- Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cellsLiza Konnikova
Department of Physiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, Massachusetts 02111, USA
BMC Cancer 3:23. 2003..STAT3, signal transducer and activator of transcription 3, participates in several human cancers by inducing cell proliferation and inhibiting apoptosis and is frequently activated in astrocytomas...
- Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cellsLiza Konnikova
Department of Physiology, Tufts University, Boston, Massachusetts 02111, USA
Cancer Res 65:6516-20. 2005..In addition, we find that growth factors and cytokines stimulate hTERT expression in primary human cells in a STAT3-dependent manner. Thus, STAT3 is a key regulator of hTERT expression in both normal and tumor cells...