Genomes and Genes
University of Pennsylvania
Organization: University of Pennsylvania
- Intraoperative electrophysiological monitoring in spine surgeryNeil R Malhotra
Department of Neurological Surgery, University of Pennsylvania School of Medicine, Pennsylvania Hospital, Philadelphia, PA 19107, USA
Spine (Phila Pa 1976) 35:2167-79. 2010..Review of the literature with analysis of pooled data...
- Unsentimental ethics: towards a content-specific account of the moral-conventional distinctionEdward B Royzman
Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Cognition 112:159-74. 2009....
- MRI features of cellular angiomyofibroma with pathologic correlationPhillip J Koo
Department of Radiology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, Pennsylvania 19107, USA
J Magn Reson Imaging 29:1195-8. 2009..We present the MRI features of cellular angiofibroma that are consistent with the pathological characteristics of this entity-a benign cellular and fibrous tumor with prominent vascularity...
- The relationship of case managers' expressed emotion to clients' outcomesPhyllis Solomon
School of Social Policy and Practice, University of Pennsylvania, 3701 Locust Walk, Philadelphia, PA 19104, USA
Soc Psychiatry Psychiatr Epidemiol 45:165-74. 2010..EE has been assessed on a limited basis among non-familial care providers and determined that providers can also have high EE which results in poor quality of life and negative consequences for their clients...
- Impact of pulmonary artery pressure on exercise function in severe COPDMichael W Sims
Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Chest 136:412-9. 2009..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
- On the minimization of task switch costs following long-term trainingMarian E Berryhill
Dartmouth College, Hanover, New Hampshire, USA
Atten Percept Psychophys 71:503-14. 2009..e., the finger pressing the key). Finally, retention tests revealed that these learned S-R associations were remarkably durable, since no decrements in fluent task-switching performance were observed after 10 months without practice...
- Immunity in natural SIV infectionsG Silvestri
Department of Pathology, Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Intern Med 265:97-109. 2009....
- Effect of extended-release naltrexone (XR-NTX) on quality of life in alcohol-dependent patientsHelen M Pettinati
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Alcohol Clin Exp Res 33:350-6. 2009..2005). A 24-week, randomized, double-blind, placebo-controlled study established the efficacy and safety of XR-NTX in this patient population. In this report, the effect of XR-NTX on quality of life (QOL) was examined...
- Cognitive timing: neuropsychology and anatomic basisH Branch Coslett
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Brain Res 1254:38-48. 2009..There was a significant correlation between impaired performance and lesions of the parietal lobe but there was no effect of laterality of lesion or correlation between lateral frontal lobe lesions and impairment on any task...
- Designing safety into the minimally invasive surgical revolution: a commentary based on the Jacques Perissat Lecture of the International Congress of the European Association for Endoscopic SurgeryJohn R Clarke
Department of Surgery, Drexel University, Philadelphia, USA
Surg Endosc 23:216-20. 2009..Effective teams plan, rehearse, distribute the workload, and debrief. Surgeons doing minimally invasive surgery have a unique opportunity to incorporate the principles of safety into the development of their discipline...
- The neurobiology of psychopathyAndrea L Glenn
Department of Psychology, University of Pennsylvania, 3809 Walnut Street, PA 19104, USA
Psychiatr Clin North Am 31:463-75, vii. 2008..Potential factors that may affect the development of brain impairments, as well as how some systems may be targeted for potential treatment, are discussed...
- Biochemical-Based Assays for HTS --CHI's 14th Annual ConferenceAndrew Napper
University of Pennsylvania, Institute for Medicine and Engineering, Vagelos Research Labs, 3340 Smith Walk, Philadelphia, PA 19104, USA
IDrugs 11:493-6. 2008
- Optimizing transdermal drug therapyAmanda M Ball
The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Health Syst Pharm 65:1337-46. 2008..The pharmacokinetics, benefits, risks, and future of transdermal drug products are reviewed...
- Hospital purchasing alliances: utilization, services, and performanceLawton R Burns
Department of Health Care Systems, The Wharton School, University of Pennsylvania, Philadelphia, USA
Health Care Manage Rev 33:203-15. 2008..Pooling alliances have been discussed in the health care management literature for years but have never received much empirical investigation. They represent a potentially important source of economies of scale for hospitals...
- Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's diseaseDaniel Weintraub
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Mov Disord 24:1461-7. 2009..A positive screen should be followed by a comprehensive, clinical interview to determine the range and severity of symptoms, as well as need for clinical management...
- Exploring patient and provider level variables that may impact depression outcomes among African American adolescentsBridgette M Brawner
Center for Health Disparities Research, University of Pennsylvania School of Nursing, Philadelphia, PA, USA
J Child Adolesc Psychiatr Nurs 22:69-76. 2009..Optimizing development outcomes among African American adolescents with depression...
- Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma: results of a large phase 2 studyDavid J Vaughn
Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer 115:4110-7. 2009..The activity and safety of vinflunine was evaluated in patients with locally advanced or metastatic urothelial carcinoma (UC) who developed disease progression within 12 months of platinum-containing chemotherapy...
- Automated extraction of radiation dose information for CT examinationsTessa S Cook
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Am Coll Radiol 7:871-7. 2010..The automated extraction pipeline enables compliance with the ACR's reporting guidelines and greater awareness of radiation dose to patients, thus resulting in improved patient care and management...
- Bioethics, raw and cooked: extraordinary conflict and everyday practiceCharles L Bosk
Department of Sociology, University of Pennsylvania, Philadelphia, PA 19104 6299, USA
J Health Soc Behav 51:S133-46. 2010..Two issues--the right to die and the protection of research subjects--serve to illustrate the process through which bioethics established a large institutional footprint in health care...
- Intraocular osteosarcoma in an Umbrella Cockatoo (Cacatua alba)Margaret Fordham
Section of Special Species Medicine and Surgery, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104 6051, USA
Vet Ophthalmol 13:103-8. 2010..To our knowledge, this is the first case of an intraocular osteosarcoma reported in a bird, and the first case of attempted treatment of osteosarcoma in a bird by a combination of surgery and radiation therapy...
- Curettage and graft alleviates athletic-limiting pain in benign lytic bone lesionsVincent M Moretti
Department of Orthopaedic Surgery, University of Pennsylvania, Garfield Duncan Building, Suite 2C, 301 S 8th Street, Philadelphia, PA 19106 6192, USA
Clin Orthop Relat Res 469:283-8. 2011..We present a series of lesions that caused performance-limiting pain in young athletes, a symptom phenomenon and possible treatment indication that has been poorly described in the literature...
- Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusionDoina Atanasiu
Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Virol 84:3825-34. 2010..Upon triggering by gD, gB fusion loops are inserted into target lipid membranes. gB then interacts with gH/gL, and this interaction is eventually followed by fusion...
- Efficacy of a theory-based abstinence-only intervention over 24 months: a randomized controlled trial with young adolescentsJohn B Jemmott
Department of Psychiatry, Center for Health Behavior and Communication Research, University of Pennsylvania School of Medicine, 3535 Market St, Ste 520, Philadelphia, PA 19104 3309, USA
Arch Pediatr Adolesc Med 164:152-9. 2010..To evaluate the efficacy of an abstinence-only intervention in preventing sexual involvement in young adolescents...
- Advances in adult asthma diagnosis and treatment in 2009Andrea J Apter
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Allergy Clin Immunol 125:79-84. 2010..In this review of asthma-related publications from the Journal in 2009, efforts to standardize methodology and reporting of translational research, the influence of the environment, therapeutics, and management of asthma are highlighted...
- Development and evaluation of an international, interdisciplinary palliative care workshop in BotswanaMary Ersek
John A Hartford Center of Geriatric Nursing Excellence and Center for Integrative Science in Ageing, University of Pennsylvania School of Nursing, USA
Int J Palliat Nurs 16:13-21. 2010..This paper reports the development and evaluation of an interdisciplinary, international palliative care workshop presented in Gaborone, Botswana...
- A bupropion smoking cessation clinical trial for cancer patientsRobert A Schnoll
Department of Psychiatry, University of Pennsylvania, 3535 Market Street, 4th Floor, Philadelphia, PA, 19104, USA
Cancer Causes Control 21:811-20. 2010..Many cancer patients continue to smoke post diagnosis, yet there have been few smoking cessation trials for this population. Depression, which is prevalent among cancer patients, may be a barrier to cessation...
- Factors associated with mortality and brain injury after falls from the standing positionBabak Sarani
Division of Traumatology and Surgical Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Trauma 67:954-8. 2009..The purpose of the current study was to assess risk factors associated with brain injury and death after fall from the standing position only...
- Role of matrix vesicles in biomineralizationEllis E Golub
Biochemistry Department, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104, USA
Biochim Biophys Acta 1790:1592-8. 2009..During this period, their exact role, if any in the nucleation of hydroxyapatite mineral, and its subsequent association with the collagen fibrils in the organic matrix has been debated and remains controversial...
- Investigating the link between gun possession and gun assaultCharles C Branas
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Room 936 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
Am J Public Health 99:2034-40. 2009..We investigated the possible relationship between being shot in an assault and possession of a gun at the time...
- MicroRNA-modulated targeting of vascular smooth muscle cellsMichael S Parmacek
University of Pennsylvania Cardiovascular Institute and Department of Medicine, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 119:2526-8. 2009..This important discovery will open the door to new avenues of investigation and potentially future therapies for vascular diseases...
- Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humansJohn P Plastaras
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Biol Ther 7:628-35. 2008....
- An HSV-1 gD mutant virus as an entry-impaired live virus vaccineSita Awasthi
Infectious Disease Division, Department of Medicine, School of Medicine, Philadelphia, PA 19104 6073, USA
Vaccine 26:1195-203. 2008..Therefore, this gD mutant virus impaired in entry may represent a novel candidate for an attenuated live HSV-1 vaccine...
- Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanismsTakashi Miwa
Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, 1254 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
Am J Pathol 170:1258-66. 2007..Together, these results reveal multiple mechanisms of action for DAF in ameliorating systemic autoimmunity...
- Construction of bicyclic ring systems via a transannular SmI2-mediated ketone-olefin cyclization strategyGary A Molander
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104 6323, USA
J Org Chem 72:1755-64. 2007..These results demonstrate the efficiency and the potential of the transannular cyclization tactic for the creation of bicyclic ring systems...
- De novo aneurysm formation and regression after brain arteriovenous malformation embolization: case reportMichael F Stiefel
Department of Neurosurgery, Division of Interventional Neuroradiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Surg Neurol 67:99-101; discussion 101. 2007..Development of aneurysms is not commonly seen in vessels whose flow has been directly decreased by therapeutic or natural occlusion...
- Numerical modeling of the transport to an intravascular bubble in a tube with a soluble/insoluble surfactantPortonovo S Ayyaswamy
Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
Ann N Y Acad Sci 1077:270-87. 2006..For identical surface concentrations of the surfactant, the effect of the presence of a soluble surfactant is more severe on the retardation of the bubble motion than that of an insoluble surfactant...
- Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disordersJosep Dalmau
Department of Neurology, Section of Neuro Oncology, University of Pennsylvania, 3 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Hematol Oncol Clin North Am 20:1319-35. 2006..This article summarizes the authors' findings of limbic encephalitis and postulates that a similar approach can be used for syndromes involving other areas of the nervous system...
- Association of anti-mullerian hormone levels with obesity in late reproductive-age womenEllen W Freeman
Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
Fertil Steril 87:101-6. 2007..To describe anti-mullerian hormone (AMH) levels in healthy late reproductive age women and test the hypothesis that AMH levels are lower in obese compared to non-obese women...
- When perfusion meets diffusion: in vivo measurement of water permeability in human brainJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Cereb Blood Flow Metab 27:839-49. 2007..The potential for in vivo magnetic resonance mapping of water permeability was showed using two diffusion weighted ASL measurements with b=0 and 50 secs/mm2 in both healthy subjects and a case of brain tumor...
- Placental inflammation and viral infection are implicated in second trimester pregnancy lossSindhu K Srinivas
Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
Am J Obstet Gynecol 195:797-802. 2006....
- Visual working memory is impaired when the medial temporal lobe is damagedIngrid R Olson
Center for Cognitie Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
J Cogn Neurosci 18:1087-97. 2006..Impaired memory could not be attributed to memory load or perceptual problems. These findings suggest that the MTLs are critical for accurate visual WM...
- Unit bias. A new heuristic that helps explain the effect of portion size on food intakeAndrew B Geier
Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104 6241, USA
Psychol Sci 17:521-5. 2006..We argue that unit bias is a general feature in human choice and discuss possible origins of this bias, including consumption norms...
- Psychosocial therapy for posttraumatic stress disorderEdna B Foa
Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, PA 19104, USA
J Clin Psychiatry 67:40-5. 2006..This will entail the use of culturally sensitive materials and the adaptation of training methods to enable large numbers of mental health professionals to be trained together...
- Treatment of heparin-induced thrombocytopenia in cardiovascular patientsWilliam H Matthai
Penn Presbyterian Medical Center, WS 392, Philadelphia, PA 19104, USA
Expert Opin Pharmacother 7:267-76. 2006..These agents and their use in cardiac patients, including patients with acute coronary syndrome, percutaneous coronary interventions, acute ST elevation myocardial infarction or cardiac surgery, will be reviewed...
- A randomized controlled trial of financial incentives for smoking cessationKevin G Volpp
CHERP, Philadelphia Veterans Affairs Medical Center, University and Woodland Ave, Philadelphia, PA 19104 6021, USA
Cancer Epidemiol Biomarkers Prev 15:12-8. 2006..The objective of this study was to determine whether modest financial incentives increase the rate of smoking cessation program enrollment, completion, and quit rates in a outpatient clinical setting...
- Ozonolysis of unsaturated organotrifluoroboratesGary A Molander
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
J Org Chem 72:3558-60. 2007..The process provides oxo-functionalized organotrifluoroborates that cannot be prepared directly via either transmetalation or hydroboration protocols...
- Noninvasive measurement of transit time in short bowel syndromeCharlene Compher
School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6096, USA
JPEN J Parenter Enteral Nutr 31:240-5. 2007..We sought to evaluate noninvasive measurements of intestinal transit time to aid in research questions where transit is measured repeatedly...
- Sniff magnitude test: relationship to odor identification, detection, and memory tests in a clinic populationIsabelle A Tourbier
Department of Otorhinolaryngology, Head and Neck Surgery, Smell and Taste Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Chem Senses 32:515-23. 2007..disorders clinic, the relationship of SMT scores to those from 3 standardized psychophysical tests: the University of Pennsylvania Smell Identification Test (UPSIT), a phenyl ethyl alcohol odor detection threshold test, and a short-..
- A randomized, controlled, double-blind trial of patient-controlled sedation with propofol/remifentanil versus midazolam/fentanyl for colonoscopyJeff E Mandel
Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Anesth Analg 106:434-9, table of contents. 2008..We hypothesized that, by using remifentanil in conjunction with propofol and using PCS in both arms of the study, we could demonstrate marked improvements in facility use compared with fentanyl plus midazolam...
- Post-acute referral decisions made by multidisciplinary experts compared to hospital clinicians and the patients' 12-week outcomesKathryn H Bowles
New Courtland Center for Health and Transitions, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
Med Care 46:158-66. 2008..Anticipating post-acute needs and making referrals for follow-up care are crucial for quality discharge planning. Several studies reveal serious gaps in quality for these common and important processes...
- Ac-ing the clockAmita Sehgal
Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuron 57:8-10. 2008..Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of the relevant E3 ligases are known. In addition, Hirayama et al. recently identified acetylation as a clock regulatory mechanism...
- Solid-state nanopore technologies for nanopore-based DNA analysisKen Healy
University College Cork, Department of Electrical and Electronic Engineering, Ireland
Nanomedicine (Lond) 2:875-97. 2007..The review concludes with an outlook on the future of solid-state nanopores...
- Declining public health burden of digoxin toxicity from 1991 to 2004K Haynes
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Clin Pharmacol Ther 84:90-4. 2008..The public health burden of digoxin toxicity declined dramatically from 1991 to 2004 in the United Kingdom and the United States...
- Complementary and alternative medicine for sleep disturbances in older adultsNalaka S Gooneratne
Division of Geriatric Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3615 Chestnut Street, Philadelphia, PA 19104, USA
Clin Geriatr Med 24:121-38, viii. 2008..Future work examining CAM has the potential to significantly add to our treatment options for sleep disorders in older adults...
- Social support web-based resources for patients with chronic painRosemary C Polomano
University of Pennsylvania School of Nursing, 420 Guardian Drive, Philadelphia, PA 19104, USA
J Pain Palliat Care Pharmacother 21:49-55. 2007..The internet can empower patients to self-manage their pain and seek out effective social support venues for improving their lives...
- Airway segmentation and measurement in CT imagesIrene Cheng
NSERC Research Fellow, Computer and Information Sciences Department, University of Pennsylvania, PA, USA
Conf Proc IEEE Eng Med Biol Soc 2007:795-9. 2007..Following this, a 3D model is constructed. We then estimate the volume of the airway based on segmented 3D shape...
- T-tubule formation in cardiacmyocytes: two possible mechanisms?Alessandro Di Maio
Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Anat Chem building, Room B42, Philadelphia, PA 19104 6058, USA
J Muscle Res Cell Motil 28:231-41. 2007..In the remaining CRUs, activation of Ca(2+) release must be dependent on some other mechanisms...
- Human cone photoreceptor dependence on RPE65 isomeraseSamuel G Jacobson
Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 104:15123-8. 2007....
- Identifying interventions that promote belt-positioning booster seat use for parents with low educational attainmentFlaura K Winston
The Center for Injury Research and Prevention at The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Trauma 63:S29-38. 2007..This study aimed to identify interventions that promoted booster seat use among this population...
- Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioningTerri E Weaver
Biobehavioral and Health Sciences Division, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
Sleep 30:711-9. 2007..This study, employing probit analyses and piecewise regression to estimate dose-response functions, estimated likelihoods of return to normal levels of sleepiness and daily functioning relative to nightly duration of CPAP...
- Outcomes based medicine in veterinary surgery: getting hard measures of subjective outcomesDorothy Cimino Brown
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
Vet Surg 36:289-92. 2007
- Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposureJames D Lewis
Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 15:39-45. 2006..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse...
- CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESISGARY MOLANDER; Fiscal Year: 2002..4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination. ..
- INTRAMOLECULAR REDUCTIVE COUPLING REACTIONSGARY MOLANDER; Fiscal Year: 1999..develop more efficient and selective general methods for the synthesis of organic molecules that can be utilized by medicinal chemists, toxicologist, pharmacologists, and bioorganic chemists for the study of biologically active materials ..
- Agilent 5973 GC/MS SystemGARY MOLANDER; Fiscal Year: 2002..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
- Catalytic Processes for Selective Organic SynthesisGARY MOLANDER; Fiscal Year: 2005..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
- Organotrifluoroborates in Selective Organic SynthesisGary A Molander; Fiscal Year: 2010..In this way, new drug entities can be delivered to the public more rapidly and efficiently at lower cost. ..
- Coupling Reactions-Methods Development and ApplicationsGARY MOLANDER; Fiscal Year: 2007..These types of transformations are anticipated to have broad generality and will thus prove valuable for the rapid, efficient, and unique assembly of complex organic molecules throughout the pharmaceutical industry and beyond. ..
- Development of Heterosubstituted OrganotrifluoroboratesGary A Molander; Fiscal Year: 2010....
- Organotrifluoroborates in Selective Organic SynthesisGary A Molander; Fiscal Year: 2010..In this way, new drug entities can be delivered to the public more rapidly and efficiently at lower cost. ..
- INTRAMOLECULAR REDUCTIVE COUPLING REACTIONSGARY MOLANDER; Fiscal Year: 2003..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
- Coupling Reactions-Methods Development and ApplicationsGARY MOLANDER; Fiscal Year: 2007..abstract_text> ..
- Development of Heterosubstituted OrganotrifluoroboratesGARY MOLANDER; Fiscal Year: 2007....
- ANTICANCER AGENTS--STRUCTURE AND SYNTHESISAMOS SMITH; Fiscal Year: 2007..Thus, as we develop an approach to each target structure, we will also prepare model compounds designed to permit the elucidation of structure-activity relationships. ..
- SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTSAMOS SMITH; Fiscal Year: 2007..abstract_text> ..
- NMR systems : 2 Bruker Avance 500 ConsolesAMOS SMITH; Fiscal Year: 2006The Department of Chemistry at the University of Pennsylvania has 17 faculty directing 158 graduate students and post-doctoral fellows conducting frontier research in synthetic organic and inorganic chemistry, bioorganic and bioinorganic ..
- SYNTHESIS OF BIOACTIVE NATURAL PRODUCTSAmos B Smith; Fiscal Year: 2010..Our experience with discodermolide gives us great confidence in this area. ..
- ANTICANCER AGENTS--STRUCTURE AND SYNTHESISAMOS SMITH; Fiscal Year: 2004..The design of new and possibly more effective agents should then be feasible. ..
- SYNTHESIS OF PHYLLANTHOSIDE RELATED ANTITUMOR AGENTSAMOS SMITH; Fiscal Year: 1991..Once such features are identified, the design of new and possibly more effective antitumor drugs should be feasible...