University of Cincinnati

Summary

Organization: University of Cincinnati
Country: USA

Top Publications

  1. doi Safety and efficacy of esreboxetine in patients with fibromyalgia: An 8-week, multicenter, randomized, double-blind, placebo-controlled study
    Lesley M Arnold
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
    Clin Ther 32:1618-32. 2010
  2. ncbi Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells
    Quan Wang
    Department of Research, Shriners Hospital for Children, Cincinnati OH 45229 3095, USA
    Shock 29:531-7. 2008
  3. pmc Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, ML 0506, Reading, OH 45237, United States
    Physiol Behav 92:924-30. 2007
  4. ncbi Treatment costs related to bipolar disorder and comorbid conditions among Medicaid patients with bipolar disorder
    Jeff J Guo
    Division of Pharmacy Practice and Administrative Sciences, College of Pharmacy and the Institute for the Study of Health, University of Cincinnati Academic Health Center, 3225 Eden Avenue, Cincinnati, OH 45267 0004, USA
    Psychiatr Serv 58:1073-8. 2007
  5. ncbi Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    J Psychiatr Res 42:458-68. 2008
  6. ncbi Airway trauma
    Lindsey A Nelson
    Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0764, USA
    Int Anesthesiol Clin 45:99-118. 2007
  7. ncbi Gastric bypass in chronic renal failure and renal transplant
    J Wesley Alexander
    Center for Surgical Weight Loss, University of Cincinnati, Cincinnati, OH 45219, USA
    Nutr Clin Pract 22:16-21. 2007
  8. ncbi Flexible biosensors on spirally rolled micro tube for cardiovascular in vivo monitoring
    Chunyan Li
    Microsystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering and Computer Science, University of Cincinnati, 814 Rhodes Hall, Cincinnati, OH 45221 0030, USA
    Biosens Bioelectron 22:1988-93. 2007
  9. ncbi Estrogen response system in the reproductive tract of the male turtle: an immunocytochemical study
    Daniel H Gist
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Gen Comp Endocrinol 151:27-33. 2007
  10. ncbi Humidification of respired gases during mechanical ventilation: mechanical considerations
    Richard D Branson
    Division of Trauma Critical Care, Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Respir Care Clin N Am 12:253-61. 2006

Research Grants

  1. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
  2. Human HNSCC: CYP1B1/1A1/1A2 and AHR Gene Polymorphisms
    Daniel Nebert; Fiscal Year: 2007
  3. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  4. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
  5. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
  6. MOLECULAR GENETICS OF CD TOXICITY
    Daniel Nebert; Fiscal Year: 2004
  7. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2007
  8. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2010
  9. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
  10. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009

Detail Information

Publications62

  1. doi Safety and efficacy of esreboxetine in patients with fibromyalgia: An 8-week, multicenter, randomized, double-blind, placebo-controlled study
    Lesley M Arnold
    University of Cincinnati College of Medicine, Cincinnati, Ohio 45219, USA
    Clin Ther 32:1618-32. 2010
    ..Esreboxetine is an investigational, highly selective norepinephrine reuptake inhibitor that has been reported to have antinociceptive effects in preclinical pain models...
  2. ncbi Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells
    Quan Wang
    Department of Research, Shriners Hospital for Children, Cincinnati OH 45229 3095, USA
    Shock 29:531-7. 2008
    ..SB203580 also prevented the CytoMix-induced permeability increase and reduced NO, IL-6, and IL-8 levels. The results suggest that p38 MAPK plays an important role in regulating epithelial barrier function during inflammation...
  3. pmc Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats
    Jon F Davis
    University of Cincinnati, Department of Psychiatry, ML 0506, Reading, OH 45237, United States
    Physiol Behav 92:924-30. 2007
    ..These results suggest that binge-intake behavior occurs on a nutritionally complete high-fat diet and that this regimen is capable of altering both body composition and endocrine profile...
  4. ncbi Treatment costs related to bipolar disorder and comorbid conditions among Medicaid patients with bipolar disorder
    Jeff J Guo
    Division of Pharmacy Practice and Administrative Sciences, College of Pharmacy and the Institute for the Study of Health, University of Cincinnati Academic Health Center, 3225 Eden Avenue, Cincinnati, OH 45267 0004, USA
    Psychiatr Serv 58:1073-8. 2007
    ..This study assessed costs among patients with bipolar disorder for treatment related to bipolar disorder and to comorbid conditions. Risk factors associated with costs were also assessed...
  5. ncbi Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    J Psychiatr Res 42:458-68. 2008
    ....
  6. ncbi Airway trauma
    Lindsey A Nelson
    Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0764, USA
    Int Anesthesiol Clin 45:99-118. 2007
  7. ncbi Gastric bypass in chronic renal failure and renal transplant
    J Wesley Alexander
    Center for Surgical Weight Loss, University of Cincinnati, Cincinnati, OH 45219, USA
    Nutr Clin Pract 22:16-21. 2007
    ..The use of gastric bypass surgery to achieve weight loss in morbidly obese patients with chronic renal failure (CRF) and postrenal transplant patients has not been studied adequately...
  8. ncbi Flexible biosensors on spirally rolled micro tube for cardiovascular in vivo monitoring
    Chunyan Li
    Microsystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering and Computer Science, University of Cincinnati, 814 Rhodes Hall, Cincinnati, OH 45221 0030, USA
    Biosens Bioelectron 22:1988-93. 2007
    ..The spirally rolled glucose sensors showed good performance in the typical glucose concentration range in human blood from 60 mg/dL to 120 mg/dL with different rolled diameters at different working temperature...
  9. ncbi Estrogen response system in the reproductive tract of the male turtle: an immunocytochemical study
    Daniel H Gist
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Gen Comp Endocrinol 151:27-33. 2007
    ..ERbeta immunoreactivity was found in both the spermatogonia and Sertoli cells in the testis, and in the epithelial cells of excurrent canals...
  10. ncbi Humidification of respired gases during mechanical ventilation: mechanical considerations
    Richard D Branson
    Division of Trauma Critical Care, Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Respir Care Clin N Am 12:253-61. 2006
    ..The author's group has used the data reviewed here to modify their previous algorithm for choosing a humidification device (see Fig. 2). Humidification requirements for noninvasive ventilation need further study...
  11. pmc Changing marital status and desistance from intimate assault
    John Wooldredge
    Division of Criminal Justice, University of Cincinnati, OH 45221 0389, USA
    Public Health Rep 121:428-34. 2006
    ..This study examined whether the odds of subsequent domestic violence by married men are reduced when women file for divorce, and whether these odds are further influenced by the timing of divorce proceedings...
  12. ncbi Geriatric medicine and geriatric psychiatry clinical services affiliated with U.S. academic medical centers
    Gregg A Warshaw
    Office of Geriatric Medicine, Department of Family Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Am Geriatr Soc 54:690-5. 2006
    ..Using data from the survey, the first directory of GM and GP clinical services at academic medical centers was created (http://www.ADGAPSTUDY.uc.edu)...
  13. ncbi Assessment of the pregnant trauma patient
    Betty J Tsuei
    Division of Trauma and Critical Care, University of Cincinnati, OH 45267, USA
    Injury 37:367-73. 2006
    ..This paper will review the physiology of pregnancy, discuss recent changes in assessment and resuscitation, and identify special injuries and issues specific to the pregnant trauma patient...
  14. ncbi Telemedicine systems and telecommunications
    Brett Harnett
    Center for Surgical Innovation, University of Cincinnati, Ohio 45267 0558, USA
    J Telemed Telecare 12:4-15. 2006
    ..Equipment and the telecommunications medium are a necessary, but not sufficient, pre-requisite for a successful telemedicine programme. The right people are also required and they must be properly trained...
  15. pmc A novel emergency department based prevention intervention program for people living with HIV: evaluation of early experiences
    Michael S Lyons
    Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Health Serv Res 7:164. 2007
    ..Emergency Departments (EDs) frequently care for PLWH, but do not typically endorse a prevention mission. We conducted a pilot exploratory evaluation of the first reported ED program to address the prevention needs of PLWH...
  16. pmc A simple, efficient tool for assessment of mice after unilateral cortex injury
    Shirley B Shelton
    Department of Neurosurgery, Division of Research, University of Cincinnati, 231 Albert Sabin Way, Medical Science Building, Cincinnati, OH 45267 0515, United States
    J Neurosci Methods 168:431-42. 2008
    ..SNAP provided a sensitive, reliable, time-efficient and cost-effective means of assessing neurological deficits in mice after unilateral brain injury...
  17. doi Effect of extracurricular geriatric medicine training: a model based on student reflections on healthcare delivery to elderly people
    Linda M Goldenhar
    Office of Medical Education, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Am Geriatr Soc 56:548-52. 2008
    ..of a qualitative analysis of student reflections from participating in such a program implemented at the University of Cincinnati College of Medicine...
  18. pmc International variations in the clinical, diagnostic, and treatment characteristics of emergency department patients with acute heart failure syndromes
    Sean P Collins
    Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA
    Eur J Heart Fail 12:1253-60. 2010
    ..We examine differences in the presentation and management of emergency department (ED) patients with dyspnoea from acute heart failure syndromes (AHFS) between the USA, Western Europe, and Eastern Europe...
  19. pmc Recent advances in combined modality therapy
    Michelle L Mierzwa
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Oncologist 15:372-81. 2010
    ..This review highlights the recent clinical data in support of newer generation cytotoxic chemotherapies and systemic targeted agents in combination with radiation therapy...
  20. pmc Predictors of post-treatment relapse to smoking in successful quitters: pooled data from two phase III varenicline trials
    Jaimee L Heffner
    Tri State Tobacco and Alcohol Research Center, University of Cincinnati Genome Research Institute, 2120 E Galbraith Rd, Bldg A, Cincinnati, OH 45237, USA
    Drug Alcohol Depend 109:120-5. 2010
    ..Identifying predictors of smoking relapse helps to elucidate the challenges of long-term smoking cessation and provides direction for improved treatment development...
  21. ncbi Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillation
    Mark H Eckman
    University of Cincinnati Medical Center, Cincinnati, OH 45267 0535, USA
    Ann Intern Med 150:73-83. 2009
    ..In 2007, the U.S. Food and Drug Administration changed the labeling for warfarin (Coumadin, Bristol-Myers Squibb, Princeton, New Jersey), suggesting that clinicians consider genetic testing before initiating therapy...
  22. pmc Health values in adolescents with or without inflammatory bowel disease
    Michael S Yi
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0535, USA
    J Pediatr 154:527-34. 2009
    ..To examine for differences in and predictors of health value/utility scores in adolescents with or without inflammatory bowel disease (IBD)...
  23. doi University students' perceived self-efficacy in identifying suicidal warning signs and helping suicidal friends find campus intervention resources
    Keith A King
    University of Cincinnati, Cincinnati, OH 45221 0068, USA
    Suicide Life Threat Behav 38:608-17. 2008
    ..Most (71%) were not aware of on-campus help resources. These findings underscore the importance of suicide prevention education throughout the high school and college years...
  24. pmc Hemodynamic diagnostics of epicardial coronary stenoses: in-vitro experimental and computational study
    Rupak K Banerjee
    Department of Mechanical, Industrial and Nuclear Engineering, 601B Rhodes Hall, University of Cincinnati, Clifton Avenue, Cincinnati, OH, USA
    Biomed Eng Online 7:24. 2008
    ..This experimental and numerical study focuses on the characterization of the diagnostic parameter, pressure drop coefficient, and also evaluates the pressure recovery downstream of stenoses...
  25. pmc From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions
    Daniel W Nebert
    Division of Human Genetics, Department of Pediatrics and Molecular Developmental Biology, Cincinnati, Ohio 45267 0056, USA
    Drug Metab Rev 40:187-224. 2008
    ..It remains unclear whether personalized medicine or individualized drug therapy will ever be achievable by means of DNA testing alone...
  26. doi Genetics in critical care
    Theresa A Beery
    College of Nursing, University of Cincinnati, Cincinnati, OH 45221 0038, USA
    Crit Care Nurs Clin North Am 20:ix-x. 2008
  27. doi Adsorbed fibrinogen regulates the behavior of human dendritic cells in a CD18-dependent manner
    Robert I Thacker
    Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0529, USA
    Exp Mol Pathol 84:122-30. 2008
    ..We propose a model whereby adsorbed fibrinogen plays a distinct causatory role in inflammation through its beta(2) integrin-mediated interaction with dendritic cells...
  28. doi Intensive care unit nurses' perceptions of safety after a highly specific safety intervention
    N C Elder
    Department of Family Medicine, University of Cincinnati, PO Box 670589, Cincinnati, OH 45267, USA
    Qual Saf Health Care 17:25-30. 2008
    ..It is unknown if successful changes in specific safety practices in the intensive care unit (ICU) generalize to broader concepts of patient safety by staff nurses...
  29. doi Drug insight: autoimmune effects of medications-what's new?
    Anne Barbara Mongey
    Division of Immunology at University of Cincinnati, Cincinnati, OH 45267 0563, USA
    Nat Clin Pract Rheumatol 4:136-44. 2008
    ..Arthralgias and inflammatory arthritis have also been reported in association with the use of aromatase inhibitors and other biologic agents such as interleukins and interferons...
  30. doi Lower-body parkinsonism: reconsidering the threshold for external lumbar drainage
    Alberto J Espay
    Department of Neurology, University of Cincinnati, 231 Albert Sabin Way, MSB 4503, Cincinnati, OH 45267 0525, USA
    Nat Clin Pract Neurol 4:50-5. 2008
    ..He had experienced multiple falls and two hospitalizations for sudden-onset freezing of gait...
  31. ncbi Maternal cholesterol in fetal development: transport of cholesterol from the maternal to the fetal circulation
    Laura A Woollett
    Department of Pathology, 2120 East Galbraith Road, Genome Research Institute, University of Cincinnati, Cincinnati, OH 45236 0507, USA
    Am J Clin Nutr 82:1155-61. 2005
    ..On the other hand, it could also accelerate the development of various age-related diseases, such as atherosclerosis...
  32. ncbi Mini-BEAM and autologous hematopoietic stem-cell transplant for treatment of post-transplant lymphoproliferative disorders
    Rami S Komrokji
    Department of Medicine, University of Cincinnati and Veterans Administration Medical Center, Cincinnati, Ohio 45267, USA
    Am J Hematol 79:211-5. 2005
    ..With over 30 months of follow-up, both patients remain in complete remission with excellent allograft function...
  33. ncbi Workload, error detection, and experienced stress in a simulated pharmacy verification task
    Sean Reilley
    University of Cincinnati, Department of Psychology, 429 Dyer Hall ML 376, Cincinnati, OH 45221 0376, USA
    Percept Mot Skills 95:27-46. 2002
    ....
  34. ncbi IL-4 promotes Stat6-dependent survival of autoreactive B cells in vivo without inducing autoantibody production
    Suzanne C Morris
    Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 169:1696-704. 2002
    ....
  35. ncbi Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines
    J Wiest
    Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267 0056, USA
    Genes Chromosomes Cancer 32:384-9. 2001
    ..These results suggest that although PLK3/PRK expression is downregulated in a majority of lung carcinoma samples, mutational inactivation of the coding sequence of the PLK3/PRK gene appears to be a rare event in lung cancer...
  36. ncbi Role of CD40 ligand signaling in defective type 1 cytokine response in human immunodeficiency virus infection
    C S Subauste
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    J Infect Dis 183:1722-31. 2001
    ..Together, impaired CD40L induction is likely to contribute to defective IL-12 and IFN-gamma production in HIV infection...
  37. ncbi Subjective organization and the visibility of illusory contours
    D V Gunn
    Department of Psychology, University of Cincinnati, Cincinnati, OH 45221 0376, USA
    Am J Psychol 113:553-68. 2000
    ....
  38. ncbi Home sweet home? A case study of household dust contamination in Hong Kong
    S T Tong
    Department of Geography, University of Cincinnati, OH 45221 0131, USA
    Sci Total Environ 256:115-23. 2000
    ..Another finding of interest is that the color of the wall paint used in the house may be another factor influencing the contamination levels...
  39. ncbi Glipizide-induced pigmented purpuric dermatosis
    B B Adams
    University of Cincinnati, College of Medicine, Department of Dermatology, Ohio 45267 0523, USA
    J Am Acad Dermatol 41:827-9. 1999
    ..Pigmented purpuric dermatosis can occasionally be caused by various medications. No reported cases of oral hypoglycemic agents causing pigmented purpuric dermatosis exist. We report a case of glipizide-induced pigmented dermatosis...
  40. ncbi Adult onset verrucous epidermal nevus
    B B Adams
    University of Cincinnati, College of Medicine, Department of Dermatology, Ohio 45267 0523, USA
    J Am Acad Dermatol 41:824-6. 1999
    ..Histologic examination revealed the characteristic findings of verrucous epidermal nevus. This is the oldest patient reported with an adult onset verrucous epidermal nevus...
  41. ncbi Transport of thiamine in human intestine: mechanism and regulation in intestinal epithelial cell model Caco-2
    H M Said
    Veterans Affairs Medical Center, Long Beach, California, 90822, USA
    Am J Physiol 277:C645-51. 1999
    ..This system is Na(+) independent and is different from the transport systems of organic cations. Furthermore, a CaM-mediated pathway appears to play a role in regulating thiamine uptake in these cells...
  42. ncbi Gastrin-releasing peptide suppresses independent but not intraoral intake
    P A Rushing
    Department of Psychiatry, Cornell University Medical College, New York Hospital Cornell Medical Center, White Plains 10605, USA
    Peptides 20:737-41. 1999
    ..From these results, we conclude that GRP affects appetitive-related aspects of the feeding process to reduce food intake...
  43. pmc Patterns of instability of expanded CAG repeats at the ERDA1 locus in general populations
    R Deka
    Department of Environmental Health, University of Cincinnati, 3223 Eden Avenue, Cincinnati, OH, USA
    Am J Hum Genet 65:192-8. 1999
    ..The implications of the existence of massively expanded alleles in the general populations are not yet understood...
  44. ncbi Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder
    D G Baker
    Psychiatry Service, Cincinnati VA Medical Center, OH, USA
    Am J Psychiatry 156:585-8. 1999
    ..They also sought to assess the relationship among PTSD symptoms, adrenocortical activity, and CSF CRH levels...
  45. ncbi Prolongation of intermeal interval by gastrin-releasing peptide depends upon time of delivery
    P A Rushing
    Department of Psychiatry, Cornell University Medical College, New York Hospital Cornell Medical Center, White Plains 10605, USA
    Peptides 19:1439-42. 1998
    ..These results are consistent with the hypothesis that endogenous GRP acts in conjunction with events occurring shortly after meal termination to extend the duration of the IMI...
  46. ncbi Discordance between HbA1c and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy
    Robert M Cohen
    Division of Endocrinology, Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0547, USA
    Diabetes Care 26:163-7. 2003
    ..We termed this the glycosylation gap (GG) and sought to determine its relationship to diabetic nephropathy...
  47. ncbi Role of the aryl hydrocarbon receptor in cell cycle regulation
    Alvaro Puga
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, 123 E Shields Street, Cincinnati, OH 45267 0056, USA
    Toxicology 181:171-7. 2002
    ..The activated receptor acts as an environmental sensor and cell cycle checkpoint that commits cells exposed to adverse environmental stimuli to arrest before the onset of DNA replication...
  48. pmc Progression of alachlor-induced olfactory mucosal tumours
    Mary Beth Genter
    Department of Environmental Health, University of Cincinnati, ML 670056, Cincinnati, OH 45267 0056, USA
    Int J Exp Pathol 83:303-8. 2002
    ..This study demonstrated that abbreviated alachlor exposure did not result in subsequent tumour formation within the 6-month observation period...
  49. ncbi Ventilator-associated pulmonary infection: the germ theory of disease remains viable
    Joseph S Solomkin
    Division of Trauma and Critical Care, Department of Surgery, University of Cincinnati College of Medicine, 231 Albert B Sabin Way, Cincinnati, OH 45267 0558, USA
    Microbes Infect 7:279-91. 2005
    ..The key issue with timing of therapy now centers around early termination of therapy if quantitative cultures are negative...
  50. ncbi Effects of zonisamide on the electroencephalogram of a patient with juvenile myoclonic epilepsy
    Jerzy P Szaflarski
    Department of Neurology, University of Cincinnati Medical Center, Cincinnati, OH 45267 0525, USA
    Epilepsy Behav 5:1024-6. 2004
    ..This case report suggests that zonisamide may be effective in the treatment of medication-resistant idiopathic generalized epilepsy and that it may lead to a significant improvement of the EEG...
  51. ncbi Effectiveness of multilevel (tongue and palate) radiofrequency tissue ablation for patients with obstructive sleep apnea syndrome
    David L Steward
    Department of Otolaryngology Head and Neck Surgery and The Neuroscience Institute, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, U S A
    Laryngoscope 114:2073-84. 2004
    ..The secondary objective is to compare multilevel TCRFTA to nasal continuous positive airway pressure (CPAP)...
  52. ncbi Postviral olfactory loss
    Allen M Seiden
    Department of Otolaryngology, University of Cincinnati, 231 Albert Sabin Way, M L 528, Cincinnati, OH 45267, USA
    Otolaryngol Clin North Am 37:1159-66. 2004
    ..Although no available therapy has proved effective, long-term follow-up data have found that approximately two thirds of these patients eventually experience a significant improvement in their olfactory function...
  53. ncbi A clinical score to predict acute renal failure after cardiac surgery
    Charuhas V Thakar
    Department of Nephrology and Hypertension, Cleveland Clinic Foundation, Cincinnati, OH, USA
    J Am Soc Nephrol 16:162-8. 2005
    ..82; 95% CI 0.80 to 0.85; P = 0.39). In conclusion, a score is valid and accurate in predicting ARF after open-heart surgery; along with increasing its clinical utility, the score can help in planning future clinical trials of ARF...
  54. ncbi Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure
    Alvaro Puga
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Cardiovasc Toxicol 4:385-404. 2004
    ..We conclude that vSMCS may be useful aorta surrogates to study early gene expression responses to dioxin exposure, provided that analyses focus on this subset of genes...
  55. ncbi Fundamentals and pitfalls of bone densitometry using dual-energy X-ray absorptiometry (DXA)
    Nelson B Watts
    University of Cincinnati Bone Health and Osteoporosis Center, 222 Piedmont Avenue, Suite 4300, Cincinnati, OH 45219, USA
    Osteoporos Int 15:847-54. 2004
    ..This paper reviews the fundamentals of positioning, scan analysis, and interpretation for central DXA and highlights some of the common pitfalls that may lead to erroneous results...
  56. ncbi Gastric bypass in morbidly obese patients with chronic renal failure and kidney transplant
    J Wesley Alexander
    UC Surgeons, Inc Center for Surgical Weight Loss, University of Cincinnati, Cincinnati, OH 45267 0558, USA
    Transplantation 78:469-74. 2004
    ..Morbid obesity is also associated with an increased risk of complications and death in transplant patients and is often a cause for denial for access to transplantation...
  57. pmc The relationship between genotype, developmental stability and mating performance: disentangling the epigenetic causes
    Michal Polak
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Proc Biol Sci 271:1815-21. 2004
    ..The results suggest that deficits in the developmental apparatus underlying one particular trait can compromise individual sexual performance, and weaken the hypothesis that FA is a cue of overall 'genetic quality'...
  58. ncbi Genetic effects of habitat fragmentation in Viola pubescens (Violaceae), a perennial herb with chasmogamous and cleistogamous flowers
    Theresa M Culley
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006 USA
    Mol Ecol 12:2919-30. 2003
    ..pubescens in small woodlots remain susceptible to potentially detrimental effects of fragmentation such as genetic drift and reduced levels of genetic variation...
  59. ncbi NF-kappaB as an integrator of diverse signaling pathways: the heart of myocardial signaling?
    W Keith Jones
    Department of Pharmacology, Cell Biophysics, University of Cincinnati, Cincinnati, OH 45267, USA
    Cardiovasc Toxicol 3:229-54. 2003
    ..These results support the concept that NF-kappaB may be an important therapeutic target for specific cardiovascular diseases...
  60. ncbi Technique to decrease lower extremity and pelvic ischemia during thoracoabdominal aortic aneurysm repair
    Joseph S Giglia
    Division of Vascular Surgery, University of Cincinnati, PO Box 670558, Cincinnati, OH 45267 0558, USA
    J Vasc Surg 38:401-2. 2003
  61. ncbi Occupational asthma caused by exposure to low-molecular-weight chemicals
    David I Bernstein
    Division of Immunology and Allergy, Department of Internal Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0563, USA
    Immunol Allergy Clin North Am 23:221-34, vi. 2003
    ..An early diagnosis followed by cessation of exposure can result in asthma remission and is likely to prevent progression to chronic disabling obstructive disease...
  62. ncbi Effects of continuous infusion of endothelin-1 in pregnant sheep
    S G Greenberg
    Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Ohio 45267 0526, USA
    Hypertension 30:1585-90. 1997
    ..This supports the hypothesis that endothelial cell damage and/or dysfunction that is associated with increased production of endothelin-1 could directly contribute to the progression of preeclampsia...

Research Grants62

  1. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  2. Human HNSCC: CYP1B1/1A1/1A2 and AHR Gene Polymorphisms
    Daniel Nebert; Fiscal Year: 2007
    ..Establishing important phenotype-genotype associations between HNSCC and these four genes would provide the first unequivocal data that humans are similar to laboratory animals regarding cancer and one or more of these genes. ..
  3. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  4. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2006
    ..rhsp 60 serves as a paradigm, and the data emerging from this proposal may be broadly applicable to other antigens against intracellular pathogens. ..
  5. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  6. MOLECULAR GENETICS OF CD TOXICITY
    Daniel Nebert; Fiscal Year: 2004
    ..These studies will enhance our understanding of heavy metal toxicity by identifying and characterizing, for the first time, a major gene responsible for susceptibility to cadmium-induced toxicity. ..
  7. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2007
    ....
  8. Chemokine-Cytokine Nexus in Fungal Immunity
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for appropriate signaling through a surface receptor for a particular chemokine in order that the host can survive. ..
  9. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  10. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  11. Molecular Genetics of Cadmium Toxicity
    Daniel Nebert; Fiscal Year: 2009
    ....
  12. Immunopathogenesis in Histoplasmosis
    GEORGE DEEPE; Fiscal Year: 2009
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  13. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  14. Immunopathogenesis in Histoplasmosis
    George S Deepe; Fiscal Year: 2010
    ..Our work will demonstrate how important it is for lymphocytes and macrophages to die in order that the host can survive. ..
  15. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 1993
    ..Thus, it may be possible to correlate the functional activity of T cells with their expression of specific T cell receptor family. Furthermore, HIS-62 and HIS-80 may serve as a paradigm for the interaction of Hc antigens with T cells...
  16. CYPIAI GENE AND ENVIRONMENTAL Toxicity
    Daniel Nebert; Fiscal Year: 2003
    ..Our original aim to generate the mt1A1 and mc1A1 mice and then study BaP vs dioxin toxicity in these lines remains unchanged. ..
  17. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..S. population. ..
  18. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2002
    ....
  19. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 1999
    ....
  20. GENOTOXICITY IN CYP1A2-DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 1993
    ..This is particularly important, since recent studies have demonstrated a trimodal distribution and >60-fold interindividual variation in the constitutive expression of CYP1A2 in human liver...