Genomes and Genes
University of North Carolina
Organization: University of North Carolina
- Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestosKelly E Duncan
Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 118:420-34. 2010..5) was more potent at inducing a proinflammatory response than LA(2.5). This difference could not be explained by differences in mineral contamination between the two samples, TSA, or oxidant generation by the samples...
- Is maternal diet supplementation beneficial? Optimal development of infant depends on mother's dietSteven H Zeisel
Nutrition Research Institute, and the Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Am J Clin Nutr 89:685S-7S. 2009..The infant is not protected from the inadequate diet of the mother...
- Reference production in young speakers with and without autism: effects of discourse status and processing constraintsJennifer E Arnold
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3270, USA
Cognition 110:131-46. 2009..Furthermore, referential choices for all participants were modulated by factors related to the cognitive effort of language production...
- Modular synthesis of functional nanoscale coordination polymersWenbin Lin
Department of Chemistry, CB 3290, University of North Carolina, Chapel Hill, NC 27599, USA
Angew Chem Int Ed Engl 48:650-8. 2009..These results underscore the exciting opportunities of developing next-generation functional nanomaterials based on molecular components...
- A simple approach for fitting linear relative rate models in SASDavid B Richardson
Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Epidemiol 168:1333-8. 2008..Cary, North Carolina). This approach is illustrated via analyses of data from a study of mortality in a cohort of South Carolina asbestos textile workers (1940-2001)...
- Direct health care costs of Crohn's disease and ulcerative colitis in US children and adultsMichael D Kappelman
Division of Pediatric Gastroenterology, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Gastroenterology 135:1907-13. 2008....
- Modifications of a large HIV prevention clinical trial to fit changing realities: a case study of the Breastfeeding, Antiretroviral, and Nutrition (BAN) protocol in Lilongwe, MalawiCharles van der Horst
University of North Carolina at Chapel Hill, North Carolina, USA
Contemp Clin Trials 30:24-33. 2009..We highlight some of the successes, challenges, and lessons learned at different stages during the conduct of the trial...
- Individual and neighborhood socioeconomic status characteristics and prevalence of metabolic syndrome: the Atherosclerosis Risk in Communities (ARIC) StudyKristal L Chichlowska
Department of Epidemiology, School of Public Health, The University of North Carolina at Chapel Hill, North Carolina, USA
Psychosom Med 70:986-92. 2008..The objective of this study was to examine the association of individual socioeconomic status (iSES) and neighborhood SES (nSES) on the prevalence of metabolic syndrome (MetS) in the Atherosclerosis Risk in Communities Study (1987-1999)...
- "Feeling blue" in Spanish: a qualitative inquiry of depression among Mexican immigrantsGerald F Lackey
Department of Sociology, University of North Carolina, 27 Manning Hall, Campus Box 3355, Chapel Hill, NC 27599 3355, United States
Soc Sci Med 67:228-37. 2008..Colloquial terms are provided in both Spanish and English and direct quotes from the focus group discussions are included...
- Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injuryBruce A Cairns
Department of Surgery and North Carolina Jaycee Burn Center, Chapel Hill, North Carolina, USA
J Trauma 64:1069-77; discussion 1077-8. 2008..In this study, we hypothesized that burn injury results in altered cytokine secretion profiles after TLR2 or TLR4 ligation that is associated with altered TLR expression on innate immune cells...
- The dilemma of data-safety monitoring: provision of significant new data to research participantsJeffery Peppercorn
Division of Hematology Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7305, USA
Lancet 371:527-9. 2008
- The spread of health services and fertility transitionSarah R Brauner-Otto
Carolina Population Center, University of North Carolina at Chapel Hill, CB 8120, University Square, 123 West Franklin Street, Chapel Hill, NC 27516 2524, USA
Demography 44:747-70. 2007..These results provide new information about the consequences of maternal and child health services and the importance of these services in shaping fertility transitions...
- The effect of offering different numbers of colorectal cancer screening test options in a decision aid: a pilot randomized trialJennifer M Griffith
Center for Decision Making Research, Cecil Sheps Center for Health Services Research, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
BMC Med Inform Decis Mak 8:4. 2008..We sought to compare, in a pilot randomized trial, two colorectal cancer (CRC) screening decision aids that differed in the number of screening options presented...
- Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic reviewAndrew S Bomback
Department of Medicine, Division of Nephrology and Hypertension, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Kidney Dis 51:199-211. 2008....
- Cross-cultural and international adaptation of peer support for diabetes managementEdwin B Fisher
Department of Health Behavior and Health Education, University of North Carolina at Chapel Hill, 27599 7440, USA
Fam Pract 27:i6-16. 2010....
- Removal of a well-fixed metal-metal hip resurfacing acetabular componentPaul F Lachiewicz
Department of Orthopaedic Surgery, University of North Carolina, 3151 Bioinformatics Building, CB 7055, 130 Mason Farm Road, Chapel Hill, NC 27514, USA
J Surg Orthop Adv 18:51-3. 2009..Well-fixed metal-metal hip resurfacing components are removed for infection, instability, or hypersensitivity reactions. This article presents a technique for removal of a porous resurfacing acetabular component with minimal bone loss...
- Open-label trial of lamotrigine focusing on efficacy in vulvodyniaSamantha E Meltzer-Brody
Department of Psychiatry, University of North Carolina at Chapel Hill, Campus Box 7160, Chapel Hill, NC 27599, USA
J Reprod Med 54:171-8. 2009..Vulvodynia, a vulvar pain syndrome that includes vulvar vestibulitis, is the most common subtype of CPP. This study examined the efficacy of lamotrigine for the treatment of CPP using an open-label design...
- Obesity and diabetes genetic variants associated with gestational weight gainAlison M Stuebe
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA
Am J Obstet Gynecol 203:283.e1-17. 2010..We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain...
- Integrative package for low back pain with leg pain in Korea: a prospective cohort studyJongbae J Park
Asian Medicine and Acupuncture Research, Department of Physical Medicine and Rehabilitation, School of Medicine, University of North Carolina, Memorial Hospital, Chapel Hill, NC 27599, USA
Complement Ther Med 18:78-86. 2010..With no unequivocal support for surgery versus conservative treatment, an integrative approach has become popular in Korea...
- Receptor-promoted exocytosis of airway epithelial mucin granules containing a spectrum of adenine nucleotidesSilvia M Kreda
Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, 4029A Thurston Bowles Building, Chapel Hill, NC 27599 7248, USA
J Physiol 588:2255-67. 2010....
- Use of passive diffusion tubes to monitor air pollutantsDavid G Nash
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
J Air Waste Manag Assoc 60:204-9. 2010..Passive diffusion tubes may be particularly useful in surveys where the spatial variability in concentrations is high and where the cost of traditional monitoring instruments is a concern...
- Economic grand rounds: did Medicare Part D improve access to medications?Marisa Elena Domino
Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 1104G McGavran Greenberg Hall, CB 7411, Chapel Hill, NC 27599 7411, USA
Psychiatr Serv 61:118-20. 2010..There was no strong evidence that Part D was associated with large changes in access to medications in the four classes of medications examined here...
- Evaluation and management of hip pain: the emerging role of hip arthroscopyChristopher M Larson
Minnesota Sports Medicine, Eden Prairie, MN, 55344, USA
Phys Sportsmed 33:26-32. 2005..Although hip pain in athletes is often managed conservatively, specific disorders and injuries are appropriately and successfully treated with hip arthroscopy...
- The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008A Leslie Morrow
Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
Alcohol 43:521-30. 2009..Professor Patrizia Porcu of the University of North Carolina, USA described a potential neuroactive steroid biomarker that may predict heavy drinking in monkeys and ..
- trans-Fatty acid consumption and its association with distal colorectal cancer in the North Carolina Colon Cancer Study IILisa C Vinikoor
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Cancer Causes Control 21:171-80. 2010..98 (95%CI: 0.47, 2.05) and 0.87 (95%CI 0.42, 1.81), respectively]. In conclusion, high consumption of trans-fatty acids was positively associated with distal colorectal cancer among Whites...
- Psychophysiological correlates of parenting behavior in mothers of young childrenW Roger Mills-Koonce
Center for Developmental Science The University of North Carolina at Chapel Hill 100 East Franklin Street, 8115 Chapel Hill, NC 27599, USA
Dev Psychobiol 51:650-61. 2009....
- Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitisLawrence E Ostrowski
The University of North Carolina at Chapel Hill School of Medicine, Cystic Fibrosis Pulmonary Research and Treatment Center, CB 7248, 6123A Thurston Bowles Bldg, Chapel Hill, NC 27599 7248, USA
Am J Respir Cell Mol Biol 43:55-63. 2010..This model will be useful for the study of the pathogenesis and treatment of PCD...
- Control of healthcare-associated Staphylococcus aureus: Survey of practices in North Carolina hospitalsDavid J Weber
University of North Carolina, Department of Hospital Epidemiology, Chapel Hill, USA
Infect Control Hosp Epidemiol 30:909-11. 2009..We report here the results of a survey of 70 hospitals in North Carolina with regard to current management issues surrounding methicillin-resistant S. aureus...
- Disclosure of research results from cancer genomic studies: state of the scienceLynn G Dressler
University of North Carolina School of Pharmacy, Division of Pharmaceutical Outcomes and Policy, Institute for Pharmacogenomics and Individualized Therapy, Chapel Hill, North Carolina, USA
Clin Cancer Res 15:4270-6. 2009..These assessments, along with what is considered useful information, requires the involvement of the research subject community to inform decision-making and move the policy process forward...
- Normal tissue tolerance for high-grade gliomas: is it an issue?David E Morris
Department of Radiation Oncology, UNC School of Medicine, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA
Semin Radiat Oncol 19:187-92. 2009....
- Residency training in pyloromyotomy: a survey of 331 pediatric surgeonsGraham H Cosper
University of North Carolina School of Medicine, Coastal Area Health Education Center, New Hanover Regional Medical Center, Wilmington, NC 28402 9025, USA
J Pediatr Surg 43:102-8. 2008..Laparoscopic pyloromyotomy (LAP), and changes in referral patterns have affected the training of pediatric surgery fellows and general surgery residents. We surveyed pediatric surgeons regarding these issues...
- Usefulness of routine conventional cytogenetic analysis in tissues submitted for "lymphoma work-up"Cherie Dunphy
Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Leuk Lymphoma 49:75-80. 2008....
- Identifying supports and barriers to physical activity in patients at risk for diabetesKatrina E Donahue
University of North Carolina at Chapel Hill, Department of Family Medicine, Campus Box 7595 Manning Dr, Chapel Hill, NC 27599, USA
Prev Chronic Dis 3:A119. 2006....
- Degrees of difficulty of water-consuming reactions in the absence of enzymesRichard Wolfenden
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Chem Rev 106:3379-96. 2006
- Effectiveness of mailing "Bathing Without a Battle" to all US nursing homesDiane C Calleson
Public Health Leadership Program, Department of Family Medicine, The University of North Carolina at Chapel Hill, School of Public Health, Chapel Hill, NC 27599, USA
Gerontol Geriatr Educ 27:67-79. 2006..The long-term outcomes of this educational program continue to be monitored...
- Long-term outcomes after surgical and nonsurgical management of chronic pelvic pain: one year after evaluation in a pelvic pain specialty clinicGeorgine Lamvu
Division of Advanced Laparoscopy and Pelvic Pain, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7508, USA
Am J Obstet Gynecol 195:591-8; discussion 598-600. 2006..The purpose of this study was to describe long-term outcomes for women with chronic pelvic pain (CPP) after evaluation in a CPP specialty clinic...
- Automatic segmentation of intra-treatment CT images for adaptive radiation therapy of the prostateB C Davis
Department of Computer Science, University of North Carolina, USA
Med Image Comput Comput Assist Interv 8:442-50. 2005..In this paper, we describe our approach and present a study of its accuracy for adaptive radiation therapy of the prostate. All experiments are carried out on 3-dimensional CT images...
- Predictors of opioid misuse in patients with chronic pain: a prospective cohort studyTimothy J Ives
Division of General Internal Medicine and Clinical Epidemiology, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
BMC Health Serv Res 6:46. 2006..We conducted a prospective cohort study to determine the one-year incidence and predictors of opioid misuse among patients enrolled in a chronic pain disease management program within an academic internal medicine practice...
- Basis of the gabamimetic profile of ethanolG R Breese
Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA
Alcohol Clin Exp Res 30:731-44. 2006..Collectively, this series of reports support the GABAmimetic profile of acutely administered ethanol being dependent on several specific mechanisms distinct from a direct effect on the major synaptic isoforms of GABA(A) receptors...
- Understanding the development and prevention of type 2 diabetes in youth (part 1)Diane Berry
University of North Carolina at Chapel Hill, School of Nursing, 27599 7460, USA
J Pediatr Health Care 20:3-10. 2006..Secondary prevention is aimed at preventing those with pre-diabetes from developing diabetes, and tertiary prevention is aimed at preventing the complications of type 2 diabetes...
- Commentary: obesity claims and controversiesJune Stevens
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Int J Epidemiol 35:77-8; discussion 81-2. 2006
- I'm not a doctor but I play one on TV: E.R. and the place of contemporary health care in fixing crisisJonathan Lepofsky
Department of Geography, University of North Carolina Chapel Hill, Saunders Hall, Campus Box 3220, Chapel Hill, NC 27599 3220, USA
Health Place 12:180-94. 2006..What E.R. provides is a powerful, if limited, "realistic" portrayal about the role of health care today-a role that is increasingly considered to be shaped by the need to intervene in crisis...
- IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study ProjectRebecca J Cleveland
Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Carcinogenesis 27:758-65. 2006..Our results demonstrate a role for alleles with fewer than (CA)19 repeats as a risk factor for breast cancer and also suggest that several traditional breast cancer risk factors modify the association of the IGF1 (CA)19 repeat genotype...
- Classroom goal structure, student motivation, and academic achievementJudith L Meece
School of Education, University of North Carolina, Chapel Hill, North Carolina 27599 3500, USA
Annu Rev Psychol 57:487-503. 2006..The implications of achievement goal theory for examining the impact of school reform are discussed...
- Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfacesHirotoshi Matsui
Cystic Fibrosis Pulmonary Research and Treatment Center and Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
J Immunol 175:1090-9. 2005..We conclude that concentrated ("thick") mucus inhibits neutrophil migration and killing and is a key component in the failure of defense against chronic airways infection in CF...
- Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular eventsLeslie A Lange
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
JAMA 296:2703-11. 2006..C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD)...
- Current and best practices for testing of sexually transmitted diseasesArlene C Sena
Division of Infectious Diseases, University of North Carolina at Chapel Hill, USA
N C Med J 67:359-63. 2006
- Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot studySteven Offenbacher
Department of Periodontology, Center for Oral and Systemic Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7455, USA
J Periodontol 77:2011-24. 2006..Few studies have examined the potential effects of periodontal treatment during pregnancy on pregnancy outcomes, periodontal status, and inflammatory biomarkers...
- Functional outcomes of cleft lip surgery. Part I: Study design and surgeon ratings of lip disability and need for lip revisionCARROLL ANN TROTMAN
Department of Orthodontics, University of North Carolina at Chapel Hill 27599 7450, USA
Cleft Palate Craniofac J 44:598-606. 2007..In this article, the design of the clinical trial is described and results of a study on subjective evaluations of facial form by surgeons for or against the need for lip revision surgery are presented...
- Pulling together: interagency coordination and HIV/STD preventionJames C Thomas
Department of Epidemiology, Campus Box 7435, University of North Carolina, Chapel Hill, NC 27599, USA
J Public Health Manag Pract 14:E1-6. 2008..The measures of network exchanges employed in this study may be appropriate for future assessment of service provision of funded prevention programs...
- Mortality among workers at the Savannah River SiteDavid B Richardson
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Am J Ind Med 50:881-91. 2007..We therefore compared the observed deaths among workers to expectations based upon death rates for referent populations...
- Evaluation of bacterial inactivation in prestorage pooled, leukoreduced, whole blood-derived platelet concentrates suspended in plasma prepared with photochemical treatmentMark E Brecher
Department of Pathology and Laboratory Medicine, University of North Carolina, 101 Manning Drive, Chapel Hill, NC 27514, USA
Transfusion 47:1896-901. 2007..Because PLT additive solutions (ASs) are not used in the United States, this study evaluated the ability of the PCT process to inactivate low levels of bacteria in pooled whole blood-derived PLTs (RDP) suspended in 100 percent plasma...
- If you say thee uh you are describing something hard: the on-line attribution of disfluency during reference comprehensionJennifer E Arnold
Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
J Exp Psychol Learn Mem Cogn 33:914-30. 2007..The authors conclude that listeners can make situation-specific inferences about likely sources of disfluency, but there are some limitations to these attributions...
- Self-management education for persons with arthritis: Managing comorbidity and eliminating health disparitiesJean Goeppinger
University of North Carolina at Chapel Hill, Schools of Nursing and Public Health, Chapel Hill, NC 27599 7460, USA
Arthritis Rheum 57:1081-8. 2007....
- Immunostimulatory sequences in immunotherapyDeidra A Blanks
Department of Otolaryngology Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7070, USA
Curr Opin Otolaryngol Head Neck Surg 15:281-5. 2007....
- Late diagnosis of HIV in young men in North CarolinaElizabeth A Torrone
Department of Epidemiology, University of North Carolina at Chapel Hill School of Public Health, Raleigh, NC 27599, USA
Sex Transm Dis 34:846-8. 2007
- Caveolin-1 knockout mice have increased bone size and stiffnessJanet Rubin
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Bone Miner Res 22:1408-18. 2007..Cell studies showed that cav-1 deficiency leads to increased osteoblast differentiation. These results suggest that cav-1 helps to maintain osteoblast progenitors in a less differentiated state...
- Primary failure of eruption: further characterization of a rare eruption disorderSylvia A Frazier-Bowers
Department of Orthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7450, USA
Am J Orthod Dentofacial Orthop 131:578.e1-11. 2007....
- Passive sampler for PM10-2.5 aerosolDavid Leith
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
J Air Waste Manag Assoc 57:332-6. 2007..The degree of agreement between passive and FRM concentrations measured here suggests that passive measurements may not be overly dependent on accurate knowledge of these parameters...
- Do Russian and American normal adults perform similarly on neuropsychological tests? Preliminary findings on the relationship between culture and test performanceAnna V Agranovich
Department of Psychology, University of North Carolina, Chapel Hill, NC 27599, USA
Arch Clin Neuropsychol 22:273-82. 2007..ANCOVA suggested that intergroup differences were not fully explained by differences in subjective relevance of the tasks to culture-specific experiences. The rest of the tests appeared similar for potential application in both cultures...
- Relationships between equilibrium spreading pressure and phase equilibria of phospholipid bilayers and monolayers at the air-water interfaceHeidi M Mansour
School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, Wisconsin 53705 2222, USA
Langmuir 23:3809-19. 2007..2 mN/m forming equilibrated gaseous monolayers, whereas spread monolayers collapse at a value of pic remaining around 30 mN/m, indicative of metastable gel bilayer formation...
- Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial cleftsAndrew F Olshan
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Am J Med Genet A 135:268-73. 2005..Future, larger studies, examining additional repair genes, birth defects, and interaction with exposures are recommended...
- Enantioselective Synthesis of PolyethersMichael T Crimmins; Fiscal Year: 2010..The total synthesis of brevetoxin A, sorangicin A, brevenal sclerophytin A, brianthein A and verillin will be carried out. New enantioselective methods for the synthesis of cyclic ethers and carbocycles will be investigated. ..
- ASYMMETRIC SYNTHESIS OF MEDIUM RING POLYETHERSMICHAEL CRIMMINS; Fiscal Year: 2003..abstract_text> ..
- ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTSMICHAEL CRIMMINS; Fiscal Year: 2003..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
- Micromass LCT Mass SpectrometerMICHAEL CRIMMINS; Fiscal Year: 2004..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
- ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTSMICHAEL CRIMMINS; Fiscal Year: 2001..An anti selective variant of the oxazolidinethione aldo will be investigated. The synthesis of laurencin, and laurallene will be pursued to demonstrate the potential of the aldol- metathesis combination. ..
- ASYMMETRIC SYNTHESIS OF ANTITUMOR POLYKETIDESMICHAEL CRIMMINS; Fiscal Year: 2001..Leucasandrolide A displayed significant cytotoxicity (IC50=0.05 and 0.25 mug/ml with KB and P388 cells, respectively) as well as very strong inhibition ofCandida albicans, a pathogenic yeast that attacks AIDS patients. ..
- ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTSMICHAEL CRIMMINS; Fiscal Year: 2005..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
- ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTSMICHAEL CRIMMINS; Fiscal Year: 2006..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
- Asymmetric Synthesis of PolyethersMICHAEL CRIMMINS; Fiscal Year: 2007..abstract_text> ..
- SYNTHESIS OF CYCLOPENTANOIDS BY PHOTOCYCLOADDITONSMICHAEL CRIMMINS; Fiscal Year: 1993..Finally, a project directed toward the development of an auxiliary directed asymmetric [2+2] photocycloaddition on 2-carboalkoxycyclopent-2-en-l-ones will be initiated...
- Reproducibility and Clinical Implications of Masked HypertensionAnthony J Viera; Fiscal Year: 2010..The findings are expected to lead to clinical strategies enabling greater recognition of hypertension, and therefore, ultimately to a reduction in cardiovascular morbidity and mortality in the population. ..
- Monitoring Social Change: Health, Reproduction, AgingBarry Popkin; Fiscal Year: 2007..The instruments include data collection at the community as well as individual and household levels through a monitoring of prices, a wide range of services, and infrastructure. ..
- Monitoring Social Change: Health, Reproduction, AgingBarry Popkin; Fiscal Year: 2009....
- Spousal communication and cancer prevention behaviorKELLY EVENSON; Fiscal Year: 2006..The long-term goal of this research is to develop better interventions which help prevent cancer, and other chronic health conditions, by involving spouses in preventive behavior change programs. ..
- CHILD HEALTH EFFECTS OF RAPID SOCIO-DEMOGRAPHIC CHANGEBarry Popkin; Fiscal Year: 2004..Finally, we will compare results across countries to determine whether there is a consistent pattern or structure of relationships across countries at different levels of development. ..