A M Cuervo

Summary

Affiliation: Tufts University
Country: USA

Publications

  1. ncbi Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 55:529-45. 1999
  2. ncbi Selective degradation of annexins by chaperone-mediated autophagy
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 275:33329-35. 2000
  3. ncbi A receptor for the selective uptake and degradation of proteins by lysosomes
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Science 273:501-3. 1996
  4. ncbi Unique properties of lamp2a compared to other lamp2 isoforms
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, Boston, MA, USA
    J Cell Sci 113:4441-50. 2000
  5. pmc IkappaB is a substrate for a selective pathway of lysosomal proteolysis
    A M Cuervo
    Department of Physiology, Tufts University, School of Medicine, Boston, Massachusetts 02111, USA
    Mol Biol Cell 9:1995-2010. 1998
  6. pmc Chaperone-mediated autophagy
    S Kaushik
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, NY, USA
    Methods Mol Biol 445:227-44. 2008
  7. ncbi LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells
    C N Adra
    Division of Hematology Oncology, Harvard Medical School, Boston, Massachusetts, 02215, USA
    Genomics 35:328-37. 1996
  8. pmc Autophagy as a cell-repair mechanism: activation of chaperone-mediated autophagy during oxidative stress
    S Kaushik
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building room 611D, Bronx, NY 10461, USA
    Mol Aspects Med 27:444-54. 2006

Collaborators

  • J A Barnes
  • S Kaushik
  • C N Adra
  • J L Ko
  • J D Rowley
  • J C Guillemot
  • J M Lelias
  • S Zhu
  • H Kobayashi
  • B Lim
  • T Horiuchi

Detail Information

Publications8

  1. ncbi Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Kidney Int 55:529-45. 1999
    ..Because a portion of alpha 2 mu resides in the cytosol of kidney cells, we decided to analyze whether this cytosolic form also contributes to the abnormal lysosomal accumulation of alpha 2 mu after exposure to chemicals...
  2. ncbi Selective degradation of annexins by chaperone-mediated autophagy
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 275:33329-35. 2000
    ..These results provide striking evidence for the importance of KFERQ motifs in substrates of chaperone-mediated autophagy...
  3. ncbi A receptor for the selective uptake and degradation of proteins by lysosomes
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Science 273:501-3. 1996
    ..Overexpression of human LGP96 in Chinese hamster ovary cells increased the activity of the selective lysosomal proteolytic pathway in vivo and in vitro...
  4. ncbi Unique properties of lamp2a compared to other lamp2 isoforms
    A M Cuervo
    Department of Physiology, Tufts University School of Medicine, Boston, MA, USA
    J Cell Sci 113:4441-50. 2000
    ..These characteristics may be important for lamp2a to act as a receptor for chaperone-mediated autophagy...
  5. pmc IkappaB is a substrate for a selective pathway of lysosomal proteolysis
    A M Cuervo
    Department of Physiology, Tufts University, School of Medicine, Boston, Massachusetts 02111, USA
    Mol Biol Cell 9:1995-2010. 1998
    ..In addition, the response of nuclear factor kappa B to several stimuli increases when this lysosomal pathway of proteolysis is activated...
  6. pmc Chaperone-mediated autophagy
    S Kaushik
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, NY, USA
    Methods Mol Biol 445:227-44. 2008
    ..However, the most unequivocal method to measure CMA is by directly tracking the translocation of substrate proteins into isolated lysosomes...
  7. ncbi LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells
    C N Adra
    Division of Hematology Oncology, Harvard Medical School, Boston, Massachusetts, 02215, USA
    Genomics 35:328-37. 1996
    ..The expression pattern of the gene together with preliminary evidence that the protein interacts with ubiquitin indicates that the protein may have a special functional role during embryogenesis and in adult hematopoietic cells...
  8. pmc Autophagy as a cell-repair mechanism: activation of chaperone-mediated autophagy during oxidative stress
    S Kaushik
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building room 611D, Bronx, NY 10461, USA
    Mol Aspects Med 27:444-54. 2006
    ..The consequences of an impairment in CMA activity, observed during aging and in some age-related disorders, are also discussed...