Grace M Aldrovandi
Affiliation: University of Southern California
- Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmissionLaura Heath
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
PLoS ONE 5:e10213. 2010..The basis of this restriction and the genetic relationship between breast milk and blood variants are not well established...
- Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected womenHae Young Kim
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA
BMC Pediatr 12:138. 2012..Here we examine risk factors for these adverse pregnancy outcomes in a cohort of HIV-infected women in Zambia considering the impact of infant HIV status...
- Immunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: a cross-sectional studyJan Walter
Department of Plant Pathology and Microbiology, University of California, Riverside, USA
BMC Infect Dis 11:263. 2011....
- Morphologic and metabolic abnormalities in vertically HIV-infected children and youthGrace M Aldrovandi
Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California, USA
AIDS 23:661-72. 2009..To compare the distribution of lipid and glucose abnormalities and altered fat distribution among vertically HIV-infected patients and controls...
- What infants and breasts can teach us about natural protection from HIV infectionGrace M Aldrovandi
Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
J Infect Dis 202:S366-70. 2010..In this review, we discuss the advantages and disadvantages of mother‐to‐child HIV transmission as a model in which to elucidate correlates of immune protection...
- Antiretroviral exposure and lymphocyte mtDNA content among uninfected infants of HIV-1-infected womenGrace M Aldrovandi
Saban Research Institute of Childrens Hospital Los Angeles, University of Southern California, Los Angeles, California 90027, USA
Pediatrics 124:e1189-97. 2009..Nucleoside reverse transcriptase inhibitor ARV agents can inhibit DNA polymerase gamma, impairing mitochondrial DNA (mtDNA) synthesis and resulting in depletion or dysfunction...
- Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort studyJan Walter
Childrens Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA
BMC Infect Dis 8:172. 2008..The effects of these mutations on the efficacy of SDNVP use in a subsequent pregnancy are not well understood...
- Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeedingLars Bode
Division of Neonatology and the Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of California, San Diego, CA, USA
Am J Clin Nutr 96:831-9. 2012..The inefficiency of HIV breast-milk transmission may be caused by the presence of immunologically active factors, including human milk oligosaccharides (HMOs)...
- Coverage of primary mother-to-child HIV transmission isolates by second-generation broadly neutralizing antibodiesKyle J Nakamura
Department of Pediatrics, Children s Hospital of Los Angeles, Los Angeles, CA, USA
AIDS 27:337-46. 2013..To assess the neutralization potency and coverage of a panel of second-generation bNAbs, we cloned and phenotypically characterized 227 primary HIV-1 envelopes from 23 mother-to-child transmission (MTCT) pairs...
- High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmissionJan Walter
Children s Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
J Infect Dis 200:1498-502. 2009..IL-15-mediated immunity may protect against HIV transmission during breast-feeding...
- Breast milk and in utero transmission of HIV-1 select for envelope variants with unique molecular signaturesKyle J Nakamura
Division of Infectious Diseases, Children s Hospital Los Angeles, Los Angeles, CA, USA
Retrovirology 14:6. 2017..HIV-1 infection is frequently initiated by a single founder viral variant, but the factors that influence particular variant selection are poorly understood...
- Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021Alexandra Ruan
Keck School of Medicine at the University of Southern California, Los Angeles, CA Department of Pediatrics, Children s Hospital Los Angeles, Los Angeles, CA Department of Medicine, University of California at San Francisco, San Francisco, CA and Department of Pediatrics, Duke University, Durham, NC
J Acquir Immune Defic Syndr 72:372-5. 2016....
- 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphismsKyle J Nakamura
Department of Pediatrics, Childrens Hospital of Los Angeles, Los Angeles, California, United States of America
PLoS ONE 5:e9786. 2010..Our data provide important caveats for vaccine development targeting the MPER. Naturally occurring Env variants described in our study also represent unique tools for probing the structure-function of HIV-1 envelope...
- Review of HIV antiretroviral drug resistanceTempe K Chen
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Pediatr Infect Dis J 27:749-52. 2008
- Human milk galectin-3 binding protein and breast-feeding-associated HIV transmissionChristina S Chan
From the Divisions of Neonatology and Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of California, San Diego, CA Gertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY Lusaka District Health Management Team University Teaching Hospital, University of Zambia, Lusaka, Zambia Center for International Health and Development, Boston University School of Public Health, Boston, MA and Department of Pediatrics, Children s Hospital Los Angeles, University of Southern California, Los Angeles, CA
Pediatr Infect Dis J 32:e473-5. 2013..This suggests that although milk galectin-3 binding protein is a marker of advanced maternal disease, it does not independently modify transmission risk. ..
- Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spotsJan Walter
Childrens Hospital Los Angeles, University of Southern California, 4546 Sunset Boulevard, Los Angeles, CA 90027, USA
J Clin Microbiol 47:2989-91. 2009..The codetection of DNA and RNA did not result in an overall higher sensitivity compared to that of DNA alone. Discordant results were associated with low levels of HIV DNA, indicating that the sample amount may be critical...
- Using cluster heat maps to investigate relationships between body composition and laboratory measurements in HIV-infected and HIV-uninfected children and young adultsJane C Lindsey
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA
J Acquir Immune Defic Syndr 59:325-8. 2012..Of these, 1 cluster had more participants with higher body fat and insulin resistance, which are risk factors for future cardiovascular disease, and the other had relatively normal measurements on all outcomes...
- Immunology of pediatric HIV infectionNicole H Tobin
Children s Hospital Los Angeles, Los Angeles, CA, USA
Immunol Rev 254:143-69. 2013....
- Advances in basic science understanding of mother-to-child HIV-1 transmissionJan Walter
aChildren s Hospital Los Angeles, University of Southern California, Los Angeles, California, USA bGertrude H Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
Curr Opin HIV AIDS 3:146-50. 2008..The present review summarizes and discusses studies on the mechanisms underlying mother-to-child HIV transmission published in 2006-2007...
- Investigation of a suspected nosocomial transmission of blaKPC3-mediated carbapenem-resistant Klebsiella pneumoniae by whole genome sequencingShangxin Yang
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, USA
Diagn Microbiol Infect Dis 84:337-42. 2016..While WGS provided additional information that was not available by PFGE, in this study, neither method could definitively conclude the relatedness between the isolates. ..
- Maternal HIV infection influences the microbiome of HIV-uninfected infantsJeffrey M Bender
Children s Hospital Los Angeles, Los Angeles, CA 90027, USA Department of Pediatrics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
Sci Transl Med 8:349ra100. 2016..The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants. ..
- Are infants unique in their ability to be "functionally cured" of HIV-1?Nicole H Tobin
Department of Pediatrics, Children s Hospital Los Angeles, 4650 Sunset Blvd, MS 51, Los Angeles, CA, 90027, USA
Curr HIV/AIDS Rep 11:1-10. 2014..We will also compare the path to infant "cure" to cures in adults. ..
- 2050: Ending the odyssey of the great white plague. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo MolteniMandeep S Jassal
Division of Pediatric Pulmonology, Children s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, United States
Pharmacol Res 64:176-9. 2011..All such endeavors will require not only more focused research initiatives, but greater institutional support from the pharmaceutical industry, non-governmental organizations and national health sectors...