University of Texas Southwestern Medical Center

Summary

Organization: University of Texas Southwestern Medical Center
Country: USA

Top Publications

  1. pmc Fido, a novel AMPylation domain common to fic, doc, and AvrB
    Lisa N Kinch
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e5818. 2009
  2. ncbi Inappropriate expression of IgD from a transgene inhibits the function of antigen-specific memory B cells
    D Yuan
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Cell Immunol 211:61-70. 2001
  3. ncbi Development. The path to the heart and the road not taken
    E N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 291:2327-8. 2001
  4. ncbi Diseases of liporegulation: new perspective on obesity and related disorders
    R H Unger
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    FASEB J 15:312-21. 2001
  5. ncbi Providing primary care for long-term survivors of childhood acute lymphoblastic leukemia
    K C Oeffinger
    Department of Family Practice and Community Medicine, University of Texas Southwestern Medical Center at Dallas, and Children s Medical Center of Dallas, 75390 9067, USA
    J Fam Pract 49:1133-46. 2000
  6. ncbi Lipotoxic diseases of nonadipose tissues in obesity
    R H Unger
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8854, USA
    Int J Obes Relat Metab Disord 24:S28-32. 2000
  7. ncbi Chlamydia pneumoniae and atherosclerosis
    J D Rutherford
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Curr Atheroscler Rep 2:218-25. 2000
  8. ncbi Role of the cytoskeleton in sperm entry during fertilization in the freshwater bivalve Dreissena polymorpha
    M J Misamore
    Department of Biological Sciences, Louisiana State University, Baton Rouge 70803, USA
    Biol Bull 199:144-56. 2000
  9. ncbi Clinical assessment of drug-induced disease
    R S Gruchalla
    Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas 75390 8859, USA
    Lancet 356:1505-11. 2000
  10. ncbi Intimate partner violence and drinking patterns among white, black, and Hispanic couples in the U.S
    R Caetano
    University of Texas, Dallas, USA
    J Subst Abuse 11:123-38. 2000

Research Grants

Detail Information

Publications62

  1. pmc Fido, a novel AMPylation domain common to fic, doc, and AvrB
    Lisa N Kinch
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e5818. 2009
    ..The VopS fic domain includes a conserved sequence motif (HPFx[D/E]GN[G/K]R) that contributes to AMPylation. Fic domains are found in a variety of species, including bacteria, a few archaea, and metazoan eukaryotes...
  2. ncbi Inappropriate expression of IgD from a transgene inhibits the function of antigen-specific memory B cells
    D Yuan
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Cell Immunol 211:61-70. 2001
    ..Thus, the decrease in IgD expression on normal B cells after activation may be necessary for optimal activation of memory cells...
  3. ncbi Development. The path to the heart and the road not taken
    E N Olson
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 291:2327-8. 2001
  4. ncbi Diseases of liporegulation: new perspective on obesity and related disorders
    R H Unger
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8854, USA
    FASEB J 15:312-21. 2001
    ..Given the evidence for a similar etiology for the complications of human obesity, it would be appropriate to develop strategies to avert the predicted epidemic of lipotoxic disorders...
  5. ncbi Providing primary care for long-term survivors of childhood acute lymphoblastic leukemia
    K C Oeffinger
    Department of Family Practice and Community Medicine, University of Texas Southwestern Medical Center at Dallas, and Children s Medical Center of Dallas, 75390 9067, USA
    J Fam Pract 49:1133-46. 2000
    ....
  6. ncbi Lipotoxic diseases of nonadipose tissues in obesity
    R H Unger
    Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8854, USA
    Int J Obes Relat Metab Disord 24:S28-32. 2000
    ....
  7. ncbi Chlamydia pneumoniae and atherosclerosis
    J D Rutherford
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Curr Atheroscler Rep 2:218-25. 2000
    ..It is possible that C. pneumoniae enhances atherogenesis by causing inflammation and eliciting immune responses and may be one of the factors contributing to this multifactorial disease process...
  8. ncbi Role of the cytoskeleton in sperm entry during fertilization in the freshwater bivalve Dreissena polymorpha
    M J Misamore
    Department of Biological Sciences, Louisiana State University, Baton Rouge 70803, USA
    Biol Bull 199:144-56. 2000
    ..The sperm aster was significantly smaller than the spindle associated with the female pronucleus, suggesting a reduced role for the sperm aster in amphimixis...
  9. ncbi Clinical assessment of drug-induced disease
    R S Gruchalla
    Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas 75390 8859, USA
    Lancet 356:1505-11. 2000
    ..Unfortunately, however, until we are able to better understand the mechanisms responsible for drug-induced reactions, our management tools will remain limited...
  10. ncbi Intimate partner violence and drinking patterns among white, black, and Hispanic couples in the U.S
    R Caetano
    University of Texas, Dallas, USA
    J Subst Abuse 11:123-38. 2000
    ..S., and assessed the contribution of drinking patterns, psychosocial, and other sociodemographic factors to the risk of partner violence...
  11. ncbi Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading
    F Grinnell
    Dept of Cell Biology, UT Southwestern Medical School, Dallas, TX 75235 9039, USA
    Trends Cell Biol 10:362-5. 2000
    ..Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction...
  12. ncbi The nature of help-seeking during psychiatric emergency service visits by a patient and an accompanying adult
    C A Claassen
    Division of Clinical Psychology, University of Texas Southwestern Medical Center, Dallas 75235 9070, USA
    Psychiatr Serv 51:924-7. 2000
    ....
  13. ncbi Role of acyl-coenzyme A:cholesterol acyltransferase-1 in the control of hepatic very low density lipoprotein secretion and low density lipoprotein receptor expression in the mouse and hamster
    D K Spady
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:27005-12. 2000
    ....
  14. ncbi Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture
    A J Brown
    Cell Biology Group, Heart Research Institute, Sydney 2050, Australia
    J Biol Chem 275:27627-33. 2000
    ....
  15. pmc Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis
    Nitin J Karandikar
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    J Clin Invest 109:641-9. 2002
    ....
  16. ncbi Oxidative stress, alpha-tocopherol therapy, and atherosclerosis
    Andrea Harris
    University of Texas Southwestern Medical Center, Dallas, 75390 09073, USA
    Curr Atheroscler Rep 4:373-80. 2002
    ..Clearly, more clinical trials are required in individuals with increased oxidative stress before a definitive recommendation can be made with respect to AT supplementation in atherosclerosis...
  17. ncbi Ephrins in reverse, park and drive
    Chad A Cowan
    Center for Developmental Biology, Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Trends Cell Biol 12:339-46. 2002
    ....
  18. pmc Synaptic vesicle fusion
    Josep Rizo
    Department of Biochemistry, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nat Struct Mol Biol 15:665-74. 2008
    ..Elucidation of the release mechanism will require a full understanding of the network of interactions among all these proteins and the membranes...
  19. ncbi Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus
    Mikhail Khvotchev
    Department of Neuroscience, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:12147-55. 2007
    ..Viewed together, our data indicate that binding of Munc18 to the syntaxin N terminus unites different modes of Munc18/SNARE interactions and is essential for exocytic membrane fusion...
  20. pmc MUMMALS: multiple sequence alignment improved by using hidden Markov models with local structural information
    Jimin Pei
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Nucleic Acids Res 34:4364-74. 2006
    ....
  21. ncbi Metabolic cycles as an underlying basis of biological oscillations
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Nat Rev Mol Cell Biol 7:696-701. 2006
    ..We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations...
  22. pmc Site-2 protease regulated intramembrane proteolysis: sequence homologs suggest an ancient signaling cascade
    Lisa N Kinch
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9050, USA
    Protein Sci 15:84-93. 2006
    ..Finally, conserved genomic neighborhoods of S2P homologs allow functional predictions for PDZ-containing transmembrane proteases in extra-cytoplasmic stress response and lipid metabolism...
  23. pmc PALSSE: a program to delineate linear secondary structural elements from protein structures
    Indraneel Majumdar
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    BMC Bioinformatics 6:202. 2005
    ..Success of such structural comparison methods depends crucially on the accurate identification and delineation of secondary structure elements...
  24. pmc Identification of novel restriction endonuclease-like fold families among hypothetical proteins
    Lisa N Kinch
    Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Nucleic Acids Res 33:3598-605. 2005
    ..Finally, our method identifies a novel restriction endonuclease-like domain in the C-terminus of RecC that is not detected with structure-based searches of the existing PDB database...
  25. ncbi Reminiscences of a long-time colleague and friend, Philip C. Hanawalt
    Errol C Friedberg
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Mutat Res 577:9-13. 2005
    ..Philip Hanawalt is a long time contributor to many areas of the DNA repair field. This article summarizes aspect of his relationship with the author over the past 36 years...
  26. pmc Estimates of statistical significance for comparison of individual positions in multiple sequence alignments
    Ruslan I Sadreyev
    Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323, Harry Hines Blvd, Dallas, TX 75390 9050, USA
    BMC Bioinformatics 5:106. 2004
    ....
  27. ncbi The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon
    S Sri Krishna
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9050, USA
    Cell Cycle 3:1046-9. 2004
    ..By comparative sequence and structural analysis, we show that the previously uncharacterized finger domain insert to the catalytic core of HAUSP is a zinc ribbon that has lost its zinc-binding ability...
  28. ncbi RecA mediated initial alignment of homologous DNA molecules displays apparent first order kinetics with little effect of heterology
    Shwetal Patel
    Department of Chemical Engineering, University of Delaware, Newark, DE 19716, USA
    DNA Repair (Amst) 3:61-5. 2004
    ....
  29. ncbi Androgen physiology: unsolved problems at the millennium
    Jean D Wilson
    Medical Branch, Department of Internal Medicine, University of Texas Southwestern Medical Center, Room J6 110, 5323 Harry Hines Blvd, Dallas, TX 75390 8857, USA
    Mol Cell Endocrinol 198:1-5. 2002
    ..5alpha-adiol is the predominant androgen in neonatal testes in several placental mammals, but it is unclear whether it plays a similar role in other mammalian species...
  30. ncbi The crystallographic fast Fourier transform. I. p3 symmetry
    Małgorzata Rowicka
    Department of Biochemistry, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Acta Crystallogr A 58:574-9. 2002
    ..The algorithm has been tested and benchmarked against FFT on the unit cell, revealing the expected increase in speed. This is a non-trivial example of a more general approach developed recently by the authors...
  31. ncbi Screening sinus CT scans in pediatric bone marrow transplant patients
    K R Billings
    Division of Pediatric Otolaryngology, Children s Medical Center, Dallas, TX, USA
    Int J Pediatr Otorhinolaryngol 52:253-60. 2000
    ..To determine how sinus disease noted on pre-bone marrow transplant (BMT) screening sinus computed tomography (CT) scans relates to subsequent development of clinical and/or radiographic sinusitis and correlates with overall prognosis...
  32. ncbi Focal adhesion kinase up-regulation and signaling in activated keratinocytes
    L T Kim
    Surgical Service, Veterans Affairs North Texas Health Care System, Dallas, Texas, USA
    J Surg Res 91:65-9. 2000
    ..Focal adhesion kinase (FAK) is a key component of integrin-mediated intracellular signaling. We investigated the induction of FAK and its signaling activity during keratinocyte activation...
  33. ncbi Hyper-responsiveness of adrenal sympathetic nerve activity in spontaneously hypertensive rats to ganglionic blockade, mental stress and neuronglucopenia
    W Zhang
    Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Stockholm, Sweden
    Pflugers Arch 437:56-60. 1998
    ....
  34. ncbi Our new understanding of heart failure: the role of beta-blockers in treatment
    E J Eichhorn
    Department of Internal Medicine Cardiology Division, University of Texas Southwestern, Dallas, USA
    Cleve Clin J Med 65:428-35. 1998
    ..Beta-blockers, long considered contraindicated in heart failure, improve left ventricular function in this disease by improving the biology of cardiac myocytes. Whether they improve survival remains to be determined...
  35. ncbi Myocardial viability during dobutamine echocardiography predicts survival in patients with coronary artery disease and severe left ventricular systolic dysfunction
    I Afridi
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, USA
    J Am Coll Cardiol 32:921-6. 1998
    ....
  36. ncbi Electrophysiological and biochemical responses of mouse vomeronasal receptor cells to urine-derived compounds: possible mechanism of action
    R L Moss
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Chem Senses 23:483-9. 1998
    ..The results suggest that pheromones have an inhibitory influence on action potential generation and on cAMP levels in receptor cells of the VNO...
  37. ncbi Peptide modulation of inflammatory processes within the brain
    J M Lipton
    University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
    Neuroimmunomodulation 5:178-83. 1998
    ..The results indicate that, much as for inflammation in the periphery, alpha-MSH modulates brain inflammatory responses mediated by proinflammatory agents...
  38. ncbi Evolving lipoprotein risk factors: lipoprotein(a) and oxidized low-density lipoprotein
    I Jialal
    University of Texas Southwestern Medical Center at Dallas, 75235 9072, USA
    Clin Chem 44:1827-32. 1998
    ..Although both LDL oxidation and Lp(a) are evolving risk factors for cardiovascular disease, more data are needed before they become part of the established lipoprotein repertoire...
  39. ncbi Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide
    K S Lau
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 75235 9040, USA
    FEBS Lett 431:71-4. 1998
    ..Arteriolar dilation was attenuated in contracting muscles from mdx but not C57 mice. NO generated in contracting skeletal muscle may contribute to vasodilation in response to exercise...
  40. ncbi The 6th joint national committee report (JNC-6): new guidelines for hypertension therapy from the USA
    N M Kaplan
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235 8899, USA
    Keio J Med 47:99-105. 1998
    ..Recommendations are made for improved adherence to therapy, therapy of resistant hypertension and hypertensive crises...
  41. ncbi Del (X)(p21.2) in a mother and two daughters with variable ovarian function
    A R Zinn
    Department of Internal Medicine and Eugene McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas 75235, USA
    Clin Genet 52:235-9. 1997
    ..These observations have implications for the diagnosis of Ullrich-Turner syndrome and genotype/phenotype correlations of X chromosome deletions...
  42. ncbi The role of lipid signaling in constitutive membrane traffic
    M G Roth
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas 75235 9038, USA
    Curr Opin Cell Biol 9:519-26. 1997
    ....
  43. ncbi Measurement of gluconeogenesis and pyruvate recycling in the rat liver: a simple analysis of glucose and glutamate isotopomers during metabolism of [1,2,3-(13)C3]propionate
    J G Jones
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, USA
    FEBS Lett 412:131-7. 1997
    ..This indicates that a direct measure of gluconeogenesis and pyruvate recycling may be obtained from a single 13C-NMR spectrum of blood collected after oral administration of enriched propionate...
  44. ncbi A randomized trial of empyema therapy
    M A Wait
    Division of Thoracic and Cardiovascular Surgery, Parkland Memorial Hospital, Dallas, TX 75235, USA
    Chest 111:1548-51. 1997
    ....
  45. ncbi Androgen metabolism in the prostate of the finasteride-treated, adult rat: a possible explanation for the differential action of testosterone and 5 alpha-dihydrotestosterone during development of the male urogenital tract
    F W George
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235 8857, USA
    Endocrinology 138:871-7. 1997
    ....
  46. ncbi Distal myasthenia gravis
    S P Nations
    Department of Neurology, University of Texas Southwestern Medical School, Dallas 75235 8897, USA
    Neurology 52:632-4. 1999
    ..Hand muscles, particularly finger extensors, were involved more frequently than were distal leg and foot muscles...
  47. ncbi Defining excess resource utilization and identifying associated factors for trauma victims
    G E O'Keefe
    Department of Surgery, University of Texas, Southwestern Medical Center, Dallas 75235 9158, USA
    J Trauma 46:473-8. 1999
    ..The purpose of this study is to estimate expected hospital LOS after trauma and determine the consequences of excessive LOS...
  48. ncbi Effects of fluoxetine on the polysomnogram in outpatients with major depression
    M H Trivedi
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Neuropsychopharmacology 20:447-59. 1999
    ..Conversely, subjective measures of sleep indicated a steady improvement during acute phase treatment. After fluoxetine was discontinued, total REM sleep and sleep efficiency were found to be increased as compared to baseline...
  49. ncbi Urinary retention in patients with BPH treated with finasteride or placebo over 4 years. Characterization of patients and ultimate outcomes. The PLESS Study Group
    C G Roehrborn
    The University of Texas Southwestern Medical Center, Dallas, TX 07525 9110, USA
    Eur Urol 37:528-36. 2000
    ....
  50. ncbi Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from the spinal cord is mediated by nitric oxide but not by cyclic GMP
    M G Garry
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9174, USA
    Brain Res 861:208-19. 2000
    ..Finally, these data suggest that while capsaicin-evoked iCGRP release is modified by NO, this release does not require the activation of guanylate cyclase and subsequent production of cyclic GMP...
  51. ncbi Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle
    G A Ordway
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9040, USA
    J Appl Physiol (1985) 88:1134-41. 2000
    ..These results support the potential role of the ubiquitin-proteasome pathway of protein degradation in the contraction-induced remodeling of skeletal muscle...
  52. ncbi Novel role of estrogen receptors in vascular endothelium
    P W Shaul
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75235 9063, USA
    Semin Perinatol 24:70-4. 2000
    ..Thus, the acute effect of estrogen on eNOS is mediated by ERalpha functioning in a novel, nongenomic manner to activate the enzyme via calcium-dependent, MAP kinase-dependent mechanisms...
  53. ncbi Angiotensin II indirectly vasoconstricts the ovine uterine circulation
    B E Cox
    Department of Pediatrics, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Am J Physiol Regul Integr Comp Physiol 278:R337-44. 2000
    ....
  54. ncbi Mesopontine cholinergic and non-cholinergic neurons in schizophrenia
    D C German
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235 9070, USA
    Neuroscience 94:33-8. 1999
    ..The present data do not support the previous observation of increased numbers of mesopontine cholinergic neurons in schizophrenia...
  55. ncbi Retinopathy and attenuated circadian entrainment in Crx-deficient mice
    T Furukawa
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 23:466-70. 1999
    ..Expression of several photoreceptor- and pineal-specific genes was reduced in Crx mutants. Circadian entrainment was also affected in Crx-/- mice...
  56. ncbi Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24
    B Y Reed
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas 75235 8885, USA
    J Clin Endocrinol Metab 84:3907-13. 1999
    ..3-megabase region between markers D1S2681 (centromere) and D1S2815. A trait associated with intestinal hyperabsorption of calcium in a severe form of absorptive hypercalciuria has been mapped to chromosome 1q23.3-q24...
  57. ncbi Cardiovascular effect of 7.5% sodium chloride-dextran infusion after thermal injury
    J T Murphy
    Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Arch Surg 134:1091-7. 1999
    ..5% sodium chloride in 6% dextran-70 (hypertonic saline-dextran-70 [HSD]) given as an adjuvant to a standard resuscitation with lactated Ringer (RL) solution following severe thermal injury...
  58. ncbi Horsefeathers: a commentary on "evolutionary versus prototype analyses of the concept of disorder"
    J Z Sadler
    Psychiatry Department, University of Texas Southwestern Medical Center at Dallas 75235 9070, USA
    J Abnorm Psychol 108:433-7. 1999
    ..These arguments and limitations, however, harbor serious problems when confronted with actual disputes about disorders. The conclusion notes some virtues to Wakefield's inquiry, in style and substance...
  59. ncbi Differentiation of NK1.1+, Ly49+ NK cells from flt3+ multipotent marrow progenitor cells
    N S Williams
    Department of Pathology, Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Immunol 163:2648-56. 1999
    ..Thus, we have established an in vitro system in which Ly49 expression on developing NK cells can be analyzed and possibly experimentally manipulated...
  60. ncbi Lipid regulators of membrane traffic through the Golgi complex
    M G Roth
    Dept of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235 9038, USA
    Trends Cell Biol 9:174-9. 1999
    ..As discussed in this article, one potential mechanism for the involvement of lipids is to control the GTPase cycle of a small GTP-binding protein, ARF (ADP-ribosylation factor)...
  61. pmc Treatment of atypical depression with cognitive therapy or phenelzine: a double-blind, placebo-controlled trial
    R B Jarrett
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 75235 9149, USA
    Arch Gen Psychiatry 56:431-7. 1999
    ..Since there is only 1 placebo-controlled trial of cognitive therapy, this trial fills a gap in the literature on psychotherapy for depression...
  62. pmc Unitary cardiac Na+, Ca2+ exchange current magnitudes determined from channel-like noise and charge movements of ion transport
    D W Hilgemann
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas 75235 9040, USA
    Biophys J 71:759-68. 1996
    ..The Na+ transport reactions are disabled or "immobilized" by exchanger inactivation reactions, thus confirming that inactivation generates fully inactive exchanger states...

Research Grants62

  1. Computational methods for structural-functional studies of proteins
    Nick V Grishin; Fiscal Year: 2010
    ..We will improve alignment accuracy and using the new method will analyze kinases, which are a medically important group of enzymes attracting high interest because of their relevance to many diseases, cancer in particular. ..
  2. Computations of Fold Changes in Evolution of Proteins
    Nick Grishin; Fiscal Year: 2006
    ..Finally, we will perform in silico evolution of model proteins under functional constraints and compare the results to those deduced from the analysis of natural sequences and structures. ..
  3. STRUCTURE/FUNCTION OF SYNTAXIN 1
    JOSE RIZO REY; Fiscal Year: 2001
    ..Finally, the results will aid in the design of therapies for diseases of the nervous system arising from defects in synaptic transmission. ..
  4. SYNAPTOTAGMIN AND C2 DOMAINS--STRUCTURE AND FUNCTION
    JOSE RIZO REY; Fiscal Year: 2004
    ..Characterization of these properties will not only yield insights into the functions of C2-domains in neurotransmitter release but will also facilitate future studies that will further clarify these functions. ..
  5. 800 MHZ NMR SPECTROMETER
    JOSE RIZO REY; Fiscal Year: 2002
    The University of Texas Southwestern Medical Center in Dallas has initiated a major expansion in its NMR faculty and facilities...
  6. Neurotransmitter release machinery: structure and function
    JOSE RIZO REY; Fiscal Year: 2010
    ....
  7. Synaptotagmin and C2-Domains: Structure and Function
    JOSE RIZO REY; Fiscal Year: 2010
    ..Moreover, since many neurological disorders are treated with drugs that alter synaptic transmission, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders. ..
  8. Synaptotagmin and C2-Domains: Structure and Function
    JOSE RIZO REY; Fiscal Year: 2009
    ..Moreover, since many neurological disorders are treated with drugs that alter synaptic transmission, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders. ..
  9. Neurotransmitter release machinery: structure and function
    JOSE RIZO REY; Fiscal Year: 2009
    ....
  10. Synaptotagmin and C2-Domains: Structure and Function
    JOSE RIZO REY; Fiscal Year: 2007
    ....
  11. Neurotransmitter release machinery: structure and function
    JOSE RIZO REY; Fiscal Year: 2007
    ....
  12. Structure and Function of Syntaxin 1
    JOSE RIZO REY; Fiscal Year: 2006
    ....
  13. MEMORY AND EFFECTOR CTL RESPONSES TO VIRUS INFECTIONS
    Joseph Casazza; Fiscal Year: 2001
    ..abstract_text> ..
  14. Crystallographic Analysis of NMN Adenylytransferases
    Hong Zhang; Fiscal Year: 2005
    ..influenzae, and the crystallization trials are in progress. Elucidating the structures of NadR in its various ligand-bound forms and its complex with DNA will reveal how its conformation and function are modulated by both NAD and ATP. ..
  15. Crystallographic Analysis of GHMP kinases
    Hong Zhang; Fiscal Year: 2005
    ....
  16. EFFECT OF FISH OIL ON LIPOPROTEIN METABOLISM
    DAVID SPADY; Fiscal Year: 1993
    ....
  17. DIET, HDL, AND REVERSE CHOLESTEROL TRANSPORT
    DAVID SPADY; Fiscal Year: 2001
    ..abstract_text> ..
  18. MUTAGENESIS OF FIXL, AN O2 SENSING PAS DOMAIN PROTEIN
    Marie Alda Gilles Gonzalez; Fiscal Year: 2003
    ..Some possible applications are the development of novel antibiotics directed at specific sensors in bacteria and anti-cancer drugs targeting O2 sensors that are implicated in angiogenesis. ..
  19. INTRACELLULAR TRAFFICKING OF TROPOELASTIN
    Elaine Davis; Fiscal Year: 2001
    ....
  20. X-RAY CRYSTALLOGRAPHY OF MACROMOLECULES
    Zbyszek Otwinowski; Fiscal Year: 2003
    ..The third area for development will be in standardizing optimal data collection strategies and data archiving. ..