University of Pennsylvania

Summary

Organization: University of Pennsylvania
Country: USA

Top Publications

  1. doi Intraoperative electrophysiological monitoring in spine surgery
    Neil R Malhotra
    Department of Neurological Surgery, University of Pennsylvania School of Medicine, Pennsylvania Hospital, Philadelphia, PA 19107, USA
    Spine (Phila Pa 1976) 35:2167-79. 2010
  2. doi Unsentimental ethics: towards a content-specific account of the moral-conventional distinction
    Edward B Royzman
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Cognition 112:159-74. 2009
  3. doi MRI features of cellular angiomyofibroma with pathologic correlation
    Phillip J Koo
    Department of Radiology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, Pennsylvania 19107, USA
    J Magn Reson Imaging 29:1195-8. 2009
  4. doi The relationship of case managers' expressed emotion to clients' outcomes
    Phyllis Solomon
    School of Social Policy and Practice, University of Pennsylvania, 3701 Locust Walk, Philadelphia, PA 19104, USA
    Soc Psychiatry Psychiatr Epidemiol 45:165-74. 2010
  5. pmc Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
  6. doi On the minimization of task switch costs following long-term training
    Marian E Berryhill
    Dartmouth College, Hanover, New Hampshire, USA
    Atten Percept Psychophys 71:503-14. 2009
  7. doi Immunity in natural SIV infections
    G Silvestri
    Department of Pathology, Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Intern Med 265:97-109. 2009
  8. pmc Effect of extended-release naltrexone (XR-NTX) on quality of life in alcohol-dependent patients
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 33:350-6. 2009
  9. pmc Cognitive timing: neuropsychology and anatomic basis
    H Branch Coslett
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain Res 1254:38-48. 2009
  10. doi Designing safety into the minimally invasive surgical revolution: a commentary based on the Jacques Perissat Lecture of the International Congress of the European Association for Endoscopic Surgery
    John R Clarke
    Department of Surgery, Drexel University, Philadelphia, USA
    Surg Endosc 23:216-20. 2009

Research Grants

  1. CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS
    GARY MOLANDER; Fiscal Year: 2002
  2. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 1999
  3. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
  4. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
  5. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
  6. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007
  7. Development of Heterosubstituted Organotrifluoroborates
    Gary A Molander; Fiscal Year: 2010
  8. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
  9. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2003
  10. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007

Detail Information

Publications62

  1. doi Intraoperative electrophysiological monitoring in spine surgery
    Neil R Malhotra
    Department of Neurological Surgery, University of Pennsylvania School of Medicine, Pennsylvania Hospital, Philadelphia, PA 19107, USA
    Spine (Phila Pa 1976) 35:2167-79. 2010
    ..Review of the literature with analysis of pooled data...
  2. doi Unsentimental ethics: towards a content-specific account of the moral-conventional distinction
    Edward B Royzman
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Cognition 112:159-74. 2009
    ....
  3. doi MRI features of cellular angiomyofibroma with pathologic correlation
    Phillip J Koo
    Department of Radiology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, Pennsylvania 19107, USA
    J Magn Reson Imaging 29:1195-8. 2009
    ..We present the MRI features of cellular angiofibroma that are consistent with the pathological characteristics of this entity-a benign cellular and fibrous tumor with prominent vascularity...
  4. doi The relationship of case managers' expressed emotion to clients' outcomes
    Phyllis Solomon
    School of Social Policy and Practice, University of Pennsylvania, 3701 Locust Walk, Philadelphia, PA 19104, USA
    Soc Psychiatry Psychiatr Epidemiol 45:165-74. 2010
    ..EE has been assessed on a limited basis among non-familial care providers and determined that providers can also have high EE which results in poor quality of life and negative consequences for their clients...
  5. pmc Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
    ..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
  6. doi On the minimization of task switch costs following long-term training
    Marian E Berryhill
    Dartmouth College, Hanover, New Hampshire, USA
    Atten Percept Psychophys 71:503-14. 2009
    ..e., the finger pressing the key). Finally, retention tests revealed that these learned S-R associations were remarkably durable, since no decrements in fluent task-switching performance were observed after 10 months without practice...
  7. doi Immunity in natural SIV infections
    G Silvestri
    Department of Pathology, Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Intern Med 265:97-109. 2009
    ....
  8. pmc Effect of extended-release naltrexone (XR-NTX) on quality of life in alcohol-dependent patients
    Helen M Pettinati
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Alcohol Clin Exp Res 33:350-6. 2009
    ..2005). A 24-week, randomized, double-blind, placebo-controlled study established the efficacy and safety of XR-NTX in this patient population. In this report, the effect of XR-NTX on quality of life (QOL) was examined...
  9. pmc Cognitive timing: neuropsychology and anatomic basis
    H Branch Coslett
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain Res 1254:38-48. 2009
    ..There was a significant correlation between impaired performance and lesions of the parietal lobe but there was no effect of laterality of lesion or correlation between lateral frontal lobe lesions and impairment on any task...
  10. doi Designing safety into the minimally invasive surgical revolution: a commentary based on the Jacques Perissat Lecture of the International Congress of the European Association for Endoscopic Surgery
    John R Clarke
    Department of Surgery, Drexel University, Philadelphia, USA
    Surg Endosc 23:216-20. 2009
    ..Effective teams plan, rehearse, distribute the workload, and debrief. Surgeons doing minimally invasive surgery have a unique opportunity to incorporate the principles of safety into the development of their discipline...
  11. doi The neurobiology of psychopathy
    Andrea L Glenn
    Department of Psychology, University of Pennsylvania, 3809 Walnut Street, PA 19104, USA
    Psychiatr Clin North Am 31:463-75, vii. 2008
    ..Potential factors that may affect the development of brain impairments, as well as how some systems may be targeted for potential treatment, are discussed...
  12. ncbi Biochemical-Based Assays for HTS --CHI's 14th Annual Conference
    Andrew Napper
    University of Pennsylvania, Institute for Medicine and Engineering, Vagelos Research Labs, 3340 Smith Walk, Philadelphia, PA 19104, USA
    IDrugs 11:493-6. 2008
  13. doi Optimizing transdermal drug therapy
    Amanda M Ball
    The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Health Syst Pharm 65:1337-46. 2008
    ..The pharmacokinetics, benefits, risks, and future of transdermal drug products are reviewed...
  14. doi Hospital purchasing alliances: utilization, services, and performance
    Lawton R Burns
    Department of Health Care Systems, The Wharton School, University of Pennsylvania, Philadelphia, USA
    Health Care Manage Rev 33:203-15. 2008
    ..Pooling alliances have been discussed in the health care management literature for years but have never received much empirical investigation. They represent a potentially important source of economies of scale for hospitals...
  15. pmc Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease
    Daniel Weintraub
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mov Disord 24:1461-7. 2009
    ..A positive screen should be followed by a comprehensive, clinical interview to determine the range and severity of symptoms, as well as need for clinical management...
  16. doi Exploring patient and provider level variables that may impact depression outcomes among African American adolescents
    Bridgette M Brawner
    Center for Health Disparities Research, University of Pennsylvania School of Nursing, Philadelphia, PA, USA
    J Child Adolesc Psychiatr Nurs 22:69-76. 2009
    ..Optimizing development outcomes among African American adolescents with depression...
  17. doi Vinflunine in platinum-pretreated patients with locally advanced or metastatic urothelial carcinoma: results of a large phase 2 study
    David J Vaughn
    Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer 115:4110-7. 2009
    ..The activity and safety of vinflunine was evaluated in patients with locally advanced or metastatic urothelial carcinoma (UC) who developed disease progression within 12 months of platinum-containing chemotherapy...
  18. doi Automated extraction of radiation dose information for CT examinations
    Tessa S Cook
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Radiol 7:871-7. 2010
    ..The automated extraction pipeline enables compliance with the ACR's reporting guidelines and greater awareness of radiation dose to patients, thus resulting in improved patient care and management...
  19. doi Bioethics, raw and cooked: extraordinary conflict and everyday practice
    Charles L Bosk
    Department of Sociology, University of Pennsylvania, Philadelphia, PA 19104 6299, USA
    J Health Soc Behav 51:S133-46. 2010
    ..Two issues--the right to die and the protection of research subjects--serve to illustrate the process through which bioethics established a large institutional footprint in health care...
  20. pmc Intraocular osteosarcoma in an Umbrella Cockatoo (Cacatua alba)
    Margaret Fordham
    Section of Special Species Medicine and Surgery, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104 6051, USA
    Vet Ophthalmol 13:103-8. 2010
    ..To our knowledge, this is the first case of an intraocular osteosarcoma reported in a bird, and the first case of attempted treatment of osteosarcoma in a bird by a combination of surgery and radiation therapy...
  21. pmc Curettage and graft alleviates athletic-limiting pain in benign lytic bone lesions
    Vincent M Moretti
    Department of Orthopaedic Surgery, University of Pennsylvania, Garfield Duncan Building, Suite 2C, 301 S 8th Street, Philadelphia, PA 19106 6192, USA
    Clin Orthop Relat Res 469:283-8. 2011
    ..We present a series of lesions that caused performance-limiting pain in young athletes, a symptom phenomenon and possible treatment indication that has been poorly described in the literature...
  22. pmc Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion
    Doina Atanasiu
    Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Virol 84:3825-34. 2010
    ..Upon triggering by gD, gB fusion loops are inserted into target lipid membranes. gB then interacts with gH/gL, and this interaction is eventually followed by fusion...
  23. doi Efficacy of a theory-based abstinence-only intervention over 24 months: a randomized controlled trial with young adolescents
    John B Jemmott
    Department of Psychiatry, Center for Health Behavior and Communication Research, University of Pennsylvania School of Medicine, 3535 Market St, Ste 520, Philadelphia, PA 19104 3309, USA
    Arch Pediatr Adolesc Med 164:152-9. 2010
    ..To evaluate the efficacy of an abstinence-only intervention in preventing sexual involvement in young adolescents...
  24. pmc Advances in adult asthma diagnosis and treatment in 2009
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    J Allergy Clin Immunol 125:79-84. 2010
    ..In this review of asthma-related publications from the Journal in 2009, efforts to standardize methodology and reporting of translational research, the influence of the environment, therapeutics, and management of asthma are highlighted...
  25. ncbi Development and evaluation of an international, interdisciplinary palliative care workshop in Botswana
    Mary Ersek
    John A Hartford Center of Geriatric Nursing Excellence and Center for Integrative Science in Ageing, University of Pennsylvania School of Nursing, USA
    Int J Palliat Nurs 16:13-21. 2010
    ..This paper reports the development and evaluation of an interdisciplinary, international palliative care workshop presented in Gaborone, Botswana...
  26. doi A bupropion smoking cessation clinical trial for cancer patients
    Robert A Schnoll
    Department of Psychiatry, University of Pennsylvania, 3535 Market Street, 4th Floor, Philadelphia, PA, 19104, USA
    Cancer Causes Control 21:811-20. 2010
    ..Many cancer patients continue to smoke post diagnosis, yet there have been few smoking cessation trials for this population. Depression, which is prevalent among cancer patients, may be a barrier to cessation...
  27. doi Factors associated with mortality and brain injury after falls from the standing position
    Babak Sarani
    Division of Traumatology and Surgical Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Trauma 67:954-8. 2009
    ..The purpose of the current study was to assess risk factors associated with brain injury and death after fall from the standing position only...
  28. pmc Role of matrix vesicles in biomineralization
    Ellis E Golub
    Biochemistry Department, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1790:1592-8. 2009
    ..During this period, their exact role, if any in the nucleation of hydroxyapatite mineral, and its subsequent association with the collagen fibrils in the organic matrix has been debated and remains controversial...
  29. pmc Investigating the link between gun possession and gun assault
    Charles C Branas
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Room 936 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Am J Public Health 99:2034-40. 2009
    ..We investigated the possible relationship between being shot in an assault and possession of a gun at the time...
  30. pmc MicroRNA-modulated targeting of vascular smooth muscle cells
    Michael S Parmacek
    University of Pennsylvania Cardiovascular Institute and Department of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:2526-8. 2009
    ..This important discovery will open the door to new avenues of investigation and potentially future therapies for vascular diseases...
  31. ncbi Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans
    John P Plastaras
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Biol Ther 7:628-35. 2008
    ....
  32. pmc An HSV-1 gD mutant virus as an entry-impaired live virus vaccine
    Sita Awasthi
    Infectious Disease Division, Department of Medicine, School of Medicine, Philadelphia, PA 19104 6073, USA
    Vaccine 26:1195-203. 2008
    ..Therefore, this gD mutant virus impaired in entry may represent a novel candidate for an attenuated live HSV-1 vaccine...
  33. pmc Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanisms
    Takashi Miwa
    Institute for Translational Medicine and Therapeutics and Department of Pharmacology, University of Pennsylvania School of Medicine, 1254 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Pathol 170:1258-66. 2007
    ..Together, these results reveal multiple mechanisms of action for DAF in ameliorating systemic autoimmunity...
  34. pmc Construction of bicyclic ring systems via a transannular SmI2-mediated ketone-olefin cyclization strategy
    Gary A Molander
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104 6323, USA
    J Org Chem 72:1755-64. 2007
    ..These results demonstrate the efficiency and the potential of the transannular cyclization tactic for the creation of bicyclic ring systems...
  35. ncbi De novo aneurysm formation and regression after brain arteriovenous malformation embolization: case report
    Michael F Stiefel
    Department of Neurosurgery, Division of Interventional Neuroradiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Surg Neurol 67:99-101; discussion 101. 2007
    ..Development of aneurysms is not commonly seen in vessels whose flow has been directly decreased by therapeutic or natural occlusion...
  36. ncbi Numerical modeling of the transport to an intravascular bubble in a tube with a soluble/insoluble surfactant
    Portonovo S Ayyaswamy
    Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
    Ann N Y Acad Sci 1077:270-87. 2006
    ..For identical surface concentrations of the surfactant, the effect of the presence of a soluble surfactant is more severe on the retardation of the bubble motion than that of an insoluble surfactant...
  37. pmc Clinical and immunological diversity of limbic encephalitis: a model for paraneoplastic neurologic disorders
    Josep Dalmau
    Department of Neurology, Section of Neuro Oncology, University of Pennsylvania, 3 Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Hematol Oncol Clin North Am 20:1319-35. 2006
    ..This article summarizes the authors' findings of limbic encephalitis and postulates that a similar approach can be used for syndromes involving other areas of the nervous system...
  38. ncbi Association of anti-mullerian hormone levels with obesity in late reproductive-age women
    Ellen W Freeman
    Department of Obstetrics Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Fertil Steril 87:101-6. 2007
    ..To describe anti-mullerian hormone (AMH) levels in healthy late reproductive age women and test the hypothesis that AMH levels are lower in obese compared to non-obese women...
  39. ncbi When perfusion meets diffusion: in vivo measurement of water permeability in human brain
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Cereb Blood Flow Metab 27:839-49. 2007
    ..The potential for in vivo magnetic resonance mapping of water permeability was showed using two diffusion weighted ASL measurements with b=0 and 50 secs/mm2 in both healthy subjects and a case of brain tumor...
  40. ncbi Placental inflammation and viral infection are implicated in second trimester pregnancy loss
    Sindhu K Srinivas
    Department of Obstetrics and Gynecology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Am J Obstet Gynecol 195:797-802. 2006
    ....
  41. ncbi Visual working memory is impaired when the medial temporal lobe is damaged
    Ingrid R Olson
    Center for Cognitie Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cogn Neurosci 18:1087-97. 2006
    ..Impaired memory could not be attributed to memory load or perceptual problems. These findings suggest that the MTLs are critical for accurate visual WM...
  42. ncbi Unit bias. A new heuristic that helps explain the effect of portion size on food intake
    Andrew B Geier
    Department of Psychology, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104 6241, USA
    Psychol Sci 17:521-5. 2006
    ..We argue that unit bias is a general feature in human choice and discuss possible origins of this bias, including consumption norms...
  43. ncbi Psychosocial therapy for posttraumatic stress disorder
    Edna B Foa
    Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Psychiatry 67:40-5. 2006
    ..This will entail the use of culturally sensitive materials and the adaptation of training methods to enable large numbers of mental health professionals to be trained together...
  44. ncbi Treatment of heparin-induced thrombocytopenia in cardiovascular patients
    William H Matthai
    Penn Presbyterian Medical Center, WS 392, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 7:267-76. 2006
    ..These agents and their use in cardiac patients, including patients with acute coronary syndrome, percutaneous coronary interventions, acute ST elevation myocardial infarction or cardiac surgery, will be reviewed...
  45. ncbi A randomized controlled trial of financial incentives for smoking cessation
    Kevin G Volpp
    CHERP, Philadelphia Veterans Affairs Medical Center, University and Woodland Ave, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 15:12-8. 2006
    ..The objective of this study was to determine whether modest financial incentives increase the rate of smoking cessation program enrollment, completion, and quit rates in a outpatient clinical setting...
  46. pmc Ozonolysis of unsaturated organotrifluoroborates
    Gary A Molander
    Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6323, USA
    J Org Chem 72:3558-60. 2007
    ..The process provides oxo-functionalized organotrifluoroborates that cannot be prepared directly via either transmetalation or hydroboration protocols...
  47. ncbi Noninvasive measurement of transit time in short bowel syndrome
    Charlene Compher
    School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6096, USA
    JPEN J Parenter Enteral Nutr 31:240-5. 2007
    ..We sought to evaluate noninvasive measurements of intestinal transit time to aid in research questions where transit is measured repeatedly...
  48. ncbi Sniff magnitude test: relationship to odor identification, detection, and memory tests in a clinic population
    Isabelle A Tourbier
    Department of Otorhinolaryngology, Head and Neck Surgery, Smell and Taste Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chem Senses 32:515-23. 2007
    ..disorders clinic, the relationship of SMT scores to those from 3 standardized psychophysical tests: the University of Pennsylvania Smell Identification Test (UPSIT), a phenyl ethyl alcohol odor detection threshold test, and a short-..
  49. doi A randomized, controlled, double-blind trial of patient-controlled sedation with propofol/remifentanil versus midazolam/fentanyl for colonoscopy
    Jeff E Mandel
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 106:434-9, table of contents. 2008
    ..We hypothesized that, by using remifentanil in conjunction with propofol and using PCS in both arms of the study, we could demonstrate marked improvements in facility use compared with fentanyl plus midazolam...
  50. pmc Post-acute referral decisions made by multidisciplinary experts compared to hospital clinicians and the patients' 12-week outcomes
    Kathryn H Bowles
    New Courtland Center for Health and Transitions, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA
    Med Care 46:158-66. 2008
    ..Anticipating post-acute needs and making referrals for follow-up care are crucial for quality discharge planning. Several studies reveal serious gaps in quality for these common and important processes...
  51. doi Ac-ing the clock
    Amita Sehgal
    Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 57:8-10. 2008
    ..Degradation of these proteins usually involves ubiquitylation or sumoylation, and some of the relevant E3 ligases are known. In addition, Hirayama et al. recently identified acetylation as a clock regulatory mechanism...
  52. ncbi Solid-state nanopore technologies for nanopore-based DNA analysis
    Ken Healy
    University College Cork, Department of Electrical and Electronic Engineering, Ireland
    Nanomedicine (Lond) 2:875-97. 2007
    ..The review concludes with an outlook on the future of solid-state nanopores...
  53. ncbi Declining public health burden of digoxin toxicity from 1991 to 2004
    K Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 84:90-4. 2008
    ..The public health burden of digoxin toxicity declined dramatically from 1991 to 2004 in the United Kingdom and the United States...
  54. pmc Complementary and alternative medicine for sleep disturbances in older adults
    Nalaka S Gooneratne
    Division of Geriatric Medicine, Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, 3615 Chestnut Street, Philadelphia, PA 19104, USA
    Clin Geriatr Med 24:121-38, viii. 2008
    ..Future work examining CAM has the potential to significantly add to our treatment options for sleep disorders in older adults...
  55. ncbi Social support web-based resources for patients with chronic pain
    Rosemary C Polomano
    University of Pennsylvania School of Nursing, 420 Guardian Drive, Philadelphia, PA 19104, USA
    J Pain Palliat Care Pharmacother 21:49-55. 2007
    ..The internet can empower patients to self-manage their pain and seek out effective social support venues for improving their lives...
  56. ncbi Airway segmentation and measurement in CT images
    Irene Cheng
    NSERC Research Fellow, Computer and Information Sciences Department, University of Pennsylvania, PA, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:795-9. 2007
    ..Following this, a 3D model is constructed. We then estimate the volume of the airway based on segmented 3D shape...
  57. ncbi T-tubule formation in cardiacmyocytes: two possible mechanisms?
    Alessandro Di Maio
    Department of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Anat Chem building, Room B42, Philadelphia, PA 19104 6058, USA
    J Muscle Res Cell Motil 28:231-41. 2007
    ..In the remaining CRUs, activation of Ca(2+) release must be dependent on some other mechanisms...
  58. pmc Human cone photoreceptor dependence on RPE65 isomerase
    Samuel G Jacobson
    Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:15123-8. 2007
    ....
  59. ncbi Identifying interventions that promote belt-positioning booster seat use for parents with low educational attainment
    Flaura K Winston
    The Center for Injury Research and Prevention at The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Trauma 63:S29-38. 2007
    ..This study aimed to identify interventions that promoted booster seat use among this population...
  60. pmc Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning
    Terri E Weaver
    Biobehavioral and Health Sciences Division, School of Nursing, University of Pennsylvania, Philadelphia, PA 19104 6096, USA
    Sleep 30:711-9. 2007
    ..This study, employing probit analyses and piecewise regression to estimate dose-response functions, estimated likelihoods of return to normal levels of sleepiness and daily functioning relative to nightly duration of CPAP...
  61. ncbi Outcomes based medicine in veterinary surgery: getting hard measures of subjective outcomes
    Dorothy Cimino Brown
    School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6010, USA
    Vet Surg 36:289-92. 2007
  62. ncbi Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposure
    James D Lewis
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 15:39-45. 2006
    ..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse...

Research Grants62

  1. CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS
    GARY MOLANDER; Fiscal Year: 2002
    ..4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination. ..
  2. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 1999
    ..develop more efficient and selective general methods for the synthesis of organic molecules that can be utilized by medicinal chemists, toxicologist, pharmacologists, and bioorganic chemists for the study of biologically active materials ..
  3. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  4. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  5. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
    ..In this way, new drug entities can be delivered to the public more rapidly and efficiently at lower cost. ..
  6. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007
    ..These types of transformations are anticipated to have broad generality and will thus prove valuable for the rapid, efficient, and unique assembly of complex organic molecules throughout the pharmaceutical industry and beyond. ..
  7. Development of Heterosubstituted Organotrifluoroborates
    Gary A Molander; Fiscal Year: 2010
    ....
  8. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2010
    ..In this way, new drug entities can be delivered to the public more rapidly and efficiently at lower cost. ..
  9. INTRAMOLECULAR REDUCTIVE COUPLING REACTIONS
    GARY MOLANDER; Fiscal Year: 2003
    ..The study of the mechanism of action of GPI-anchoring inhibitors may lead to therapies for parasitic protozoan infections. ..
  10. Coupling Reactions-Methods Development and Applications
    GARY MOLANDER; Fiscal Year: 2007
    ..abstract_text> ..
  11. Development of Heterosubstituted Organotrifluoroborates
    GARY MOLANDER; Fiscal Year: 2007
    ....
  12. ANTICANCER AGENTS--STRUCTURE AND SYNTHESIS
    AMOS SMITH; Fiscal Year: 2007
    ..Thus, as we develop an approach to each target structure, we will also prepare model compounds designed to permit the elucidation of structure-activity relationships. ..
  13. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  14. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    The Department of Chemistry at the University of Pennsylvania has 17 faculty directing 158 graduate students and post-doctoral fellows conducting frontier research in synthetic organic and inorganic chemistry, bioorganic and bioinorganic ..
  15. SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    Amos B Smith; Fiscal Year: 2010
    ..Our experience with discodermolide gives us great confidence in this area. ..
  16. ANTICANCER AGENTS--STRUCTURE AND SYNTHESIS
    AMOS SMITH; Fiscal Year: 2004
    ..The design of new and possibly more effective agents should then be feasible. ..
  17. SYNTHESIS OF PHYLLANTHOSIDE RELATED ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 1991
    ..Once such features are identified, the design of new and possibly more effective antitumor drugs should be feasible...