Chang Han

Summary

Affiliation: Tulane University
Country: USA

Publications

  1. pmc MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Gastroenterology 143:246-56.e8. 2012
  2. pmc Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth
    Chang Han
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hepatology 52:644-55. 2010
  3. pmc Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
    Kyoungsub Song
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
    Hepatology 58:1681-92. 2013
  4. pmc Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease
    Hyunjoo Kwon
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
    Hepatology 63:1155-69. 2016
  5. pmc 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins
    Dongdong Lu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 288:19484-502. 2013
  6. pmc Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
    Kyoungsub Song
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    Oncotarget 6:40822-35. 2015
  7. pmc miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT
    Weina Chen
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue SL 79, New Orleans, Louisiana, United States of America
    PLoS ONE 10:e0132734. 2015
  8. pmc Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression
    Lu Yao
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Cancer Res 75:1388-98. 2015
  9. pmc miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor
    Ximena V Qadir
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Am J Pathol 185:3141-51. 2015
  10. pmc miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF)
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Pathol 182:1629-39. 2013

Collaborators

  • Tong Wu
  • Kyu Lim
  • George K Michalopoulos
  • Jinqiang Zhang
  • Kyoungsub Song
  • Dongdong Lu
  • Weina Chen
  • Ying Wang
  • Hanqing Zhu
  • Ximena V Qadir
  • Hyunjoo Kwon
  • Srikanta Dash
  • Lu Lu
  • Lu Yao
  • Kathleen Byrnes
  • Susan Magliato
  • Mark Feitelson

Detail Information

Publications17

  1. pmc MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Gastroenterology 143:246-56.e8. 2012
    ..MicroRNAs (miRNAs) have been implicated in the development and progression of human cancers. We investigated the roles and mechanisms of miR-26a in human cholangiocarcinoma...
  2. pmc Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth
    Chang Han
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Hepatology 52:644-55. 2010
    ..The interplays between TGF-beta and cPLA(2)alpha signaling pathways were examined in rat primary hepatocytes, human hepatocellular carcinoma cells, and hepatocytes isolated from newly developed cPLA(2)alpha transgenic mice...
  3. pmc Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
    Kyoungsub Song
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
    Hepatology 58:1681-92. 2013
    ..The aforementioned DNA-protein complex also contains SUV39H1, an H3K9 histone methyl transferase, which down-regulates miR-122 expression...
  4. pmc Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease
    Hyunjoo Kwon
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA
    Hepatology 63:1155-69. 2016
    ....
  5. pmc 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins
    Dongdong Lu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Biol Chem 288:19484-502. 2013
    ..These findings disclose a novel 15-PGDH-mediated 15-keto-PGE2 signaling cascade that interacts with PPAR-γ, Smad2/3, and TAP63. ..
  6. pmc Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
    Kyoungsub Song
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    Oncotarget 6:40822-35. 2015
    ....
  7. pmc miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT
    Weina Chen
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue SL 79, New Orleans, Louisiana, United States of America
    PLoS ONE 10:e0132734. 2015
    ..These findings demonstrate that miR-150 deficiency prevents Fas-induced hepatocyte apoptosis and liver injury through regulation of the Akt pathway...
  8. pmc Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression
    Lu Yao
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Cancer Res 75:1388-98. 2015
    ..Taken together, our results reveal a novel mechanism for ω-3 PUFA-induced expression of 15-PGDH in human cholangiocarcinoma and provide a preclinical rationale for the evaluation of ω-3 PUFA in treatment of this malignancy...
  9. pmc miR-223 Deficiency Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury through Targeting Insulin-Like Growth Factor 1 Receptor
    Ximena V Qadir
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Am J Pathol 185:3141-51. 2015
    ..Further in vitro and in vivo data indicate that miR-223 regulates Fas-induced hepatocyte apoptosis and liver injury by targeting the insulin-like growth factor 1 receptor...
  10. pmc miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF)
    Jinqiang Zhang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Am J Pathol 182:1629-39. 2013
    ..This study established a novel tumor-suppressor role of miR-101 in cholangiocarcinoma and it suggests the possibility of targeting miR-101 and related signaling pathways for future therapy...
  11. pmc miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth
    Lu Lu
    Authors Affiliation Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Mol Cancer Res 12:890-900. 2014
    ..In parallel, cyclooxygenase-2 (COX2) overexpression and PGE2 treatment increased miR-21 levels and enhanced miR-21 promoter activity in human cholangiocarcinoma cells...
  12. pmc miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway
    Ximena V Qadir
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Am J Pathol 184:2355-64. 2014
    ..Thus, reactivation or induction of miR-185 may represent a novel therapeutic strategy for HCC treatment. ..
  13. pmc Deletion of Mir155 prevents Fas-induced liver injury through up-regulation of Mcl-1
    Weina Chen
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Am J Pathol 185:1033-44. 2015
    ..Taken together, these findings demonstrate that deletion of Mir155 prevents Fas-induced hepatocyte apoptosis and liver injury through the up-regulation of Mcl1...
  14. pmc miR-17-92 cluster promotes cholangiocarcinoma growth: evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator
    Hanqing Zhu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana
    Am J Pathol 184:2828-39. 2014
    ..Taken together, our findings disclose a novel IL-6/Stat3-miR-17-92 cluster-PTEN signaling axis that is crucial for cholangiocarcinogenesis and tumor progression. ..
  15. pmc MiR-17-92 cluster promotes hepatocarcinogenesis
    Hanqing Zhu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Avenue SL 79, New Orleans, LA 70112, USA
    Carcinogenesis 36:1213-22. 2015
    ..Our findings demonstrate an important role of the miR-17-92 cluster in hepatocarcinogenesis and suggest the possibility of targeting this pivotal miRNA cluster for potential therapy. ..
  16. pmc Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
    Ying Wang
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA, USA
    Hepatology 58:995-1010. 2013
    ..In a tumor xenograft model using SCID mice inoculated with Huh7 cells, administration of GANT61 inhibited tumor formation and decreased tumor volume; this effect was partially blocked by the autophagy inhibitor, 3-MA...
  17. pmc Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression
    Dongdong Lu
    Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Gastroenterology 140:2084-94. 2011
    ..Although COX-2 is involved in the development and progression of various human cancers, the role of mPGES-1 in carcinogenesis has not been determined. We investigated the role of mPGES-1 in human cholangiocarcinoma growth...