John A Twomey
- An open-label study to evaluate the safety and efficacy of tissue plasminogen activator in treatment of severe frostbiteJohn A Twomey
Department of Surgery, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
J Trauma 59:1350-4; discussion 1354-5. 2005..One of the mechanisms of cold injury to human tissue is vascular thrombosis. The effect of tissue plasminogen activator (tPA) and heparin in limb and digit preservation in severe frostbite patients has not been previously studied...