Jose M Ordovas

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. pmc Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism
    Kris Richardson
    Nutrition and Genomics Laboratory, Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Genome Med 1:96. 2009
  2. ncbi request reprint The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 63:145-52. 2004
  3. pmc APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
    Arch Intern Med 169:1897-906. 2009
  4. pmc Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:327-32. 2010
  5. ncbi request reprint Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 45:2096-105. 2004
  6. ncbi request reprint Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Circulation 113:2062-70. 2006
  7. pmc Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women
    Mireia Junyent
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:842-8. 2009
  8. pmc WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:593-600. 2009
  9. pmc Low-density lipoprotein receptor-related protein 1 variant interacts with saturated fatty acids in Puerto Ricans
    Caren E Smith
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 21:602-8. 2013
  10. pmc A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 141:2219-25. 2011

Detail Information

Publications115 found, 100 shown here

  1. pmc Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism
    Kris Richardson
    Nutrition and Genomics Laboratory, Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Genome Med 1:96. 2009
    ..Here, we review recent functional genomic research that, combined with results from genome-wide association studies, provides a powerful tool to identify novel candidate genes relevant to cholesterol metabolism...
  2. ncbi request reprint The quest for cardiovascular health in the genomic era: nutrigenetics and plasma lipoproteins
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 63:145-52. 2004
    ..This knowledge should lead to successful dietary recommendations partly based on genetic factors that may help to reduce cardiovascular risk more efficiently than the current universal recommendations...
  3. pmc APOA2, dietary fat, and body mass index: replication of a gene-diet interaction in 3 independent populations
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111 1524, USA
    Arch Intern Med 169:1897-906. 2009
    ..However, replication has been low. Our aim was to study interaction among a functional APOA2 polymorphism, food intake, and body mass index (BMI) in independent populations to replicate findings and to increase their evidence level...
  4. pmc Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 18:327-32. 2010
    ..Analyses of gene-gene interactions may improve understanding of genetically based obesity risk, and underscore the need for further study of groups with multiple ancestral admixtures...
  5. ncbi request reprint Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 45:2096-105. 2004
    ..In women, the -1131C allele was associated with a higher hazard ratio for CVD (1.85; 95% confidence interval, 1.03-3.34; P = 0.04), in agreement with the association of this SNP with higher RLPs...
  6. ncbi request reprint Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Circulation 113:2062-70. 2006
    ..Apolipoprotein A5 gene (APOA5) variation is associated with plasma triglycerides (TGs). However, little is known about whether dietary fat modulates this association...
  7. pmc Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women
    Mireia Junyent
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:842-8. 2009
    ..This gene x BMI x diet interaction offers the potential to identify dietary and other lifestyle changes that may obviate the onset of MetS in individuals with a specific genetic background...
  8. pmc WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:593-600. 2009
    ..Given the high frequency of the major alleles in both populations, we suggest that WDTC1 variation may be an important risk factor contributing to obesity in these populations...
  9. pmc Low-density lipoprotein receptor-related protein 1 variant interacts with saturated fatty acids in Puerto Ricans
    Caren E Smith
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 21:602-8. 2013
    ..Animal models and in vitro studies support a role for LRP1 in adipocyte metabolism and leptin signaling, but genetic polymorphisms have not been evaluated for obesity in people...
  10. pmc A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 141:2219-25. 2011
    ..006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations...
  11. pmc Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 89:391-9. 2009
    ..Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR) genes has been associated with fasting plasma triacylglycerol...
  12. ncbi request reprint Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study
    Roberto Elosua
    US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 47:990-6. 2006
    ..APOA5 variants were associated with CCA IMT, particularly in obese participants. The mechanism of these associations and the effect modification by obesity are independent of fasting triglyceride levels...
  13. ncbi request reprint The L162V polymorphism at the peroxisome proliferator activated receptor alpha locus modulates the risk of cardiovascular events associated with insulin resistance and diabetes mellitus: the Veterans Affairs HDL Intervention Trial (VA-HIT)
    E Shyong Tai
    Nutrition and Genomics Unit, Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, USA
    Atherosclerosis 187:153-60. 2006
    ..We hypothesized that the association between a functional polymorphism at the PPARA locus (L162V) and the risk of a CV event, as well as response to fibrate therapy, might be greatest in those with either IR or DM (DM/IR) in VA-HIT...
  14. ncbi request reprint Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations
    Pablo Perez-Martinez
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 87:744-52. 2008
    ..Several perilipin (PLIN) polymorphic sites have been studied for their potential use as markers for obesity and the metabolic syndrome...
  15. pmc MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 91:1377-86. 2010
    ..The S-adenosylmethionine synthetase type 1 (MAT1A) gene encodes a key enzyme in one-carbon nutrient metabolism...
  16. pmc Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111 1524, USA
    Diabetes Care 31:910-5. 2008
    ..We investigated the influences of CRP polymorphisms on baseline CRP levels and fenofibrate-induced CRP changes in subjects with the metabolic syndrome...
  17. pmc Apolipoprotein A5 polymorphisms interact with total dietary fat intake in association with markers of metabolic syndrome in Puerto Rican older adults
    Josiemer Mattei
    Jean Mayer USDA Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
    J Nutr 139:2301-8. 2009
    ..Dietary fat intake seems to modulate these associations. The results contribute to the understanding of health disparities in this population...
  18. pmc Matrix Gla protein polymorphisms are associated with coronary artery calcification in men
    Michael D Crosier
    USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    J Nutr Sci Vitaminol (Tokyo) 55:59-65. 2009
    ..The results of this study suggest a role for MGP genetic variants in coronary atherosclerosis among men that is not reflected in serum MGP concentrations...
  19. ncbi request reprint A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, USA
    Atherosclerosis 180:407-15. 2005
    ..We concluded that the CYP7A1 A-204C promoter variant was associated with poor response to atorvastatin, which were additively enhanced by common variants in another locus, APOE...
  20. ncbi request reprint Polyunsaturated fatty acids interact with the PPARA-L162V polymorphism to affect plasma triglyceride and apolipoprotein C-III concentrations in the Framingham Heart Study
    E Shyong Tai
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    J Nutr 135:397-403. 2005
    ..Our data show that the effect of the L162V polymorphism on plasma TG and apoC-III concentrations depends on the dietary PUFA, with a high intake triggering lower TG in carriers of the 162V allele...
  21. pmc The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study
    Mireia Junyent
    The Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University School of Medicine, Boston, MA, USA
    J Lipid Res 50:565-73. 2009
    ..002) among smokers. In conclusion, ABCG5/G8 genetic variants modulate HDL-C concentrations, leading to an HDL-C-lowering effect and thereby a potential increased risk for atherosclerosis only in smokers...
  22. pmc Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults
    Denish Moorthy
    Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Nutr 142:1554-60. 2012
    ..The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression...
  23. ncbi request reprint Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men
    Toshiko Tanaka
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1402-8. 2007
    ..These data suggest that PPARalpha variants may modulate the risk of cardiovascular disease by influencing both fasting and postprandial lipid concentrations...
  24. pmc Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin
    Caren E Smith
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University School of Medicine, Boston, MA 02111, USA
    J Nutr 138:1852-8. 2008
    ..These interactions may be relevant to dietary management of obesity...
  25. ncbi request reprint Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population
    Lu Qi
    Nutrition and Genomics Laboratory, Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Mol Med (Berl) 83:448-56. 2005
    ..28 (95% CI 1.45-3.57) and Indians OR 2.04 (95% CI 1.08-3.64). These results support the role of the PLIN locus as an ethnically dependent modulator of obesity risk in humans...
  26. pmc ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study
    Daruneewan Warodomwichit
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:510-7. 2009
    ..Our findings support a significant association between the -11391G>A SNPs and obesity-related traits and the potential to moderate such effects using dietary modification...
  27. pmc Acculturation and sociocultural influences on dietary intake and health status among Puerto Rican adults in Massachusetts
    Maria I Van Rompay
    Gerald J and Dorothy R Friedman School of Nutrition Science and Policy, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Acad Nutr Diet 112:64-74. 2012
    ..Despite prevalent type 2 diabetes and low socioeconomic status (SES) among Puerto Rican adults living on the US mainland, little is known about acculturation in this group...
  28. pmc The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults
    Xingwang Ye
    Department of Health Sciences, Northeastern University, Boston, MA 02115, USA
    Psychosom Med 73:385-92. 2011
    ..To examine the associations between variants of genes involved in the uptake, retention, and metabolism of folate and depressive symptoms and to analyze whether such associations are direct or through mediation by folate or homocysteine...
  29. pmc Population admixture associated with disease prevalence in the Boston Puerto Rican health study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Hum Genet 125:199-209. 2009
    ....
  30. ncbi request reprint Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Mass 02111, USA
    Circulation 106:2315-21. 2002
    ..This allele has been associated with decreased HL activity and increased HDL-C concentrations. However, the effect is variable among populations...
  31. ncbi request reprint Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians
    Haiqing Shen
    Nutrition and Genomics Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obesity (Silver Spring) 14:656-61. 2006
    ..Our findings indicate that the uncoupling protein 2 gene -866G/A polymorphism may increase the risks of central obesity and metabolic syndrome, with greater effects on Asian men...
  32. ncbi request reprint Polymorphisms in the gene encoding lipoprotein lipase in men with low HDL-C and coronary heart disease: the Veterans Affairs HDL Intervention Trial
    Margaret E Brousseau
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, and Department of Medicine, New England Medical Center, Boston, MA, USA
    J Lipid Res 45:1885-91. 2004
    ....
  33. ncbi request reprint Fenofibrate effect on triglyceride and postprandial response of apolipoprotein A5 variants: the GOLDN study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 27:1417-25. 2007
    ..Apolipoprotein A5 (APOA5) is a key determinant of plasma triglyceride (TG) concentrations. Genetic variation at the APOA5 locus could be responsible for some of the observed differences in response to fenofibrate therapy...
  34. pmc Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites
    Josiemer Mattei
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    BMC Genet 10:45. 2009
    ....
  35. pmc Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study
    Jian Shen
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Am J Clin Nutr 91:337-42. 2010
    ..Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved...
  36. ncbi request reprint Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes Care 29:1313-9. 2006
    ..To investigate the association between genetic variation in the adipocyte protein perilipin (PLIN) and insulin resistance in an Asian population as well as to examine their modulation by macronutrient intake...
  37. ncbi request reprint Gender-specific association of a perilipin gene haplotype with obesity risk in a white population
    Lu Qi
    Nutrition and Genomics Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obes Res 12:1758-65. 2004
    ..Our purpose was to examine the association between common single-nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus and obesity, as well as related phenotypes, in unrelated American adults...
  38. ncbi request reprint The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 16:153-66. 2005
    ..In addition, we use genomic information from several species to draw inferences about the location of functional variants within this cluster...
  39. ncbi request reprint The -256T>C polymorphism in the apolipoprotein A-II gene promoter is associated with body mass index and food intake in the genetics of lipid lowering drugs and diet network study
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111 1524, USA
    Clin Chem 53:1144-52. 2007
    ..Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis...
  40. pmc A traditional rice and beans pattern is associated with metabolic syndrome in Puerto Rican older adults
    Sabrina E Noel
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 139:1360-7. 2009
    ..8, 95% CI: 1.03, 3.3). Dietary patterns were significantly associated with metabolic syndrome and its components. More research is needed to make appropriate nutritional recommendations for this high-risk population...
  41. ncbi request reprint Gender-specific effects of estrogen receptor alpha gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: interaction with apolipoprotein AI gene polymorphism
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 178:331-8. 2005
    ....
  42. pmc The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 49:1839-45. 2008
    ..This phenomenon could be responsible for the observed association of this genetic variant with cardiovascular disease risk...
  43. pmc PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes 57:809-16. 2008
    ....
  44. ncbi request reprint APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    J Mol Med (Berl) 85:119-28. 2007
    ..In conclusion, the APOA5-1131T>C SNP, which is present in approximately 13% of this population, modulates the effect of fat intake on BMI and obesity risk in both men and women...
  45. pmc Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site
    Kris Richardson
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Am J Hum Genet 92:5-14. 2013
    ..This work provides biological and potential clinical relevance for previously reported GWAS variants associated with plasma lipid phenotypes...
  46. pmc A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study
    Natalie E Cusano
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Calcif Tissue Int 90:96-107. 2012
    ..Identification of genes that influence human height may lead to a better understanding of the processes involved in growth and development...
  47. pmc Vitamin K, circulating cytokines, and bone mineral density in older men and women
    M Kyla Shea
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:356-63. 2008
    ..Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro...
  48. ncbi request reprint Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome
    Jian Shen
    Nutrition and Genomics Laboratory, JM U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 137:1846-51. 2007
    ..These results suggested that IL1beta genetic variants were associated with measures of chronic inflammation and the MetS risk, and that genetic influences were more evident among subjects with low (n-3) PUFA intake...
  49. pmc Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia
    Daruneewan Warodomwichit
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 139:439-46. 2009
    ..62% of energy intake) were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 rs7903146 SNP and may predispose them to MetS, diabetes, and cardiovascular disease...
  50. ncbi request reprint Informative-transmission disequilibrium test (i-TDT): combined linkage and association mapping that includes unaffected offspring as well as affected offspring
    Chao Yu Guo
    Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA
    Genet Epidemiol 31:115-33. 2007
    ..Applying the i-TDT to the Framingham Heart Study data, we found that the apolipoprotein E (APOE) gene is significantly linked and associated with cross-sectional measures and longitudinal changes in total cholesterol...
  51. ncbi request reprint Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 175:287-93. 2004
    ..The other ABCG5/G8 polymorphisms did not show any significant interactions with the CYP7A1 polymorphism. We conclude that the ABCG8 H19 and CYP7A1 C-204 alleles appear to interact in a dose-dependent manner on atorvastatin response...
  52. pmc Adherence to an (n-3) fatty acid/fish intake pattern is inversely associated with metabolic syndrome among Puerto Rican adults in the Greater Boston area
    Sabrina E Noel
    USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 140:1846-54. 2010
    ..Identifying optimal combinations of fatty acids may be beneficial for understanding relationships with health outcomes given their diverse effects on metabolism...
  53. ncbi request reprint ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    J Lipid Res 45:653-6. 2004
    ..These results suggest that, in patients with hypercholesterolemia, the ABCG8 D19H variant is associated with greater LDLC-lowering response to atorvastatin therapy...
  54. ncbi request reprint Nutritional risk and the metabolic syndrome in women: opportunities for preventive intervention from the Framingham Nutrition Study
    Barbara E Millen
    Department of Family Medicine and the Graduate Medical Sciences Division, Boston University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 84:434-41. 2006
    ..Diet is recognized as a key factor in the cause and management of the metabolic syndrome (MetS). However, policies to guide preventive clinical nutrition interventions of the condition are limited...
  55. ncbi request reprint Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study
    Roberto Elosua
    The Department of Biostatistics, Boston University, Boston, MA, United States The USDA Human Nutrition Research Center on Aging, Tufts University, MA, USA
    Atherosclerosis 189:222-8. 2006
    ..To determine the association of well-characterized lipoprotein-related genetic variants with carotid intimal medial thickness (IMT) and stenosis...
  56. ncbi request reprint Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study
    Qiong Yang
    Department of Biostatistics, Boston University, Boston, MA 02118, USA
    J Lipid Res 46:1416-25. 2005
    ..03). Further study of the linkage region and exploration of other variants in PLAGL1 are warranted to define the potential functional variants of HDL-C metabolism...
  57. pmc Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
    Am J Epidemiol 172:271-8. 2010
    ..Prospective studies are needed to elucidate whether elevated urinary 8-OHdG concentrations can predict the rate of cognitive decline and incident dementia...
  58. ncbi request reprint Obesity modulates the association among APOE genotype, insulin, and glucose in men
    Roberto Elosua
    Nutrition and Genomics Laboratory and Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Obes Res 11:1502-8. 2003
    ..Obesity, insulin resistance, and apolipoprotein E (APOE) genotype have all been associated with coronary heart disease. We examined the interaction between obesity and APOE genotype in determining fasting insulin and glucose levels...
  59. pmc The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site
    Kris Richardson
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17944. 2011
    ..These results suggest variation at the PLIN4 locus, and its interaction with PUFA as a modulator of obesity related phenotypes, acts in part through creation of a miR-522 regulatory site...
  60. pmc Impact of genetic and environmental factors on hsCRP concentrations and response to therapeutic agents
    Jian Shen
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Clin Chem 55:256-64. 2009
    ..Both baseline hsCRP concentrations and drug-induced hsCRP changes are highly variable and potentially subject to genetic regulation...
  61. ncbi request reprint Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study
    Doreen Osgood
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 88:2869-79. 2003
    ..03 for interaction). Similar results were obtained for HDL(2)-C. In conclusion, SR-BI gene variation modulates the lipid profile, particularly in type 2 diabetes, contributing to the metabolic abnormalities in these subjects...
  62. pmc Vitamin K supplementation and progression of coronary artery calcium in older men and women
    M Kyla Shea
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1799-807. 2009
    ..A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-dependent calcification inhibitor...
  63. ncbi request reprint Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:5121-6. 2005
    ..Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity...
  64. pmc Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study
    Mireia Junyent
    JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 90:686-94. 2009
    ..Of the environmental factors that determine HDL cholesterol, high-carbohydrate diets have been shown to be associated with low concentrations...
  65. pmc Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia...
  66. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care...
  67. pmc Allostatic load is associated with chronic conditions in the Boston Puerto Rican Health Study
    Josiemer Mattei
    Tufts University, Boston, MA, USA
    Soc Sci Med 70:1988-96. 2010
    ..These results have prospective research implications for Puerto Ricans and other ethnic groups...
  68. ncbi request reprint Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status
    Robert R McLean
    Research and Training Institute, Hebrew Rehabilitation Center for Aged, Boston, Massachusetts 01702, USA
    J Bone Miner Res 19:410-8. 2004
    ..Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status...
  69. ncbi request reprint Fish consumption shifts lipoprotein subfractions to a less atherogenic pattern in humans
    Zhengling Li
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 134:1724-8. 2004
    ..Neither diet affected VLDL and LDL particle size. Our data indicate that within the context of a diet restricted in fat and cholesterol, a higher fish content favorably affects VLDL and HDL subspecies...
  70. ncbi request reprint Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging, Nutrition and Genomics, Tufts University, Boston, MA 02111, United States
    Mech Ageing Dev 128:237-49. 2007
    ....
  71. ncbi request reprint B vitamins and plasma homocysteine concentrations in an urban and rural area of Costa Rica
    Mi Kyung Kim
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Am Coll Nutr 22:224-31. 2003
    ..Plasma folate and vitamin B(12) concentrations were measured in women...
  72. ncbi request reprint The metabolic syndrome: a crossroad for genotype-phenotype associations in atherosclerosis
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 6:186-96. 2004
    ....
  73. ncbi request reprint Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort
    Giuseppina T Russo
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3416-21. 2003
    ..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations...
  74. pmc Fatty acid interactions with genetic polymorphisms for cardiovascular disease
    Caren E Smith
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 13:139-44. 2010
    ..However, understanding the limitations and challenges of interaction studies, whether of observational or interventional design, is essential for critical evaluation of these studies...
  75. ncbi request reprint Identification of a functional polymorphism at the adipose fatty acid binding protein gene (FABP4) and demonstration of its association with cardiovascular disease: a path to follow
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Meyer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Nutr Rev 65:130-4. 2007
    ..In this regard, genetic variability at the FABP4 locus has been shown to be associated with plasma lipid levels, type 2 diabetes, and coronary heart disease risk...
  76. pmc Pharmacogenetics of lipid diseases
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Hum Genomics 1:111-25. 2004
    ....
  77. ncbi request reprint Metabolic syndrome pathophysiology: the role of adipose tissue
    Martin Laclaustra
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 17:125-39. 2007
    ..Variations at multiple gene loci will be partially responsible for these interindividual differences. Two of those candidate genes, the adiponectin (APM1) and the perilipin (PLIN) genes, are discussed in more detail...
  78. ncbi request reprint Scavenger receptor class B type I (SCARB1) c.1119C>T polymorphism affects postprandial triglyceride metabolism in men
    Toshiko Tanaka
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Nutr 137:578-82. 2007
    ..923) or total TG (Pgeno x time = 0.529) did not differ by genotype. These results suggest that the c.1119C>T polymorphism is associated with a lower postprandial TG response in the smaller, partially catabolized lipoprotein fraction...
  79. ncbi request reprint Association of apo A-IV 360 (Gln --> His) polymorphism with plasma lipids and lipoproteins: the Framingham Offspring Study
    Maysa S Cendoroglo
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 179:169-75. 2005
    ..In conclusion, the apo A-IV-2 allele is associated with a modest reduction in plasma triglyceride levels in the general population...
  80. pmc Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet
    Aron M Troen
    Vitamin Metabolism and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Age (Dordr) 29:29-39. 2007
    ..Such defined diets can be used to identify lifespan-modifying pathways and specific gene-nutrient interactions in Drosophila...
  81. ncbi request reprint Genetic variation and lipid metabolism: modulation by dietary factors
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Cardiol Rep 7:480-6. 2005
    ..In summary, there is need for both large population studies and well-standardized intervention studies...
  82. pmc Epigenetics and cardiovascular disease
    Jose M Ordovas
    Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nat Rev Cardiol 7:510-9. 2010
    ..Further examination of these mechanisms may lead to earlier prevention and novel therapy for CVD...
  83. ncbi request reprint Gender, a significant factor in the cross talk between genes, environment, and health
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Gend Med 4:S111-22. 2007
    ..Sex influences the risk of nearly all common diseases that affect both men and women, including atherosclerosis and diabetes and their preceding risk factors (eg, hyperlipidemia, insulin resistance, and obesity)...
  84. ncbi request reprint Pharmacogenetics of Lipid-lowering Therapies
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 4:183-92. 2002
    ..Future progress in this area will be driven by studying gene-gene and gene-treatment interactions in much larger patient populations...
  85. ncbi request reprint Genetic links between diabetes mellitus and coronary atherosclerosis
    Jose M Ordovas
    Nutrition and Genetics, JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Curr Atheroscler Rep 9:204-10. 2007
    ....
  86. ncbi request reprint Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study
    Ernst J Schaefer
    Lipid Research Laboratory, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Diabetes Care 25:989-94. 2002
    ..We hypothesized that diabetic patients would have higher remnant levels than nondiabetic patients...
  87. ncbi request reprint Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study
    Jose M Ordovas
    Nutrition and Genomics Laboratory, the Lipid Metabolism Laboratory and the Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
    Am J Clin Nutr 75:38-46. 2002
    ..The A allele was shown to be associated with higher HDL-cholesterol concentrations in some studies but not in others...
  88. ncbi request reprint Nutrient-gene interactions in lipoprotein metabolism - an overview
    Jose M Ordovas
    Nutrition and Genomics Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Forum Nutr 60:102-9. 2007
  89. ncbi request reprint Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis
    Jimmy W Crott
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Carcinogenesis 25:69-76. 2004
    ....
  90. ncbi request reprint The -1131T-->C polymorphism in the apolipoprotein A5 gene is associated with postprandial hypertriacylglycerolemia; elevated small, dense LDL concentrations; and oxidative stress in nonobese Korean men
    Yangsoo Jang
    Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, Seoul, Korea
    Am J Clin Nutr 80:832-40. 2004
    ..Apolipoprotein A5 plays an important role in modulating triacylglycerol metabolism in experimental animal models...
  91. ncbi request reprint Visceral fat accumulation determines postprandial lipemic response, lipid peroxidation, DNA damage, and endothelial dysfunction in nonobese Korean men
    Yangsoo Jang
    Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, Seoul, 120 749 Korea
    J Lipid Res 44:2356-64. 2003
    ..001). In conclusion, our data indicate that visceral fat accumulation, even in nonobese men, is a major factor contributing to increased CVD risk...
  92. ncbi request reprint Dietary fat interacts with the -514C>T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey
    E Shyong Tai
    Department of Endocrinology, Singapore General Hospital, Singapore 169608
    J Nutr 133:3399-408. 2003
    ..Specifically, the TT genotype is associated with a more atherogenic lipid profile when subjects consume diets with a fat content > 30%...
  93. ncbi request reprint Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population
    E Shyong Tai
    Department of Endocrinology, Singapore General Hospital, Singapore 169608
    J Lipid Res 45:674-85. 2004
    ..38, 95% CI 0.15-0.92; P = 0.032). For both polymorphisms, normal subjects carrying the less prevalent allele had higher BMI (P < 0.05). The PUFA/SFA did not modify the effect of these polymorphisms on BMI or insulin...
  94. ncbi request reprint Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Atherosclerosis 184:113-20. 2006
    ..The presence of individual alleles in this population was associated with differences in plasma lipids and LDL size. However, these relationships were independent of dietary cholesterol...
  95. ncbi request reprint Associations of LPL and APOC3 gene polymorphisms on plasma lipids in a Mediterranean population: interaction with tobacco smoking and the APOE locus
    Dolores Corella
    Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain
    J Lipid Res 43:416-27. 2002
    ..Understanding this gene-gene-environmental interaction may facilitate preventive interventions to reduce coronary artery disease risk...
  96. ncbi request reprint Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study
    Serkalem Demissie
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, TE425 Boston, MA 02118, USA
    Atherosclerosis 185:210-8. 2006
    ..30T-c.454-397T-c.454-351A haplotype (frequency, 46%), where L and S are long and short TA repeats. Our results suggest that common ESR1 polymorphisms have a significant effect on lipoprotein metabolism in women...
  97. ncbi request reprint Association of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans
    Yangsoo Jang
    Division of Cardiology, Cardiovascular Genome Center, Yonsei Medical Institute, Yonsei University, Seoul, Korea
    Am J Clin Nutr 82:760-7. 2005
    ..The adiponectin gene is known to modulate adiponectin concentrations and diabetes mellitus development...
  98. doi request reprint Atherogenecity of LDL and unfavorable adipokine profile in metabolically obese, normal-weight woman
    Y J Hyun
    Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea
    Obesity (Silver Spring) 16:784-9. 2008
    ..We aimed to investigate the association between visceral adiposity and adipocytokines and cardiovascular disease (CVD) risk factors in MONW Korean women with normal glucose tolerance...
  99. pmc Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response, and cardiovascular disease incidence in PROSPER
    Eliana Polisecki
    Cardiovascular Research and Lipid Metabolism Laboratories, Friedman School of Nutrition Science and Policy, Tufts University School of Medicine and the Jean Mayer USDA Human Nutrition Research Center at Tufts University, Boston, MA USA
    Atherosclerosis 200:109-14. 2008
    ..Our data indicate that genetic variation at the LDLR locus can affect baseline lipids, response to pravastatin, and CVD risk in subjects placed on statin treatment...
  100. pmc A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study
    Sekar Kathiresan
    National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S17. 2007
    ..Genome-wide association is a promising approach to map genetic loci related to these heritable phenotypes...
  101. pmc Genetic predisposition, nongenetic risk factors, and coronary infarct
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    Arch Intern Med 168:891-6. 2008
    ..Using a genetic predisposition score (GPS), additively integrating the associations of 11 polymorphisms with coronary heart disease (CHD), we examined the consequences of the joint presence of a high GPS and nongenetic CHD risk factors...