Georgios D Kitsios

Summary

Affiliation: Tufts Medical Center
Country: USA

Publications

  1. pmc Genome-wide association studies: hypothesis-"free" or "engaged"?
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Boston, MA, USA Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Transl Res 154:161-4. 2009
  2. pmc Against pragmatism: on efficacy, effectiveness and the real world
    David M Kent
    Institute for Clinical Research and Health Policy Studies and Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, USA
    Trials 10:48. 2009
  3. pmc Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA
    Circ Cardiovasc Genet 4:58-67. 2011
  4. pmc ACE (I/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation
    Georgios Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    BMC Med Genet 10:50. 2009
  5. pmc Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis
    Issa J Dahabreh
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Genet Med 12:606-15. 2010
  6. doi request reprint Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Street, Biopolis, Larissa 41110, Greece
    Am J Epidemiol 171:851-8. 2010
  7. doi request reprint Management strategies for asymptomatic carotid stenosis: a systematic review and meta-analysis
    Gowri Raman
    Center for Clinical Evidence Synthesis and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 158:676-85. 2013
  8. doi request reprint Self-measured blood pressure monitoring in the management of hypertension: a systematic review and meta-analysis
    Katrin Uhlig
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 159:185-94. 2013
  9. pmc Recurrent stroke on imaging and presumed paradoxical embolism: a cross-sectional analysis
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Neurology 78:993-7. 2012
  10. pmc Do observational studies using propensity score methods agree with randomized trials? A systematic comparison of studies on acute coronary syndromes
    Issa J Dahabreh
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Box No 63, Boston, MA 02111, USA
    Eur Heart J 33:1893-901. 2012

Detail Information

Publications27

  1. pmc Genome-wide association studies: hypothesis-"free" or "engaged"?
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Boston, MA, USA Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Transl Res 154:161-4. 2009
    ....
  2. pmc Against pragmatism: on efficacy, effectiveness and the real world
    David M Kent
    Institute for Clinical Research and Health Policy Studies and Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, USA
    Trials 10:48. 2009
    ..Simplistic interpretation of pragmatic trials runs the risk of driving harmful policies...
  3. pmc Heterogeneity of the phenotypic definition of coronary artery disease and its impact on genetic association studies
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center and Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA
    Circ Cardiovasc Genet 4:58-67. 2011
    ..We assessed the extent of phenotypic heterogeneity and quantified its impact in a large literature sample of association studies...
  4. pmc ACE (I/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation
    Georgios Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    BMC Med Genet 10:50. 2009
    ..The role of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in modifying the response to treatment modalities in coronary artery disease is controversial...
  5. pmc Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis
    Issa J Dahabreh
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, USA
    Genet Med 12:606-15. 2010
    ..We performed a meta-analysis of published studies investigating the association between ischemic stroke and two nonsynonymous PON1 polymorphisms, rs662 (p.Q192R) and rs854560 (p.L55M) in humans...
  6. doi request reprint Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, 2 Panepistimiou Street, Biopolis, Larissa 41110, Greece
    Am J Epidemiol 171:851-8. 2010
    ..CUMAGAS-OSTEO may be a useful tool for identifying pertinent gene-osteoarthritis associations and providing an updated summary of risk effects...
  7. doi request reprint Management strategies for asymptomatic carotid stenosis: a systematic review and meta-analysis
    Gowri Raman
    Center for Clinical Evidence Synthesis and Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 158:676-85. 2013
    ..Adults with asymptomatic carotid artery stenosis are at increased risk for ipsilateral carotid territory ischemic stroke...
  8. doi request reprint Self-measured blood pressure monitoring in the management of hypertension: a systematic review and meta-analysis
    Katrin Uhlig
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann Intern Med 159:185-94. 2013
    ..Clinical guidelines recommend that adults with hypertension self-monitor their blood pressure (BP)...
  9. pmc Recurrent stroke on imaging and presumed paradoxical embolism: a cross-sectional analysis
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Neurology 78:993-7. 2012
    ..Such clinical indicators of paradoxical embolism are commonly viewed as risk factors for CS recurrence, but precise risk estimates are lacking...
  10. pmc Do observational studies using propensity score methods agree with randomized trials? A systematic comparison of studies on acute coronary syndromes
    Issa J Dahabreh
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, 800 Washington Street, Box No 63, Boston, MA 02111, USA
    Eur Heart J 33:1893-901. 2012
    ..We aimed to systematically assess agreement between observational studies using PS methods and RCTs on therapeutic interventions for ACS...
  11. pmc XbaI GLUT1 gene polymorphism and the risk of type 2 diabetes with nephropathy
    Ioannis Stefanidis
    Department of Nephrology, University of Thessaly, School of Medicine, Larissa, Greece
    Dis Markers 27:29-35. 2009
    ..12 (0.55-2.26). Thus, the GLUT1 XbaI(-) allele is associated with DM, and possibly with a more severe form of the disease that can lead to development of DN...
  12. pmc Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database
    Georgios D Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Am J Hypertens 23:305-13. 2010
    ..To clarify these data, a systematic assessment of GAS for adrenoceptor family genes in hypertension was conducted...
  13. pmc An NOS3 Haplotype is Protective against Hypertension in a Caucasian Population
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Tufts MC no 63, Boston, MA 02111, USA
    Int J Hypertens 2010:865031. 2010
    ..5%) compared to cases (2%). These results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension...
  14. doi request reprint Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer: a genetic association study and meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    J Hum Genet 55:743-8. 2010
    ..The available evidence from our study and the meta-analysis cannot support a major contributory role of these common NOS3 polymorphisms in BC, although future larger studies may help in drawing safer conclusions about the genetics of BC...
  15. doi request reprint Can We Trust Observational Studies Using Propensity Scores in the Critical Care Literature? A Systematic Comparison With Randomized Clinical Trials
    Georgios D Kitsios
    1Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 2Center for Evidence Based Medicine, School of Public Health, Brown University, Providence, RI 3Department of Health Services, Policy and Practice, School of Public Health, Brown University, Providence, RI 4Division Pulmonary, Critical Care, Allergy, and Sleep, Medical University of South Carolina, Charleston, SC 5Predictive Analytics and Comparative Effectiveness Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 6Department of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, MA
    Crit Care Med 43:1870-9. 2015
    ..To assess the degree of agreement between propensity score studies and randomized clinical trials in critical care research...
  16. pmc Auto-titrating versus fixed continuous positive airway pressure for the treatment of obstructive sleep apnea: a systematic review with meta-analyses
    Stanley Ip
    Institute of Clinical Research and Health Policy Studies, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA
    Syst Rev 1:20. 2012
    ..Obstructive sleep apnea is a relatively common disorder that can lead to lost productivity and cardiovascular disease. The form of positive airway treatment that should be offered is unclear...
  17. doi request reprint Improved amputation-free survival in unreconstructable critical limb ischemia and its implications for clinical trial design and quality measurement
    Eric Benoit
    The Cardio Vascular Center, Tufts Medical Center, Boston, MA 02111, USA
    J Vasc Surg 55:781-9. 2012
    ....
  18. pmc Patent foramen ovale closure and medical treatments for secondary stroke prevention: a systematic review of observational and randomized evidence
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
    Stroke 43:422-31. 2012
    ..We synthesized the available evidence on secondary stroke prevention in patients with patent foramen ovale and cryptogenic stroke...
  19. doi request reprint Randomized trials of dopamine agonists in restless legs syndrome: a systematic review, quality assessment, and meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Clin Ther 32:221-37. 2010
    ..The use of dopamine agonists (DAs) for the treatment of restless legs syndrome (RLS) has been assessed in numerous randomized clinical trials (RCTs)...
  20. doi request reprint MTHFR gene polymorphisms and response to chemotherapy in colorectal cancer: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa 41222, Greece
    Pharmacogenomics 10:1285-94. 2009
    ..In an attempt to interpret these results, a meta-analysis of all eligible studies published up until January 2009 was carried out...
  21. doi request reprint Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis
    Elias Zintzaras
    Center for Clinical Evidence Synthesis, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Arch Intern Med 168:1077-89. 2008
    ..To shed light on these inconclusive findings, we conducted a meta-analysis of studies relating the ACE I/D polymorphic variant to the risk of CAD...
  22. doi request reprint The vulnerable atherosclerotic plaque: scope of the literature
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Tufts University School of Medicine, Boston, MA, USA
    Ann Intern Med 153:387-95. 2010
    ..Large prospective studies in patients with and without previous cardiovascular events during long follow-up are required to validate this concept...
  23. pmc Laboratory mouse models for the human genome-wide associations
    Georgios D Kitsios
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13782. 2010
    ....
  24. pmc Genomic convergence of genome-wide investigations for complex traits
    Georgios D Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa 41222, Greece
    Ann Hum Genet 73:514-9. 2009
    ....
  25. ncbi request reprint Genetic variation associated with ischemic heart failure: a HuGE review and meta-analysis
    Georgios Kitsios
    Department of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece
    Am J Epidemiol 166:619-33. 2007
    ..Case-control studies that investigate gene-gene and gene-environment interactions might further elucidate the genetics of ischemic heart failure...
  26. ncbi request reprint Heterogeneity-based genome search meta-analysis for preeclampsia
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, Larissa, 41222, Greece
    Hum Genet 120:360-70. 2006
    ..Results should be interpreted with caution as the p values were modest. Further investigation of these regions by genotyping with additional markers and families may help to direct the identification of candidate genes for preeclampsia...
  27. ncbi request reprint Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis
    Elias Zintzaras
    Department of Biomathematics, University of Thessaly School of Medicine, Papakyriazi 22, 41222 Larissa, Greece
    Hypertension 48:700-10. 2006
    ..In conclusion, there is evidence of association only between 4b/a polymorphism and hypertension; however, studies exploring combinations of the polymorphisms may help us better understand the genetics of hypertension...