Ligi Paul

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. doi request reprint Interaction between excess folate and low vitamin B12 status
    Ligi Paul
    Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, 02111, USA Electronic address
    Mol Aspects Med . 2016
  2. pmc High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort
    Ligi Paul
    JM USDA HNRC, Tufts University, 711 Washington St, Boston, MA, 02111, USA
    Eur J Nutr 54:235-41. 2015
  3. pmc Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR
    Ligi Paul
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    BMC Microbiol 7:2. 2007
  4. doi request reprint Diet, nutrition and telomere length
    Ligi Paul
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 22:895-901. 2011
  5. doi request reprint Telomere length in peripheral blood mononuclear cells is associated with folate status in men
    Ligi Paul
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1273-8. 2009
  6. pmc Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake
    Hathairat Sawaengsri
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA
    Am J Clin Nutr 104:1665-1670. 2016
  7. pmc Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 104:1562-75. 2012
  8. doi request reprint Folic acid fortification: why not vitamin B12 also?
    Jacob Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Biofactors 37:269-71. 2011
  9. doi request reprint Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation
    Ligi Paul
    JM USDA HNRC, Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 71:239-44. 2013
  10. doi request reprint High folic acid intake reduces natural killer cell cytotoxicity in aged mice
    Hathairat Sawaengsri
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111
    J Nutr Biochem 30:102-7. 2016

Detail Information

Publications13

  1. doi request reprint Interaction between excess folate and low vitamin B12 status
    Ligi Paul
    Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, 02111, USA Electronic address
    Mol Aspects Med . 2016
    ..This review summarizes the current knowledge on the interaction between folate and vitamin B12 and the associated health outcomes...
  2. pmc High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort
    Ligi Paul
    JM USDA HNRC, Tufts University, 711 Washington St, Boston, MA, 02111, USA
    Eur J Nutr 54:235-41. 2015
    ..Telomere length is influenced by DNA integrity and DNA and histone methylation. Folate plays a role in providing precursors for nucleotides and methyl groups for methylation reactions and has the potential to influence telomere length...
  3. pmc Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR
    Ligi Paul
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    BMC Microbiol 7:2. 2007
    ....
  4. doi request reprint Diet, nutrition and telomere length
    Ligi Paul
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 22:895-901. 2011
    ....
  5. doi request reprint Telomere length in peripheral blood mononuclear cells is associated with folate status in men
    Ligi Paul
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:1273-8. 2009
    ..065) with increased telomere length at below-median folate status. We propose that folate status influences telomere length by affecting DNA integrity and the epigenetic regulation of telomere length through DNA methylation...
  6. pmc Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake
    Hathairat Sawaengsri
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA
    Am J Clin Nutr 104:1665-1670. 2016
    ..This effect may reduce the availability of vitamin B-12 to tissues even when vitamin B-12 intake is adequate. Clinical outcomes associated with vitamin B-12 insufficiency could potentially be worsened by high folate intake...
  7. pmc Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Natl Cancer Inst 104:1562-75. 2012
    ..Folic acid, vitamin B(6), and vitamin B(12) act in concert in the one-carbon metabolism and may protect against colorectal neoplasia. We examined the effect of combined B-vitamin treatment on the occurrence of colorectal adenoma...
  8. doi request reprint Folic acid fortification: why not vitamin B12 also?
    Jacob Selhub
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Biofactors 37:269-71. 2011
    ..Hence any food fortification policy that includes folic acid should also include vitamin B12...
  9. doi request reprint Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation
    Ligi Paul
    JM USDA HNRC, Tufts University, Boston, Massachusetts 02111, USA
    Nutr Rev 71:239-44. 2013
    ....
  10. doi request reprint High folic acid intake reduces natural killer cell cytotoxicity in aged mice
    Hathairat Sawaengsri
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, 02111
    J Nutr Biochem 30:102-7. 2016
    ..This study demonstrates a causal relationship between high folic acid intake and reduced NK cell cytotoxicity and provides some insights into the potential mechanisms behind this relationship. ..
  11. pmc Unmetabolized Folic Acid in Prediagnostic Plasma and the Risk of Colorectal Cancer
    Eunyoung Cho
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA EC, XZ, MKT, BR, WCW, ELG Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, RI EC Department of Epidemiology, Brown University School of Public Health, Providence, RI EC Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA JS, LP Department of Biostatistics BR, Department of Nutrition WCW, ELG, and Department of Epidemiology WCW, ELG, Harvard TH Chan School of Public Health, Boston, MA Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA CSF
    J Natl Cancer Inst 107:djv260. 2015
    ..20, 95% CI = 1.22 to 3.94 for ≥0.5 nmol/L vs undetectable, Pinteraction=0.02). In conclusion, prediagnostic plasma levels of UFA from the prefortification period were not associated with risk of CRC...
  12. pmc Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh
    Maitreyi Mazumdar
    Department of Neurology, Boston Children s Hospital, 300 Longwood Avenue, Boston, MA, USA
    Environ Health 14:34. 2015
    ....
  13. pmc Determination of unmetabolized folic acid in human plasma using affinity HPLC
    Renee Kalmbach
    Vitamin Metabolism and Aging Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 94:343S-347S. 2011
    ..Folic acid (FA) fortification of food created the need to determine whether fortification elevated concentrations of unmetabolized FA in plasma and whether this form of the vitamin in blood is associated with adverse health outcomes...