Tufts University

Summary

Organization: Tufts University
Country: USA

Top Publications

  1. doi Electron microscopic findings in skin biopsies from patients with Danon disease
    Joseph Alroy
    Department of Pathology, Tufts University, Cummings Veterinary School, Boston, Massachusetts, USA
    Ultrastruct Pathol 34:333-6. 2010
  2. pmc Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Cancer 123:519-25. 2008
  3. ncbi Effect of Tribolium castaneum (Coleoptera: Tenebrionidae) nutritional environment, sex, and mating status on response to commercial pheromone traps
    T Y Fedina
    Department of Biology, Tufts University, Medford, MA 02155, USA
    J Econ Entomol 100:1924-7. 2007
  4. doi Follow-on drugs and indications: the importance of incremental innovation to medical practice
    Joshua Cohen
    Tufts Center for the Study of Drug Development, Tufts University, Boston, MA 02111, USA
    Am J Ther 15:89-91. 2008
  5. ncbi Response to teriparatide in patients with baseline 25-hydroxyvitamin D insufficiency or sufficiency
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111 1524, USA
    J Clin Endocrinol Metab 92:4630-6. 2007
  6. pmc Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis
    Elena N Naumova
    Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston MA 02111, USA
    Environ Health 6:21. 2007
  7. pmc Seasonality in six enterically transmitted diseases and ambient temperature
    E N Naumova
    Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Epidemiol Infect 135:281-92. 2007
  8. ncbi Role of LCAT in HDL remodeling: investigation of LCAT deficiency states
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:592-9. 2007
  9. ncbi Effect of rehabilitation facility location on outcomes in head and neck surgical patients
    N Bhatia
    Tufts University School of Medicine, Boston, MA, USA
    Eur J Cancer Care (Engl) 15:458-62. 2006
  10. pmc Highly fit ancestors of a partly sexual haploid population
    I M Rouzine
    Department of Microbiology and Molecular Biology, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
    Theor Popul Biol 71:239-50. 2007

Research Grants

  1. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
  2. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2007
  3. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
  5. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2005
  6. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2010
  7. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2009
  8. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis C Theoharides; Fiscal Year: 2010
  9. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose M Ordovas; Fiscal Year: 2010
  10. Vitamin K: Genetics of Vascular Calcification
    Jose Ordovas; Fiscal Year: 2005

Detail Information

Publications62

  1. doi Electron microscopic findings in skin biopsies from patients with Danon disease
    Joseph Alroy
    Department of Pathology, Tufts University, Cummings Veterinary School, Boston, Massachusetts, USA
    Ultrastruct Pathol 34:333-6. 2010
    ..In the current study we demonstrated that electron microscopy of a more accessible tissue, skin biopsies, is a useful method in the diagnosis of Danon disease...
  2. pmc Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2
    Zhenhua Liu
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Int J Cancer 123:519-25. 2008
    ....
  3. ncbi Effect of Tribolium castaneum (Coleoptera: Tenebrionidae) nutritional environment, sex, and mating status on response to commercial pheromone traps
    T Y Fedina
    Department of Biology, Tufts University, Medford, MA 02155, USA
    J Econ Entomol 100:1924-7. 2007
    ..These results suggest that estimating T. castaneum population densities based on trap catches might be improved by incorporating information about the nutritional quality of infested stored products...
  4. doi Follow-on drugs and indications: the importance of incremental innovation to medical practice
    Joshua Cohen
    Tufts Center for the Study of Drug Development, Tufts University, Boston, MA 02111, USA
    Am J Ther 15:89-91. 2008
  5. ncbi Response to teriparatide in patients with baseline 25-hydroxyvitamin D insufficiency or sufficiency
    Bess Dawson-Hughes
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, Massachusetts 02111 1524, USA
    J Clin Endocrinol Metab 92:4630-6. 2007
    ..Serum 25-hydroxyvitamin D (25OHD) concentrations greater than 30 ng/ml have been recommended for lowering fracture risk...
  6. pmc Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis
    Elena N Naumova
    Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston MA 02111, USA
    Environ Health 6:21. 2007
    ....
  7. pmc Seasonality in six enterically transmitted diseases and ambient temperature
    E N Naumova
    Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Epidemiol Infect 135:281-92. 2007
    ..This highly relevant to disease surveillance approach can be used to generate and test hypotheses related to disease seasonality and potential routes of transmission with respect to environmental factors...
  8. ncbi Role of LCAT in HDL remodeling: investigation of LCAT deficiency states
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Lipid Res 48:592-9. 2007
    ....
  9. ncbi Effect of rehabilitation facility location on outcomes in head and neck surgical patients
    N Bhatia
    Tufts University School of Medicine, Boston, MA, USA
    Eur J Cancer Care (Engl) 15:458-62. 2006
    ..The length of stay, hospital re-admission rate and frequency of complications does not correlate with the proximity of the rehabilitation facility to the hospital where the patients received their surgery...
  10. pmc Highly fit ancestors of a partly sexual haploid population
    I M Rouzine
    Department of Microbiology and Molecular Biology, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
    Theor Popul Biol 71:239-50. 2007
    ..We generalize these results to the case of moderately small r to conclude that, regardless of fitness of an individual, all its distant ancestors are exceptionally well fit...
  11. ncbi Should we target HDL-cholesterol to reduce coronary heart disease risk?
    Ernst J Schaefer
    Cardiovascular Research Laboratory, Tufts University School of Medicine, Boston, MA 02111, USA
    Nat Clin Pract Endocrinol Metab 2:358-9. 2006
  12. ncbi Cholesteryl ester transfer protein inhibition, high-density lipoprotein metabolism and heart disease risk reduction
    Ernst J Schaefer
    Cardiovascular Research and Lipid Metabolism Laboratories, Tufts University, Boston, Massachusetts, USA
    Curr Opin Lipidol 17:394-8. 2006
    ....
  13. ncbi Barriers to assessment and treatment of pain in laboratory animals
    Alicia Z Karas
    Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA 01536, USA
    Lab Anim (NY) 35:38-45. 2006
    ..The author attempts to identify specific barriers to reduction of pain in laboratory animals. She then seeks to determine the relative importance of each obstacle and to develop approaches to overcoming each obstacle...
  14. ncbi Energy requirements and aging
    Susan B Roberts
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington St, Boston, MA 02111, USA
    Public Health Nutr 8:1028-36. 2005
    ..To summarise the literature on energy requirements and aging...
  15. pmc Waist-to-height ratio is correlated with height in US children and adolescents aged 2-18 years
    David J Tybor
    Friedman School of Nutrition Science and Policy at Tufts University, Boston, MA, USA
    Int J Pediatr Obes 3:148-51. 2008
    ..Future research should investigate how this affects relationships between central adiposity and cardiovascular disease risk factors across these ages, and how using a power other than 1 might reduce bias and improve precision...
  16. pmc Time travel through language: temporal shifts rapidly decrease information accessibility during reading
    Tali Ditman
    Tufts University, Medford, Massachusetts 02155, USA
    Psychon Bull Rev 15:750-6. 2008
    ..For the anaphor, the N400 was modulated in the opposite direction. Thus, the introduction of a temporal discontinuity leads to immediate neural integration costs, as well as to decreased accessibility of earlier information...
  17. doi MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings
    Mitch McVey
    Department of Biology, Tufts University, 165 Packard Avenue, Medford, MA 02155, USA
    Trends Genet 24:529-38. 2008
    ..We propose a mechanistic model for MMEJ and highlight important questions for future research...
  18. doi Vitamin D and autoimmune rheumatologic disorders
    Christina F Pelajo
    Floating Hospital for Children, Tufts Medical Center, United States
    Autoimmun Rev 9:507-10. 2010
    ..If vitamin D deficiency occurs at a higher rate in patients with autoimmune disorders, then appropriate supplementation may be indicated...
  19. pmc Antibodies to watch in 2010
    Janice M Reichert
    Tufts Center for the Study of Drug Development, Boston, MA, USA
    MAbs 2:84-100. 2010
    ..Current as of October 2009, the results presented here will serve as a baseline against which future progress can be measured...
  20. pmc Electron lambda-tomography
    Eric Todd Quinto
    Department of Mathematics, Tufts University, Medford, MA 02155, USA
    Proc Natl Acad Sci U S A 106:21842-7. 2009
    ..In particular, compared to these standard methods, electron lambda-tomography is less sensitive to artifacts that come from structures outside the region that is being reconstructed, and it can sharpen boundaries...
  21. pmc Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway
    Thomas M van Himbergen
    Lipid Metabolism Laboratory, Tufts University, 711 Washington Street, Boston, MA 02111 1524, USA
    Arterioscler Thromb Vasc Biol 30:113-20. 2010
    ..In light of prior metabolic and genetic research, our purpose was to ascertain whether FCH cases had significant abnormalities of plasma markers of cholesterol synthesis and absorption as compared to unaffected kindred members...
  22. pmc Global gene expression patterns in the post-pneumonectomy lung of adult mice
    Julia A Paxson
    Department of Clinical Sciences, Lung Function Testing Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA
    Respir Res 10:92. 2009
    ..We examined the transcriptomic responses to single lung pneumonectomy in adult mice in order to elucidate prospective molecular signaling mechanisms used in this species during lung regeneration...
  23. doi A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study
    M Junyent
    The Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University School of Medicine, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 20:157-64. 2010
    ....
  24. ncbi The Massachusetts Commonwealth Health Insurance Connector: structure and functions
    Amy M Lischko
    Tufts University School of Medicine, USA
    Issue Brief (Commonw Fund) 55:1-14. 2009
    ..National policymakers looking to achieve similar policy goals may find some of the structural components and functions of the Connector to be transferable to a national health reform model, say the authors...
  25. pmc Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD
    Nirupa R Matthan
    Cardiovascular Nutrition, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 50:1927-35. 2009
    ..These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population...
  26. ncbi Reconstruction of nonvital teeth using direct fiber-reinforced composite resin: a pilot clinical study
    Simone Deliperi
    Tufts University School of Dental Medicine, Boston, MA, USA
    J Adhes Dent 11:71-8. 2009
    ..To evaluate the clinical performance of direct Class II fiber-reinforced composite restorations on nonvital teeth...
  27. pmc Seasonality of cryptosporidiosis: A meta-analysis approach
    Jyotsna S Jagai
    Department of Public Health and Family Medicine, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Environ Res 109:465-78. 2009
    ..We developed methodology for and conducted a meta-analysis to examine how seasonal patterns of cryptosporidiosis, a primarily waterborne diarrheal illness, relate to precipitation and temperature fluctuations worldwide...
  28. doi Designing graduate training programs in conservation medicine-producing the right professionals with the right tools
    Gretchen E Kaufman
    Tufts Center for Conservation Medicine, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA 01536, USA
    Ecohealth 5:519-27. 2008
    ..We review existing programs that offer conservation medicine content, and provide examples of where opportunities exist for those interested in pursuing a conservation medicine career...
  29. ncbi Alpha-Tocopherol counteracts ritonavir-induced proinflammatory cytokines expression in differentiated THP-1 cells
    Weimin Guo
    Vascular Biology Laboratory, JM USDA HNRCA at Tufts University, Boston, MA 02111, USA
    Biofactors 31:171-9. 2007
    ....
  30. doi Nutrition and age-associated inflammation: implications for disease prevention
    Simin Nikbin Meydani
    JMUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    JPEN J Parenter Enteral Nutr 32:626-9. 2008
    ..Nutrient/dietary medications, such as antioxidants and certain lipids have suggested a promising route to reduce the age-related increase in COX activity and PGE(2) production that is associated with several disease states...
  31. ncbi Towards the simplest hydrodynamic lattice-gas model
    Bruce M Boghosian
    Department of Mathematics, Tufts University, Medford, MA 02155, USA
    Philos Trans A Math Phys Eng Sci 360:333-44. 2002
    ..In this work, we derive the equilibrium distribution function for this lattice-gas automaton and carry out the Chapman-Enskog analysis to determine the form of the Navier-Stokes equations...
  32. ncbi Transgenerational consequences of adolescent morphine exposure in female rats: effects on anxiety-like behaviors and morphine sensitization in adult offspring
    Elizabeth M Byrnes
    Department of Biomedical Sciences, Tufts University, Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA
    Psychopharmacology (Berl) 182:537-44. 2005
    ..The purpose of the present study was to determine whether exposing female rats to morphine during the peripubertal period can alter the adult behavior of their offspring...
  33. ncbi Pharmacogenetics of Lipid-lowering Therapies
    Jose M Ordovas
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Curr Atheroscler Rep 4:183-92. 2002
    ..Future progress in this area will be driven by studying gene-gene and gene-treatment interactions in much larger patient populations...
  34. ncbi Client donation program for acquiring dogs and cats to teach veterinary gross anatomy
    A M Kumar
    Department of Biomedical Sciences, School of Veterinary Medicine, Tufts University, 200 Westboro Road, N Grafton, MA 01536, USA
    J Vet Med Educ 28:73-7. 2001
    ..for procuring dogs and cats to meet the needs of anatomical instruction was initiated six years ago at Tufts University School of Veterinary Medicine...
  35. pmc Corticosterone levels predict survival probabilities of Galapagos marine iguanas during El Nino events
    L M Romero
    Department of Biology, Tufts University, Medford, MA 02155, USA
    Proc Natl Acad Sci U S A 98:7366-70. 2001
    ..Our results lend support to the use of corticosterone as a rapid quantitative predictor of survival in wild animal populations...
  36. ncbi Cross-sectional imaging techniques in veterinary ophthalmology
    D Penninck
    Department of Clinical Sciences, Section of Radiology, School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA 01536, USA
    Clin Tech Small Anim Pract 16:22-39. 2001
    ..Representative clinical cases are presented to illustrate the interpretation principles as well as to provide an illustrative reference for common ocular and orbital changes...
  37. pmc Transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology
    I M Rouzine
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
    Microbiol Mol Biol Rev 65:151-85. 2001
    ..We discuss in detail the application of our results to human immunodeficiency virus population in vivo, sampling effects, and limitations of the model...
  38. ncbi Diagnostic management of interdental spacing
    N Chaimattayompol
    Tufts University School of Dental Medicine, Boston, Mass, USA
    J Prosthet Dent 84:467-9. 2000
    ..This procedure can be used as proposed or for various situations in which complex restorative treatment is needed...
  39. ncbi Vitamin A equivalence of beta-carotene in a woman as determined by a stable isotope reference method
    G Tang
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Eur J Nutr 39:7-11. 2000
    ..Quantitative information on conversion of beta-carotene to vitamin A in humans is limited...
  40. ncbi LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits
    M E Brousseau
    Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Arterioscler Thromb Vasc Biol 20:450-8. 2000
    ..Moreover, LCAT's antiatherogenic effect requires only a single functional LDLr allele, identifying LCAT as an attractive gene therapy candidate for the majority of dyslipoproteinemic patients...
  41. ncbi Hypothalamic involvement in the regulation of maternal behaviour in the rat: inhibitory roles for the ventromedial hypothalamus and the dorsal/anterior hypothalamic areas
    R S Bridges
    Department of Biomedical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA
    J Neuroendocrinol 11:259-66. 1999
    ..These findings indicate that the VMH as well as the DH/AHA exert chronic steroid-dependent inhibitory influences on the induction of maternal behaviour...
  42. pmc A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
    P J Bagley
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 95:13217-20. 1998
    ....
  43. ncbi Recurrent aggressive episodes entrain ultradian heart rate and core temperature rhythms
    W Tornatzky
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Physiol Behav 63:845-53. 1998
    ..We interpret the synchronization of the hemicircadian acrophases to the time point of social confrontations as anticipating the physiological demands of the aggressive encounters...
  44. pmc Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells
    J Coburn
    Division of Rheumatology and Immunology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Infect Immun 66:1946-52. 1998
    ..Our results show that multiple integrins mediate attachment of Lyme disease spirochetes to host cells...
  45. ncbi Oxidative renaturation of hen egg-white lysozyme. Folding vs aggregation
    E De Bernardez Clark
    Department of Chemical Engineering, Tufts University, Medford, Massachusetts 02155, USA
    Biotechnol Prog 14:47-54. 1998
    ..Under conditions which promote disulfide bonding, aggregate size, but not concentration, may increase due to disulfide bond formation, resulting in covalently bonded aggregates...
  46. ncbi A sensitive technique to clone low abundance receptor transcripts from single microdissected tissue punches
    Xinhai Yang
    Anesthesia Research Lab, Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Brain Res Brain Res Protoc 9:135-46. 2002
    ..Several ORs were amplified, cloned and sequenced from a series of individual tissue punches, and in situ hybridization was used to verify the presence of mRNA corresponding to the cloned OR sequences in MOB sections...
  47. ncbi Folate, homocysteine, and neurological function
    Martha Savaria Morris
    Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, 9th Floor, Boston, MA 02111, USA
    Nutr Clin Care 5:124-32. 2002
    ....
  48. ncbi Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3
    Susan S Harris
    Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University Boston, Massachusetts 02111, USA
    J Am Coll Nutr 21:357-62. 2002
    ..This study was conducted to determine whether there are age differences in the plasma parent vitamin D and 25-hydroxyvitamin D (25OHD) responses to eight weeks of supplementation with 20 microg/day of vitamin D3...
  49. pmc Background gamma rhythmicity and attention in cortical local circuits: a computational study
    Christoph Börgers
    Department of Mathematics, Tufts University, Medford, MA 02155, USA
    Proc Natl Acad Sci U S A 102:7002-7. 2005
    ..We suggest that such rhythms accompany states of preparatory attention or vigilance and report simulations demonstrating that their presence can amplify stimulus-specific responses and enhance stimulus competition within a local circuit...
  50. pmc A contact-activated kinase signals Candida albicans invasive growth and biofilm development
    Carol A Kumamoto
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 102:5576-81. 2005
    ..Because responding to contact appropriately allows coordinated cellular behavior in a metazoan, commensal C. albicans cells behave like a part of the host, using contact-activated signaling to regulate fungal behavior...
  51. ncbi The APOA1/C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk
    Chao Qiang Lai
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Curr Opin Lipidol 16:153-66. 2005
    ..In addition, we use genomic information from several species to draw inferences about the location of functional variants within this cluster...
  52. ncbi Collecting baseline corticosterone samples in the field: is under 3 min good enough?
    L Michael Romero
    Department of Biology, Tufts University, Medford, MA 02155, USA
    Comp Biochem Physiol A Mol Integr Physiol 140:73-9. 2005
    ....
  53. pmc CD155/PVR plays a key role in cell motility during tumor cell invasion and migration
    Kevin E Sloan
    Department of Physiology, Tufts University School of Medicine, Boston, MA, USA
    BMC Cancer 4:73. 2004
    ..Invasion is an important early step of cancer metastasis that is not well understood. Developing therapeutics to limit metastasis requires the identification and validation of candidate proteins necessary for invasion and migration...
  54. ncbi Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
    Bela F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    J Lipid Res 45:448-55. 2004
    ....
  55. ncbi A new method for quantifying encephalization in the growing individual
    Tracey H Joffe
    Institute of Child Health, MRC Childhood Nutrition Research Centre, 30 Guilford Street, London WC1N 1EH, UK
    J Theor Biol 225:361-7. 2003
    ..Derived SD scores may also be applied to correlation and regression analyses where statistical relationships with other variables are of interest...
  56. ncbi Human requirements for fat-soluble vitamins, and other things concerning these nutrients
    Norman I Krinsky
    Department of Biochemistry, Sackler School of Graduate Biomedical Science, School of Medicine and the USDA Human Nutrition Research Center on Aging at Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA
    Mol Aspects Med 24:317-24. 2003
  57. ncbi Ral-GTPases: approaching their 15 minutes of fame
    Larry A Feig
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    Trends Cell Biol 13:419-25. 2003
    ..Recent studies have yielded insights into previously unappreciated roles for Ral-GTPases in intensively investigated disciplines such as vesicle trafficking, cell morphology, transcription and possibly even human oncogenesis...
  58. ncbi Human cytochromes mediating gepirone biotransformation at low substrate concentrations
    David J Greenblatt
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts New England Medical Center, Boston MA 02111, USA
    Biopharm Drug Dispos 24:87-94. 2003
    ..CYP2D6 would account for less than 5% of net clearance. The findings are consistent with previous in vitro studies of gepirone using higher substrate concentrations...
  59. ncbi Biobehavioral influences on energy intake and adult weight gain
    Megan A McCrory
    Energy Metabolism Laboratory, The Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    J Nutr 132:3830S-3834S. 2002
    ..We provide a brief overview of the evidence to date for the role of these biobehavioral factors in contributing to excess energy intake and increases in body weight over time...
  60. ncbi Weight loss and body-composition changes in men and women infected with HIV
    Janet E Forrester
    Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Clin Nutr 76:1428-34. 2002
    ..The nature of body-composition changes in HIV-associated weight loss is unclear...
  61. ncbi Calcium supplement and bone medication use in a US Medicare health maintenance organization
    B Dawson-Hughes
    Calcium and Bone Metabolism Laboratory at the Jean Mayer USDA Human Nutrition Research Center, Boston, MA 02111, USA
    Osteoporos Int 13:657-62. 2002
    ..Based on the results of this survey, many elderly men and women may benefit from increased utilization of calcium supplements and bone-active medications...
  62. ncbi A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans
    F R Jackson
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Genomics 41:444-52. 1997
    ..These common sequence features and comparisons among a large collection of RRM proteins suggest that the human and mouse proteins represent homologues of Drosophila lark...

Research Grants62

  1. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..They may also help explain some key events in the pathophysiology of migraines, the clinical symptoms of which are often precipitated by stress. ..
  2. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2007
    ..This is an important and under investigated area of skin pathophysiology that has potential applicability to understanding the pathogenesis of skin diseases and screening compounds that may develop into novel and effective treatments. ..
  3. Mast cells, antidepressants and chronic fatigue syndrome
    Theoharis Theoharides; Fiscal Year: 2007
    ..Future studies will build on these findings to develop in vitro and in vivo models of CFS and lead to clinical trials with select antidepressants or other molecules that inhibit brain mast cells. ..
  4. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..Our findings may be relevant to the pathophysiology of IC and may suggest new therapeutic approaches. ..
  5. Stress Induces Skin Mast Cell Activation & Vasodilation
    Theoharis Theoharides; Fiscal Year: 2005
    ..They will also help investigate the pathophysiology of skin syndromes exacerbated by stress, such as atopic dermatitis or psoriasis, especially since CRH and CRH receptors have been identified in human skin. ..
  6. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2010
    ..The proposed research is expected to advance our understanding of how activation of brain mast cells can contribute to inflammation and CFS, as well as to the development of novel and effective treatments. ..
  7. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis Theoharides; Fiscal Year: 2009
    ..This is an important and under investigated area of skin pathophysiology that has potential applicability to understanding the pathogenesis of skin diseases and screening compounds that may develop into novel and effective treatments. ..
  8. STRESS INDUCED SKIN MAST CELL ACTIVATION & VASODILATION
    Theoharis C Theoharides; Fiscal Year: 2010
    ..This is an important and under investigated area of skin pathophysiology that has potential applicability to understanding the pathogenesis of skin diseases and screening compounds that may develop into novel and effective treatments. ..
  9. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose M Ordovas; Fiscal Year: 2010
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
  10. Vitamin K: Genetics of Vascular Calcification
    Jose Ordovas; Fiscal Year: 2005
    ..This research should provide the basis for more comprehensive genetic studies aimed to provide better identification of risk and more precise therapeutic approaches for these age-related disorders. ..
  11. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2009
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
  12. PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
    Jose Ordovas; Fiscal Year: 2009
    ....
  13. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 1999
    ....
  14. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2007
    ..This evidence-based knowledge will contribute to a rational approach toward more effective dietary recommendations aimed to decrease health disparities and to a better CVD prevention. ..
  15. PAT PROTEINS: GENE-DIET INTERACTIONS OBESITY RISK AND HEALTH
    Jose Ordovas; Fiscal Year: 2007
    ....
  16. GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS
    Jose Ordovas; Fiscal Year: 2004
    ..This knowledge will facilitate the generation of genetic screening panels that will assist in individual assessment of CHD risk and dietary therapeutic counseling. ..
  17. MDR1 and Related Proteins during HIV PI Exposure
    David Greenblatt; Fiscal Year: 2005
    ..The findings will be of importance in understanding lipid disorders related to PIs as well as the kinetics of drugs used to treat HIV and related disorders. ..
  18. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 2005
    ....
  19. CHRONIC BENZODIAZEPINES--BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 1999
    ..Age-dependent differences in response to chronic benzodiazepine administration and withdrawal, and the possible role of EAA coregulation, studied using matched cohorts of young and old animals. ..
  20. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2006
    ..This study should provide important mechanistic information on the role of age, gender, and ethnicity as sources of variability in CYP3A-mediated drug metabolism and response. ..
  21. GARLIC PREPARATIONS AND ANTIRETROVIRAL DRUGS
    David Greenblatt; Fiscal Year: 2004
    ..The work will provide immediately applicable clinical data on garlic interactions with antiretrovirals, as well as mechanistic data identifying the interaction process and its predictability from in vitro models. ..
  22. ANTIRETROVIRAL THERAPIES AND SUBSTANCE ABUSE
    David Greenblatt; Fiscal Year: 2002
    ..The in vitro model, if validated, has the potential to provide clinically important information on interactions involving HIV treatments and abusable drugs, at relatively low cost and with no human drug exposure. ..
  23. HAART Regimens in Substance Abusers
    David Greenblatt; Fiscal Year: 2003
    ....
  24. Metabolic Consequences of HAART: CYP3A and P-gp
    David Greenblatt; Fiscal Year: 2003
    ..This multidisciplinary proposal provides a clinical and scientific basis to assess the effects of currently available as well as experimental HAART medications on human CYP3A and P-gp. ..
  25. CHRONIC BENZODIAZEPINES: BEHAVIOR AND NEUROCHEMISTRY
    David Greenblatt; Fiscal Year: 1992
    ..The proposed studies will provide a broad picture of effects of chronic benzodiazepines at the molecular level, together with evaluation of interventions that have direct relevance to prevention of benzodiazepine withdrawal...