparison of the Effect of Exercise on Late-Phase LTP of the Dentate Gyrus and CA1 of Alzheimer's Disease Model
    An T Dao
    Department of PPS, College of Pharmacy, University of Houston, Houston, TX, 77204 5037, USA
    Mol Neurobiol 53:6859-6868. 2016
    ..The protective effect of regular exercise can be a promising therapeutic measure for countering or delaying the AD-like pathology...
  34. doi request reprint Prevention by Regular Exercise of Acute Sleep Deprivation-Induced Impairment of Late Phase LTP and Related Signaling Molecules in the Dentate Gyrus
    Munder A Zagaar
    Departmentof Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA
    Mol Neurobiol 53:2900-10. 2016
    ..The current findings show that our exercise regimen prevents sleep deprivation-induced deficits in L-LTP as well as the basal and poststimulation levels of key signaling molecules. ..
  35. pmc Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats
    Farida Allam
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA
    J Nutr 143:835-42. 2013
    ..We suggest that by regulating brain ERK-1/2, GLO-1, GSR-1, CAMK-IV, CREB, and BDNF levels, grape powder prevents oxidative stress-induced anxiety, memory impairment, and hypertension in rats...
  36. ncbi request reprint Combination of hypothyroidism and stress abolishes early LTP in the CA1 but not dentate gyrus of hippocampus of adult rats
    N Z Gerges
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204-5515, USA
    Brain Res 922:250-60. 2001
    ..These results suggest that impaired memory because of hypothyroidism or stress may be related to impairment of the E-LTP in the Schaffer collateral synapses but not of that of the perforant path synapses...
  37. ncbi request reprint Hypothyroidism impairs long-term potentiation in sympathetic ganglia: electrophysiologic and molecular studies
    K H Alzoubi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5515, USA
    J Neurosci Res 78:393-402. 2004
    ..In addition, the results indicate that synaptic plasticity in sympathetic ganglia may involve a molecular sequence of events similar to that proposed for LTP in the hippocampus...
  38. ncbi request reprint Impaired long-term potentiation in obese zucker rats: possible involvement of presynaptic mechanism
    N Z Gerges
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5515, USA
    Neuroscience 120:535-9. 2003
    ..The results emphasize the potential deleterious effect of obesity on learning and memory functions of the CNS...
  39. ncbi request reprint The sliding threshold of modification hypothesis: application to the effect of hypothyroidism or chronic psychosocial stress and nicotine on synaptic plasticity
    K H Alzoubi
    Departments of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5515, USA
    Neurosci Lett 430:203-6. 2008
    ..The data correlate with our previous findings: a shift in the balance of kinase/phosphatase toward phosphatase during psychosocial stress or hypothyroidism, which is restored by chronic nicotine treatment...
  40. ncbi request reprint Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: electrophysiological and molecular studies
    K H Alzoubi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5515, USA
    Exp Neurol 195:330-41. 2005
    ..The results demonstrated that thyroxin therapy normalized the electrophysiological and molecular effects of hypothyroidism on the CA1 region and emphasized the critical role P-CaMKII plays in hypothyroidism-induced LTP impairment...
  41. doi request reprint Moderate Treadmill Exercise Protects Synaptic Plasticity of the Dentate Gyrus and Related Signaling Cascade in a Rat Model of Alzheimer's Disease
    An T Dao
    Department of PPS, College of Pharmacy, University of Houston, Houston, TX, 77204 5037, USA
    Mol Neurobiol 52:1067-76. 2015
    ..Our data suggests that by restoring the balance of kinase-phosphatase, 4 weeks of moderate treadmill exercise prevents DG synaptic deficits and deleterious alterations in signaling pathways associated with AD...
  42. ncbi request reprint A comparative study of the actions of histamine H2 receptor antagonists on transmission in the isolated superior cervical ganglion of the rat
    K A Alkadhi
    Department of Pharmacology, University of Houston, Texas 77204 5515
    Neuropharmacology 29:285-90. 1990
    ..It is suggested that the ganglion effect may be due to the action of these agents on the acetylcholine receptor-ion channel complex in the postsynaptic membrane...
  43. ncbi request reprint Nicotine prevents disruption of the late phase LTP-related molecular cascade in adult-onset hypothyroidism
    K H Alzoubi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204 5515, USA
    Hippocampus 17:654-64. 2007
    ....
  44. ncbi request reprint A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism
    K H Alzoubi
    Department Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77204 5515, USA
    Exp Neurol 203:63-71. 2007
    ....
  45. ncbi request reprint Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies
    K H Alzoubi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204 5515, USA
    J Neurosci Res 84:944-53. 2006
    ..These results show that chronic nicotine treatment prevents hypothyroidism-induced impairment of spatial cognition and LTP...
  46. ncbi request reprint Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF
    A M Aleisa
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5515, USA
    Neurobiol Dis 22:453-62. 2006
    ..These results indicate that normalization by nicotine of the stress-induced changes in the levels of signaling molecules including BDNF may contribute to the recovery of LTP...
  47. doi request reprint Caffeine treatment prevents rapid eye movement sleep deprivation-induced impairment of late-phase long-term potentiation in the dentate gyrus
    Ibrahim A Alhaider
    Department of Pharmacological and Pharmaceutical Sciences, 521E Science and Research 2 Bldg, College of Pharmacy, University of Houston, Houston, TX 77204 5037, USA
    Eur J Neurosci 42:2843-50. 2015
    ..The current findings show that caffeine treatment prevents acute sleep deprivation-induced deficits in brain function...
  48. ncbi request reprint Molecular studies on the protective effect of nicotine in adult-onset hypothyroidism-induced impairment of long-term potentiation
    K H Alzoubi
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    Hippocampus 16:861-74. 2006
    ..We conclude that the neuroprotective effects of nicotine in adult-onset hypothyroidism may result from restoration of CaMKII and calcineurin activity...
  49. ncbi request reprint Effects of felodipine and verapamil on transmission in the isolated superior cervical ganglion of the rat
    K A Alkadhi
    Department of Pharmacology, College of Pharmacy, University of Houston, Texas 77004
    Arch Int Pharmacodyn Ther 288:50-8. 1987
    ..The results suggest that the observed ganglionic blocking effects of these drugs are apparently unrelated to Ca2+ channel blockade...
  50. ncbi request reprint Role of phosphorylated CaMKII and calcineurin in the differential effect of hypothyroidism on LTP of CA1 and dentate gyrus
    N Z Gerges
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5515, USA
    Hippocampus 15:480-90. 2005
    ..These findings suggest that the DG may possess a compensatory mechanism whereby calcineurin levels are reduced, to allow sufficient CaMKII activity to produce an apparently normal LTP in hypothyroid rats...
  51. ncbi request reprint Nicotine prevents stress-induced enhancement of long-term depression in hippocampal area CA1: electrophysiological and molecular studies
    A M Aleisa
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, Texas 77204 5515, USA
    J Neurosci Res 83:309-17. 2006
    ..Therefore, the increase in the levels of calcineurin and P-CaMKII during expression of LTD in area CA1 may explain the enhanced magnitude of LTD in chronically stressed rats...
  52. ncbi request reprint Chronic but not acute nicotine treatment reverses stress-induced impairment of LTP in anesthetized rats
    A M Aleisa
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204 5515, USA
    Brain Res 1097:78-84. 2006
    ..did not reverse chronic-stress-induced impairment of LTP. The results show that the impairment of LTP during chronic stress can be blocked by chronic, but not acute, nicotine treatment...
  53. ncbi request reprint Chronic psychosocial stress decreases calcineurin in the dentate gyrus: a possible mechanism for preservation of early ltp
    N Z Gerges
    Department of Pharmacological Sciences, College of Pharmacy, University of Houston, 77204 5515, Houston, TX, USA
    Neuroscience 117:869-74. 2003
    ..The results of this work will increase understanding of why certain brain regions are more resistant to deleterious effects of conditions that deteriorate learning and memory...
  54. ncbi request reprint Reduced basal CaMKII levels in hippocampal CA1 region: possible cause of stress-induced impairment of LTP in chronically stressed rats
    N Z Gerges
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, Texas 77204 5515, USA
    Hippocampus 14:402-10. 2004
    ..Our results suggest that decreased P-CaMKII levels may be primarily responsible for the stress-induced reduction in LTP expression...
  55. ncbi request reprint Impaired neural transmission and synaptic plasticity in superior cervical ganglia from β-amyloid rat model of Alzheimer's disease
    K H Alzoubi
    Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan
    Curr Alzheimer Res 8:377-84. 2011
    ..Results of the current study could explain some of the peripheral nervous system manifestations of Alzheimer's disease...