Simonetta Friso

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi request reprint A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Anal Chem 74:4526-31. 2002
  2. ncbi request reprint Gene-nutrient interactions and DNA methylation
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2382S-2387S. 2002
  3. pmc Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 104:24-30. 2010
  4. ncbi request reprint Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    Mary K Keyes
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
    J Nutr 137:1713-7. 2007
  5. ncbi request reprint Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:1206-12. 2003
  6. ncbi request reprint Folate supplementation increases genomic DNA methylation in the liver of elder rats
    SANG WOON CHOI
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:31-5. 2005
  7. ncbi request reprint Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Eur J Nutr . 2015
  8. pmc Aging and alcohol interact to alter hepatic DNA hydroxymethylation
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts
    Alcohol Clin Exp Res 38:2178-85. 2014
  9. doi request reprint Nutritional influences on epigenetics and age-related disease
    Lara K Park
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 71:75-83. 2012
  10. pmc DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging
    Kyong Chol Kim
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 20:917-26. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Anal Chem 74:4526-31. 2002
    ..9 (within-day) and 1.7 (day-to-day). This LC/MS method for quantitative determination of genomic DNA methylation status is rapid, sensitive, selective, and precise...
  2. ncbi request reprint Gene-nutrient interactions and DNA methylation
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2382S-2387S. 2002
    ....
  3. pmc Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 104:24-30. 2010
    ....
  4. ncbi request reprint Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    Mary K Keyes
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
    J Nutr 137:1713-7. 2007
    ..041), but not in the folate-deplete group. In conclusion, aging decreases genomic DNA methylation and increases promoter methylation and expression of p16 in mouse colons. This effect is dependent on the level of dietary folate...
  5. ncbi request reprint Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:1206-12. 2003
    ..However, folate supplementation is as effective at sustaining adequate colonic folate status in elder rats as it is in the young...
  6. ncbi request reprint Folate supplementation increases genomic DNA methylation in the liver of elder rats
    SANG WOON CHOI
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:31-5. 2005
    ..48, P=0.004). In the liver of this animal model, dietary folate over a wide range of intakes modulates genomic DNA methylation...
  7. ncbi request reprint Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Eur J Nutr . 2015
    ....
  8. pmc Aging and alcohol interact to alter hepatic DNA hydroxymethylation
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts
    Alcohol Clin Exp Res 38:2178-85. 2014
    ..Furthermore, it has not been tested whether aging and alcohol interact to modify this epigenetic phenomenon, thereby having an independent effect on gene expression...
  9. doi request reprint Nutritional influences on epigenetics and age-related disease
    Lara K Park
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Proc Nutr Soc 71:75-83. 2012
    ..Future work in this field seeks to characterise the epigenetic pattern of healthy aging to ultimately identify nutritional measures to achieve this pattern...
  10. pmc DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging
    Kyong Chol Kim
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr Biochem 20:917-26. 2009
    ..In this review, we address the effect of folate on early development and aging through an epigenetic mechanism, DNA methylation...
  11. ncbi request reprint Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort
    Giuseppina T Russo
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3416-21. 2003
    ..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations...
  12. ncbi request reprint Interactions between folate and aging for carcinogenesis
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem Lab Med 43:1151-7. 2005
    ..These studies have further indicated that modest folate supplementation may reverse or partially ameliorate those adverse effects induced by folate depletion and aging...
  13. ncbi request reprint Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    J Nutr 134:750-5. 2004
    ..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis...
  14. pmc A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:5606-11. 2002
    ..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status...
  15. pmc Iron Supplementation Reverses the Reduction of Hydroxymethylcytosine in Hepatic DNA Associated With Chronic Alcohol Consumption in Rats
    Stephanie A Tammen
    Friedman School of Nutrition Science and Policy Tufts University, Boston, MA, USA
    J Cancer Prev 21:264-270. 2016
    ..In the present study we aimed to determine the effects of alcohol on DNA hydroxymethylation and further effects of iron on alcohol associated epigenetic changes...
  16. pmc Epigenetics: the link between nature and nurture
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University, Boston, MA 02111, USA
    Mol Aspects Med 34:753-64. 2013
    ..The interaction between types of epigenetic modifications in response to environmental factors and how environmental cues affect epigenetic patterns will further elucidate how gene transcription can be affectively altered...
  17. pmc Epigenetics: A New Bridge between Nutrition and Health
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111
    Adv Nutr (Bethesda) 1:8-16. 2010
    ....
  18. doi request reprint Vitamin B6 and cardiovascular disease
    Simonetta Friso
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:265-90. 2012
    ....
  19. doi request reprint Vitamins B6 and cancer
    SANG WOON CHOI
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:247-64. 2012
    ..This chapter addressed currently available information regarding the relationship between vitamin B6 and cancer...
  20. ncbi request reprint The potential cocarcinogenic effect of vitamin B12 deficiency
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Clin Chem Lab Med 43:1158-63. 2005
    ....
  21. ncbi request reprint Gene-nutrient interactions in one-carbon metabolism
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico Giambattista Rossi, P le L A Scuro, 10, 37134 Verona, Italy
    Curr Drug Metab 6:37-46. 2005
    ....
  22. ncbi request reprint The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico Giambattista Rossi, Piazza Ludovico Antonio Scuro, 10, 37134 Verona, Italy
    Cancer Epidemiol Biomarkers Prev 14:938-43. 2005
    ..Further mechanistic studies are warranted to investigate how single polymorphisms as well as MTHFR combined genotypes exert their effect on cancer susceptibility...
  23. ncbi request reprint Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona, Italy
    Br J Nutr 97:617-21. 2007
    ....
  24. ncbi request reprint Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and "insulin-resistant" T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Clin Chem 51:360-7. 2005
    ..The T-455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apo C-III concentrations. Long-chain n-3 polyunsaturated fatty acids (PUFAs) contained in fish have well-known apo C-III-lowering properties...
  25. pmc Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    PLoS ONE 3:e1523. 2008
    ..The aim of this study was to evaluate the combined effect of ten common prothrombotic polymorphisms as a determinant of MI...
  26. ncbi request reprint Influence of polymorphisms in the factor VII gene promoter on activated factor VII levels and on the risk of myocardial infarction in advanced coronary atherosclerosis
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Thromb Haemost 92:541-9. 2004
    ..This study highlights a "within-gene" interaction, and the need to explore polymorphisms in candidate gene(s) in detail...
  27. doi request reprint Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Atherosclerosis 199:323-7. 2008
    ..Little is known, however, of human HSD11B2 epigenetic control and its relationship with the onset of hypertension...
  28. ncbi request reprint Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    J Lipid Res 44:2374-81. 2003
    ..6% vs. 34.8%, P < 0.05). In conclusion, apoC-III-rich lipoprotein metabolism and the APOC3 polymorphism have relevant impacts on the CAD risk of MS patents...
  29. ncbi request reprint The interaction between MTHFR 677 C-->T genotype and folate status is a determinant of coronary atherosclerosis risk
    Domenico Girelli
    Department of Clinical and Experimental Medicine, Institute of Biology and Genetics, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    J Nutr 133:1281-5. 2003
    ..8, 95% CI, 1.03-3.15). A gene-nutrient interaction that defines a higher risk for CAD is determined by folate levels below specific thresholds, which differ depending on the MTHFR 677 C-->T genotype...
  30. ncbi request reprint S-adenosyl-L-methionine increases skeletal muscle mitochondrial DNA density and whole body insulin sensitivity in OLETF rats
    Cheng Ji Jin
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Nutr 137:339-44. 2007
    ..752, P<0.001). In conclusion, SAM treatment increased mtDNA density in the skeletal muscle, improved whole body insulin sensitivity, and prevented body weight gain in OLETF rats...