David E Thaler

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. pmc Determinants of antithrombotic choice for patent foramen ovale in cryptogenic stroke
    David E Thaler
    From the Department of Neurology D E T, D M K, and Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies R R, J S L, D M K, Tufts Medical Center Tufts University School of Medicine, Boston, MA Department of Neurology, University of Duisburg Essen C W, Germany Neurology Department at the Hospital Universitari Doctor Josep Trueta Institut d Investigació Biomèdica de Girona J S, Spain Department of Neurology, Inselspital H P M, M L M, University of Bern Division of Neurology at the Triemli Municipal Hospital K N, Zurich, Switzerland Department of Public Health and Primary Care E D A, Cambridge University, UK Departments of Neurology and Epidemiology M S V E, and Division of Cardiology M R D T, S H, Columbia University, NY Neurology Service, Centre Hospitalier Universitaire Vaudois P M, Switzerland Department of Cardiology B M, Swiss Cardiovascular Center, Inselspital, University of Bern, Switzerland and Department of Neurology A J F, Case Western Reserve University, Cleveland, OH
    Neurology 83:1954-7. 2014
  2. pmc Recurrent stroke predictors differ in medically treated patients with pathogenic vs. other PFOs
    David E Thaler
    From the Department of Neurology D E T, D M K and the Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies R R, J S L, J G, D M K, Tufts Medical Center Tufts University School of Medicine, Boston, MA the University of Duisburg Essen C W, Germany Hôpital Sainte Anne J L M, Paris Descartes University, France the Department of Neurology J S, Hospital Universitari Doctor Josep Trueta Institut d Investigació Biomèdica de Girona, Spain the Department of Public Health and Primary Care E D A, Cambridge University, UK the Department of Cardiology F P, Sapienza University of Rome, Italy the Departments of Cardiology S H and Neurology and Epidemiology M S V E and the Division of Cardiology M R D T, Columbia University, New York Inselspital H P M, M L M, University of Bern the Division of Neurology K N, Triemli Municipal Hospital, Zurich, Switzerland the University of Toronto C J, Canada and Centre Hospitalier Universitaire Vaudois P M, Switzerland
    Neurology 83:221-6. 2014
  3. pmc Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale
    David E Thaler
    Department of Neurology, Tufts Medical Center, Boston, MA 02111, USA
    Stroke 44:675-80. 2013
  4. pmc Recurrent stroke on imaging and presumed paradoxical embolism: a cross-sectional analysis
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Neurology 78:993-7. 2012
  5. doi request reprint Cryptogenic stroke and patent foramen ovale
    David E Thaler
    The Comprehensive Stroke Center, Tufts Medical Center, Boston, MA 02111, USA
    Curr Opin Cardiol 23:537-44. 2008
  6. pmc Rethinking trial strategies for stroke and patent foramen ovale
    David E Thaler
    Department of Neurology, Boston, Massachusetts, USA
    Curr Opin Neurol 23:73-8. 2010
  7. pmc An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, MA, USA
    Neurology 81:619-25. 2013
  8. pmc Transesophageal echocardiography in cryptogenic stroke and patent foramen ovale: analysis of putative high-risk features from the risk of paradoxical embolism database
    Benjamin S Wessler
    Division of Cardiology, Tufts Medical Center, Boston, MA
    Circ Cardiovasc Imaging 7:125-31. 2014
  9. pmc The risk of paradoxical embolism (RoPE) study: initial description of the completed database
    David E Thaler
    Department of Neurology, Tufts Medical Center Tufts University School of Medicine, Boston, MA, USA
    Int J Stroke 8:612-9. 2013
  10. pmc The Risk of Paradoxical Embolism (RoPE) Study: developing risk models for application to ongoing randomized trials of percutaneous patent foramen ovale closure for cryptogenic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, MA 02111, USA
    Trials 12:185. 2011

Collaborators

Detail Information

Publications21

  1. pmc Determinants of antithrombotic choice for patent foramen ovale in cryptogenic stroke
    David E Thaler
    From the Department of Neurology D E T, D M K, and Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies R R, J S L, D M K, Tufts Medical Center Tufts University School of Medicine, Boston, MA Department of Neurology, University of Duisburg Essen C W, Germany Neurology Department at the Hospital Universitari Doctor Josep Trueta Institut d Investigació Biomèdica de Girona J S, Spain Department of Neurology, Inselspital H P M, M L M, University of Bern Division of Neurology at the Triemli Municipal Hospital K N, Zurich, Switzerland Department of Public Health and Primary Care E D A, Cambridge University, UK Departments of Neurology and Epidemiology M S V E, and Division of Cardiology M R D T, S H, Columbia University, NY Neurology Service, Centre Hospitalier Universitaire Vaudois P M, Switzerland Department of Cardiology B M, Swiss Cardiovascular Center, Inselspital, University of Bern, Switzerland and Department of Neurology A J F, Case Western Reserve University, Cleveland, OH
    Neurology 83:1954-7. 2014
    ....
  2. pmc Recurrent stroke predictors differ in medically treated patients with pathogenic vs. other PFOs
    David E Thaler
    From the Department of Neurology D E T, D M K and the Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies R R, J S L, J G, D M K, Tufts Medical Center Tufts University School of Medicine, Boston, MA the University of Duisburg Essen C W, Germany Hôpital Sainte Anne J L M, Paris Descartes University, France the Department of Neurology J S, Hospital Universitari Doctor Josep Trueta Institut d Investigació Biomèdica de Girona, Spain the Department of Public Health and Primary Care E D A, Cambridge University, UK the Department of Cardiology F P, Sapienza University of Rome, Italy the Departments of Cardiology S H and Neurology and Epidemiology M S V E and the Division of Cardiology M R D T, Columbia University, New York Inselspital H P M, M L M, University of Bern the Division of Neurology K N, Triemli Municipal Hospital, Zurich, Switzerland the University of Toronto C J, Canada and Centre Hospitalier Universitaire Vaudois P M, Switzerland
    Neurology 83:221-6. 2014
    ..To examine predictors of stroke recurrence in patients with a high vs a low likelihood of having an incidental patent foramen ovale (PFO) as defined by the Risk of Paradoxical Embolism (RoPE) score...
  3. pmc Neuroimaging findings in cryptogenic stroke patients with and without patent foramen ovale
    David E Thaler
    Department of Neurology, Tufts Medical Center, Boston, MA 02111, USA
    Stroke 44:675-80. 2013
    ..We examined whether specific radiological findings are associated with PFO among subjects with cryptogenic stroke and known PFO status...
  4. pmc Recurrent stroke on imaging and presumed paradoxical embolism: a cross-sectional analysis
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Neurology 78:993-7. 2012
    ..Such clinical indicators of paradoxical embolism are commonly viewed as risk factors for CS recurrence, but precise risk estimates are lacking...
  5. doi request reprint Cryptogenic stroke and patent foramen ovale
    David E Thaler
    The Comprehensive Stroke Center, Tufts Medical Center, Boston, MA 02111, USA
    Curr Opin Cardiol 23:537-44. 2008
    ..Controversy surrounds the issue of patent foramen ovale (PFO), stroke, and secondary prevention strategies. Paradoxical embolism is usually a presumed diagnosis, incidental PFOs are common, and treatment options have not been well compared...
  6. pmc Rethinking trial strategies for stroke and patent foramen ovale
    David E Thaler
    Department of Neurology, Boston, Massachusetts, USA
    Curr Opin Neurol 23:73-8. 2010
    ..This has generally been attributed to paradoxical embolism. Regardless of mechanism, nearly 30,000 young patients each year have a cryptogenic stroke and PFO. Optimal management is uncertain...
  7. pmc An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, MA, USA
    Neurology 81:619-25. 2013
    ..We aimed to create an index to stratify cryptogenic stroke (CS) patients with patent foramen ovale (PFO) by their likelihood that the stroke was related to their PFO...
  8. pmc Transesophageal echocardiography in cryptogenic stroke and patent foramen ovale: analysis of putative high-risk features from the risk of paradoxical embolism database
    Benjamin S Wessler
    Division of Cardiology, Tufts Medical Center, Boston, MA
    Circ Cardiovasc Imaging 7:125-31. 2014
    ..The association of these transesophageal echocardiography features with other markers of pathogenicity has not been examined...
  9. pmc The risk of paradoxical embolism (RoPE) study: initial description of the completed database
    David E Thaler
    Department of Neurology, Tufts Medical Center Tufts University School of Medicine, Boston, MA, USA
    Int J Stroke 8:612-9. 2013
    ..However, individual databases generally have too few stroke recurrences to support risk modeling. Prior studies of this population have been limited by low statistical power for examining factors related to recurrence...
  10. pmc The Risk of Paradoxical Embolism (RoPE) Study: developing risk models for application to ongoing randomized trials of percutaneous patent foramen ovale closure for cryptogenic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, MA 02111, USA
    Trials 12:185. 2011
    ..These probabilities are likely to be important determinants of the benefits of PFO closure in CS...
  11. pmc Anticoagulant vs. antiplatelet therapy in patients with cryptogenic stroke and patent foramen ovale: an individual participant data meta-analysis
    David M Kent
    Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, 800 Washington St, Box 63, Boston, MA 02111, USA Department of Neurology, Tufts Medical Center Tufts University School of Medicine, Boston, MA, USA
    Eur Heart J 36:2381-9. 2015
    ..We pooled multiple observational studies and used propensity score-based methods to estimate the comparative effectiveness of oral anticoagulation (OAC) compared with antiplatelet therapy (APT)...
  12. pmc Device Closure of Patent Foramen Ovale After Stroke: Pooled Analysis of Completed Randomized Trials
    David M Kent
    Predictive Analytics and Comparative Effectiveness PACE Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center Tufts University School of Medicine, Boston, Massachusetts Department of Neurology, Tufts Medical Center Tufts University School of Medicine, Boston, Massachusetts Electronic address
    J Am Coll Cardiol 67:907-17. 2016
    ..The comparative effectiveness of percutaneous closure of patent foramen ovale (PFO) plus medical therapy versus medical therapy alone for cryptogenic stroke is uncertain...
  13. pmc The RoPE Score and Right-to-Left Shunt Severity by Transcranial Doppler in the CODICIA Study
    Benjamin S Wessler
    Division of Cardiology, Tufts Medical Center, Boston, Mass, USA
    Cerebrovasc Dis 40:52-8. 2015
    ..Our aim was to determine the significance of RLSh grade by c-TCD in patients with PFO and CS...
  14. pmc Patent foramen ovale closure and medical treatments for secondary stroke prevention: a systematic review of observational and randomized evidence
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
    Stroke 43:422-31. 2012
    ..We synthesized the available evidence on secondary stroke prevention in patients with patent foramen ovale and cryptogenic stroke...
  15. pmc Is patent foramen ovale a modifiable risk factor for stroke recurrence?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Box 63, 800 Washington St, Boston, MA 02111, USA
    Stroke 41:S26-30. 2010
    ....
  16. doi request reprint Management strategies for asymptomatic carotid stenosis: a systematic review and meta-analysis
    Gowri Raman
    Center for Clinical Evidence Synthesis and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 158:676-85. 2013
    ..Adults with asymptomatic carotid artery stenosis are at increased risk for ipsilateral carotid territory ischemic stroke...
  17. pmc Does case misclassification threaten the validity of studies investigating the relationship between neck manipulation and vertebral artery dissection stroke? Yes
    Jessica K Paulus
    Predictive Analytics and Comparative Effectiveness PACE Center, Institute for Clinical Research and Health Policy Studies ICRHPS, Tufts Medical Center Tufts University School of Medicine, Boston, MA USA
    Chiropr Man Therap 24:42. 2016
    ..For patients and health care providers who are considering spinal manipulative therapy of the neck, it is crucial to establish if it is a trigger for cervical artery dissection and/or stroke, and if it is, the magnitude of the risk...
  18. pmc Case misclassification in studies of spinal manipulation and arterial dissection
    Xuemei Cai
    Department of Neurology, Brigham and Women s Hospital and Massachusetts General Hospital, Boston, Massachusetts
    J Stroke Cerebrovasc Dis 23:2031-5. 2014
    ..We hypothesize that case misclassification occurred in these previous studies and an underestimation of the strength of the association. We also predicted that case misclassification would differ by patient age...
  19. pmc Patent foramen ovale in cryptogenic stroke: incidental or pathogenic?
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Division of Cardiology, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 40:2349-55. 2009
    ..Patent foramen ovale (PFO) is significantly associated with cryptogenic stroke (CS). However, even in patients with CS, a PFO can be an incidental finding. We sought to estimate the probability that a PFO in a patient with CS is incidental...
  20. doi request reprint Anorgasmia with gabapentin may be common in older patients
    Michael D Perloff
    Department of Neurology, Boston University School of Medicine, Boston University Medical Center, Massachusetts, USA
    Am J Geriatr Pharmacother 9:199-203. 2011
    ..It is preferred for its well-tolerated side effect profile. Anorgasmia with gabapentin use is reported, with most cases in young patients...
  21. doi request reprint Stroke due to late device thrombosis following successful percutaneous patent foramen ovale closure
    Ravikiran Korabathina
    Cardiac Catheterization Laboratory, Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Catheter Cardiovasc Interv 80:498-502. 2012
    ..We discuss risk factors that may have contributed to device thrombosis and raise concerns regarding the lack of a dedicated PFO closure device for clinical use in the United States...