Affiliation: University of California
- Anatomic site and immune function correlate with relative cytokine mRNA expression levels in lymphoid tissues of normal rhesus macaquesK Abel
Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
Cytokine 16:191-204. 2001..Pro-inflammatory cytokine mRNA expression levels were highest in lymphoid tissues draining mucosal surfaces. Thus, a correlation exists between cytokine mRNA levels in lymphoid tissues and the anatomical site...
- The rhesus macaque pediatric SIV infection model - a valuable tool in understanding infant HIV-1 pathogenesis and for designing pediatric HIV-1 prevention strategiesKristina Abel
California National Primate Research Center, and Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, University of California Davis, CA, USA
Curr HIV Res 7:2-11. 2009..Thus, the pediatric SIV infection model provides a unique resource for preclinical studies of novel intervention therapies and vaccine strategies to stop MTCT of HIV-1...
- The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-alpha/beta) and IFN-alpha/beta-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infectionKristina Abel
Center for Comparative Medicine, University of California Davis, 95616, USA
J Virol 76:8433-45. 2002..In fact, Mx mRNA levels were associated with high viral RNA levels in lymphoid tissues of chronically infected animals...
- Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid denKristina Abel
Center for Comparative Medicine, University of California Davis, CA 95616, USA
Clin Diagn Lab Immunol 12:606-21. 2005..Based on these findings, A and C class CpG ODN, but not B class CpG ODN, may be particularly suited for use as therapeutic or prophylactic antiviral interventions...
- Gamma interferon-mediated inflammation is associated with lack of protection from intravaginal simian immunodeficiency virus SIVmac239 challenge in simian-human immunodeficiency virus 89.6-immunized rhesus macaquesKristina Abel
Center for Comparative Medicine, California National Primate Research Center, University of California Davis, Davis, California 95616, USA
J Virol 78:841-54. 2004..Unlike all unvaccinated monkeys, most monkeys vaccinated with SHIV89.6 did not develop IFN-gamma-driven inflammation, but they did develop effective antiviral CD8(+)-T-cell responses...
- Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infectionKristina Abel
UC Davis, CCM CNPRC, County Rd 98 Hutchison Dr, Davis, CA 95616, USA
J Virol 79:12164-72. 2005....
- Rapid virus dissemination in infant macaques after oral simian immunodeficiency virus exposure in the presence of local innate immune responsesKristina Abel
CNPRC CCM, School of Medicine, Division of Infectious Diseases, University of California at Davis, One Shields Ave, Davis, CA 95616, USA
J Virol 80:6357-67. 2006....
- Efficacy of a SHIV 89.6 proviral DNA vaccine against mucosal SIVmac239 challengeMarc Busch
California National Primate Research Center, University California Davis, County Road 98, Hutchison Drive, Davis, CA 95616, USA
Vaccine 23:4036-47. 2005..These results suggest that the delay in systemic infection resulting from delivery of SHIV 89.6 as a plasmid decreased the effectiveness of this live attenuated vaccine...
- Simian-human immunodeficiency virus SHIV89.6-induced protection against intravaginal challenge with pathogenic SIVmac239 is independent of the route of immunization and is associated with a combination of cytotoxic T-lymphocyte and alpha interferon responKristina Abel
Center for Comparative Medicine, California National Primate Research Center, School of Veterinary Medicine, University of California Davis, California 95616, USA
J Virol 77:3099-118. 2003..Thus, innate as well as cellular anti-SIV immune responses appeared to contribute to the SHIV89.6-induced protection against intravaginal challenge with pathogenic SIVmac239...
- Abrogation of attenuated lentivirus-induced protection in rhesus macaques by administration of depo-provera before intravaginal challenge with simian immunodeficiency virus mac239Kristina Abel
Center for Comparative Medicine, and California National Primate Research Center, University of California at Davis, Davis, California 95616, USA
J Infect Dis 190:1697-705. 2004..6-immunized macaques. In the primate model of sexual transmission of human immunodeficiency virus, treatment with progesterone before IVAG challenge with a pathogenic virus can decrease the efficacy of a model "vaccine."..
- High beta-chemokine expression levels in lymphoid tissues of simian/human immunodeficiency virus 89.6-vaccinated rhesus macaques are associated with uncontrolled replication of simian immunodeficiency virus challenge inoculumLisa LaFranco-Scheuch
Center for Comparative Medicine, California National Primate Research Center, University of California Davis, 1 Shields Ave, Davis, CA 95616, USA
J Virol 78:6399-408. 2004..6-mediated control of viral replication after intravaginal challenge with SIVmac239...
- A heterologous DNA prime/protein boost immunization strategy for rhesus cytomegalovirusKristina Abel
California National Primate Research Center, University of California, Davis, CA 95616, USA
Vaccine 26:6013-25. 2008..These results demonstrate that a heterologous DNA prime/protein boost strategy greatly expands the breadth of antiviral immune responses and greatly reduces the level of viral replication at the primary site of challenge infection...
- Immunogenicity of viral vector, prime-boost SIV vaccine regimens in infant rhesus macaques: attenuated vesicular stomatitis virus (VSV) and modified vaccinia Ankara (MVA) recombinant SIV vaccines compared to live-attenuated SIVKoen K A Van Rompay
California National Primate Research Center, University of California Davis, Davis, CA 95616, United States
Vaccine 28:1481-92. 2010....
- The strength of B cell immunity in female rhesus macaques is controlled by CD8+ T cells under the influence of ovarian steroid hormonesF X Lu
California Regional Primate Research Center, School of Veterinary Medicine, University of California Davis, CA 95616, USA
Clin Exp Immunol 128:10-20. 2002..Understanding, and eventually manipulating, the CD8+ regulatory cell-B cell interactions in females may produce novel therapeutic approaches for autoimmune diseases and new vaccine strategies to prevent sexually transmitted diseases...
- Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIVKoen K A Van Rompay
California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA
J Acquir Immune Defic Syndr 38:124-34. 2005..The results of these investigations suggest that immunization of human infants with poxvirus-based HIV vaccine candidates may offer protection against early and late HIV infection through breastfeeding...
- Retroviral recombination in vivo: viral replication patterns and genetic structure of simian immunodeficiency virus (SIV) populations in rhesus macaques after simultaneous or sequential intravaginal inoculation with SIVmac239Deltavpx/Deltavpr and SIVmac23Eun Young Kim
Division of Infectious Diseases, The Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
J Virol 79:4886-95. 2005..These findings show that recombination can occur readily in vivo after mucosal SIV exposure and thus contributes to the generation of viral genetic diversity and enhancement of viral fitness...
- The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaquesYichuan Wang
California National Primate Research Center, University of California Davis, Davis, California 95616, USA
J Virol 79:14355-70. 2005..We conclude that induction of mucosal innate immunity including an IFN-alpha response is not sufficient to prevent sexual transmission of human immunodeficiency virus...
- Enhanced in vivo immunogenicity of SIV vaccine candidates with cationic liposome-DNA complexes in a rhesus macaque pilot studyJeff Fairman
Juvaris BioTherapeutics, Inc, Burlingame, CA, USA
Hum Vaccin 5:141-50. 2009..Thus, CLDC should be explored further as a potential immunomodulatory adjuvant in HIV vaccine design...
- Pegylated interferon-alpha 2a treatment of chronic SIV-infected macaquesD M Asmuth
Division of Infectious Diseases, Department of Internal Medicine, University of California Davis Medical Center, 4150 V Street, Sacramento, CA 95817, USA
J Med Primatol 37:26-30. 2008..Limited investigations have explored the innate or adaptive immune responses of IFN-alpha on SIV replication in vivo...
- A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculationsZhong Min Ma
California National Primate Research Center, University of California Davis, CA, USA
J Virol 78:14048-52. 2004..Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model...
- Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effectsKoen K A Van Rompay
California National Primate Research Center, University of California, Davis, California 95616, USA
Antimicrob Agents Chemother 52:3144-60. 2008..In conclusion, these findings illustrate the safety and sustained benefits of prolonged TFV-containing regimens throughout development from infancy to adulthood, including pregnancy...
- Ozone and allergen exposure during postnatal development alters the frequency and airway distribution of CD25+ cells in infant rhesus monkeysLisa A Miller
Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Toxicol Appl Pharmacol 236:39-48. 2009..We conclude that a window of postnatal development is sensitive to air pollutant and allergen exposure, resulting in immunomodulation of peripheral blood and airway lymphocyte frequency and trafficking...
- Evaluation of recombinant modified vaccinia Ankara virus-based rhesus cytomegalovirus vaccines in rhesus macaquesYujuan Yue
Center for Comparative Medicine, University of California Davis, County Rd 98 and Hutchison Dr, Davis, CA 95616, USA
Med Microbiol Immunol 197:117-23. 2008..This study demonstrates the immunogenicity and protective efficacy of rMVA-based RhCMV subunit vaccines in a primate host and warrants further investigation to improve the efficacy of subunit vaccines against CMV...
- Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus diseaseJohn P Capitanio
California National Primate Research Center, Department of Psychology, University of California, One Shields Avenue, Davis, CA 95616, USA
Brain Behav Immun 22:676-89. 2008....
- Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virusChristopher J Miller
Center for Comparative Medicine, University of California Davis, Davis, CA 95616, USA
J Virol 79:9217-27. 2005....
- Antiviral antibodies are necessary for control of simian immunodeficiency virus replicationChristopher J Miller
Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
J Virol 81:5024-35. 2007..0001). These observations indicate that antiviral antibody responses are critical in maintaining effective control of SIV replication at early time points postinfection...
- Effects of environmental tobacco smoke on the developing immune system of infant monkeysLei Wang
Center for Health and the Environment, University of California, Davis, CA 95616, USA
J Allergy Clin Immunol 120:445-51. 2007..Exposure to environmental tobacco smoke (ETS) is associated with an increased incidence of allergic and infectious diseases among children that is thought to be partly due to the immaturity of the immune system...
- Effects of early experience and genotype on serotonin transporter regulation in infant rhesus macaquesE L Kinnally
Department of Psychology, and California National Primate Research Center, School of Veterinary Medicine, University of California Davis, Davis, CA, USA
Genes Brain Behav 7:481-6. 2008..We also showed that GCs may stimulate 5-HTT expression but that there likely exist faster-acting transcriptional regulators of 5-HTT that are in place as a function of experience...
- Transcriptional activation of interferon-stimulated genes but not of cytokine genes after primary infection of rhesus macaques with dengue virus type 1Carlos A Sariol
Unit of Comparative Medicine, Primate Research Center, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936 5067
Clin Vaccine Immunol 14:756-66. 2007..Transcription of the genes of interleukin-10 (IL-10), IL-8, IL-6, and tumor necrosis factor alpha was neither up-regulated nor down-regulated. Results were confirmed by real-time PCR and by multiplex cytokine detection in serum samples...
- Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progressionKristina Abel
Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 204:2679-92. 2007..In aggregate, these observations suggest that the T reg cell compartment of the infant macaque facilitates rapid disease progression, at least in part by incapacitating SIV-specific CD4(+) T cell responses...
- Characterization of virus-responsive plasmacytoid dendritic cells in the rhesus macaqueEugene Chung
UMDNJ NJMS, Department of Pathology and Laboratory Medicine, 185 S Orange Ave, Newark, NJ 07101, USA
Clin Diagn Lab Immunol 12:426-35. 2005..These findings establish the phenotypic and functional similarity of human and macaque PDC and confirm the utility of tools developed for studying human PDC in this animal model...
- Immune mechanisms associated with protection from vaginal SIV challenge in rhesus monkeys infected with virulence-attenuated SHIV 89.6Christopher J Miller
California National Primate Research Center
J Med Primatol 34:271-81. 2005..6 mounted effective anti-viral CD8+ T cell responses while avoiding the self-destructive inflammatory cycle found in the lymphoid tissues of unprotected and unvaccinated monkeys...
- CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too littleMatthew R Reynolds
Wisconsin Primate Research Center, University of Wisconsin, Madison 53715, USA
J Virol 79:9228-35. 2005....
- Detection of macaque perforin expression and release by flow cytometry, immunohistochemistry, ELISA, and ELISpotBartek Zuber
Mabtech, Box 1233, SE 131 28 Nacka, Sweden
J Immunol Methods 312:45-53. 2006..These macaque PFN-reactive mAbs and immunoassays will be valuable new tools for investigation of cytotoxic T lymphocyte (CTL) responses in non-human primate models of infectious diseases as well as for vaccine development...
- Perforin expression in the gastrointestinal mucosa is limited to acute simian immunodeficiency virus infectionMaire F Quigley
Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden
J Virol 80:3083-7. 2006..These findings demonstrate the presence of a robust perforin-positive response in gastrointestinal CD8 T cells during acute, but not chronic, SIV infection...