Affiliation: University of North Carolina
- Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motifAmir Aghajanian
Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, United States of America
PLoS ONE 4:e8045. 2009..We hypothesized that this redox-based mechanism occurs in cells and affects cytoskeletal dynamics, and in this report we conclude this is indeed a novel mechanism of regulating the GTPase RhoA...
- Redox regulation of Ras and Rho GTPases: mechanism and functionLauren Mitchell
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Antioxid Redox Signal 18:250-8. 2013..We also discuss the debate within the literature regarding whether 2e(-) oxidation mechanisms also regulate Ras GTPase activity...