Stefania Lamon-Fava

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. doi request reprint Statins and lipid metabolism: an update
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 24:221-6. 2013
  2. pmc Changes in remnant and high-density lipoproteins associated with hormone therapy and progression of coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 205:325-30. 2009
  3. pmc Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1672-8. 2008
  4. ncbi request reprint Regulation of apoA-I gene expression: mechanism of action of estrogen and genistein
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 45:106-12. 2004
  5. doi request reprint Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:575-9. 2008
  6. pmc Effect of hormone replacement therapy on plasma lipoprotein levels and coronary atherosclerosis progression in postmenopausal women according to type 2 diabetes mellitus status
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 59:1794-800. 2010
  7. ncbi request reprint Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1746-53. 2007
  8. pmc Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 52:1181-7. 2011
  9. pmc Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein A-I kinetics in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:385-91. 2006
  10. ncbi request reprint Differences in serum sex hormone and plasma lipid levels in Caucasian and African-American premenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:4516-20. 2005

Research Grants

  1. Estrogen, HDL, and coronary heart disease in women
    Stefania Lamon Fava; Fiscal Year: 2005

Detail Information

Publications60

  1. doi request reprint Statins and lipid metabolism: an update
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 24:221-6. 2013
    ..Emerging evidence indicates that statins exert multiple effects on lipoprotein metabolism, including chylomicrons and HDLs...
  2. pmc Changes in remnant and high-density lipoproteins associated with hormone therapy and progression of coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States
    Atherosclerosis 205:325-30. 2009
    ....
  3. pmc Extended-release niacin alters the metabolism of plasma apolipoprotein (Apo) A-I and ApoB-containing lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:1672-8. 2008
    ..Extended-release niacin effectively lowers plasma TG levels and raises plasma high-density lipoprotein (HDL) cholesterol levels, but the mechanisms responsible for these effects are unclear...
  4. ncbi request reprint Regulation of apoA-I gene expression: mechanism of action of estrogen and genistein
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Lipid Res 45:106-12. 2004
    ..These results indicate that the MAP kinase pathway is involved in the regulation of apoA-I gene expression by genistein and E2, possibly through downstream regulation of transcription factors binding to the promoter region...
  5. doi request reprint Plasma levels of HDL subpopulations and remnant lipoproteins predict the extent of angiographically-defined coronary artery disease in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 28:575-9. 2008
    ..The association of coronary heart disease (CHD) with subpopulations of triglyceride (TG)-rich lipoproteins and high-density lipoproteins (HDL) is established in men, but has not been well characterized in women...
  6. pmc Effect of hormone replacement therapy on plasma lipoprotein levels and coronary atherosclerosis progression in postmenopausal women according to type 2 diabetes mellitus status
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 59:1794-800. 2010
    ..Faster progression of coronary atherosclerosis in women with diabetes could be mediated in part by a worse lipoprotein profile in these women than in women without diabetes, both before and during HRT...
  7. ncbi request reprint Effects of different doses of atorvastatin on human apolipoprotein B-100, B-48, and A-I metabolism
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:1746-53. 2007
    ..Atorvastatin-mediated changes in cholesterol homeostasis may contribute to apoB PR regulation...
  8. pmc Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 52:1181-7. 2011
    ..The assessment of apo(a) isoform size in this cohort does not add significant information about CHD risk. In addition, the cholesterol content in Lp(a) is not a significant predictor of CHD risk...
  9. pmc Role of the estrogen and progestin in hormonal replacement therapy on apolipoprotein A-I kinetics in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research, Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:385-91. 2006
    ..Hormonal replacement therapy (HRT) affects plasma HDL cholesterol levels, with estrogen increasing HDL cholesterol levels and progestins blunting this effect. This study was designed to assess the mechanism responsible for these effects...
  10. ncbi request reprint Differences in serum sex hormone and plasma lipid levels in Caucasian and African-American premenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:4516-20. 2005
    ..Risk of coronary heart disease is higher in African-American than in Caucasian women...
  11. ncbi request reprint TRL, IDL, and LDL apolipoprotein B-100 and HDL apolipoprotein A-I kinetics as a function of age and menopausal status
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:1691-6. 2005
    ..To determine mechanisms contributing to the altered lipoprotein profile associated with aging and menopause, apolipoprotein B-100 (apoB-100) and apoA-I kinetic behavior was assessed...
  12. pmc Sex hormone modulation of proinflammatory cytokine and C-reactive protein expression in macrophages from older men and postmenopausal women
    Michael P Corcoran
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Endocrinol 206:217-24. 2010
    ..Our results indicate that testosterone may exert anti-inflammatory effects by reducing macrophage TNF-alpha expression, while the effects of estrogen on macrophage CRP expression may depend upon the extracellular lipid environment...
  13. pmc Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects
    Seiko Otokozawa
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Metabolism 58:1536-42. 2009
    ..Median apo B-48 values in healthy subjects are about 0.5 mg/dL and increase more than 100% in the fed state. Elevated levels are observed in obese and hyperlipidemic subjects...
  14. ncbi request reprint Gender-specific effects of estrogen receptor alpha gene haplotype on high-density lipoprotein cholesterol response to atorvastatin: interaction with apolipoprotein AI gene polymorphism
    Kouji Kajinami
    Lipid Research Laboratory, Division of Endocrinology Metabolism and Molecular Biology, Tufts New England Medical Center, Boston, MA, USA
    Atherosclerosis 178:331-8. 2005
    ....
  15. pmc Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Endocrinol (Oxf) 72:169-75. 2010
    ..Subjects Postmenopausal Caucasian women (n = 208) participating in a placebo-controlled randomized trial of 3.2 years of hormone therapy (HT)...
  16. pmc Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse
    Shu Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 204:147-55. 2009
    ..These data suggest that lower omega-6:EPA+DHA ratio diets lowered some measures of inflammation and Mphi cholesterol accumulation, which was associated with less aortic lesion formation in LDLr-/- mice...
  17. pmc Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring Study
    Masumi Ai
    Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Atherosclerosis 217:543-8. 2011
    ..Our aim was to determine whether plasma adiponectin levels were an independent predictor of coronary heart disease (CHD) risk...
  18. pmc The effect of 17β-estradiol on cholesterol content in human macrophages is influenced by the lipoprotein milieu
    Michael P Corcoran
    Lipid Metabolism Laboratory, Tufts University, Boston, Massachusetts 02111, USA
    J Mol Endocrinol 47:109-117. 2011
    ..In THP-1 cells, this effect is reduced in the presence of oxLDL, indicating that a pro-atherogenic lipoprotein milieu is an important variable in sex hormone modulation of CHD...
  19. ncbi request reprint Effects of estrogen and medroxyprogesterone acetate on subpopulations of triglyceride-rich lipoproteins and high-density lipoproteins
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory and the Biostatistics Unit, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 52:1330-6. 2003
    ....
  20. pmc Effects of Therapeutic Lifestyle Change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects
    Esther M M Ooi
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 53:1958-67. 2012
    ..Both diets decreased LDL apoB-100 concentration by increasing LDL apoB-100 FCR and decreased HDL apoA-I concentration by decreasing HDL apoA-I PR...
  21. pmc Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet
    Shu Wang
    Cardiovascular Nutrition Laboratory, JM USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Lipids 45:701-11. 2010
    ....
  22. ncbi request reprint Plasma lipid and lipoprotein levels during the follicular and luteal phases of the menstrual cycle
    Junaidah B Barnett
    Nutrition Infection Unit, Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 89:776-82. 2004
    ..Studies involving premenopausal women need to more clearly define and validate menstrual cycle phase in the design and interpretation of study results...
  23. ncbi request reprint The metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein (a) in human beings
    Jennifer L Jenner
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Metabolism 54:361-9. 2005
    ....
  24. doi request reprint Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids
    Yu Lin Kuang
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Br J Nutr 108:1351-9. 2012
    ..The observed n-3 PUFA-mediated changes in gene expression are predicted to reduce the rate of HDL particle formation and maturation...
  25. pmc Linkage between C-reactive protein and triglyceride-rich lipoprotein metabolism
    Nuntakorn Thongtang
    Lipid Metabolism Laboratory, Tufts University, Boston, MA 02111, USA
    Metabolism 62:369-75. 2013
    ..Elevated C-reactive protein (CRP) levels are associated with a greater risk of cardiovascular disease. Our goal was to study CRP metabolism, and to determine its relationship with lipoprotein metabolism using stable isotope methodology...
  26. ncbi request reprint Apolipoprotein A-I, B-100, and B-48 metabolism in subjects with chronic kidney disease, obesity, and the metabolic syndrome
    Marcelo C Batista
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Metabolism 53:1255-61. 2004
    ....
  27. pmc Effects of atorvastatin on human C-reactive protein metabolism
    Nuntakorn Thongtang
    Lipid Metabolism Laboratory, Tufts University, Boston, MA, USA Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Atherosclerosis 226:466-70. 2013
    ..Statins are known to reduce plasma C-reactive protein (CRP) concentrations. Our goal was to define the mechanisms by which CRP was reduced by maximal dose atorvastatin...
  28. ncbi request reprint Apolipoprotein B metabolism in humans: studies with stable isotope-labeled amino acid precursors
    Julian B Marsh
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 162:227-44. 2002
    ..Because of the advances which have been made in mass spectrometry techniques, the advantages of using non-radioactive tracers in humans have made stable isotope kinetic studies the present day standard in this area of research...
  29. pmc Effect of body mass index on apolipoprotein A-I kinetics in middle-aged men and postmenopausal women
    Francine K Welty
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 56:910-4. 2007
    ..Sixty-two percent of the variability in PR and 71% of the variability in FCR were due to BMI in men and only 3% and 23%, respectively, in women. In conclusion, BMI has a significant effect on apo A-I PR and FCR in men but not in women...
  30. ncbi request reprint Fish consumption shifts lipoprotein subfractions to a less atherogenic pattern in humans
    Zhengling Li
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 134:1724-8. 2004
    ..Neither diet affected VLDL and LDL particle size. Our data indicate that within the context of a diet restricted in fat and cholesterol, a higher fish content favorably affects VLDL and HDL subspecies...
  31. pmc Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a)
    Margaret R Diffenderfer
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA Electronic address
    Metabolism 65:381-90. 2016
    ..Lipoprotein(a) [Lp(a)] is mainly similar in composition to LDL, but differs in having apolipoprotein (apo) (a) covalently linked to apoB-100. Our purpose was to examine the individual metabolism of apo(a) and apoB-100 within plasma Lp(a)...
  32. pmc Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits
    Hassan S Dashti
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
    Diabetes Care 38:1456-66. 2015
    ....
  33. ncbi request reprint Effect of hormonal replacement therapy on C-reactive protein and cell-adhesion molecules in postmenopausal women
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Am J Cardiol 91:252-4. 2003
  34. doi request reprint The high-fat high-fructose hamster as an animal model for niacin's biological activities in humans
    Beth A Connolly
    Tufts University Sackler School of Graduate Biomedical Sciences, Department of Biochemistry, Boston, MA, USA Arisaph Pharmaceuticals, Boston, MA, USA
    Metabolism 62:1840-9. 2013
    ..The objective of this study was to determine if the dyslipidemic hamster could serve as such a model...
  35. doi request reprint Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature
    Hassan S Dashti
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Am J Hypertens 29:132-40. 2016
    ..Accounting for environmental temperature may be necessary to correct for seasonal bias...
  36. pmc Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants
    Hassan S Dashti
    From the Nutrition and Genomics Laboratory HSD, CES, Kr, and JMO, Nutritional Epidemiology Laboratory PFJ, and Cardiovascular Nutrition Laboratory SL F, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA the Department of Mathematics, Computer Science, and Cooperative Engineering, University of St Thomas, Houston, TX JLF the Translational Gerontology Branch TT and LF and Laboratory of Neurogenetics DGH, National Institute on Aging, Baltimore, MD the Divisions of Sleep and Circadian Disorders BEC, DJG, RS, and FAJLS and Cardiovascular Medicine and Channing Division of Network Medicine DM, Brigham and Women s Hospital, Boston, MA the Divisions of Sleep Medicine BEC, DJG, and FAJLS and Cardiovascular Medicine and Channing Division of Network Medicine DM, Harvard Medical School, Boston, MA the Sleep Disorders Center, VA Boston Healthcare System, Boston, MA DJG the Department of Nutrition, Harvard School of Public Health, Boston, MA AH and DM the Center for Human Genetic Research and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA RS the Departments of Mental Health and Substance Abuse Services LK and TP and Chronic Disease Prevention M MP, MP, ASH, USA
    Am J Clin Nutr 101:135-43. 2015
    ..Also, common genetic variants in the human Circadian Locomotor Output Cycles Kaput (CLOCK) show associations with ghrelin and total energy intake...
  37. ncbi request reprint Association of apo A-IV 360 (Gln --> His) polymorphism with plasma lipids and lipoproteins: the Framingham Offspring Study
    Maysa S Cendoroglo
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Atherosclerosis 179:169-75. 2005
    ..In conclusion, the apo A-IV-2 allele is associated with a modest reduction in plasma triglyceride levels in the general population...
  38. pmc Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study
    Hassan S Dashti
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Sleep Res 25:404-11. 2016
    ..The association between sleep and higher energy intake could mediate, in part, the link between short sleep or sleep fragmentation index and metabolic abnormalities. ..
  39. ncbi request reprint Men and women differ in lipoprotein response to dietary saturated fat and cholesterol restriction
    Zhengling Li
    Lipid Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3428-33. 2003
    ..These data are consistent with the concept that middle aged/elderly men may have a more favorable lipoprotein response to a low fat, low cholesterol diet than postmenopausal women...
  40. ncbi request reprint The effect of 17{beta}-estradiol on cholesterol content in human macrophages is influenced by the lipoprotein milieu
    Michael P Corcoran
    Lipid Metabolism Laboratory Cardiovascular Nutrition Laboratory Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Mol Endocrinol 47:109-17. 2011
    ..In THP-1 cells, this effect is reduced in the presence of oxLDL, indicating that a pro-atherogenic lipoprotein milieu is an important variable in sex hormone modulation of CHD...
  41. pmc Comparing fluorescence-based cell-free assays for the assessment of antioxidative capacity of high-density lipoproteins
    Fumiyoshi Tsunoda
    From the Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Lipids Health Dis 15:163. 2016
    ..HDL has different functions, including the ability to protect biological molecules from oxidation. Our aim was to evaluate the performance of two fluorescence-based assays in assessing the antioxidative capacity of HDL...
  42. pmc Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages
    Kaori L Honda
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Prostaglandins Leukot Essent Fatty Acids 97:27-34. 2015
    ..The differential effect of DHA on TNFα and IL-6 mRNA expression may be mediated via reduction in NFκB activity. ..
  43. pmc EPA and DHA exposure alters the inflammatory response but not the surface expression of Toll-like receptor 4 in macrophages
    Kaori L Honda
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA
    Lipids 50:121-9. 2015
    ..These data suggest that membrane fatty acid profiles influence the TLR4-mediated inflammatory response in macrophages, via mechanisms that occur downstream of TLR4 receptor activation...
  44. pmc Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment
    David Mischoulon
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Spectr 17:76-86. 2012
    ..To examine the prevalence of the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and the A2756G polymorphism of methionine synthase (MS), and their impact on antidepressant response...
  45. doi request reprint Docosahexaenoic acid suppresses apolipoprotein A-I gene expression through hepatocyte nuclear factor-3β
    Yu Lin Kuang
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 94:594-600. 2011
    ..The underlying mechanism responsible for this effect is not fully understood...
  46. ncbi request reprint Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise
    Michael P Corcoran
    Lipid Metabolism Laboratory and the Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 85:662-77. 2007
    ..This review summarizes the current understanding of the effects of elevated intramyocellular lipids on insulin signaling and how these effects may be altered by varying dietary fat composition and exercise...
  47. doi request reprint Effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular disease risk factors: a randomized clinical trial
    Ivor B Asztalos
    Cardiovascular Research Associates, Boston, MA, USA Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Metabolism 65:1636-1645. 2016
    ..Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the primary omega-3 fatty acids in fish oil, have been shown to reduce cardiovascular disease (CVD) risk...
  48. doi request reprint Effects of oral eicosapentaenoic acid versus docosahexaenoic acid on human peripheral blood mononuclear cell gene expression
    Fumiyoshi Tsunoda
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Atherosclerosis 241:400-8. 2015
    ..Our aim was to assess the effect of a six-week supplementation with either olive oil, EPA, or DHA on gene expression in peripheral blood mononuclear cells (PBMC)...
  49. doi request reprint Dietary modulators of statin efficacy in cardiovascular disease and cognition
    Huifen Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA
    Mol Aspects Med 38:1-53. 2014
    ..Nevertheless, this area is important because were the effects of statins and diet additive or synergistic harnessing the effect could potentially lead to the use of a lower intensity statin or dose. ..
  50. ncbi request reprint Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tuffs University, Boston, MA 02111, USA
    Arch Neurol 63:1545-50. 2006
    ..Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia...
  51. pmc In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation
    Shu Wang
    JM USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Br J Nutr 102:497-501. 2009
    ..In summary, individual long-chain PUFA have differential effects on inflammatory response and markers of cholesterol flux in MPhi which are not related to the n position of the first double bond, chain length or degree of saturation...
  52. doi request reprint Lipoprotein(a) metabolism
    Stefania Lamon-Fava
    aCardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University bGerald J and Dorothy R Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA cNorthwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington, USA
    Curr Opin Lipidol 25:189-93. 2014
    ..Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein. The metabolism of this lipoprotein is still not well understood...
  53. pmc Linoleic acid suppresses cholesterol efflux and ATP-binding cassette transporters in murine bone marrow-derived macrophages
    Nicole L Spartano
    J M USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, USA, 02111
    Lipids 49:415-22. 2014
    ..The effect of 18:2 relative to 16:0 on macrophages cholesterol homeostasis may exacerbate the predisposition of individuals with T2DM to increased CVD risk. ..
  54. ncbi request reprint Elevated cholesterol levels associated with nonresponse to fluoxetine treatment in major depressive disorder
    Shamsah B Sonawalla
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, Massachusetts 02114, USA
    Psychosomatics 43:310-6. 2002
    ..05). Elevated serum cholesterol levels appear to be associated with poorer response to fluoxetine treatment. Further studies are needed to confirm our findings...
  55. doi request reprint Heat shock protein 90beta: a novel mediator of vitamin D action
    Giana Angelo
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Mineral Bioavailability Laboratory, 711 Washington Street, Boston, MA 02111, USA
    Biochem Biophys Res Commun 367:578-83. 2008
    ..These findings indicate that Hsp90beta is needed for optimal vitamin D responsiveness in the enterocyte and demonstrate a specific role for Hsp90beta in VDR signaling...
  56. pmc Tissue Concentrations of Vitamin K and Expression of Key Enzymes of Vitamin K Metabolism Are Influenced by Sex and Diet but Not Housing in C57Bl6 Mice
    Stephanie G Harshman
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA
    J Nutr 146:1521-7. 2016
    ..There has been limited characterization of biological variables that impact vitamin K metabolism. This gap in knowledge can limit the translation of data obtained from preclinical animal studies to future human studies...
  57. doi request reprint Association between statin use and serum cholesterol concentrations is modified by whole-grain consumption: NHANES 2003-2006
    Huifen Wang
    From the Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA
    Am J Clin Nutr 100:1149-57. 2014
    ..Dietary whole grains have been reported to improve plasma lipid profiles. Little is known about potential interactions between statins and whole grains...
  58. doi request reprint S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages
    Anna C Pfalzer
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts and Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, and
    Physiol Genomics 46:617-23. 2014
    ..Our data indicate that SAM modulates the expression of inflammatory genes in association with changes in specific gene promoter DNA methylation. ..
  59. ncbi request reprint High-density lipoproteins: effects of alcohol, estrogen, and phytoestrogens
    Stefania Lamon-Fava
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Rev 60:1-7. 2002
    ..The molecular mechanisms of action of alcohol, estrogen, and phytoestrogens on HDL are under investigation...
  60. ncbi request reprint Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona, Italy
    Br J Nutr 97:617-21. 2007
    ....

Research Grants1

  1. Estrogen, HDL, and coronary heart disease in women
    Stefania Lamon Fava; Fiscal Year: 2005
    ..The proposed analyses provide a unique opportunity to shed light on the physiological role of HDL subpopulations and HRT on CHD in women. ..