Hanna E Abboud

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases
    Assaad A Eid
    University of Texas Health Science Center, Department of Medicine, San Antonio, Texas, USA
    Diabetes 58:1201-11. 2009
  2. doi request reprint Synthetic oleanane triterpenoids: magic bullets or not?
    Hanna E Abboud
    Nephrology Division, University of Texas Health Sciences Center San Antonio, Texas, USA
    Kidney Int 83:785-7. 2013
  3. doi request reprint Mesangial cell biology
    Hanna E Abboud
    University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Exp Cell Res 318:979-85. 2012
  4. pmc Evaluation of gremlin 1 (GREM1) as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type 2 diabetes mellitus
    Farook Thameem
    Division of Nephrology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Metabolism 58:1496-502. 2009
  5. pmc Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Genet 124:557-9. 2008
  6. pmc PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA
    Jill M Ricono
    Department of Molecular Medicine, Institute of Biotechnology, Univ of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 296:F406-17. 2009
  7. pmc TSC2 deficiency increases PTEN via HIF1alpha
    Lenin Mahimainathan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 284:27790-8. 2009
  8. ncbi request reprint Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB
    Karen Block
    Department of Medicine, Audie L Murphy Memorial Hospital Division, The University of Texas Health Science Center, San Antonio, 78229 3900, USA
    Antioxid Redox Signal 8:1497-508. 2006
  9. pmc microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e37366. 2012
  10. pmc The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans
    Subrata D Nath
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
    Mol Cell Biochem 331:201-5. 2009

Research Grants

Detail Information

Publications79

  1. pmc Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases
    Assaad A Eid
    University of Texas Health Science Center, Department of Medicine, San Antonio, Texas, USA
    Diabetes 58:1201-11. 2009
    ....
  2. doi request reprint Synthetic oleanane triterpenoids: magic bullets or not?
    Hanna E Abboud
    Nephrology Division, University of Texas Health Sciences Center San Antonio, Texas, USA
    Kidney Int 83:785-7. 2013
    ..Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects...
  3. doi request reprint Mesangial cell biology
    Hanna E Abboud
    University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Exp Cell Res 318:979-85. 2012
    ..Identification of biological responses of MCs that are not mediated by the renin-angiotensin system should help development of novel and effective therapeutic strategies to treat diseases characterized by MC pathology...
  4. pmc Evaluation of gremlin 1 (GREM1) as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type 2 diabetes mellitus
    Farook Thameem
    Division of Nephrology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Metabolism 58:1496-502. 2009
    ..In conclusion, the variants examined at GREM1 are not significant contributors to variation in ACR in Mexican Americans, although they appear to minimally influence risk factors related to ACR...
  5. pmc Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Hum Genet 124:557-9. 2008
    ..The data suggest that the polymorphisms examined in the RAS may modulate the risk factors associated with cardiovascular-renal disease...
  6. pmc PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA
    Jill M Ricono
    Department of Molecular Medicine, Institute of Biotechnology, Univ of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 296:F406-17. 2009
    ..During kidney development, PDGFR beta-mediated ROS generation and Ca(2+) influx suppress PDGF AA-induced chemotaxis in metanephric mesenchyme...
  7. pmc TSC2 deficiency increases PTEN via HIF1alpha
    Lenin Mahimainathan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 284:27790-8. 2009
    ..These data suggest that PTEN may safeguard against developing malignant tumors in patients with TSC deficiency...
  8. ncbi request reprint Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB
    Karen Block
    Department of Medicine, Audie L Murphy Memorial Hospital Division, The University of Texas Health Science Center, San Antonio, 78229 3900, USA
    Antioxid Redox Signal 8:1497-508. 2006
    ..Moreover, this pathway mediates the effect of Ang II on Akt/PKB-induced protein synthesis and fibronectin expression...
  9. pmc microRNA-21 governs TORC1 activation in renal cancer cell proliferation and invasion
    Nirmalya Dey
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e37366. 2012
    ..Our results uncover a layer of post-transcriptional regulation of PTEN by transcriptional activation of miR-21 to force the canonical oncogenic Akt/TORC1 signaling conduit to drive renal cancer cell proliferation and invasion...
  10. pmc The 27-bp repeat polymorphism in intron 4 (27 bp-VNTR) of endothelial nitric oxide synthase (eNOS) gene is associated with albumin to creatinine ratio in Mexican Americans
    Subrata D Nath
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
    Mol Cell Biochem 331:201-5. 2009
    ....
  11. pmc Evaluation of polymorphisms in paraoxonase 2 (PON2) gene and their association with cardiovascular-renal disease risk in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA
    Kidney Blood Press Res 32:200-4. 2009
    ....
  12. pmc Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase
    Simona Simone
    George O Brien Kidney Research Center, Department of Medicine, Division of Nephrology, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 57:2626-36. 2008
    ..To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells...
  13. pmc ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice
    Bridget M Ford
    Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Am J Physiol Renal Physiol 305:F323-32. 2013
    ..Additionally, our study is the first to provide evidence that Nox4 is downstream of ADAM17. ..
  14. pmc Genetics of variation in serum uric acid and cardiovascular risk factors in Mexican Americans
    V Saroja Voruganti
    Department of Genetics, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, Texas 78227, USA
    J Clin Endocrinol Metab 94:632-8. 2009
    ..However, the role of uric acid as an independent risk factor for CVD is not yet clear...
  15. pmc The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling
    Farook Thameem
    Division of Nephrology, The University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 61:2385-93. 2012
    ..Taken together, the data provide the first evidence that genetic variation in IRS1 may influence variation in GFR probably through impaired insulin receptor signaling...
  16. pmc Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells
    Yves Gorin
    Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Biochem J 381:231-9. 2004
    ..This pathway involving AA, Rac1, Nox4, reactive oxygen species and ERK1/ERK2 may play an important role in Ang II-induced mesangial cell hypertrophy...
  17. ncbi request reprint Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney
    Yves Gorin
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:39616-26. 2005
    ..These data establish a role for Nox4 as the major source of ROS in the kidneys during early stages of diabetes and establish that Nox4-derived ROS mediate renal hypertrophy and increased fibronectin expression...
  18. pmc Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase
    Falguni Das
    Veterans Affairs Research, South Texas Veterans Health Care System, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 287:3808-22. 2012
    ..These results unravel a previously unrecognized cell-autonomous function of TORC1 and TORC2 in the up-regulation of PTEN, which prevents phosphorylation of Akt and may shield against the development of malignancy in TSC patients...
  19. pmc Subcellular localization of Nox4 and regulation in diabetes
    Karen Block
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:14385-90. 2009
    ..Our data provide evidence that a functional Nox4 is present and regulated in mitochondria, indicating the existence of a previously undescribed source of ROS in this organelle...
  20. ncbi request reprint Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
    Brent Wagner
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Am Soc Nephrol 18:2903-11. 2007
    ..In conclusion, the present study demonstrates Nox4 involvement in PDGF-induced DNA synthesis in metanephric mesenchymal cells and provides the first evidence that PDGF-induced PI3-K activity enhances production of ROS by Nox4...
  21. pmc Novel mechanism of regulation of the DNA repair enzyme OGG1 in tuberin-deficient cells
    Samy L Habib
    Department of Geriatrics, Geriatric Research, Education, and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX 78229, USA
    Carcinogenesis 31:2022-30. 2010
    ..These data indicate a novel role for tuberin in the regulation of OGG1 through the transcription factor AP4. This regulation may be important in the pathogenesis of kidney tumours in patients with TSC disease...
  22. ncbi request reprint ZO-1 expression and phosphorylation in diabetic nephropathy
    Hernan Rincon-Choles
    South Texas Veterans Health Care System, San Antonio, TX, USA
    Diabetes 55:894-900. 2006
    ..These findings suggest that alterations in the content and localization of ZO-1 may be relevant to the pathogenesis of proteinuria in diabetes...
  23. pmc AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes
    Assaad A Eid
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 285:37503-12. 2010
    ..The data indicate the potential therapeutic utility of AMPK activators to block Nox4 and reactive oxygen species generation and to reduce urinary albumin excretion in type 1 diabetes...
  24. pmc Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B
    Balachandar Venkatesan
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    FASEB J 22:3469-82. 2008
    ..PTP1B significantly inhibited PDGF-induced DNA synthesis without inducing apoptosis. These results for the first time provide evidence that the stilbene resveratrol targets PTP1B to inhibit PDGFR mitogenic signaling...
  25. pmc Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Diab Vasc Dis Res 5:109-13. 2008
    ..In conclusion, of the genetic polymorphisms examined at the eNOS locus, only 27bp-VNTR appears to be a minor contributor to the variation in T2DM-related traits in Mexican Americans...
  26. ncbi request reprint P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:513-7. 2007
    ....
  27. pmc Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes
    Rita M Maalouf
    Dept of Medicine, Division of Cardiology, Univ of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Physiol Cell Physiol 302:C597-604. 2012
    ..This study provides strong evidence that Nox4 is an important source of ROS in the left ventricle and that Nox4-derived ROS contribute to cardiomyopathy at early stages of type 1 diabetes...
  28. pmc NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts
    Corry D Bondi
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 21:93-102. 2010
    ..Taken together, these results suggest that TGF-beta1-induced conversion of fibroblasts to a myofibroblast phenotype involves a signaling cascade through Smad3, NAD(P)H oxidase, and ERK1/2...
  29. pmc Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury
    Assaad A Eid
    Department of Medicine, South Texas Veterans Healthcare System and the University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 62:2935-47. 2013
    ..Thus, mTOR and/or NADPH oxidase inhibition may represent a therapeutic modality of diabetic kidney disease. ..
  30. pmc Reciprocal induction of simple organogenesis by mouse kidney progenitor cells in three-dimensional co-culture
    Chakradhar Velagapudi
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Am J Pathol 180:819-30. 2012
    ..These studies indicate that tubulogenesis and vasculogenesis can be partially recapitulated by recombining individual MM and UB cell lineages, providing a new model system to study organogenesis ex vivo...
  31. pmc The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin
    Karen Block
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Pathol 176:2447-55. 2010
    ..Our data provide the first evidence that p22(phox)-based Nox oxidases maintain HIF-2alpha protein expression through inactivation of tuberin and downstream activation of ribosomal protein S6 kinase 1/4E-BP1 pathway...
  32. pmc A genome-wide search for linkage to chronic kidney disease in a community-based sample: the SAFHS
    Nedal H Arar
    Department of Medicine Nephrology, University of Texas Health Science Center, South Texas Veterans Health Care System, 7400 Merton Minter Blvd, San Antonio, TX 78229 4404, USA
    Nephrol Dial Transplant 23:3184-91. 2008
    ..Therefore, the purpose of this study is to identify susceptible chromosomal regions for CKD phenotypes in Mexican American families enrolled in the San Antonio Family Heart Study (SAFHS)...
  33. ncbi request reprint Kidney involvement in a nongenetic rat model of type 2 diabetes
    Ratna S Danda
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Kidney Int 68:2562-71. 2005
    ..We postulated that rats with noninsulinopenic (type 2) diabetes develop lesions of diabetic nephropathy significantly more prominent than those seen in classic insulinopenic (type 1) diabetic rats...
  34. pmc Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy
    Falguni Das
    Veterans Affairs Research, South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
    J Biol Chem 288:7756-68. 2013
    ..Our results support that TGFβ-stimulated Smad 3 acts as a key node to instill a feedback loop between deptor down-regulation and TORC1/2 activation in driving mesangial cell hypertrophy...
  35. pmc IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells
    David D New
    University of Texas Health Science Center Department of Medicine, San Antonio, Texas 78229 3900, USA
    Am J Physiol Cell Physiol 302:C122-30. 2012
    ..Taken together, these results provide the first evidence for a role of Nox4 in IGF-I-induced Akt phosphorylation and fibronectin expression in tubular epithelial cells...
  36. ncbi request reprint Tuberin regulates the DNA repair enzyme OGG1
    Samy L Habib
    George O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 294:F281-90. 2008
    ..These data provide the first evidence that tuberin regulates a specific DNA repair enzyme, OGG1. This regulation may be important in the pathogenesis of kidney tumors in patients with TSC...
  37. pmc Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells
    Hak Joo Lee
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 287:4451-61. 2012
    ..Hydrogen sulfide is a newly identified modulator of protein synthesis in the kidney, and reduction in its generation may contribute to kidney injury in diabetes...
  38. ncbi request reprint Redox dependence of glomerular epithelial cell hypertrophy in response to glucose
    Nam Ho Kim
    University of Texas Health Science Center, Department of Medicine, Division of Nephrology, MC 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 290:F741-51. 2006
    ..Enhanced ROS generation accounts for the additive effects of high glucose and ANG II, suggesting that this signaling cascade contributes to GEC injury in diabetes...
  39. pmc The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo
    Khaled Khazim
    Univ of Texas Health Science Center, Dept of Medicine, Division of Nephrology MC 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 305:F691-700. 2013
    ..In conclusion, this study demonstrates a protective effect of silybin against HG-induced podocyte injury and extends this finding to an animal model of diabetic nephropathy. ..
  40. doi request reprint Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation
    Chandi C Mandal
    Department of Pathology, University of Texas Health Science Center at San Antonio, TX 78229, USA
    Biochem J 433:393-402. 2011
    ..Our results provide the first evidence for a new signalling pathway linking BMP-2-stimulated Nox4-derived physiological ROS to BMP-2 expression and osteoblast differentiation...
  41. pmc Genetic variants in transient receptor potential cation channel, subfamily M 1 (TRPM1) and their risk of albuminuria-related traits in Mexican Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Clin Chim Acta 412:2058-62. 2011
    ..The objective of this study is to scan a positional candidate gene, Transient Receptor Potential cation channel, subfamily M 1 (TRPM1), for genetic variants that may contribute to the variation in albumin-to-creatinine ratio (ACR)...
  42. ncbi request reprint NAD(P)H oxidases regulate HIF-2alpha protein expression
    Karen Block
    Division of Nephrology, Department of Medicine, George O Brien Kidney Research Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 282:8019-26. 2007
    ..Collectively, the data demonstrate that VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation...
  43. ncbi request reprint Differential expression of calcineurin A isoforms in the diabetic kidney
    Jennifer L Gooch
    Department of Medicine, Division of Nephrology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 15:1421-9. 2004
    ..Increased expression of CnA-alpha, in particular, is observed in glomeruli and CD and participates in regulation of AQP2 expression, phosphorylation, and function...
  44. pmc The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes
    Chakradhar Velagapudi
    The University of Texas Health Science Center, Department of Medicine MSC 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Am Soc Nephrol 22:262-73. 2011
    ..Furthermore, gene silencing of tuberin with siRNA decreased cleavage of PARP. These data show that the tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes, mediated in part by cleavage of PARP by YY1...
  45. pmc Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors
    Samy L Habib
    O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Mol Cancer 7:10. 2008
    ..We investigated the distribution of protein expression and the activity of OGG1 and 8-oxo-dG and correlated it with the expression of tuberin in kidneys of wild type and Eker rats and tumor from Eker rat...
  46. pmc A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF
    Amit Bera
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas and
    Am J Physiol Cell Physiol 306:C1089-100. 2014
    ..Thus our data unfold the presence of a positive feedback microcircuit between Erk5 and Akt downstream of PI3-kinase nodal point for PDGF-induced mesangial cell proliferation. ..
  47. ncbi request reprint TGFbeta intercepts nuclear glycogen synthase kinase 3beta to inhibit PDGF-induced DNA synthesis in mesangial cells
    Falguni Das
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    FEBS Lett 581:5259-67. 2007
    ..These results provide the first evidence that TGFbeta intercepts Akt kinase activity in the nucleus to block inactivation of GSK3beta, leading to attenuation of PDGF-induced CDK2 activity and DNA synthesis...
  48. pmc Renal histopathology of a baboon model with type 2 diabetes
    Hernan Rincon-Choles
    Audie L Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas, USA
    Toxicol Pathol 40:1020-30. 2012
    ..One diabetic animal had a Kimmestiel-Wilson nodule. We conclude that the baboon represents a useful primate model of diabetes and nephropathy that resembles the nephropathy associated with type 2 diabetes in humans...
  49. ncbi request reprint Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells
    Yves Gorin
    Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 285:F219-29. 2003
    ..These data provide the first evidence that activation by AA of a Rac1-regulated, Nox4-based NAD(P)H oxidase and subsequent generation of ROS mediate the effect of ANG II on Akt/PKB activation and protein synthesis in MCs...
  50. ncbi request reprint PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression
    Balachandar A Venkatesan
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78220 3900, USA
    Cell Signal 18:508-18. 2006
    ..These data provide the first evidence that PI 3 kinase-dependent Akt and PKCepsilon activation independently regulate MAPK activity and serine phosphorylation of STAT1alpha to increase expression of MCP-1...
  51. ncbi request reprint Genome scan for determinants of serum uric acid variability
    Subrata D Nath
    Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Am Soc Nephrol 18:3156-63. 2007
    ..Given the relationship between uric acid level and these conditions, future studies should investigate potential candidate susceptibility genes found in this region...
  52. pmc NFκB-mediated cyclin D1 expression by microRNA-21 influences renal cancer cell proliferation
    Amit Bera
    Department of Medicine, University of Texas Health Science Center at San Antonio, TX, United States
    Cell Signal 25:2575-86. 2013
    ..Together, our results establish a molecular order of a phosphatase-kinase couple involving PTEN/Akt/IKKβ and NFκB-dependent cyclin D1 expression for renal carcinoma cell proliferation by increased miR-21 levels. ..
  53. pmc Relation of low glomerular filtration rate to metabolic disorders in individuals without diabetes and with normoalbuminuria
    Carlos Lorenzo
    Department of Medicine, Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7873, USA
    Clin J Am Soc Nephrol 3:783-9. 2008
    ..Low glomerular filtration rate is also associated with increased cardiovascular risk, but the relation of low glomerular filtration rate to metabolic disorders is not well understood...
  54. ncbi request reprint Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation
    Jennifer L Gooch
    Department of Medicine, Division of Nephrology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 279:15561-70. 2004
    ..In conclusion, this study describes a new pathway for TGF-beta-mediated regulation of ECM via generation of ROS, calcium influx, and activation of calcineurin...
  55. ncbi request reprint Fibronectin induces ureteric bud cells branching and cellular cord and tubule formation
    Peng Ye
    Department of Pediatrics and Department of Internal Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Kidney Int 66:1356-64. 2004
    ..The extracellular matrix (ECM) protein fibronectin is involved in several stages of embryogenesis. Fibronectin exerts its effect through interaction with cellular integrin and nonintegrin receptors...
  56. ncbi request reprint Genotype by diabetes interaction effects on the detection of linkage of glomerular filtration rate to a region on chromosome 2q in Mexican Americans
    Sobha Puppala
    Southwest Foundation for Biomedical Research, Department of Genetics, P O Box 760549, San Antonio, TX 78254, USA
    Diabetes 56:2818-28. 2007
    ..We also examined the effect of genotype by diabetes interaction (G x DM) on the detection of linkage to address whether genetic effects on GFR differ in diabetic and nondiabetic subjects...
  57. pmc Susceptibility gene search for nephropathy and related traits in Mexican-Americans
    Farook Thameem
    Division of Nephrology, Department of Medicine, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA
    Mol Biol Rep 40:5769-79. 2013
    ..This paper reviews the approaches and recent efforts made to identify genetic variants contributing to risk for DN and related phenotypes in the Mexican-American population. ..
  58. ncbi request reprint Diabetic nephropathy among Mexican Americans
    Subrata Debnath
    Division of Nephrology, University of Texas Health Science Center, San Antonio, TX, USA
    Clin Nephrol 77:332-44. 2012
    ..This article reviews the epidemiology of DN in Mexican Americans, describes the pathophysiology and associated risk factors, and identifies gaps in our knowledge and understanding that needs to be addressed by future investigations...
  59. doi request reprint The 57 kb deletion in cystinosis patients extends into TRPV1 causing dysregulation of transcription in peripheral blood mononuclear cells
    Katy A Freed
    Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245 0549, USA
    J Med Genet 48:563-6. 2011
    ..Mutations in the cystinosin gene (CTNS) represent known causes for the disease. The major cystinosis mutation is a 57 kb deletion on human chromosome 17p13 that removes the majority of CTNS and the entire adjacent gene, CARKL/SHPK...
  60. ncbi request reprint Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells
    Goutam Ghosh Choudhury
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center at San Antonio and Geriatrics Research, Education and Clinical Center, Mail Code 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Cell Signal 16:31-41. 2004
    ....
  61. ncbi request reprint PDGF inactivates forkhead family transcription factor by activation of Akt in glomerular mesangial cells
    Goutam Ghosh Choudhury
    Geriatric Research, Education and Clinical Center, San Antonio, TX, USA
    Cell Signal 15:161-70. 2003
    ....
  62. ncbi request reprint Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation
    Jennifer L Gooch
    South Texas Veterans Health Care Administration, Audie Murphy Memorial Hospital, San Antonio 78284 3900, USA
    Am J Physiol Renal Physiol 284:F144-54. 2003
    ..In summary, calcineurin plays an important role in glomerular hypertrophy and ECM accumulation in diabetic nephropathy...
  63. ncbi request reprint Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species
    Denis Feliers
    Department of Medicine Nephrology, The University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio 78229 3900, USA
    Am J Physiol Renal Physiol 290:F927-36. 2006
    ..These data show that ROS, generated probably through activation of an NAD(P)H oxidase, mediate ANG II stimulation of VEGF mRNA translation...
  64. ncbi request reprint Genetic polymorphisms in OGG1 and their association with angiomyolipoma, a benign kidney tumor in patients with tuberous sclerosis
    Samy L Habib
    George O Brien Kidney Research Center, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Cancer Biol Ther 7:23-7. 2008
    ..Taken together, our findings suggest that Ser(326)Cys variant of OGG1 may confer risk for development of angiomyolipomas by increasing oxidative DNA damage...
  65. ncbi request reprint Cloning of the 5'-flanking region of the murine bone morphogenetic protein-7 gene
    Matthias Simon
    South Texas Veterans Health Care System, Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    Mol Cell Biochem 233:31-7. 2002
    ..The cloning of a 5'-flanking region of the BMP-7 gene should provide a useful tool for future studies on the transcriptional regulation of BMP-7 gene expression...
  66. ncbi request reprint Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:389-93. 2007
    ..02, RR 1.64). These data provide evidence that variation in the TCF7L2 genomic region may affect risk for type 2 diabetes in Mexican Americans, but the attributable risk may be lower than in Caucasian populations...
  67. ncbi request reprint Morphological insights into the origin of glomerular endothelial and mesangial cells and their precursors
    Jill M Ricono
    Department of Medicine, University of Texas Health Science Center, San Antonio 78229, USA
    J Histochem Cytochem 51:141-50. 2003
    ..A subpopulation of these Thy1.1- or RECA-1-positive cells may be precursors that can migrate into the cleft of comma and S-shaped bodies and proliferate in situ to form glomerular capillary tufts...
  68. ncbi request reprint Ethical issues associated with conducting genetic family studies of complex disease
    Nedal H Arar
    Division of Nephrology Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Ann Epidemiol 15:712-9. 2005
    ..To examine subjects' recognition of the risks and ethical issues associated with enrollment in genetic family studies (GFS) and explore how this recognition affects their informed and voluntary participation...
  69. ncbi request reprint Regulation of protein synthesis by IGF-I in proximal tubular epithelial cells
    Duraisamy Senthil
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, South Texas Veterans Health Care System, Geriatrics Research and Education Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Renal Physiol 283:F1226-36. 2002
    ..Our observations reveal the importance of initial events in protein translation in IGF-I-induced protein synthesis in MCT cells and identify the regulatory signaling pathways involved...
  70. ncbi request reprint Expression of apoptosis-related genes in chronic cyclosporine nephrotoxicity in mice
    Chul Woo Yang
    Division of Nephrology, Catholic University of Korea, Seoul, Korea
    Am J Transplant 2:391-9. 2002
    ..These findings suggest that local activation of the apoptosis-related genes is associated with CsA-induced apoptotic cell death...
  71. pmc MYH9 is associated with nondiabetic end-stage renal disease in African Americans
    W H Linda Kao
    Department of Epidemiology, School of Medicine and Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nat Genet 40:1185-92. 2008
    ....
  72. ncbi request reprint Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
    Jill M Ricono
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Physiol Renal Physiol 282:F211-9. 2002
    ..Collectively, the data may have implications related to the failure of PDGF AA to rescue mesangial cell phenotype in PDGF B-chain or PDGF-beta-receptor deficiency...
  73. ncbi request reprint Genetic basis of diabetic nephropathy
    Hernan Rincon-Choles
    Department of Research, The South Texas Veterans Health Care System, USA
    Am J Ther 12:555-61. 2005
    ..New knowledge in identifying and understanding the role of susceptibility gene(s) will provide valuable information that could help develop new preventive and therapeutic strategies...
  74. ncbi request reprint Genome-wide scans for diabetic nephropathy and albuminuria in multiethnic populations: the family investigation of nephropathy and diabetes (FIND)
    Sudha K Iyengar
    FIND Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 7281, USA
    Diabetes 56:1577-85. 2007
    ..Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes...
  75. ncbi request reprint Genetic polymorphisms in the renin-angiotensin system (RAS) genes and their association analysis with type 2 diabetes and related traits in Mexican Americans
    Farook Thameem
    Diabetes Res Clin Pract 79:e14-6. 2008
  76. ncbi request reprint Genome-wide scan for estimated glomerular filtration rate in multi-ethnic diabetic populations: the Family Investigation of Nephropathy and Diabetes (FIND)
    Jeffrey R Schelling
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, Rm 1300, 10900 Euclid Ave, Cleveland, OH 44106 7281, USA
    Diabetes 57:235-43. 2008
    ..Glomerular filtration rate (GFR), which characterizes diabetic nephropathy, was employed as a quantitative trait in a preliminary whole-genome scan...
  77. ncbi request reprint The Cys(311)Ser polymorphism of paraoxonase 2 (PON2) is associated with albumin-to-creatinine ratio (ACR) in Mexican Americans
    Farook Thameem
    Nephrol Dial Transplant 23:416-7. 2008
  78. pmc Heritability of the severity of diabetic retinopathy: the FIND-Eye study
    Nedal H Arar
    Family Investigation of Nephropathy and Diabetes FIND Genetic Analysis and Data Coordinating Center, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Invest Ophthalmol Vis Sci 49:3839-45. 2008
    ....
  79. ncbi request reprint Fasting serum glucose level and cancer risk in Korean men and women
    Subrata D Nath
    JAMA 293:2210-1; author reply 2211. 2005

Research Grants2

  1. The Genetic Basis of Diabetic Retinopathy in Mexican Am*
    Hanna Abboud; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  2. INFLAMMATORY MEDIATORS AND GLOMERULAR CELLS IN CULTURE
    Hanna Abboud; Fiscal Year: 2007
    ..This will be accomplished by generation of chimeric embryos expressing the mutant PDGFRb using MC- specific promoter and studying MC phenotype in these embryos. ..