University of Massachusetts Medical School

Summary

Organization: University of Massachusetts Medical School
Country: USA

Top Publications

  1. doi The role of psychopathic personality disorder in violence risk assessments using the HCR-20
    Laura S Guy
    University of Massachusetts Medical School, Rm S7 823, Worcester, MA 01655, USA
    J Pers Disord 24:551-80. 2010
  2. pmc Delays in seeking medical care in hospitalized patients with decompensated heart failure
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Med 121:212-8. 2008
  3. pmc Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness
    Lawrence J Hayward
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 118:1437-49. 2008
  4. doi Emergency medical support units to critical care transport teams in Iraq
    Sean T Collins
    Graduate School of Nursing, University of Massachusetts, Worcester, MA, USA
    Crit Care Nurs Clin North Am 20:1-11, v. 2008
  5. ncbi Regulation of airway smooth muscle cell contractility by Ca2+ signaling and sensitivity
    Michael J Sanderson
    Department of Physiology University of Massachusetts Medical School Worcester, MA 01655, USA
    Proc Am Thorac Soc 5:23-31. 2008
  6. pmc The inflammatory response to cell death
    Kenneth L Rock
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Annu Rev Pathol 3:99-126. 2008
  7. ncbi Correlates of readiness to receive Chlamydia screening among 2 populations of youths
    Diane R Blake
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Pediatr Adolesc Med 161:1088-94. 2007
  8. pmc Drug-related arrests in a cohort of public mental health service recipients
    William H Fisher
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Psychiatr Serv 58:1448-53. 2007
  9. ncbi Patient education about anticoagulant medication: is narrative evidence or statistical evidence more effective?
    Kathleen M Mazor
    Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Clinic Foundation, and Fallon Community Health Plan, United States
    Patient Educ Couns 69:145-57. 2007
  10. ncbi Optical antisense imaging of tumor with fluorescent DNA duplexes
    Xinrong Liu
    Depatment of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Bioconjug Chem 18:1905-11. 2007

Research Grants

  1. RNA Transport Within the Nucleus
    Thoru Pederson; Fiscal Year: 2005
  2. RNA PROCESSING AND RIBONUCLEOPROTEIN
    Thoru Pederson; Fiscal Year: 2001
  3. Toll like receptor - Mediated pathways in liver injury
    Gyongyi Szabo; Fiscal Year: 2010
  4. Cell Cycle Regulation of Histone Gene Expression
    Gary S Stein; Fiscal Year: 2010
  5. CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATION
    GARY S contact STEIN; Fiscal Year: 2010
  6. TLR4 Signaling in alcoholic liver disease
    Gyongyi Szabo; Fiscal Year: 2010
  7. CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATION
    Gary Stein; Fiscal Year: 2009
  8. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2007
  9. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
  10. FASEB Summer Conference on Nuclear Structure and Cancer
    Gary Stein; Fiscal Year: 2007

Detail Information

Publications62

  1. doi The role of psychopathic personality disorder in violence risk assessments using the HCR-20
    Laura S Guy
    University of Massachusetts Medical School, Rm S7 823, Worcester, MA 01655, USA
    J Pers Disord 24:551-80. 2010
    ..Areas for future study are discussed, including research on various ways to assess and incorporate into risk assessment personality traits related to violence...
  2. pmc Delays in seeking medical care in hospitalized patients with decompensated heart failure
    Robert J Goldberg
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Med 121:212-8. 2008
    ....
  3. pmc Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness
    Lawrence J Hayward
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 118:1437-49. 2008
    ....
  4. doi Emergency medical support units to critical care transport teams in Iraq
    Sean T Collins
    Graduate School of Nursing, University of Massachusetts, Worcester, MA, USA
    Crit Care Nurs Clin North Am 20:1-11, v. 2008
    ..The lessons learned from the frequency of these events are valuable to any similar transport case with critically ill and injured patients...
  5. ncbi Regulation of airway smooth muscle cell contractility by Ca2+ signaling and sensitivity
    Michael J Sanderson
    Department of Physiology University of Massachusetts Medical School Worcester, MA 01655, USA
    Proc Am Thorac Soc 5:23-31. 2008
    ....
  6. pmc The inflammatory response to cell death
    Kenneth L Rock
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Annu Rev Pathol 3:99-126. 2008
    ..Here we review what is presently known about the sterile inflammatory response and its underlying mechanisms...
  7. ncbi Correlates of readiness to receive Chlamydia screening among 2 populations of youths
    Diane R Blake
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Arch Pediatr Adolesc Med 161:1088-94. 2007
    ..To assess young people's preferences for Chlamydia testing venues and methods, attitudes about testing, sex differences among these variables, and their predictive associations with young people's readiness for screening...
  8. pmc Drug-related arrests in a cohort of public mental health service recipients
    William H Fisher
    Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Psychiatr Serv 58:1448-53. 2007
    ..This study examined the prevalence of drug arrests in a cohort of persons receiving services from a state mental health agency who were followed for roughly ten years...
  9. ncbi Patient education about anticoagulant medication: is narrative evidence or statistical evidence more effective?
    Kathleen M Mazor
    Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Clinic Foundation, and Fallon Community Health Plan, United States
    Patient Educ Couns 69:145-57. 2007
    ..To determine the relative impact of incorporating narrative evidence, statistical evidence or both into patient education about warfarin, a widely used oral anticoagulant medication...
  10. ncbi Optical antisense imaging of tumor with fluorescent DNA duplexes
    Xinrong Liu
    Depatment of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Bioconjug Chem 18:1905-11. 2007
    ..This proof of concept investigation of optical antisense targeting therefore suggests that further studies including optimization of this approach are appropriate...
  11. ncbi Collaboration of junior students and residents in a teacher course for senior medical students
    Susan J Pasquale
    University of Massachusetts Medical School, Worcester, USA
    Med Teach 29:572-6. 2007
    This paper describes the curriculum and impact of an innovative resident-as-teacher course at the University of Massachusetts Medical School. The intent of the course is to prepare students across undergraduate and graduate medical ..
  12. pmc A dietary quality comparison of popular weight-loss plans
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Am Diet Assoc 107:1786-91. 2007
    ..Dietary quality varied across popular weight-loss plans. Ornish, Weight Watchers high-carbohydrate, and New Glucose Revolution weight-loss plans have an increased capacity for cardiovascular disease prevention when assessed by the AHEI...
  13. ncbi Transmembrane interactions as immunotherapeutic targets: lessons from viral pathogenesis
    Alexander B Sigalov
    University of Massachusetts Medical School, Department of Pathology, Worcester, MA, USA
    Adv Exp Med Biol 601:335-44. 2007
    ....
  14. pmc What can we learn about fertilization from cystic fibrosis?
    Harvey M Florman
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 104:11123-4. 2007
  15. doi The American Society of Pediatric Hematology/Oncology distinguished career award goes to Laurence A. Boxer, MD
    Peter E Newburger
    Departments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Blood Cancer 50:1121-2. 2008
  16. doi In utero efficacy of cystic fibrosis gene therapy: difficult studies, positive or negative
    Terence R Flotte
    University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Ther 16:806-7. 2008
  17. pmc Cost-effectiveness of screening strategies for Chlamydia trachomatis using cervical swabs, urine, and self-obtained vaginal swabs in a sexually transmitted disease clinic setting
    Diane R Blake
    Department of Pediatrics, Division of Adolescent Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Sex Transm Dis 35:649-55. 2008
    ..We evaluated the cost-effectiveness of Chlamydia screening strategies that use different methods of specimen collection: cervical swabs, urines, and self-obtained vaginal swabs...
  18. doi One-year treatment costs of trauma care in the USA
    Sharada Weir
    University of Massachusetts Medical School, 333 South Street, Shrewsbury, MA 01545, USA
    Expert Rev Pharmacoecon Outcomes Res 10:187-97. 2010
    ..On average, 58% of cost was accounted for by the index hospitalization. Total 1-year treatment cost of adult major trauma in the USA was conservatively estimated to be US$27 billion annually (2005)...
  19. doi Correlates of weight patterns during middle age characterized by functional principal components analysis
    Molly E Waring
    Department of Community Health, Brown University, Providence, RI, USA
    Ann Epidemiol 20:201-9. 2010
    ..Describing weight trajectories using functional methods may further our understanding of how weight impacts health. We characterize weight patterns and describe correlates of these patterns...
  20. doi Endocrine parameters of cystic fibrosis: back to basics
    Michael S Stalvey
    Department of Pediatrics and the Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Biochem 108:353-61. 2009
    ..In this review, we focus on the known and hypothesized pathogenesis of these two disorders. Additionally, the molecular underpinnings of CF will be explained along with the potential interactions with endocrine disease phenotypes...
  21. pmc Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
    John E Landers
    Cecil B Day Neuromuscular Research Laboratory, Massachusetts General Hospital East, Building 114, Navy Yard, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 106:9004-9. 2009
    ..These findings support the view that genetic factors modify phenotypes in this disease and that cellular motor proteins are determinants of motor neuron viability...
  22. doi Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps
    Bernt Tore BrĂ¥tane
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Brain Res 1279:182-8. 2009
    ..Ischemic lesion determination by ADC was more accurate in final infarct prediction, rater independent, and provided exclusive information on ischemic lesion reversibility...
  23. doi Th17 cells bounce off the fungal wall
    Stuart M Levitz
    University of Massachusetts Medical School, 364 Plantation Street, LRB317, Worcester, MA 01605, USA
    Cell Host Microbe 5:311-3. 2009
    ....
  24. pmc Replacing 99mTc with 111In improves MORF/cMORF pretargeting by reducing intestinal accumulation
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655 0243, USA
    Mol Imaging Biol 11:303-7. 2009
    ..To reduce accumulation in the abdomen by MORF/cMORF pretargeting, 111In was compared to 99mTc as the radiolabel...
  25. pmc Contributions of weight perceptions to weight loss attempts: differences by body mass index and gender
    Stephenie C Lemon
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Body Image 6:90-6. 2009
    ..However, perceiving oneself to be overweight was a strong correlate for weight loss attempts across both genders. The effect of targeting accuracy of self-perceived weight status in weight loss interventions deserves research attention...
  26. pmc Exercise and energy intake in overweight, sedentary individuals
    Kristin L Schneider
    University of Illinois at Chicago, Department of Psychology MC 285, 1007 W Harrison Street, Chicago, IL 60607, USA
    Eat Behav 10:29-35. 2009
    ..Further research examining behavioral and physiological mechanisms of mood deterioration and caloric overcompensation following exercise in overweight, sedentary individuals is warranted...
  27. doi Endovascular treatment of renal artery aneurysm secondary to fibromuscular dysplasia: a case report
    Luciano Sciacca
    Division of Vascular Surgery, Department of Surgery, University of Massachusetts, Worcester, MA, USA
    Ann Vasc Surg 23:536.e9-12. 2009
    ..There are multiple treatment options for dealing with these aneurysms, both open and endovascular. This case report describes management of a left renal artery aneurysm with covered stents...
  28. pmc Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen
    Glen D Raffel
    Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 29:333-41. 2009
    ..Thus, Ott1-dependent pathways, in addition to being implicated in leukemogenesis, may also be important for the pathogenesis of placental insufficiency and cardiac malformations...
  29. pmc Sensitivity and specificity of recalled vasomotor symptoms in a multiethnic cohort
    Sybil L Crawford
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Shaw Building Room 228, Worcester, MA 01655, USA
    Am J Epidemiol 168:1452-9. 2008
    ..The approach presented here would be useful for examining other symptoms or behaviors...
  30. pmc The genome of the diploid anuran Xenopus tropicalis contains a novel array of sarcoplasmic myosin heavy chain genes expressed in larval muscle and larynx
    Brian T Nasipak
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Genes Evol 218:389-97. 2008
    ..A striking similarity of gene order between regions flanking X. tropicalis MyHC arrays and human arrays was evident; genomic organization of MyHC isoforms may thus be highly conserved across tetrapods...
  31. pmc Effect of ethanol on inflammatory responses. Implications for pancreatitis
    Gyongyi Szabo
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Pancreatology 7:115-23. 2007
    ..Alcohol use alters inflammatory cell responses. While alcohol has direct effects on pancreatic acinar cells, activation of inflammatory cells is a major component of the pathology of alcoholic pancreatitis...
  32. ncbi Barriers and strategies for recruiting study participants in clinical settings
    Susan Sullivan-Bolyai
    University of Massachusetts, Worcester, MA 01655 0002, USA
    West J Nurs Res 29:486-500. 2007
    ..Each barrier is described, and specific strategies are suggested based on the empirical literature. In some instances, the coauthors' experiences are also shared...
  33. ncbi Pathogenic interactions between alcohol and hepatitis C
    Gyongyi Szabo
    Hepatology and Liver Center, Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, 365 Plantation Street, Worcester, MA 01605, USA
    Curr Gastroenterol Rep 5:86-92. 2003
    ..Further investigation of these and other pathways by which alcohol and HCV interact should unravel the mechanisms that accelerate the progression of liver disease...
  34. pmc Recombination-promoting activity of the bacteriophage lambda Rap protein in Escherichia coli K-12
    Anthony R Poteete
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Bacteriol 184:4626-9. 2002
    ..The results of these experiments indicated that the lambda rap gene could functionally substitute for the E. coli ruvC gene in Red-mediated recombination...
  35. ncbi Mapping of the chick heme oxygenase-1 proximal promoter for responsiveness to metalloporphyrins
    Ying Shan
    Department of Medicine, and the The Liver Biliary Pancreatic Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Arch Biochem Biophys 399:159-66. 2002
    ..We conclude that the chick HO-1 promoter region contains a unique sequence that subserves up-regulation of the gene by metalloporphyrins and propose the name "metalloporphyrin-responsive element" for this sequence...
  36. ncbi Long-stay patients in state psychiatric hospitals at the end of the 20th century
    W H Fisher
    University of Massachusetts Medical School, Worcester 01655, USA
    Psychiatr Serv 52:1051-6. 2001
    ..The purpose of this study was to assess the characteristics of long-stay patients in contemporary state psychiatric hospitals and to identify factors representing possible barriers to alternative placements for these patients...
  37. ncbi A clubhouse fidelity index: preliminary reliability and validity results
    A M Lucca
    Center for Mental Health Research Services, Department of Psychiatry, University of Massachusetts Medical School, Worcester, USA
    Ment Health Serv Res 2:89-94. 2000
    ..These findings suggest the clubhouse index holds promise as a fidelity tool for researchers and administrators...
  38. ncbi PML and the oncogenic nuclear domains in regulating transcriptional repression
    H Li
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Curr Opin Cell Biol 12:641-4. 2000
    ..Recently, a POD-associated protein was found to be transcriptional repressor, suggesting a new role for PODs in regulating transcriptional repression...
  39. ncbi Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers
    M Dershwitz
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, USA
    Anesthesiology 93:619-28. 2000
    ..A new pulmonary drug delivery system produces aerosols from disposable packets of medication. This study compared the pharmacokinetics and pharmacodynamics of morphine delivered by an AERx prototype with intravenous morphine...
  40. ncbi Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus
    W J Schwartz
    Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Neuroscience 98:535-47. 2000
    ..The differential regulation of fos family genes in the ventrolateral and dorsomedial suprachiasmatic nucleus suggests that their circadian function(s) and downstream target(s) are likely to be cell specific...
  41. ncbi The role of CD40-CD154 interaction in antiviral T cell-independent IgG responses
    E Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 164:5877-82. 2000
    ..Our studies demonstrate that, although about half of the TI IgG responses to PyV are independent of CD40-CD40L interactions, these interactions occur in T cell-deficient mice and enhance antiviral TI Ab responses...
  42. ncbi Excitatory versus inhibitory modulation by ATP of neurohypophysial terminal activity in the rat
    J R Lemos
    Department of Physiology and Neuroscience Program, University of Massachusetts Medical School, Worcester 01655, USA
    Exp Physiol 85:67S-74S. 2000
    ..These multiple, conflicting effects of ATP and its metabolite adenosine could explain the patterns of AVP release observed during physiological stimulation in vivo...
  43. pmc Smoking cessation counseling with pregnant and postpartum women: a survey of community health center providers
    J G Zapka
    Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Public Health 90:78-84. 2000
    ..This study assessed providers' performance of smoking cessation counseling steps with low-income pregnant and postpartum women receiving care at community health centers...
  44. ncbi Movement and localization of RNA in the cell nucleus
    T Pederson
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    FASEB J 13:S238-42. 1999
    ..The methods we have developed and these initial results represent the first major step toward a comprehensive understanding of RNA traffic in the cell nucleus...
  45. ncbi The abnormal gene in X-linked lymphoproliferative syndrome
    J L Sullivan
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech II, Suite 318, Worcester, MA 01605, USA
    Curr Opin Immunol 11:431-4. 1999
    ....
  46. ncbi Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation
    James G Dobson
    Department of Physiology, University Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01655 0127, USA
    Am J Physiol Heart Circ Physiol 285:H1471-8. 2003
    ..These results indicate that the cardioprotective effect of adenosine afforded by its antiadrenergic action is facilitated by cardiac membrane phosphorylation...
  47. ncbi Nucleocytoplasmic shuttling of signal transducers
    Lan Xu
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 5:209-19. 2004
  48. ncbi Pancreatic head excavation: a variation on the theme of duodenum-preserving pancreatic head resection
    Dana K Andersen
    Department of Surgery, University of Massachusetts Medical School and UMass Memorial Health Care Inc, Worcester, MA 01655, USA
    Arch Surg 139:375-9. 2004
    ....
  49. ncbi Illuminating the silence: understanding the structure and function of small RNAs
    Tariq M Rana
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Rev Mol Cell Biol 8:23-36. 2007
    ..In particular, it has highlighted the assembly and function of the RNA-induced silencing complex (RISC), and has provided guidelines to efficiently silence genes for biological research and therapeutic applications of RNAi...
  50. pmc DNA replication timing: random thoughts about origin firing
    Nicholas Rhind
    Biochemistry and Molecular Pharmacology Department, University of Massachusetts Medical School, 364 Plantation Street, LRB904, Worcester, MA 01605, USA
    Nat Cell Biol 8:1313-6. 2006
    ..This model assumes varying origin efficiency instead of a strict origin-timing programme. Here, we discuss the evidence for both models...
  51. pmc Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice
    Michael A Brehm
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Blood 109:819-26. 2007
    ..We conclude that rapid production of TNF-alpha can be used to quantify naive alloreactive T cells, that it is abrogated after the induction of tolerance, and that it is a potential tool to predict allograft rejection...
  52. pmc Primary care provider concerns about management of chronic pain in community clinic populations
    Carole C Upshur
    Department of Family Medicine and Community Health, University of Massachusetts Medical School, Worcester, MA, USA
    J Gen Intern Med 21:652-5. 2006
    ..Chronic pain is a common patient complaint in primary care, yet providers and patients are often dissatisfied with treatment processes and outcomes...
  53. ncbi Integrating clinical experiences into the concept mapping process
    Catherine M Hill
    Clinical Faculty, University of Massachusetts Graduate School of Nursing, Worcester, MA 01605, USA
    Nurse Educ 31:36-9. 2006
    ..The author discusses ways a concept map can change throughout the clinical day as the student gains knowledge and confidence through patient interaction...
  54. ncbi Renal cell carcinoma presenting as a perineal mass: case report and review of the literature
    Gary Wayne Mendese
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Urology 67:847.e1-2. 2006
    ..This case illustrates the variability in RCC presentation. Also, because vaginal clear cell carcinoma is rare, all such lesions should be considered potentially renal in origin...
  55. ncbi Reproducibility of assays for steroid hormones, prolactin and insulin-like growth factor-1 in umbilical cord blood
    Inkyung Baik
    Cancer Research Center and Department of Cancer Biology, University of Masschusetts Medical School, Worcester, MA 01605, USA
    Paediatr Perinat Epidemiol 20:79-86. 2006
    ....
  56. ncbi Multitasking with neurotensin in the central nervous system
    P R Dobner
    Department of Molecular Genetics and Microbiology, Program in Neuroscience, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts, 01655, USA
    Cell Mol Life Sci 62:1946-63. 2005
    ..There is now substantial evidence indicating that NT is required for certain antipsychotic drug actions and that the peptide plays a key role in stress-induced analgesia...
  57. ncbi Against the grain? A reasoned argument for not closing a state hospital
    Jeffrey L Geller
    Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Psychiatr Q 76:177-94. 2005
    ..The Center for Mental Health Services Research of the University of Massachusetts Medical School conducted its own study concluding that maintaining a longer-term inpatient capacity in the ..
  58. ncbi Gastric cancer originating from bone marrow-derived cells
    JeanMarie Houghton
    Department of Medicine and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1568-71. 2004
    ..These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression...
  59. ncbi Stress, social support, and cortisol: inverse associations?
    Milagros C Rosal
    University of Massachusetts Medical School, Division of Preventive and Behavioral Medicine, Department of Medicine, Worcester, 01655, USA
    Behav Med 30:11-21. 2004
    ..Both findings deserve further investigation...
  60. ncbi STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
    ....
  61. ncbi The spatial organization of the genome in mammalian cells
    Thoru Pederson
    Program in Cell Dynamics and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Genet Dev 14:203-9. 2004
    ..The arrangement of chromosomes in the nucleus also has been investigated by the analysis of chromosomal translocations, with some surprising recent findings...
  62. ncbi Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity
    S Green
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA Sharone
    J Infect Dis 179:755-62. 1999
    ..05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted...

Research Grants62

  1. RNA Transport Within the Nucleus
    Thoru Pederson; Fiscal Year: 2005
    ..Another aspect of the project will address the intranuclear traffic of these RNAs in relation to proteins known to be involved in nuclear import or RNA export, i.e. the Ran-GTPase and TAP. ..
  2. RNA PROCESSING AND RIBONUCLEOPROTEIN
    Thoru Pederson; Fiscal Year: 2001
    ..The same studies should provide information on sequences required for nuclear export. These two inter-related projects test the hypothesis that the nucleolus is a more pluri-functional organelle than previously thought. ..
  3. Toll like receptor - Mediated pathways in liver injury
    Gyongyi Szabo; Fiscal Year: 2010
    ..Thus, our study may help to design new therapeutic approaches to prevent liver diseases with granulomas and to attenuate sensitization to liver injury caused by infectious pathogens. ..
  4. Cell Cycle Regulation of Histone Gene Expression
    Gary S Stein; Fiscal Year: 2010
    ..Our studies will provide insight into mechanisms that control competency for S phase progression and may yield novel targets for selective treatment of diseases, particularly cancer, in which growth control is compromised. ..
  5. CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATION
    GARY S contact STEIN; Fiscal Year: 2010
    ..Identification of bone- related miRs and their targets for control of osteoblast growth and differentiation will lead to novel approaches for treating bone diseases. ..
  6. TLR4 Signaling in alcoholic liver disease
    Gyongyi Szabo; Fiscal Year: 2010
    ..Our results suggest that the absence of TLR4 but not of the MyD88 adaptor protects mice from alcoholic liver disease. ..
  7. CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATION
    Gary Stein; Fiscal Year: 2009
    ....
  8. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2007
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  9. Hepatitis C Virus, Alcohol and Host Defense
    Gyongyi Szabo; Fiscal Year: 2007
    ..Results from these studies should reveal molecular and cellular mechanisms by which alcohol interacts with HCV infection to accelerate disease persistence and progression. ..
  10. FASEB Summer Conference on Nuclear Structure and Cancer
    Gary Stein; Fiscal Year: 2007
    ..It is realistic to anticipate insight into components of nuclear organization that can be selectively targeted for innovative cancer diagnosis and therapy. ..
  11. Ethanols role in mediation of monocyte suppression
    Gyongyi Szabo; Fiscal Year: 2007
    ..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
  12. Identification of Histone Gene Regulatory Sequences
    Gary Stein; Fiscal Year: 2006
    ..These studies will elucidate parameters of growth control that mediate competency for proliferation and cell cycle progression. ..
  13. CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATION
    Gary Stein; Fiscal Year: 1993
  14. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 1999
    ..Results from these experiments will improve the understanding of the immunomodulatory effects of acute, moderate alcohol use in humans. ..
  15. ALCOHOL AND MONOCYTE SIGNALING
    Gyongyi Szabo; Fiscal Year: 2001
    ..These studies should delineate the effect of in vivo acute alcohol on NF-kB signaling in monocytes relevant to inflammation, cirrhosis, atherosclerosis, and HIV infection. ..
  16. ETHANOLS ROLE MEDIATION OF MONOCYTE IMMUNOSUPPRESSION
    Gyongyi Szabo; Fiscal Year: 2003
    ..These experiments will define monocyte alterations leading to the combined immunosuppressive effects of in vivo ethanol uptake and trauma. ..
  17. IDENTIFICATION OF HUMAN HISTONE GENE
    Gary Stein; Fiscal Year: 1993
    ....