Hydar Ali

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT
    H Ali
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Immunol 165:7215-23. 2000
  2. pmc Anaphylatoxin C3a receptors in asthma
    Hydar Ali
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104, USA
    Respir Res 6:19. 2005
  3. ncbi request reprint Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment
    Rampura T Venkatesha
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:44606-12. 2004
  4. ncbi request reprint C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1
    Jasimuddin Ahamed
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:6961-8. 2004
  5. pmc Distinct roles of Ca2+ mobilization and G protein usage on regulation of Toll-like receptor function in human and murine mast cells
    Asifa K Zaidi
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA 19104, USA
    Immunology 119:412-20. 2006
  6. pmc Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization
    Hariharan Subramanian
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6030, USA
    J Biol Chem 286:44739-49. 2011
  7. pmc Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases
    Qiang Guo
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e22559. 2011
  8. ncbi request reprint C3a receptors signaling in mast cells
    Asifa K Zaidi
    University of Pennsylvania School of Dental Medicine, Department of Pathology, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 598:126-40. 2007
  9. ncbi request reprint Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact
    E Berla Thangam
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6002, USA
    FASEB J 19:798-800. 2005
  10. pmc β-Defensins activate human mast cells via Mas-related gene X2
    Hariharan Subramanian
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
    J Immunol 191:345-52. 2013

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT
    H Ali
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA
    J Immunol 165:7215-23. 2000
    ....
  2. pmc Anaphylatoxin C3a receptors in asthma
    Hydar Ali
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104, USA
    Respir Res 6:19. 2005
    ..Therefore, C3a likely plays an important role in asthma primarily by regulating mast cell-ASM cell interaction...
  3. ncbi request reprint Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment
    Rampura T Venkatesha
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:44606-12. 2004
    ..However, receptor phosphorylation and beta-arrestin recruitment inhibit CCL2 production by blocking both NF-kappaB activation and Ca2+/calcineurin-dependent signaling pathways...
  4. ncbi request reprint C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1
    Jasimuddin Ahamed
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 172:6961-8. 2004
    ..Furthermore, C3a enhances NGF-induced transcription factor activation and chemokine production via a G protein-mediated pathway that does not involve TrkA phosphorylation...
  5. pmc Distinct roles of Ca2+ mobilization and G protein usage on regulation of Toll-like receptor function in human and murine mast cells
    Asifa K Zaidi
    Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, PA 19104, USA
    Immunology 119:412-20. 2006
    ..These findings suggest that TLR2 activation in human LAD 2 mast cells and MLMC/BMMC promotes the release of different classes of mediators via distinct signalling pathways that depend on Ca2+ mobilization and G protein usage...
  6. pmc Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization
    Hariharan Subramanian
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6030, USA
    J Biol Chem 286:44739-49. 2011
    ....
  7. pmc Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases
    Qiang Guo
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e22559. 2011
    ..However, the roles of these GRKs on the regulation of C3aR signaling and mediator release in human mast cells remain unknown...
  8. ncbi request reprint C3a receptors signaling in mast cells
    Asifa K Zaidi
    University of Pennsylvania School of Dental Medicine, Department of Pathology, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 598:126-40. 2007
  9. ncbi request reprint Airway smooth muscle cells enhance C3a-induced mast cell degranulation following cell-cell contact
    E Berla Thangam
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6002, USA
    FASEB J 19:798-800. 2005
    ....
  10. pmc β-Defensins activate human mast cells via Mas-related gene X2
    Hariharan Subramanian
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
    J Immunol 191:345-52. 2013
    ..Furthermore, murine mast cells are resistant to hBDs for degranulation, and this reflects the absence of MrgX2 in these cells...
  11. pmc Phosphorylation of C3a receptor at multiple sites mediates desensitization, β-arrestin-2 recruitment and inhibition of NF-κB activity in mast cells
    Kshitij Gupta
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS ONE 7:e46369. 2012
    ..C3aR possesses ten potential phosphorylation sites within its carboxyl terminus but their role on desensitization, β-arrestin recruitment and NF-κB activation has not been determined...
  12. pmc G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: roles of Mas-related genes MrgX1 and MrgX2
    Sakeen W Kashem
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States
    Eur J Pharmacol 668:299-304. 2011
    ..It further reveals the novel finding that the previously characterized synthetic peptide, C3a receptor "superagonist" E7 activates human mast cells via two mechanisms; one involving the C3a receptor and the other MrgX2...
  13. ncbi request reprint PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6030, USA
    Curr Pharm Des 17:3815-22. 2011
    ....
  14. pmc Roles for NHERF1 and NHERF2 on the regulation of C3a receptor signaling in human mast cells
    Hariharan Subramanian
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 7:e51355. 2012
    ..Although C3aR possesses a class I PDZ motif, the possibility that it interacts with NHERF proteins to modulate signaling in human mast cells has not been determined...
  15. doi request reprint Akt-1 mediates survival of chondrocytes from endoplasmic reticulum-induced stress
    Jeremy Price
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Physiol 222:502-8. 2010
    ..Thus, rapid upregulation of CHOP likely contributes to chondrocyte death, while Akt-1-mediated inactivation of caspase 3 and induction of BclXL promotes survival...
  16. pmc Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells
    Arpana Vibhuti
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e19585. 2011
    ..The role of β-arrestins on C3aR activation/regulation in human mast cells, however, remains unknown...
  17. ncbi request reprint Cutting edge: Differential regulation of chemoattractant receptor-induced degranulation and chemokine production by receptor phosphorylation
    J Ahamed
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 4010 Locust Street, Philadelphia, PA 19104, USA
    J Immunol 167:3559-63. 2001
    ..These data demonstrate that receptor phosphorylation, which provides a turn off signal for degranulation, is essential for CCL2 production...
  18. pmc Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a
    Hydar Ali
    Department of Pathology, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104 6030, USA
    Immunol Lett 128:36-45. 2010
    ..It discusses the mechanisms by which anaphylatoxins activate mast cells and basophils and the associated signaling pathways via which their receptors are regulated by priming and desensitization...
  19. ncbi request reprint Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production
    Jasimuddin Ahamed
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:22685-91. 2002
    ....
  20. ncbi request reprint Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase
    Rampura T Venkatesha
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, 240 South 40th Street, Philadelphia, PA 19104 6002, USA
    Mol Immunol 42:581-7. 2005
    ..7+/-1.5%. These data demonstrate that C3a activates divergent signaling pathways to induce chemokine production in human mast cells...
  21. pmc Roles of Mas-related G protein-coupled receptor X2 on mast cell-mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases
    Hariharan Subramanian
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA
    J Allergy Clin Immunol 138:700-10. 2016
    ..Furthermore, mAbs or small-molecule inhibitors of MRGPRX2 could be developed for the treatment of MC-dependent allergic and inflammatory disorders. ..
  22. pmc Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties
    Kshitij Gupta
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Oncotarget 6:28573-87. 2015
    ..Low cost production of AMPs in plants should facilitate their advancement to the clinic overcoming major hurdles in current production systems. ..
  23. pmc Modulation of host defense peptide-mediated human mast cell activation by LPS
    Kshitij Gupta
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA
    Innate Immun 22:21-30. 2016
    ....
  24. pmc PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells
    Hariharan Subramanian
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6030, USA
    Mol Pharmacol 79:1005-13. 2011
    ..Furthermore, Trp and Arg residues are required for the ability of PMX53 to act as both a CD88 antagonist and a MrgX2 agonist...
  25. pmc Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase
    Bruce J Shenker
    Department of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104 6030, USA
    Mol Immunol 48:203-10. 2010
    ..Moreover, these studies provide evidence for the utilization of CdtB as a novel therapeutic agent for targeting the PI-3K signaling pathway...
  26. ncbi request reprint Response to C3a, mast cells, and asthma
    Asifa K Zaidi
    FASEB J 20:199. 2006