Mansoor M Ahmed

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors
    Mansoor M Ahmed
    Department of Radiation Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0084, USA
    Curr Cancer Drug Targets 4:43-52. 2004
  2. ncbi request reprint Low dose fractionated radiation potentiates the effects of taxotere in nude mice xenografts of squamous cell carcinoma of head and neck
    Paul M Spring
    Division of Otolaryngology, Department of Surgery, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Cell Cycle 3:479-85. 2004
  3. ncbi request reprint Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell lines
    Swatee Dey
    Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Clin Cancer Res 9:1557-65. 2003
  4. ncbi request reprint The impact of TNF-alpha induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiation
    Sabapathi Sathishkumar
    University of Kentucky, Department of Radiation Medicine, 800 Rose Street, Lexington, KY 40536 0293, USA
    Technol Cancer Res Treat 1:141-7. 2002
  5. ncbi request reprint Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3
    Damodaran Chendil
    Department of Clinical Science, University of Kentucky, Lexington, KY 40536, USA
    Oncogene 23:1599-607. 2004
  6. ncbi request reprint Low-dose fractionated radiation as a chemopotentiator of neoadjuvant paclitaxel and carboplatin for locally advanced squamous cell carcinoma of the head and neck: results of a new treatment paradigm
    Susanne M Arnold
    Department of Medicine, University of Kentucky Markey Cancer Center, Lexington 40536, USA
    Int J Radiat Oncol Biol Phys 58:1411-7. 2004
  7. ncbi request reprint Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3
    Damodaran Chendil
    Department of Radiation Medicine, University of Kentucky, 800, Rose Street, Lexington, Kentucky 40536, USA
    Cancer Biol Ther 1:152-60. 2002
  8. ncbi request reprint Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2
    Rachael A Alcock
    Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Oncogene 21:7883-90. 2002
  9. ncbi request reprint Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2
    Mansoor M Ahmed
    Department of Radiation Medicine, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 277:2234-46. 2002
  10. ncbi request reprint Rasagenthi lehyam (RL) a novel complementary and alternative medicine for prostate cancer
    Rama S Ranga
    Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Room No 209D, 900 South Limestone Street, Lexington, KY 40536 0200, USA
    Cancer Chemother Pharmacol 54:7-15. 2004

Collaborators

  • Swatee Dey
  • Joseph Valentino
  • William F Regine
  • Paul M Spring
  • Demetrius M Kokkinakis
  • Subodh M Lele
  • ANTHONY PEGG
  • Vivek M Rangnekar
  • S Chada
  • Berrin Tunca
  • Mohammed Mohiuddin
  • Damodaran Chendil
  • Sabapathi Sathishkumar
  • Mohammed Momin Shareef
  • Seema Gupta
  • Mohammed M Shareef
  • Susanne M Arnold
  • Rama S Ranga
  • Mahesh Kudrimoti
  • Mohammed S Inayat
  • Rachael A Alcock
  • Shahin Shajahan
  • Anna Reeves
  • Philip Desimone
  • Maqbool Halepota
  • Ayisha Siddiqua
  • Vincent S Gallicchio
  • Ali S Meigooni
  • Lutfi Ozkan
  • Meraj Mohiuddin
  • Brandee Brown
  • Sabapathi Satishkumar
  • Marianna Zagurovskaya
  • Nuan Cui
  • Ravshan Burikhanov
  • Natalia V Giltiay
  • Alexander A Karakashian
  • Krassimira Rozenova
  • Boris Boyanovsky
  • Mariana Nikolova-Karakashian
  • David Meigooni
  • Subbiah Thirugnanam
  • Daniel Kenady
  • Ramankutty Girija
  • Sabapathy Sathishkumar
  • Mohammed A Akbarsha
  • Jurgen Rohr
  • Mohammed Nur-e-Alam
  • Unal Egeli
  • George Hartman
  • Mahesh S Kudrimoti
  • Kayihan Engin
  • Ciğdem Cimen
  • Gulsah Cecener
  • Sibel Kahraman-Cetintas
  • Emel Ergul
  • Randall Rowland
  • Sema Ozuysal
  • Anindita Das
  • Nilufer Aydemir
  • Gurler Akpinar
  • Lee K Chatfield
  • Howard L Elford

Detail Information

Publications25

  1. ncbi request reprint Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors
    Mansoor M Ahmed
    Department of Radiation Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0084, USA
    Curr Cancer Drug Targets 4:43-52. 2004
    ..Together, the review of reported findings demonstrate clearly that EGR-1 is an early central gene that confers radiation sensitivity and its pro-apoptotic functions are synergized by abrogation of induced radiation resistance...
  2. ncbi request reprint Low dose fractionated radiation potentiates the effects of taxotere in nude mice xenografts of squamous cell carcinoma of head and neck
    Paul M Spring
    Division of Otolaryngology, Department of Surgery, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536 0084, USA
    Cell Cycle 3:479-85. 2004
    ..Furthermore, the G(2)/M cell cycle arrest by TXT appears to be an important component of the enhanced apoptotic effect of TXT + LDFRT combined treatment...
  3. ncbi request reprint Low-dose fractionated radiation potentiates the effects of Paclitaxel in wild-type and mutant p53 head and neck tumor cell lines
    Swatee Dey
    Department of Radiation Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Clin Cancer Res 9:1557-65. 2003
    ..These findings strongly suggest that LDFRT (at these doses, HRS phenomenon is observed) can be used in combination with Paclitaxel to overcome the antiapoptotic effects of BCL-2 and nuclear factor kappa B...
  4. ncbi request reprint The impact of TNF-alpha induction on therapeutic efficacy following high dose spatially fractionated (GRID) radiation
    Sabapathi Sathishkumar
    University of Kentucky, Department of Radiation Medicine, 800 Rose Street, Lexington, KY 40536 0293, USA
    Technol Cancer Res Treat 1:141-7. 2002
    ..Complete tumor response strongly correlated with the induction of TNF-alpha levels in the serum...
  5. ncbi request reprint Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3
    Damodaran Chendil
    Department of Clinical Science, University of Kentucky, Lexington, KY 40536, USA
    Oncogene 23:1599-607. 2004
    ..Together, these mechanisms strongly suggest that the natural compound curcumin is a potent radiosesitizer, and it acts by overcoming the effects of radiation-induced prosurvival gene expression in prostate cancer...
  6. ncbi request reprint Low-dose fractionated radiation as a chemopotentiator of neoadjuvant paclitaxel and carboplatin for locally advanced squamous cell carcinoma of the head and neck: results of a new treatment paradigm
    Susanne M Arnold
    Department of Medicine, University of Kentucky Markey Cancer Center, Lexington 40536, USA
    Int J Radiat Oncol Biol Phys 58:1411-7. 2004
    ..On the basis of the demonstrated synergy between chemotherapy and low-dose fractionated RT, a novel neoadjuvant therapy was designed using low-dose fractionated RT as a chemopotentiator for locally advanced SCCHN...
  7. ncbi request reprint Par-4, a pro-apoptotic gene, inhibits radiation-induced NF kappa B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate cancer cells PC-3
    Damodaran Chendil
    Department of Radiation Medicine, University of Kentucky, 800, Rose Street, Lexington, Kentucky 40536, USA
    Cancer Biol Ther 1:152-60. 2002
    ..Together, these mechanisms suggest that PAR-4 is functionally required to cause radiation-induced apoptosis by abrogating the survival and anti-apoptotic effects of NF kappa B activity and bcl-2 function respectively...
  8. ncbi request reprint Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2
    Rachael A Alcock
    Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Oncogene 21:7883-90. 2002
    ....
  9. ncbi request reprint Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2
    Mansoor M Ahmed
    Department of Radiation Medicine, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 277:2234-46. 2002
    ..Together, these observations imply that RII is an important component of radiation-induced TGF-beta signaling, and loss of function of RII may enhance resistance to radiation-induced apoptosis...
  10. ncbi request reprint Rasagenthi lehyam (RL) a novel complementary and alternative medicine for prostate cancer
    Rama S Ranga
    Department of Clinical Sciences, College of Health Sciences, University of Kentucky, Room No 209D, 900 South Limestone Street, Lexington, KY 40536 0200, USA
    Cancer Chemother Pharmacol 54:7-15. 2004
    ..The efficacy of RL in killing prostate cancer cells in vitro was investigated in this study to determine whether RL could be recommended as a CAM for prostate cancer...
  11. ncbi request reprint Influence of p53 status on radiation and 5-flourouracil synergy in pancreatic cancer cells
    Meraj Mohiuddin
    Department of Radiation Medicine, University of Kentucky Medical Center, Lexington 40536 0293, USA
    Anticancer Res 22:825-30. 2002
    ..This study was undertaken to evaluate the impact of wild-type or mutant p53 status on the synergistic effects of 5-Fluorouracil (5-FU) and radiation (XRT) in pancreatic tumors...
  12. ncbi request reprint Durable local responses with subtherapeutic doses of concurrent radiation and gemcitabine in a patient with refractory Hodgkin's disease
    Maqbool Halepota
    Division of Hematology Oncology, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    Clin Adv Hematol Oncol 1:413-5; discussion 416. 2003
  13. ncbi request reprint Increased expression of PSA mRNA during brachytherapy in peripheral blood of patients with prostate cancer
    Ayisha Siddiqua
    Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Urology 60:270-5. 2002
    ..The instrumentation used in the radioisotope seed placement of the prostate causes trauma to blood vessels and provides a vascular access for tumor cells that can lead to potential iatrogenic dissemination and systemic failure...
  14. ncbi request reprint Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis
    Sabapathi Sathishkumar
    Deptartment of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA
    Cancer Biol Ther 4:979-86. 2005
    ..Apparently, these changes are in the LDL-associated ceramide and may contribute to better tumor reduction after SFGRT, due to the ability of LDL-derived ceramide to sensitize endothelial cells for apoptosis...
  15. ncbi request reprint Potential use of MDA-7 as a biological adjuvant for radiation therapy
    Mohammed Momin Shareef
    Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Cancer Biol Ther 3:752-4. 2004
  16. ncbi request reprint A global perspective of radiation-induced signal transduction pathways in cancer therapeutics
    Seema Gupta
    Department of Radiation Medicine, University of Kentucky, C15, UKMC, 800 Rose Street, Lexington, KY 40536, USA
    Indian J Exp Biol 42:1153-76. 2004
    ..The complete understanding of the molecular pathways leading to apoptosis/survival of cells following ionizing radiation will help in tailoring more effective novel strategies and treatment modalities for complete eradication of cancer...
  17. doi request reprint Lack of P-glycoprotein expression by low-dose fractionated radiation results from loss of nuclear factor-kappaB and NF-Y activation in oral carcinoma cells
    Mohammed Momin Shareef
    Weis Center for Research, Geisinger Clinic, Danville, PA, USA
    Mol Cancer Res 6:89-98. 2008
    ..Together, these results provide evidence for the lack of induction of P-glycoprotein expression by LDFRT, which has important implications in combinatorial cancer therapy, including the use of LDFRT as an adjuvant for chemotherapy...
  18. ncbi request reprint Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress
    Demetrius M Kokkinakis
    The University of Pittsburgh Cancer Institute and the Department of Pathology, Hillman Cancer Institute, Pittsburgh, Pennsylvania, USA
    Cancer Res 64:7513-25. 2004
    ..It is clear that methionine stress-induced cytotoxicity is not restricted by the p53 mutational status...
  19. ncbi request reprint Investigation of genotoxic effect of taxol plus radiation on mice bone marrow cells
    Lutfi Ozkan
    Department of Radiation Oncology, Uludag University Medical College, Gorukle, Bursa, Turkey
    Teratog Carcinog Mutagen 22:1-11. 2002
    ..Forty-eight-hour pretreatment of taxol exposure followed by radiation caused significant induction of chromosomal aberrations and a reduction of mitotic index when compared to other taxol timing sequence...
  20. ncbi request reprint Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3
    Mohammed S Inayat
    Department of Biological Sciences, University of Westminster, London, UK
    Cancer Biol Ther 1:539-45. 2002
    ..These findings indicate that DX mediates a potent radiosensitizing effect in p53 null prostate cancer cells by overcoming radiation induced NFkappa-B activity and Bcl-2 expression...
  21. ncbi request reprint Role of tumor necrosis factor-alpha and TRAIL in high-dose radiation-induced bystander signaling in lung adenocarcinoma
    Mohammed M Shareef
    Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822 2616, USA
    Cancer Res 67:11811-20. 2007
    ....
  22. ncbi request reprint Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation
    Mansoor M Ahmed
    Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA
    Int J Cancer 122:63-70. 2008
    ..Thus, downregulation or loss of PAR-4 expression by oncogenic ras may provide a selective survival advantage for pancreatic tumors, through inhibition of proapoptotic pathway mediated by PAR-4...
  23. pmc Inhibition of transforming growth factor-beta signaling in normal lung epithelial cells confers resistance to ionizing radiation
    Anna Reeves
    Weis Center for Research, Geisinger Clinic, Danville, PA 17822 2616, USA
    Int J Radiat Oncol Biol Phys 68:187-95. 2007
    ....
  24. ncbi request reprint Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats
    Demetrius M Kokkinakis
    The University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, Pennsylvania 15232, USA
    J Neuropathol Exp Neurol 63:1182-99. 2004
    ..These data demonstrate that the events leading to malignancy in the rat brain in response to MNU treatment are to a great extent similar to those described for secondary glial malignancies in humans...
  25. ncbi request reprint Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine
    Demetrius M Kokkinakis
    Department of Pathology and the Cancer Institute, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 9:3801-7. 2003
    ..These results suggest that pancreatic tumors, which are resistant to DNA alkylating agents, may be sensitized to such agents when pretreated with MGMT inactivators...