University of Virginia

Summary

Organization: University of Virginia
Country: USA

Top Publications

  1. pmc Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis
    Elizabeth A Erwin
    Center for Innovation in Pediatric Practice, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Ann Allergy Asthma Immunol 104:496-502. 2010
  2. doi Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity
    Jay W Fox
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908 0734, USA
    FEBS J 275:3016-30. 2008
  3. ncbi Amebic colitis: new insights into pathogenesis and treatment
    Tracy E Bercu
    Division of Infectious Diseases and International Health, University of Virginia Health System, P O Box 801340, Charlottesville, VA 22908, USA
    Curr Gastroenterol Rep 9:429-33. 2007
  4. ncbi Histologic changes in the breast with menopausal hormone therapy use: correlation with breast density, estrogen receptor, progesterone receptor, and proliferation indices
    Jennifer A Harvey
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    Menopause 15:67-73. 2008
  5. ncbi Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome?
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
    Stroke 38:1820-5. 2007
  6. ncbi Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer
    Robert X D Song
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA
    Endocr Relat Cancer 13:S3-13. 2006
  7. ncbi Measurement of the invasion depth of extrahepatic bile duct carcinoma: An alternative method overcoming the current T classification problems of the AJCC staging system
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Surg Pathol 31:199-206. 2007
  8. pmc Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 172:671-8. 2006
  9. ncbi Cell technologies for spinal fusion
    Francis H Shen
    Department of Orthopaedic Surgery, University of Virginia Health System, PO Box 800159, Charlottesville, VA 22908, USA
    Spine J 5:231S-239S. 2005
  10. ncbi Challenges and opportunities for medications development in alcoholism: an international perspective on collaborations between academia and industry
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Alcohol Clin Exp Res 29:1528-40. 2005

Detail Information

Publications62

  1. pmc Serum IgE measurement and detection of food allergy in pediatric patients with eosinophilic esophagitis
    Elizabeth A Erwin
    Center for Innovation in Pediatric Practice, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Ann Allergy Asthma Immunol 104:496-502. 2010
    ..Although associated allergies are common and the mechanism may include long-term exposure to allergens, measurement of serum specific IgE levels has not been studied in pediatric eosinophilic esophagitis (EE)...
  2. doi Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity
    Jay W Fox
    Department of Microbiology, University of Virginia, Charlottesville, VA 22908 0734, USA
    FEBS J 275:3016-30. 2008
    ....
  3. ncbi Amebic colitis: new insights into pathogenesis and treatment
    Tracy E Bercu
    Division of Infectious Diseases and International Health, University of Virginia Health System, P O Box 801340, Charlottesville, VA 22908, USA
    Curr Gastroenterol Rep 9:429-33. 2007
    ..The disease mechanisms, clinical findings, therapeutic strategies, and important developments regarding amebiasis are discussed here...
  4. ncbi Histologic changes in the breast with menopausal hormone therapy use: correlation with breast density, estrogen receptor, progesterone receptor, and proliferation indices
    Jennifer A Harvey
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    Menopause 15:67-73. 2008
    ..This retrospective study systematically compared mammographic density with histology in women receiving or not receiving menopausal hormone therapy (HT)...
  5. ncbi Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome?
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
    Stroke 38:1820-5. 2007
    ..The purpose of this study was to combine acute clinical data and DWI lesion volume for ischemic stroke patients to determine whether DWI improves the prediction of clinical outcome...
  6. ncbi Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer
    Robert X D Song
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA
    Endocr Relat Cancer 13:S3-13. 2006
    ..A full understanding of the mechanisms underlying these relationships with the ultimate aim of abrogating specific steps, should lead to more targeted strategies for treatment of hormone-dependent breast cancer...
  7. ncbi Measurement of the invasion depth of extrahepatic bile duct carcinoma: An alternative method overcoming the current T classification problems of the AJCC staging system
    Seung Mo Hong
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Surg Pathol 31:199-206. 2007
    ....
  8. pmc Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly
    Xinyu Chen
    Center for Cell Signaling, Department of Microbiology, Health Sciences Center, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 172:671-8. 2006
    ..Our findings identify LIMK2 as a novel target of Par-3 and uncover a molecular mechanism by which Par-3 could regulate actin dynamics during cell polarization...
  9. ncbi Cell technologies for spinal fusion
    Francis H Shen
    Department of Orthopaedic Surgery, University of Virginia Health System, PO Box 800159, Charlottesville, VA 22908, USA
    Spine J 5:231S-239S. 2005
    ..This review focuses on the terminology, historical underpinnings, and current research rationale and techniques and discusses the possible future of these technologies...
  10. ncbi Challenges and opportunities for medications development in alcoholism: an international perspective on collaborations between academia and industry
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908 0623, USA
    Alcohol Clin Exp Res 29:1528-40. 2005
    ..Swift, MD, PhD; (4) A European Perspective on Medications Development, by Otto M. Lesch, MD, PhD, and (5) A Scandinavian Perspective on Evidence-Based Addiction Treatment, by Mats Berglund, MD...
  11. ncbi Racial/ethnic differences in adolescents' physical symptoms
    Hyekyun Rhee
    Department of Family, Community and Mental Health Systems, University of Virginia, School of Nursing, Charlottesville, VA 22908, USA
    J Pediatr Nurs 20:153-62. 2005
    ....
  12. pmc Effects of antismoking advertising--based beliefs on adult smokers' consideration of quitting
    Richard G Netemeyer
    McIntire School of Commerce, University of Virginia, Charlottesville, VA 29204, USA
    Am J Public Health 95:1062-6. 2005
    ..We also assessed whether interactions between such beliefs and having children living in the home were associated with consideration of quitting...
  13. ncbi Isolation of cholesterol-dependent Candida glabrata from clinical specimens
    Kevin C Hazen
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0904, USA
    Diagn Microbiol Infect Dis 52:35-7. 2005
    ....
  14. ncbi DeltaNp53 or p44: priming the p53 pump
    Heidi Scrable
    Department of Neuroscience, University of Virginia, Room 6116, MR 4, Lane Road Extended, Charlottesville, VA 22908 1392, USA
    Int J Biochem Cell Biol 37:913-9. 2005
    ..et al. (2004). Modulation of mammalian lifespan by the short isoform of p53. Genes & Development, 18, 306-319]. This links p53 to the single most important growth factor pathway known to regulate lifespan in lower organisms...
  15. doi Meyer and Overton revisited
    Carl Lynch
    Department of Anesthesiology, University of VA Health System, Charlottesville, VA 22908 0710, USA
    Anesth Analg 107:864-7. 2008
  16. doi Deterioration in asthma control when subjects receiving fluticasone propionate/salmeterol 100/50 mcg Diskus are "stepped-down"
    Steven M Koenig
    University of Virginia, Division of Pulmonary Medicine and Critical Care, Charlottesville, VA 22908, USA
    J Asthma 45:681-7. 2008
    ..This study provides support that treatment of both inflammation and smooth muscle dysfunction may be necessary to achieve and maintain asthma control in patients uncontrolled on ICS...
  17. doi The discipline gap and African Americans: defiance or cooperation in the high school classroom
    Anne Gregory
    University of Virginia, 147 Ruffner Hall, Charlottesville, VA 22903, USA
    J Sch Psychol 46:455-75. 2008
    ..Predictors of African American student trust in teacher authority included teacher caring and high expectations, offering implications for lowering the discipline gap...
  18. doi Caring for the elderly female psychiatric patient
    Mudhasir Bashir
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, Box 800623, Charlottesville, VA 22908, USA
    Psychiatr Clin North Am 33:475-85. 2010
    ..In addition, understanding late life changes, the prevalence of various mental disorders and the sometimes unique presentation of mental disorders in this age group is required to better diagnose and treat this population...
  19. pmc Association between TNF-alpha and Entamoeba histolytica diarrhea
    KRISTINE M PETERSON
    Division of Infectious Diseases, University of Virginia Health Systems, PO BOX 801337, Building MR4, Room 2115, 409 Lane Road, Charlottesville, VA, USA
    Am J Trop Med Hyg 82:620-5. 2010
    ..histolytica diarrhea compared with convalescence. We conclude that there is an association between higher TNF-alpha production and E. histolytica diarrhea...
  20. ncbi Lead poisoning in children
    Crista Warniment
    University of Virginia School of Medicine and Family Medicine Residency Program, Charlottesville, VA, USA
    Am Fam Physician 81:751-7. 2010
    ..Prevention consists of education and avoidance of lead-contaminated products...
  21. pmc Identifying single-cell molecular programs by stochastic profiling
    Kevin A Janes
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 7:311-7. 2010
    ..Thus, stochastic profiling can reveal single-cell heterogeneities without the need to measure expression in individual cells...
  22. doi Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms
    Wei Yue
    Department of Medicine, Division of Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, VA 22908, USA
    Int J Cancer 127:1748-57. 2010
    ..These observations suggest 1 mechanism whereby AIs, which block E(2) synthesis, would be more effective for breast cancer prevention than use of antiestrogens, which only block ER-mediated effects...
  23. doi Measurement and modeling of high-linearity modified uni-traveling carrier photodiode with highly-doped absorber
    Huapu Pan
    Department of Electrical and Computer Engineering, University of Virginia, 351 McCormick Road, Charlottesville, VA 22904, USA
    Opt Express 17:20221-6. 2009
    ..The third-order local intercept point is 55 dBm at low frequency (< 3 GHz) and remains as high as 47.5 dBm up to 20 GHz. The frequency characteristics of the OIP3 are well explained by an equivalent circuit model...
  24. pmc A winding road to origin discovery
    Joyce L Hamlin
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA
    Chromosome Res 18:45-61. 2010
    ..After all, in the words of George Santayana, "Those who do not learn from history are doomed to repeat it."..
  25. doi Clinical trials of herbal treatments
    Ronald B Turner
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Eval Health Prof 32:410-6. 2009
    ..These issues must be recognized and addressed if studies of herbal remedies are to provide useful information...
  26. doi Is there really a "cushion effect"?: a biomechanical investigation of crash injury mechanisms in the obese
    Richard W Kent
    University of Virginia Center for Applied Biomechanics, Charlottesville, Virginia, USA
    Obesity (Silver Spring) 18:749-53. 2010
    ..The lower extremities also experience increased excursion as a result of this hip excursion, and thus an increased risk of a hard contact and resulting injury...
  27. pmc Advances in the genetics of glioblastoma: are we reaching critical mass?
    Benjamin Purow
    Neuro Oncology Division, Neurology Department, University of Virginia, Charlottesville, VA 22908, USA
    Nat Rev Neurol 5:419-26. 2009
    ..In addition, the complex task of incorporating our updated knowledge into new--and possibly personalized--therapies for patients with glioblastoma still lies ahead...
  28. doi Aortic diameter, true lumen, and false lumen growth rates in chronic type B aortic dissection
    Kevin J Blount
    Department of Radiology, University of Virginia, 1000 Lee Street, Charlottesville, VA 22908, USA
    AJR Am J Roentgenol 192:W222-9. 2009
    ..The objective of this study was to evaluate growth rates of the aorta, true lumen, and false lumen in chronic type B aortic dissections...
  29. doi Empty nose syndrome: what are we really talking about?
    Spencer C Payne
    Division of Rhinology and Sinus Surgery, Department of Otolaryngology Head and Neck Surgery, University of Virginia, PO Box 800713, Charlottesville, VA 22908 0713, USA
    Otolaryngol Clin North Am 42:331-7, ix-x. 2009
    ..Thus, it behooves us to evaluate this latter entity with a more critical eye, so that we can avoid creating future sufferers and provide relief to those who have already been afflicted...
  30. ncbi A comparative analysis of the pedestrian injury risk predicted by mechanical impactors and post mortem human surrogates
    Jason R Kerrigan
    University of Virginia Center for Applied Biomechanics, 1011 Linden Ave, Charlottesville, VA 22902, USA
    Stapp Car Crash J 52:527-67. 2008
    ..The upper legform impactor test resulted in bending moments (361 Nm) and forces (6.3 kN) exceeding the acceptance criteria, while PMHS sustained pelvic injuries in 6 out of 7 tests...
  31. ncbi Obesity and postexercise oxidative stress in older women
    Heather K Vincent
    Center for the Study of Complementary and Alternative Therapies CSCAT, University of Virginia Health System, PO Box 800905, The Blake Center, Charlottesville, VA 22908, USA
    Med Sci Sports Exerc 37:213-9. 2005
    ..This study compared lipid peroxidation values in nonobese and obese postmenopausal women before and after acute maximal aerobic exercise (AX)...
  32. ncbi Interposition arthroplasty with bone-tendon allograft: a technique for treatment of the unstable sternoclavicular joint
    Todd C Battaglia
    Department of Orthopaedic Surgery, University of Virginia Health Sciences Center, 400 Ray C Hunt Drive, Charlottesville, VA 22908 0159, USA
    J Orthop Trauma 19:124-9. 2005
    ..We believe this method effectively stabilizes the joint, restores function, relieves pain, and has applications for traumatic sternoclavicular instability as well as instability related to other etiologies...
  33. ncbi Diagnosis of intra-abdominal infection in the critically ill patient
    H L Evans
    University of Virginia Health System, Surgical Infectious Disease Research Laboratory, Building MR4, RM3150, Lane Road, Charlottesville, VA 22908, USA
    Curr Opin Crit Care 7:117-21. 2001
    ..This has led to a renewed interest in conservative, data-dependent surgical management employing radiographic and microbiologic evidence to guide therapy...
  34. ncbi In vivo interactions of apoA-II, apoA-I, and hepatic lipase contributing to HDL structure and antiatherogenic functions
    C C Hedrick
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 42:563-70. 2001
    ..Our data suggest that as the ratio of apoA-II to apoA-I is increased, the HDL become larger because of inhibition of HL, and lose their antiatherogenic properties...
  35. ncbi Neural pathways and central sites involved in penile erection: neuroanatomy and clinical implications
    W D Steers
    University of Virginia, Health Sciences Center, Department of Urology, Box 800 422, Jefferson Park Avenue, Charlottesville, VA 22908 0422, USA
    Neurosci Biobehav Rev 24:507-16. 2000
    ..Following discussion of the anatomical substrates, a clinical correlation is then provided to confirm and reinforce these experimental observations...
  36. pmc Human immunodeficiency virus type 1 pathogenesis in SCID-hu mice correlates with syncytium-inducing phenotype and viral replication
    D Camerini
    Department of Microbiology and Myles H Thaler Center for AIDS and Human Retrovirus Research, University of Virginia, Charlottesville, Virginia 22908, USA
    J Virol 74:3196-204. 2000
    ..Our studies show that coreceptor specificity and entry efficiency are critical determinants of HIV-1 pathogenesis in vivo...
  37. ncbi Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta
    S L Gonias
    Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Biol Chem 275:5826-31. 2000
    ..Thus, FP3 may inhibit the activity of PDGF-BB...
  38. ncbi Concurrent validity of the Millon Adolescent Clinical Inventory as a measure of depression in hospitalized adolescents
    M D Hiatt
    Curry Programs in Clinical and School Psychology, University of Virginia, Charlottesville 22903 2495, USA
    J Pers Assess 73:64-79. 1999
    ..The Suicidal Tendencies scale was weakly associated with placement on suicide precautions. Overall, these results provide moderate support for the use of the MACI in the assessment of hospitalized adolescents...
  39. ncbi Generalized neighbor-joining: more reliable phylogenetic tree reconstruction
    W R Pearson
    Department of Computer Science, University of Virginia, USA
    Mol Biol Evol 16:806-16. 1999
    ..Thus, the method can find lower-cost tree topologies and near-best tree topologies that are significantly different from the best topology...
  40. ncbi Sex differences in mammalian and chicken-II gonadotropin-releasing hormone immunoreactivity in musk shrew brain
    E F Rissman
    Department of Biology, University of Virginia, Charlottesville, Virginia, 22903, USA
    Gen Comp Endocrinol 112:346-55. 1998
    ..These data suggest that the phylogenetically conserved cGnRH-II form is regulated by ovarian hormones and, thus, may be involved in the brain-pituitary-gonadal feedback axis...
  41. ncbi Psychosocial adjustment among children conceived via donor insemination by lesbian and heterosexual mothers
    R W Chan
    Department of Psychology, University of Virginia, Charlottesville 22903 2477, USA
    Child Dev 69:443-57. 1998
    ..Parents who were experiencing higher levels of parenting stress, higher levels of interparental conflict, and lower levels of love for each other had children who exhibited more behavior problems...
  42. ncbi Memory modulation across neural systems: intra-amygdala glucose reverses deficits caused by intraseptal morphine on a spatial task but not on an aversive task
    E C McNay
    Neuroscience Program and Department of Psychology, University of Virginia, Charlottesville, Virginia 22903, USA
    J Neurosci 18:3853-8. 1998
    ..Thus, the independence of neural systems responsible for processing different classes of memory is less clear than implied by studies using lesions or injections of drugs into single brain areas...
  43. ncbi Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)
    A M Brownawell
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 272:22182-90. 1997
    ..Therefore, the interaction between sorcin and synexin may serve to regulate the functions of these proteins on membrane surfaces in a Ca2+-dependent manner...
  44. ncbi High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein transport factor 2
    B M Paschal
    Departments of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 272:21534-9. 1997
    ..These data suggest that certain of the nuclear protein import functions of NTF2 and Ran/TC4 are closely linked and that NTF2 may serve to modulate a transport step involving Ran/TC4...
  45. pmc Obtaining useful information from expert based sources
    D C Slawson
    Department of Family Medicine, University of Virginia, Charlottesville 22908, USA
    BMJ 314:947-9. 1997
    ..Both members of the team, clinicians and experts, must take responsibility for their respective roles...
  46. ncbi The use of regularity as estimated by approximate entropy to distinguish saltatory growth
    M L Johnson
    Department of Pharmacology, National Science Foundation Science and Technology Center for Biological Timing, The University of Virginia Health System, Charlottesville 22908, USA
    Ann Hum Biol 28:491-504. 2001
    ..Future investigations of regularity in longitudinal time series in human biology with ApEn statistics are suggested...
  47. ncbi Real-time, cine magnetic resonance imaging for evaluation of the pediatric airway
    R A Faust
    Department of Otolaryngology Head and Neck Surgery, University of Virginia, Charlottesville, Virginia 22908 9713, USA
    Laryngoscope 111:2187-90. 2001
    ..New real-time, dynamic, cine magnetic resonance imaging (CMRI) techniques have the potential to image moving structures...
  48. ncbi Pouchitis: Part 1: Etiologies and risk factors
    Mikel Gray
    Department of Urology, School of Nursing, University of Virginia, PO Box 800422, Charlottesville, VA 22908, USA
    J Wound Ostomy Continence Nurs 29:68-73. 2002
  49. ncbi Factors regulating macrophage endocytosis of nanoparticles: implications for targeted magnetic resonance plaque imaging
    Walter J Rogers
    Department of Radiology, University of Virginia Health System, 409 Lee Street Box 801339, Charlottesville, VA 22908, USA
    Atherosclerosis 178:67-73. 2005
    ..We describe the extent to which endogenous and exogenous factors regulate Mphi uptake of SPIO particles...
  50. ncbi Why distinctive information reduces false memories: evidence for both impoverished relational-encoding and distinctiveness heuristic accounts
    Amanda C G Hege
    Department of Psychology, University of Virginia, 102 Gilmer Hall, Charlottesville, VA 22904, USA
    J Exp Psychol Learn Mem Cogn 30:787-95. 2004
    ..However, the results from a postrecall recognition test provide evidence in favor of the distinctiveness heuristic...
  51. ncbi Abnormal heart rate characteristics are associated with neonatal mortality
    M Pamela Griffin
    Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Pediatr Res 55:782-8. 2004
    ..01). The HRC index provides independent information about the risk of neonatal death in the upcoming 7 d, and the cumulative HRC is an estimate of the risk of in-hospital neonatal mortality...
  52. ncbi The evolutionarily conserved gonadotropin-releasing hormone II modifies food intake
    Alexander S Kauffman
    University of Virginia Medical School, P O Box 800733, Jordan Hall, Room 1229, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Endocrinology 145:686-91. 2004
    ..We conclude that, in addition to its permissive role in regulating reproduction, GnRH II may also modulate food intake in mammals. Because GnRH II is present in primate brain, it may also serve a similar function in humans...
  53. ncbi Functional genomics and proteomics in control of breathing
    Benjamin Gaston
    Pediatric Respiratory Medicine, University of Virginia Health System, Post Office Box 800386, Charlottesville, VA 22908, USA
    Respir Physiol Neurobiol 135:231-8. 2003
    ..Additionally, recent examples of the application of these and related molecular techniques are provided-particularly including observations regarding the role of S-nitrosylation signaling reactions in regulating ventilatory responses...
  54. ncbi Congenital urinary tract obstruction: Proceedings of the State-Of-The-Art Strategic Planning Workshop-National Institutes of Health, Bethesda, Maryland, USA, 11-12 March 2002
    Robert L Chevalier
    Department of Pediatrics, University of Virginia, Health Sciences Center, P O Box 800386, Charlottesville, VA 22908, USA
    Pediatr Nephrol 18:576-606. 2003
  55. ncbi Outcrossing rate and inbreeding depression in the herbaceous autotetraploid, Campanula americana
    L F Galloway
    Department of Biology, University of Virginia, Charlottesville, VA 22904 4328, USA
    Heredity (Edinb) 90:308-15. 2003
    ....
  56. pmc Age-specific Helicobacter pylori seropositivity rates of children in an impoverished urban area of northeast Brazil
    Anastasia Mitchell
    Department of Microbiology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Microbiol 41:1326-8. 2003
    ..1% at 0 to 11 months of age to only 39.3% by 96 to 131 months of age and were 82.1% at maturity. We observed no correlation between the seropositivity of the mothers and the seropositivity of their children...
  57. ncbi Functional electrical stimulation for ejaculation
    Stuart S Howards
    Department of Urology, University of Virginia Health System, Charlottesville, VA 22908 0376, USA
    J Long Term Eff Med Implants 12:201-9. 2002
    ..This technology is considered the best approach in patients with spinal cord injury levels below T10 or in other patients in which penile vibratory stimulation fails...
  58. ncbi Pressure ulcer prevention and management
    Courtney H Lyder
    Acute and Specialty Care of Adults, University of Virginia School of Nursing, McLeod Hall, PO Box 800782, Charlottesville, VA 22908 0782, USA
    JAMA 289:223-6. 2003
  59. ncbi Effect of generalist preceptor specialty in a third-year clerkship on career choice
    John D Gazewood
    University of Virginia Health System, Charlottesville, VA 22908, USA
    Fam Med 34:673-7. 2002
    ..This study determined if the specialty of an assigned generalist preceptor during a third-year ambulatory clerkship affected medical students' choice of a generalist career...
  60. ncbi Gene expression profile of mouse myocardium with transgenic overexpression of A1 adenosine receptors
    Amy R Lankford
    Department of Pediatrics and Cardiovascular Research Center, University of Virginia Health System, Charlottesville Virginia 22908, USA
    Physiol Genomics 11:81-9. 2002
    ..These data illustrate genes with chronically altered patterns of expression in A(1) transgenic mouse myocardium that may be related to adenosine receptor overexpression-mediated cardioprotection...
  61. ncbi Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating
    Eduardo Perozo
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22906, USA
    Nat Struct Biol 9:696-703. 2002
    ..We propose that the mechanism of mechanotransduction in MS channels is defined by both local and global asymmetries in the transbilayer pressure profile at the lipid-protein interface...
  62. ncbi Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
    D L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Comp Neurol 372:135-65. 1996
    ..In general, the pattern of alpha 2C-LI throughout the neuraxis is consistent with previously published reports of the distribution of receptor mRNA detected by hybridization histochemistry...

Research Grants62

  1. SYNTHESIS OF ANNONACEOUS ACETOGENINS AND ANALOGUES
    James Marshall; Fiscal Year: 2001
    ..The synthetic approach will employ chiral allylic and allenic organometal reagents to introduce stereogenic centers with concurrent formation of carbon-carbon bonds. ..
  2. Synthesis of Tumor Inhibitory Marine Natural Products
    James Marshall; Fiscal Year: 2004
    ..The main chemical issues to be addressed include the control of stereochemistry by means of chiral organometal chemistry and the design of new and efficient routes to structurally novel natural products. ..
  3. Renin receptor provoked renal inflammation
    Helmy Siragy; Fiscal Year: 2009
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  4. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2003
    ..The proposed studies will help understand the mechanisms that are involved in diabetic nephropathy and could lead to the development of new therapeutic modalities to prevent or slowdown the development of this disease. ..
  5. NO AND EICOSANOID MEDIATE RENAL EFFECTS OF AT2 RECEPTORS
    Helmy Siragy; Fiscal Year: 2000
    ..The proposed studies are related to the long term goal of increased understanding of the pathophysiology of body sodium and water excretion abnormalities and hypertension. ..
  6. Renin receptor provoked renal inflammation
    Helmy Siragy; Fiscal Year: 2007
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  7. Renin receptor provoked renal inflammation
    Helmy Siragy; Fiscal Year: 2009
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  8. Renin receptor provoked renal inflammation
    Helmy M Siragy; Fiscal Year: 2010
    ..Information gained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  9. Prorenin Receptors Mediate Hypertension and Kidney Disease in Diabetes
    Helmy M Siragy; Fiscal Year: 2010
    ....
  10. AT2 Receptor Modulates Renal Angiotensin II Levels
    Helmy Siragy; Fiscal Year: 2005
    ..Data obtained from this proposal will lead to increased understanding of the pathophysiology of hypertension and development of novel therapies for its management. ..
  11. Prorenin Receptors Mediate Hypertension and Kidney Disease in Diabetes
    Helmy Siragy; Fiscal Year: 2009
    ....
  12. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2006
    ..The proposed studies will help understand the mechanisms that are involved in diabetic nephropathy and could lead to the development of new therapeutic modalities to prevent or slowdown the development of this disease. ..
  13. Angiotensin II Mediates Early Changes in Diabetic Kidney
    Helmy Siragy; Fiscal Year: 2007
    ..The proposed studies will help understand the mechanisms that are involved in diabetic the development of new therapeutic modalities to prevent or slowdown the development ..
  14. Effects of Aging on Executive Processes
    Timothy Salthouse; Fiscal Year: 2006
    ..e., specific to individual variables or common to many variables) at which age-related influences operate on executive process variables. ..
  15. Short-term cognitive change in adults from 18 to 80
    Timothy Salthouse; Fiscal Year: 2007
    ....
  16. Omega-3 Fish Oil for Nonalcoholic Steatohepatitis
    Stephen Caldwell; Fiscal Year: 2007
    ....
  17. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    ROBERT CHEVALIER; Fiscal Year: 2009
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  18. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  19. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  20. CHRONOBIOLOGY OF PARTIAL EPILEPSY
    Mark Quigg; Fiscal Year: 2002
    ..In summary, these studies will provide insight into the chronoblological factors that facilitate partial seizure expression and may provide new perspectives into treatments for poorly controlled partial epilepsy. ..
  21. Identify Driving Risk Factors in T1DM and their Reduction via Behav Intervention
    DANIEL JOSEPH COX; Fiscal Year: 2010
    ..This study is intended to assist in identifying these high risk T1DM drivers and then to successfully rehabilitate them so that their risk of future driving mishaps is no greater than that of the general public. ..
  22. TREATMENT OF EARLY CHILDHOOD CONSTIPATION AND ENCOPRESIS
    Daniel Cox; Fiscal Year: 2005
    ..After 5 years we will have documented basic elements and dissemination patters of web-based pediatric behavior change programs generally, and, in particular Enhanced Toilet Training. ..
  23. Identify Driving Risk Factors in T1DM and their Reduction via Behav Intervention
    DANIEL JOSEPH COX; Fiscal Year: 2010
    ..This study is intended to assist in identifying these high risk T1DM drivers and then to successfully rehabilitate them so that their risk of future driving mishaps is no greater than that of the general public. ..