- Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytesCecilia Roh
Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Physiol Endocrinol Metab 284:E322-30. 2003..We suggest that, in adipose cells, a predominant part of leptin mRNA is compartmentalized on the endoplasmic reticulum, and leucine activates translation of these messages via the mTOR/4E-BP/PHAS-1-mediated signaling pathway...
- Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationAlexandros Tzatsos
Boston University School of Medicine, Massachusetts 02118, USA
Mol Cell Biol 26:63-76. 2006..Thus, diabetes-related hyperglycemia hyperactivates the mTOR pathway and may lead to insulin resistance due to suppression of IRS-1-dependent PI3-kinase/Akt signaling...
- Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794Alexandros Tzatsos
Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
J Biol Chem 282:18069-82. 2007..These data define a novel pathway that cooperates with other adaptive mechanisms to formulate the cellular response to energy depletion...