L Zhang

Summary

Affiliation: Uniformed Services University of the Health Sciences
Country: USA

Publications

  1. ncbi request reprint Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways
    Lei Zhang
    Behavioral Endocrinology Branch, National Institute of Mental Health, Building 36, Room 2C02, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 98:58-66. 2002
  2. doi request reprint Telomere length - a cellular aging marker for depression and Post-traumatic Stress Disorder
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, USA Electronic address
    Med Hypotheses 83:182-5. 2014
  3. ncbi request reprint Direct binding of estradiol enhances Slack (sequence like a calcium-activated potassium channel) channels' activity
    L Zhang
    Behavioral Endocrinology Branch, NIMH NIH, Building 10, Room 65340, MSC 1276, Bethesda, MD 20892 1276, USA
    Neuroscience 131:275-82. 2005
  4. ncbi request reprint Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt
    Lei Zhang
    Department of Psychiatry, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neurosci Lett 383:328-32. 2005
  5. ncbi request reprint Identification of gene markers based on well validated and subcategorized stressed animals for potential clinical applications in PTSD
    Lei Zhang
    Department of Psychiatry, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
    Med Hypotheses 66:309-14. 2006
  6. ncbi request reprint Stress-induced change of mitochondria membrane potential regulated by genomic and non-genomic GR signaling: a possible mechanism for hippocampus atrophy in PTSD
    Lei Zhang
    Department of Psychiatry, USUHS, Bethesda, MD 20814, USA
    Med Hypotheses 66:1205-8. 2006
  7. doi request reprint p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter
    L Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Neuroscience 153:1126-34. 2008
  8. doi request reprint The injury profile after the 2008 earthquakes in China
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, USUHS, Bethesda, MD 20814, United States
    Injury 40:84-6. 2009
  9. doi request reprint P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Psychiatr Res 45:435-41. 2011
  10. doi request reprint Glucocorticoid-induced p11 over-expression and chromatin remodeling: a novel molecular mechanism of traumatic stress?
    Lei Zhang
    Center for Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA
    Med Hypotheses 76:774-7. 2011

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways
    Lei Zhang
    Behavioral Endocrinology Branch, National Institute of Mental Health, Building 36, Room 2C02, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 98:58-66. 2002
    ..These findings suggest that during neurogenesis in the developing cortex, DHEA and DHEAS regulate the survival of neural precursors and progeny through the Akt signaling pathway...
  2. doi request reprint Telomere length - a cellular aging marker for depression and Post-traumatic Stress Disorder
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, USA Electronic address
    Med Hypotheses 83:182-5. 2014
    ..The nature of this relationship between stress and TL warrants further evaluation in psychiatry. ..
  3. ncbi request reprint Direct binding of estradiol enhances Slack (sequence like a calcium-activated potassium channel) channels' activity
    L Zhang
    Behavioral Endocrinology Branch, NIMH NIH, Building 10, Room 65340, MSC 1276, Bethesda, MD 20892 1276, USA
    Neuroscience 131:275-82. 2005
    ..Thus, E2 activates a potassium channel, Slack, through a non-traditional membrane binding site, adding to known non-genomic mechanisms by which E2 exerts pharmacological and toxicological effects in the CNS...
  4. ncbi request reprint Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt
    Lei Zhang
    Department of Psychiatry, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neurosci Lett 383:328-32. 2005
    ..Thus, as a survival or anti-apoptotic factor for neuronal cells, SPD may contribute to the therapeutic action of SPD in SZ treatment...
  5. ncbi request reprint Identification of gene markers based on well validated and subcategorized stressed animals for potential clinical applications in PTSD
    Lei Zhang
    Department of Psychiatry, USUHS, 4301 Jones Bridge Road, Bethesda, MD 20814, United States
    Med Hypotheses 66:309-14. 2006
    ..The validity and practicability of this hypothesis and the strategy for its testing have been supported by our preliminary laboratory data...
  6. ncbi request reprint Stress-induced change of mitochondria membrane potential regulated by genomic and non-genomic GR signaling: a possible mechanism for hippocampus atrophy in PTSD
    Lei Zhang
    Department of Psychiatry, USUHS, Bethesda, MD 20814, USA
    Med Hypotheses 66:1205-8. 2006
    ..Understanding the molecular mechanism for stress-induced cell death in the hippocampus may shed a new light on developing a mitochondrial membrane potential related therapeutic drug and/or diagnostic tool for PTSD...
  7. doi request reprint p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter
    L Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Neuroscience 153:1126-34. 2008
    ....
  8. doi request reprint The injury profile after the 2008 earthquakes in China
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, USUHS, Bethesda, MD 20814, United States
    Injury 40:84-6. 2009
    ..Most hospitals were destroyed and limited facilities were available for medical service in the earthquake regions. Over the first 5 days, three general hospitals and one children's hospital admitted 1770 injured individuals...
  9. doi request reprint P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Psychiatr Res 45:435-41. 2011
    ..These results suggest that PBMC p11 mRNA levels may be a potential adjunctive biomarker for the assessment of suicide risk in mental disorders and warrants a larger translational study to determine its clinical utility...
  10. doi request reprint Glucocorticoid-induced p11 over-expression and chromatin remodeling: a novel molecular mechanism of traumatic stress?
    Lei Zhang
    Center for Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA
    Med Hypotheses 76:774-7. 2011
    ..e., chromatin remodeling...
  11. doi request reprint P11 expression and PET in bipolar disorders
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Psychiatr Res 45:1426-31. 2011
    ..Currently, few biomarkers differentiate BD-I from BD-II. However, it is suggested that peripheral blood mononuclear cell (PBMC) mRNA levels of p11 and positron emission tomography (PET) might be potential biomarkers for BD...
  12. doi request reprint Startle response related genes
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services, University of the Health Sciences, Bethesda, MD 20814, United States
    Med Hypotheses 77:685-91. 2011
    ..This review of research strategy may provide the information for identifying a biomarker for startle response, with the objective of translating research into clinical utility: diagnosis and treatment of stress-induced mental disorders...
  13. doi request reprint P11: a potential biomarker for posttraumatic stress disorder
    Lei Zhang
    Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Methods Mol Biol 829:453-68. 2012
    ..Using these procedures will not only enhance the study of the molecular mechanisms of PTSD but also help the translation of basic science to a clinical setting...
  14. ncbi request reprint Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice
    J Gomeza
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Life Sci 68:2457-66. 2001
    ..These findings emphasize the usefulness of gene targeting approaches to shed light on the physiological and pathophysiological roles of the individual muscarinic receptor subtypes...
  15. ncbi request reprint Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway
    L Zhang
    Behavioral Endocrinology Branch, NIMH, NIH, Building 10, Room 3N238, Bethesda, MD 20892, USA
    Neurosci Lett 312:125-8. 2001
    ..Our data suggest that the neuroprotective effects of the antioxidant LA are partly mediated through activation of the PKB/Akt signaling pathway...
  16. ncbi request reprint Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt
    L Zhang
    Behavioral Endocrinology Branch NIMH, Building 10, Room 3N238, NIH, Bethesda, MD 20892, USA
    Neuroreport 12:1919-23. 2001
    ..These results indicate that the neuroprotective effects of E2 may be mediated at least in part via estrogen receptor-mediated protein kinase B activation...
  17. ncbi request reprint Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Am J Psychiatry 155:207-13. 1998
    ..The present investigation tested the hypothesis that brain serotonin transporter function is altered in chronic users of ethanol and cocaine, which might be related to a common serotonin transporter promoter polymorphism...
  18. ncbi request reprint Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors
    W C You
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7244, USA
    J Natl Cancer Inst 92:1607-12. 2000
    ..To identify such determinants, we launched a follow-up study in 1989-1990 among 3433 adults in Linqu County, China, a region with very high rates of gastric cancer...
  19. ncbi request reprint Activation of phosphatidylinositol-3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells
    B S Li
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 21:1569-79. 2001
    ..These findings indicate that the activation of both PI-3 kinase and MEK signaling pathways via muscarinic receptors is involved in stimulating DNA synthesis in the neural progenitor cells during early neurogenesis...
  20. ncbi request reprint Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study
    K Y Little
    Department of Psychiatry, University of Michigan, and Ann Arbor Veterans Affairs Medical Center, 48105, USA
    Arch Gen Psychiatry 55:793-9. 1998
    ..The present experiment tested the hypothesis in cocaine-using humans that synthesis of midbrain DAT messenger RNA increases parallel with increased striatal DAT binding sites...
  21. ncbi request reprint The expression of GABA(A) receptor alpha2 subunit is upregulated by testosterone in rat cerebral cortex
    L Zhang
    Behavioral Endocrinology Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Neurosci Lett 265:25-8. 1999
    ..As the effects of T are developmental-stage-specific, they may have an organizational impact on brain development...
  22. pmc Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice
    J Gomeza
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:10483-8. 1999
    ..Our findings offer new perspectives for the treatment of Parkinson's disease and other movement disorders that are characterized by an imbalance between muscarinic cholinergic and dopaminergic neurotransmission...
  23. ncbi request reprint Evolution of precancerous lesions in a rural Chinese population at high risk of gastric cancer
    W C You
    National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 83:615-9. 1999
    ..Int. J. Cancer, 83:615-619, 1999. Published 1999 Wiley-Liss, Inc...
  24. ncbi request reprint Genotoxic markers among butadiene polymer workers in China
    R B Hayes
    Occupational Studies Branch, National Cancer Institute, Bethesda, MD, USA
    Carcinogenesis 21:55-62. 2000
    ..Overall, the study demonstrated exposure to butadiene in these workers, by a variety of short-term and long-term measures, but did not show specific genotoxic effects, at the chromosomal or gene levels, related to that exposure...
  25. ncbi request reprint An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity
    W C You
    National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20892, USA
    Eur J Cancer Prev 10:257-63. 2001
    ..No significant differences in side-effects were observed between the placebo treatment group and the vitamins/mineral and garlic preparation treatment groups during the 39-month trial period...
  26. ncbi request reprint 5-HT1A receptor mRNA expressions differ in the embryonic spinal cord of male and female rats
    L Zhang
    Behavioral Endocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neurosci Lett 237:41-4. 1997
    ..The results suggest that this gonadal steroid is responsible for the sexual dimorphism in 5-HT1A mRNA expression occurring during the critical period...
  27. ncbi request reprint Helicobacter pylori infection in rural China: exposure to domestic animals during childhood and adulthood
    L M Brown
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7244, USA
    Scand J Infect Dis 33:686-91. 2001
    ..These findings suggest that zoonotic transmission, including that from domestic cats, is an unlikely route of H. pylori infection in this rural Chinese population...
  28. ncbi request reprint Striatal dopaminergic abnormalities in human cocaine users
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor VA Medical Center 48105, USA
    Am J Psychiatry 156:238-45. 1999
    ..Previous inconsistencies in results were perhaps related to selective radioligand affinity changes or a coexisting loss of dopamine neurons...
  29. pmc An epidemiologic study of early biologic effects of benzene in Chinese workers
    N Rothman
    Division of Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Environ Health Perspect 104:1365-70. 1996
    ....
  30. pmc Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity
    H D Hosgood
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Occup Environ Med 66:848-53. 2009
    ..Benzene is an established human haematotoxin, with substantial interindividual variation in benzene-induced toxicity...
  31. ncbi request reprint The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers
    Rulun Zhou
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland 20852, USA
    J Neurosci 25:4493-502. 2005
    ....
  32. pmc Regulation of NMDA receptors by cyclin-dependent kinase-5
    B S Li
    Laboratory of Neurochemistry, Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:12742-7. 2001
    ..These results suggest that Cdk5 plays a key role in synaptic transmission and plasticity through its up-regulation of NMDARs...
  33. ncbi request reprint Reduction of dopamine-related transcription factors Nurr1 and NGFI-B in the prefrontal cortex in schizophrenia and bipolar disorders
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Schizophr Res 84:36-56. 2006
    ..Further study may elucidate if and how these deficiencies could be associated with abnormal dopaminergic functions seen in both illnesses...
  34. ncbi request reprint Models of PTSD and traumatic stress: the importance of research "from bedside to bench to bedside"
    Robert J Ursano
    Department of Psychiatry and Center for the Study of Traumatic Stress, Uniformed Services University, Bethesda, MD, USA
    Prog Brain Res 167:203-15. 2008
    ..The 5-HT2A receptor and p11 protein and associated regulators are avenues of new investigation that warrant study and consideration in models of PTSD...
  35. doi request reprint PTSD and traumatic stress from gene to community and bench to bedside
    Robert J Ursano
    Department of Psychiatry and the Center for the Study of Traumatic Stress, Uniformed Services University, Bethesda, MD 20814, USA
    Brain Res 1293:2-12. 2009
    ..Effective treatments indicate areas for bench research on the mechanisms of the disorder...
  36. doi request reprint Posttraumatic stress disorder and traumatic stress: from bench to bedside, from war to disaster
    Robert J Ursano
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University School of Medicine, Bethesda, Maryland 20814, USA
    Ann N Y Acad Sci 1208:72-81. 2010
    ..Substantial work to encourage bench to bedside to community knowledge and communication is a core component of addressing this world health need...
  37. ncbi request reprint Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice
    L D Pozzo-Miller
    Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 19:4972-83. 1999
    ..Taken together, these results suggest a novel role for BDNF in the mobilization and/or docking of synaptic vesicles to presynaptic active zones...
  38. pmc Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD
    L Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Transl Psychiatry 5:e580. 2015
    ..These findings indicate that blood can be used as a specimen in the search for PTSD biomarkers in fatty acid metabolism and PPAR pathways, and, in addition, that CPT1B may contribute to the pathology of PTSD...
  39. ncbi request reprint Lipoprotein metabolism differs between Marek's disease susceptible and resistant chickens
    P Yuan
    Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA
    Poult Sci 91:2598-605. 2012
    ..Taken together, our data suggested that lipoprotein-cholesterol and adiponectin metabolism are different between MD susceptible and resistant chickens...
  40. pmc Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice
    J Gomeza
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:1692-7. 1999
    ..These results offer a rational basis for the development of novel muscarinic drugs...
  41. ncbi request reprint Spatial learning induced changes in expression of the ryanodine type II receptor in the rat hippocampus
    W Zhao
    Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 14:290-300. 2000
    ..Zhao, W., Meiri, N., Xu, H., Cavallaro, S., Quattrone, A., Zhang, L., Alkon, D. A. Spatial learning induced changes in expression of the ryanodine type II receptor in the rat hippocampus...
  42. ncbi request reprint Markers for carcinogenicity among butadiene-polymer workers in China
    R B Hayes
    Occupational Epidemology Branch, National Cancer Institute, National Institutes of Health, EPS 8114, Bethesda, MD, USA
    Chem Biol Interact 135:455-64. 2001
    ..Overall, the study demonstrated exposure to butadiene in these workers, by a variety of short-term and long-term measures, but did not show specific genotoxic effects, at the chromosomal or gene levels, related to that exposure...
  43. ncbi request reprint Helicobacter pylori prevalence and CagA status among children in two counties of China with high and low risks of gastric cancer
    W C You
    National Cancer Institute, Bethesda, MD 20892-7244, USA
    Ann Epidemiol 11:543-6. 2001
    ..CONCLUSIONS: The prevalence of H. pylori was nearly three times higher among children in Linqu than in Cangshan, which may contribute to the large differential in gastric cancer rates for two neighboring populations in Shandong Province...
  44. pmc Interaction of fibrin with VE-cadherin and anti-inflammatory effect of fibrin-derived fragments
    S Yakovlev
    Center for Vascular and Inflammatory Diseases and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Thromb Haemost 9:1847-55. 2011
    ..However, our previous study revealed that only a dimeric (β15-66)(2) fragment, corresponding to the full-length βN-domain and mimicking its dimeric arrangement in fibrin, bound to VE-cadherin...
  45. ncbi request reprint Decreased prefrontal CaMKII alpha mRNA in bipolar illness
    Guoqiang Xing
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Neuroreport 13:501-5. 2002
    ....
  46. ncbi request reprint Sex-related differences in neuronal cell survival and signaling in rats
    Lei Zhang
    Behavioral Endocrinology Branch, National Institute of Mental Health, NIH, Building 10, Room 3N238, 10 Center Dr MSC 1276, Bethesda, MD 20892 1276, USA
    Neurosci Lett 337:65-8. 2003
    ..Further, the appearance of sex-related differences at cellular and signaling levels in cortical neuronal cultures demonstrates that the effects of gender are not limited to parts of the brain mediating reproduction...
  47. ncbi request reprint Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    Bing Sheng Li
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4130, USA
    J Biol Chem 278:35702-9. 2003
    ..These findings suggest that Cdk5 may exert a key role in promoting neuronal survival by regulating Akt activity through the neuregulin/PI 3-kinase signaling pathway...
  48. ncbi request reprint The role of the extracellular signal-regulated kinase signaling pathway in mood modulation
    Haim Einat
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4405, USA
    J Neurosci 23:7311-6. 2003
    ..These data suggest that the ERK pathway may mediate the antimanic effects of mood stabilizers...
  49. ncbi request reprint Possible role of potassium channel, big K in etiology of schizophrenia
    Lei Zhang
    Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, United States
    Med Hypotheses 67:41-3. 2006
    ..Therefore, we hypothesize that BK channel may play a role in SZ and those agents, which can target either BK channel functions or its expression may contribute to the therapeutic actions of SZ treatment...
  50. doi request reprint Stress impairs 5-HT2A receptor-mediated serotonergic facilitation of GABA release in juvenile rat basolateral amygdala
    xiaolong Jiang
    Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Neuropsychopharmacology 34:410-23. 2009
    ....
  51. pmc Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis
    B E Hall
    Functional Genomics Section, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    J Dent Res 95:188-95. 2016
    ..With the DMP1/TNF-α(glo) mice, we have shown that TNF-α expression alone can produce inflammation similar to pulpitis and osteitis and that this mouse model can be used to study dental inflammatory pain. ..
  52. pmc Activated protein C accelerates venous thrombus resolution through heme oxygenase-1 induction
    J Gabre
    Center for Vascular and Inflammatory Diseases, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    J Thromb Haemost 12:93-102. 2014
    ..Thrombus resolution is a complex process that involves thrombosis, leukocyte-mediated thrombolysis, and the final resolution of inflammation. Activated protein C (APC) is an anticoagulant that also possesses immunoregulatory activities...
  53. ncbi request reprint Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizures
    G Xing
    Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 47:251-61. 1997
    ..kindled seizures. In addition, as r-nurr1 is prominently expressed in the specific brain sites associated with memory acquisition and consolidation, it may play a role in memory processing...
  54. ncbi request reprint Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS
    M MacKiewicz
    Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA
    Brain Res Mol Brain Res 80:252-5. 2000
    ..We postulate that adenosine deaminase plays an important role in the mechanism that controls regional concentration of adenosine in the brain and thus, it is a part of the sleep-wake regulatory mechanism...
  55. ncbi request reprint A dominant negative mutant beta 2-microglobulin blocks the extracellular folding of a major histocompatibility complex class I heavy chain
    Dawn M Hill
    Division of Monoclonal Antibodies, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Biol Chem 278:5630-8. 2003
    ..Our data support an initial interaction of beta 2m with the MHC1 alpha 3 domain in MHC1 folding. In addition, the dominant negative mutant beta 2m can block T-cell functional responses to antigenic peptide and MHC1...
  56. ncbi request reprint Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis
    Yanlei Hao
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 4405, USA
    J Neurosci 24:6590-9. 2004
    ..This cascade of events provides a potential mechanism whereby mood stabilizers alleviate cerebral morphometric deficits associated with manic-depressive illness...
  57. doi request reprint beta1- and beta2-adrenoceptor induced synaptic facilitation in rat basolateral amygdala
    Preetha Anna Abraham
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Brain Res 1209:65-73. 2008
    ..1+/-4.1 % of control amplitude in the BLA. These data suggest that beta-adrenoceptor mediated synaptic facilitation in the amygdala is mediated by both beta1 and beta2-adrenoceptor activation...
  58. pmc Valproate activates the Notch3/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life?
    Peixiong Yuan
    Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Bipolar Disord 11:256-69. 2009
    ....
  59. doi request reprint A strategy for the development of biomarker tests for PTSD
    Lei Zhang
    Center for the Study of Traumatic Stress, Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Med Hypotheses 73:404-9. 2009
    ..This strategy will enhance not only the study of the molecular mechanisms of PTSD, but also the translation of basic science to clinical implications...
  60. pmc Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3
    Bing Sheng Li
    Laboratory of Neurochemistry, NINDS, NIH, Bethesda, MD 20892 4130, USA
    EMBO J 21:324-33. 2002
    ..Taken together, these findings show that cdk5 may exert its role as a key element by negatively regulating the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway during neuronal apoptosis...
  61. ncbi request reprint Sex-related differences in MAPKs activation in rat astrocytes: effects of estrogen on cell death
    Lei Zhang
    Behavioral Endocrinology Branch, National Institute of Mental Health, NIH Bldg 10, Room 3N238, 10 Center Drive MSC 1276, Bethesda, MD 20892 1276, USA
    Brain Res Mol Brain Res 103:1-11. 2002
    ....
  62. ncbi request reprint Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium
    Thomas Pusl
    Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Biol Chem 277:27517-27. 2002
    ..Thus, subcellular targeting of parvalbumin reveals a distinct role for nuclear Ca(2+) signals in mitogen-activated protein kinase-mediated gene transcription...
  63. pmc Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts
    Maria I Kontaridis
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    Mol Cell Biol 22:3875-91. 2002
    ..We propose that SHP-2 plays a pivotal role in FGFR signaling in myoblasts via both Erk-dependent and Erk-independent pathways...
  64. ncbi request reprint PAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1, a potential role for elevated Skp2 expression
    Lei Zhang
    Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 278:27-36. 2003
    ....
  65. ncbi request reprint Induction of angiogenesis in a mouse model using engineered transcription factors
    Edward J Rebar
    Sangamo BioSciences, Richmond, California, USA
    Nat Med 8:1427-32. 2002
    ..These data establish, for the first time, that specifically designed transcription factors can regulate an endogenous gene in vivo and evoke a potentially therapeutic biophysiologic effect...
  66. ncbi request reprint Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity
    Anil K Joshi
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Biol Chem 278:33142-9. 2003
    ....
  67. ncbi request reprint (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine
    Yong Jin Wu
    Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA
    J Med Chem 46:3197-200. 2003
    ..In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride...
  68. pmc Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells
    Kaleem A Mohammed
    Department of Pharmacognosy, National Center for Natural Products Research, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677 1848, USA
    J Nat Prod 67:2002-7. 2004
    ..Compound 1 inhibits HIF-1 by blocking the induction of the oxygen-regulated HIF-1alpha protein. Mitochondrial respiration studies revealed that 1 suppresses oxygen consumption...
  69. ncbi request reprint Establishment and partial characterization of five malignant glioma cell lines
    Lei Zhang
    Department of Neurosurgery, University of Yamanashi Faculty of Medicine, Yamanashi, Japan
    Neuropathology 25:136-43. 2005
    ..These newly established malignant glioma cell lines can be used for further analysis of the mechanisms of tumor growth and progression...
  70. pmc The noncatalytic amino terminus of mitogen-activated protein kinase phosphatase 1 directs nuclear targeting and serum response element transcriptional regulation
    J Julie Wu
    Yale University School of Medicine, Department of Pharmacology, SHM B226D, 333 Cedar Street, New Haven, CT 06520 8066, USA
    Mol Cell Biol 25:4792-803. 2005
    ..Collectively, these data reveal novel roles for the NH(2) terminus of MKP-1 in nuclear targeting and transcriptional regulation...
  71. pmc Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1
    Chowdhury Faiz Hossain
    Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    Biochem Biophys Res Commun 333:1026-33. 2005
    ..In addition, preliminary structure-activity studies suggest specific structural requirements for this class of HIF-1 inhibitors...
  72. ncbi request reprint Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor
    Jinsong Yang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    J Biol Chem 280:36047-54. 2005
    ..Because disruption of individual PAS domains compromise HIF function independent of the mechanism of HIF induction, these data demonstrate the potential utility of targeting these domains for therapeutic applications...
  73. pmc Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 103:2346-51. 2006
    ..Thereby, we speculate that AEBP1 may be critically implicated in the development of atherosclerosis, and it may serve as a molecular target toward developing antiinflammatory, antiatherogenic therapeutic approaches...
  74. ncbi request reprint Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons
    Qiu Fu Ge
    Department of Pharmacology, Zheijang University School of Medicine, Hangzhou, China
    J Neurochem 97:992-1004. 2006
    ..From these results, we conclude that OGD can activate 5-LOX in primary rat cortical neurons, and that this activation may be partly mediated via activating NMDA receptor...
  75. ncbi request reprint [Homeostatic conditions affect the protective effect of edaravone on ischemic injury in neurons]
    Xin Hu
    Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310031, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 35:147-53. 2006
    ..To determine whether homeostatic conditions (pH, glycine or ion concentration) affect the protective effects of edaravone on ischemic injury in rat cortical neurons...
  76. ncbi request reprint A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
    Qing Zhang
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 10:719-29. 2006
    ..We provide evidence that HIB prevents aberrant Hh signaling posterior to the morphogenic furrow, which is essential for normal eye development...
  77. ncbi request reprint Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, protects mice against brain cold injury
    Xiao Dong Qian
    Department of Pharmacology, School of Medicine, Zhejiang University, 353, Yan An Road, Hangzhou 310031, China
    Eur J Pharmacol 549:35-40. 2006
    ..03-0.3 mg/kg) after injury. In addition, pranlukast (0.1-0.3 mg/kg) significantly reduced endogenous IgG exudation both 24 h and 72 h after injury. Thus, this study indicates the protective effect of pranlukast on brain cold injury...
  78. ncbi request reprint Caffeic acid attenuates neuronal damage, astrogliosis and glial scar formation in mouse brain with cryoinjury
    Lei Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, 388, Yu Hang Tang Road, Hangzhou 310058, People s Republic of China
    Life Sci 80:530-7. 2007
    ..These results indicate that caffeic acid exerts a protective effect in traumatic brain injury, especially on glial scar formation in the late phase, which at least is associated with its anti-oxidant ability...
  79. pmc Spn1 regulates the recruitment of Spt6 and the Swi/Snf complex during transcriptional activation by RNA polymerase II
    Lei Zhang
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA
    Mol Cell Biol 28:1393-403. 2008
    ..These findings link Spn1 functions to the transition from an inactive to an actively transcribing RNAPII complex at a postrecruitment-regulated promoter...
  80. doi request reprint Interleukin-27 upregulates major histocompatibility complex class II expression in primary human endothelial cells through induction of major histocompatibility complex class II transactivator
    Xiao Ming Feng
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin, China
    Hum Immunol 68:965-72. 2007
    ..This first demonstration that both MHC II and I expression are increased in EC after IL-27 stimulation suggests that IL-27 may be important in conferring immune function on vascular endothelium...
  81. pmc The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    Lei Zhang
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 14:377-87. 2008
    ..Finally, Sd recruits Yki to the enhancer of the pathway-responsive gene diap1, suggesting that diap1 is a direct transcriptional target of the Hpo pathway...
  82. doi request reprint Hemangiopoietin promotes endothelial cell proliferation through PI-3K/Akt pathway
    Zhong Chen
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR China
    Cell Physiol Biochem 22:307-14. 2008
    ..Moreover, rhHAPO is able to selectively enhance the mitogenic activity of VEGF for vascular endothelial cells. Overall, these findings demonstrate that HAPO induces endothelial cell proliferation through the PI-3K/Akt pathway...
  83. ncbi request reprint Increase in descending brain-spinal cord projections with age in larval lamprey: implications for spinal cord injury
    Lei Zhang
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211 6190, USA
    J Comp Neurol 447:128-37. 2002
    ..axonal regeneration by descending brain neurons, rather than the relatively slow addition of new brain-spinal cord projections with age, probably accounts for the majority of restored projections and recovery of locomotor function..
  84. pmc Specific detection of the endogenous transient receptor potential (TRP)-1 protein in liver and airway smooth muscle cells using immunoprecipitation and Western-blot analysis
    Hwei Ling Ong
    Department of Medical Biochemistry, School of Medicine, Faculty of Health Sciences, Flinders University, GPO Box 2100, Adelaide, South Australia 5001, Australia
    Biochem J 364:641-8. 2002
    ....
  85. ncbi request reprint Axonal regeneration of descending and ascending spinal projection neurons in spinal cord-transected larval lamprey
    Jon Armstrong
    Division of Biological Sciences and Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO 65211 6190, USA
    Exp Neurol 180:156-66. 2003
    ..In contrast, most dorsal cells, which are centrally located sensory neurons, exhibited very little axonal regeneration...
  86. ncbi request reprint Growth temperature downshift induces antioxidant response in Saccharomyces cerevisiae
    Lei Zhang
    Laboratory of Cellular Genetics, Department of Biotechnology, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    Biochem Biophys Res Commun 307:308-14. 2003
    ..However, deletion of YAP1 did not reduce the elevated mRNA levels of the antioxidant genes. This suggests that the temperature downshift-induced increase in the mRNA level of anti-oxidant genes is YAP1-independent...
  87. ncbi request reprint Molecular cloning and characterization of a mannose-binding lectin gene from Crinum asiaticum
    Yourong Chai
    Fudan SJTU Nottingham Plant Biotechnology R and D Center, Plant Biotechnology Research Center, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200030, P R China
    J Plant Physiol 160:913-20. 2003
    ..Northern blot analysis demonstrated that caa mRNA was constitutively expressed in all the tested tissue types including the root, bulb, leaf, rachise, flower and fruit tissues...
  88. ncbi request reprint Isolation and expression of cold-regulated cDNA from Chinese cabbage (Brassica pekinensis)
    Yongquan Lu
    Fudan SJTU Nottingham Plant Biotechnology R and D Center, Plant Biotechnology Center, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200030, People s Republic of China
    DNA Seq 14:219-22. 2003
    ..The possible functions of the cold-regulated gene and the mechanism for plants to cope with low temperature are discussed...
  89. ncbi request reprint Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice
    Jianmin Liu
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, Cleveland, OH 44109, USA
    Mech Dev 120:1059-70. 2003
    ..Slit3-deficient mice represent a genetic animal model for physiological and pathological studies of congenital diaphragmatic hernia...
  90. ncbi request reprint Molecular cloning of a new lectin gene from Z. grandiflora
    Guoyin Kai
    Fudan SJTU Nottingham Plant Biotechnology R and D Center, Plant Biotechnology Research Center, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200030, People s Republic of China
    DNA Seq 14:335-8. 2003
    ..Southern blot analysis of the genomic DNA revealed that zga belonged to a multi-copy gene family like those of many other Amaryllidaceae species such as Galanthus nivalis and Clivia miniata...
  91. ncbi request reprint Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors
    Andrew W Snowden
    Sangamo BioSciences, Inc, Richmond, California 94841, USA
    Cancer Res 63:8968-76. 2003
    ..Thus, engineered ZFP TFs are shown to be potent regulators of gene expression with therapeutic promise in the treatment of disease...
  92. ncbi request reprint Aberrant gene expression in organs of bovine clones that die within two days after birth
    Shijie Li
    The State Key Laboratory for Agrobiotechnology in Livestock and Poultry, China Agricultural University, Beijing 100094, China
    Biol Reprod 72:258-65. 2005
    ..Because these genes play important roles in embryo development and organogenesis, the aberrant transcription patterns detected in these clones may contribute to the defects of organs reported in neonatal death of clones...
  93. ncbi request reprint Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain
    Lei Zhang
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Biol Chem 280:12422-9. 2005
    ....
  94. ncbi request reprint Proteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers
    Chen Li
    Research Center for Proteome Analysis, Key Lab of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Proteomics 5:1125-39. 2005
    ..The physiological significance of the differential expressions for several candidate proteins are discussed...
  95. pmc Carbachol induces burst firing of dopamine cells in the ventral tegmental area by promoting calcium entry through L-type channels in the rat
    Lei Zhang
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s NL, Canada
    J Physiol 568:469-81. 2005
    ..This could establish the L-type channel as a target for modulating the function of the central dopamine system in disease conditions...
  96. ncbi request reprint Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing
    Jianhang Jia
    Center for Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    Dev Cell 9:819-30. 2005
    ..We propose that phosphorylation of Ci by CKI creates multiple Slimb/beta-TRCP binding sites that act cooperatively to recruit SCF(Slimb/beta-TRCP)...
  97. ncbi request reprint Anti-oxidative effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf in chronic bronchitis rats
    Yan Huang
    School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, China 230032
    Life Sci 78:2749-57. 2006
    ..These results suggest that TAL inhibits HO-1 expression and MDA production and up-regulates SOD expression in AM from CB rats, which might be one of molecular mechanisms of its anti-inflammatory effects in CB rats...
  98. ncbi request reprint A genetic model for muscle-eye-brain disease in mice lacking protein O-mannose 1,2-N-acetylglucosaminyltransferase (POMGnT1)
    Jianmin Liu
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, 650 E Adams Street, Syracuse, NY 13210, USA
    Mech Dev 123:228-40. 2006
    ..The present study provides the first genetic animal model to further dissect the roles of POMGnT1 in MEB disease...
  99. ncbi request reprint Fluorogold labeling of descending brain neurons in larval lamprey does not cause cell death
    Andrew D McClellan
    Division of Biological Sciences and Interdisciplinary Neuroscience Program, 114 Lefevre Hall, University of Missouri, Columbia, MO 65211 6190, USA
    Neurosci Lett 401:119-24. 2006
    ..Thus, in larval lamprey, FG does not appear to kill these neurons, but some FG probably is degraded and/or lost from neurons with increasing recovery times...
  100. ncbi request reprint Cysteinyl leukotriene receptors CysLT1 and CysLT2 are upregulated in acute neuronal injury after focal cerebral ischemia in mice
    Yan Jun Zhang
    Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, China
    Acta Pharmacol Sin 27:1553-60. 2006
    ..To determine whether cysteinyl leukotriene receptors (CysLT1 and CysLT2) are upregulated in acute neuronal injury after focal cerebral ischemia in mice, and to confirm CysLT1 receptor localization...
  101. pmc Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-kappaB via IkappaBalpha negative regulation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 18:930-42. 2007
    ..We speculate that AEBP1 may serve as a potential therapeutic target for the treatment of various chronic inflammatory diseases and cancer...