Susan Swain

Summary

Affiliation: Trudeau Institute
Country: USA

Publications

  1. ncbi request reprint Thanks for the memory!
    Susan L Swain
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 175:4823-6. 2005
  2. pmc CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function
    Eulogia Roman
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 196:957-68. 2002
  3. pmc CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza
    Susan L Swain
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 211:8-22. 2006
  4. pmc Homeostasis and the age-associated defect of CD4 T cells
    Susan Swain
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Semin Immunol 17:370-7. 2005
  5. ncbi request reprint T cell responses to influenza virus infection: effector and memory cells
    Susan L Swain
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Viral Immunol 17:197-209. 2004
  6. ncbi request reprint Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells
    Susan L Swain
    Trudeau Institute, PO Box 59, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Microbes Infect 5:213-9. 2003
  7. ncbi request reprint Helper T cell differentiation
    S L Swain
    Trudeau Institute, PO Box 59, Algonquin Avenue, Saranac Lake, NY 12983, USA
    Curr Opin Immunol 11:180-5. 1999
  8. ncbi request reprint Class II-independent generation of CD4 memory T cells from effectors
    S L Swain
    Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Science 286:1381-3. 1999
  9. pmc Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
    Shabaana A Khader
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 203:1805-15. 2006
  10. ncbi request reprint Vaccines against pandemic influenza
    Richard W Dutton
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Viral Immunol 20:326-7. 2007

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Thanks for the memory!
    Susan L Swain
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 175:4823-6. 2005
  2. pmc CD4 effector T cell subsets in the response to influenza: heterogeneity, migration, and function
    Eulogia Roman
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 196:957-68. 2002
    ..These results reveal a complex response, not an all-or-none one, which results in multiple effector phenotypes and implies that effector cells and the memory cells derived from them can display a broad spectrum of functional potentials...
  3. pmc CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza
    Susan L Swain
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 211:8-22. 2006
    ....
  4. pmc Homeostasis and the age-associated defect of CD4 T cells
    Susan Swain
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Semin Immunol 17:370-7. 2005
    ..We explore here whether the age-related defects in naive CD4 T cells are due to the aged environment from which they come or to intrinsic defects that are caused by homeostasis and their long lifespan...
  5. ncbi request reprint T cell responses to influenza virus infection: effector and memory cells
    Susan L Swain
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Viral Immunol 17:197-209. 2004
    ....
  6. ncbi request reprint Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells
    Susan L Swain
    Trudeau Institute, PO Box 59, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Microbes Infect 5:213-9. 2003
    ..This suggests that the same signals during infection/vaccination determine the extent and nature of both effector and memory cell development...
  7. ncbi request reprint Helper T cell differentiation
    S L Swain
    Trudeau Institute, PO Box 59, Algonquin Avenue, Saranac Lake, NY 12983, USA
    Curr Opin Immunol 11:180-5. 1999
    ..New insights into the details of CD4(+) T cell regulation will provide important clues as to how immune responses are regulated, in particular the generation of effector responses and development of long-lived immunity...
  8. ncbi request reprint Class II-independent generation of CD4 memory T cells from effectors
    S L Swain
    Biomedical Research Laboratories, Trudeau Institute, 100 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Science 286:1381-3. 1999
    ..CD4 effectors generated in vitro from naïve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II-deficient hosts, indicating no requirement for further antigen or class II recognition...
  9. pmc Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
    Shabaana A Khader
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 203:1805-15. 2006
    ..These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs...
  10. ncbi request reprint Vaccines against pandemic influenza
    Richard W Dutton
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Viral Immunol 20:326-7. 2007
    ..Vaccination with live attenuated influenza A virus (LAIV) has the potential to provide protection against the more severe consequences of pandemic flu regardless of subtype. This possibility should be explored...
  11. pmc Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection
    John E Pearl
    Trudeau Institute Inc, Saranac Lake, NY 12983, USA
    Eur J Immunol 42:3267-79. 2012
    ..These data support the hypothesis that effector T cells in mycobacterial granulomata are not a uniform effector population but exist in distinct subsets with differential susceptibility to the regulatory effects of nitric oxide...
  12. pmc Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation
    Dawn M Jelley-Gibbs
    Trudeau Institute Inc, Saranac Lake, NY 12983, USA
    J Exp Med 202:697-706. 2005
    ..Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained...
  13. ncbi request reprint CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency
    Timothy J Powell
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Clin Immunol 113:89-100. 2004
    ..These studies demonstrate how CD8(+) and CD4(+) T cells respond to influenza at early time points postinfection and the differential kinetics of antigen-specific CD4(+) and CD8(+) T cells...
  14. pmc Memory CD4+ T cells induce innate responses independently of pathogen
    Tara M Strutt
    Trudeau Institute, Saranac Lake, New York, USA
    Nat Med 16:558-64, 1p following 564. 2010
    ..This represents a previously undescribed mechanism by which memory CD4(+) T cells induce an early innate response that enhances immune protection against pathogens...
  15. doi request reprint Influencing the fates of CD4 T cells on the path to memory: lessons from influenza
    Dawn M Jelley-Gibbs
    Trudeau Institute Inc, Saranac Lake, NY 12983, USA
    Immunol Cell Biol 86:343-52. 2008
    ..We propose that novel vaccine strategies, which incorporate both microbial products and antigen targeting, may provide a flexible and long-lived memory CD4 T-cell pool...
  16. ncbi request reprint Functionally diverse subsets in CD4 T cell responses against influenza
    Tara M Strutt
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Clin Immunol 29:145-50. 2009
    ..This is likely due to both the paucity of and heterogeneity of memory CD4 T cells observed in vivo, which make analysis extremely difficult...
  17. ncbi request reprint CD4 T cell-mediated protection from lethal influenza: perforin and antibody-mediated mechanisms give a one-two punch
    Deborah M Brown
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 177:2888-98. 2006
    ....
  18. ncbi request reprint Uneven distribution of MHC class II epitopes within the influenza virus
    Sherry R Crowe
    Trudeau Institute, 154 Algoquin Ave, Saranac Lake, NY 12983, USA
    Vaccine 24:457-67. 2006
    ....
  19. pmc T-cell immunosenescence: lessons learned from mouse models of aging
    Alexander C Maue
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Trends Immunol 30:301-5. 2009
    ..This review describes key findings regarding age-related defects in T-cell function and discusses the impact these defects have on vaccine efficacy and immunity...
  20. ncbi request reprint Antigen presentation and the regulation of CD4 memory generation to influenza
    Dawn Jelley Gibbs
    Trudeau Institute Inc, Research Assistant Faculty, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Expert Rev Clin Immunol 2:601-11. 2006
    ..Since CD4 T-cell responses are required for long-lived and protective B-cell and CD8 T-cell immunity, new vaccines must be designed to elicit both T- and B-cell immunity against a broader range of influenza virus strains...
  21. ncbi request reprint Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus
    Timothy J Powell
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    J Immunol 178:1030-8. 2007
    ..Our results suggest that intranasal vaccination with cold-adapted, attenuated live virus has the potential to provide effective emergency protection against emerging influenza strains for several months...
  22. pmc IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals
    Xujian Li
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 179:939-49. 2007
    ....
  23. pmc Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
    Hirotake Tsukamoto
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 106:18333-8. 2009
    ..We suggest that the intrinsic increase in longevity helps maintain naïve T-cell homeostasis but facilitates the development of functional defects in mice...
  24. pmc Rapid default transition of CD4 T cell effectors to functional memory cells
    K Kai McKinstry
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 204:2199-211. 2007
    ....
  25. doi request reprint The effector to memory transition of CD4 T cells
    K Kai McKinstry
    Trudeau Institute, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Immunol Res 40:114-27. 2008
    ....
  26. pmc Bone marrow precursor cells from aged mice generate CD4 T cells that function well in primary and memory responses
    Sheri M Eaton
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 181:4825-31. 2008
    ..These results indicate that there are no apparent age-related intrinsic defects in BMPC with regards to generation of functional memory T cells...
  27. pmc Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge
    Hiromasa Hamada
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 182:3469-81. 2009
    ....
  28. pmc The potential of CD4 T-cell memory
    K Kai McKinstry
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunology 130:1-9. 2010
    ....
  29. ncbi request reprint Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation
    Javed N Agrewala
    Trudeau Institute Inc, Saranac Lake, New York 12983, USA
    J Biol Chem 282:6106-15. 2007
    ..These data also argue that memory cells in lymphoid sites are longer lived and not in equilibrium with those in non-lymphoid sites...
  30. ncbi request reprint CD4 T cell responses to influenza infection
    Deborah M Brown
    Trudeau Institute, Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Semin Immunol 16:171-7. 2004
    ..We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets...
  31. pmc IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge
    K Kai McKinstry
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 182:7353-63. 2009
    ..Our results show that IL-10 expression inhibits development of Th17 responses during influenza infection and that this is correlated with compromised protection during high-dose primary, but not secondary, challenge...
  32. ncbi request reprint Effect of age on naive CD4 responses: impact on effector generation and memory development
    Laura Haynes
    Trudeau Institute, P O Box 59, Saranac Lake, NY 12983, USA
    Springer Semin Immunopathol 24:53-60. 2002
  33. ncbi request reprint Regulation of memory CD4 T cells: generation, localization and persistence
    Susan L Swain
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Adv Exp Med Biol 512:113-20. 2002
  34. pmc IL-7 promotes the transition of CD4 effectors to persistent memory cells
    JiChu Li
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 198:1807-15. 2003
    ..These data indicate that IL-7 plays a critical role in promoting memory CD4 T cell generation by providing survival signals, which allow effectors to successfully become resting memory cells...
  35. pmc Repeated stimulation of CD4 effector T cells can limit their protective function
    Dawn M Jelley-Gibbs
    Trudeau Institute Inc, Saranac Lake, NY 12983, USA
    J Exp Med 201:1101-12. 2005
    ..These results suggest that duration of antigen presentation dictates CD4 effector function, and repeated T cell receptor stimulation in vitro and in vivo that exceeds an optimal threshold results in effectors with impaired function...
  36. pmc CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
    Laura Haynes
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 100:15053-8. 2003
    ..These results indicate that it is the age of the naive T cell when it first encounters antigen, rather than the age when it reencounters antigen, that is critical for good memory CD4 T cell function...
  37. pmc Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo
    Laura Haynes
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 172:5194-9. 2004
    ..We suggest that induction of inflammatory cytokines via adjuvants may enhance the efficacy of vaccinations in elderly populations...
  38. pmc IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells
    Deborah M Brown
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Cell Immunol 257:69-79. 2009
    ..These data have implications for the design of vaccines that may induce cytolytic CD4 cells in vivo and improve cell-mediated immunity to viral and bacterial infections...
  39. ncbi request reprint Germinal center B cells in Peyer's patches of aged mice exhibit a normal activation phenotype and highly mutated IgM genes
    Brian J Rogerson
    Trudeau Institute Inc, Biomedical Research Laboratories, Saranac Lake, NY 12983, USA
    Mech Ageing Dev 124:155-65. 2003
    ..It is conceivable that B-cells expressing these genes reflect the presence of a mucosal memory compartment in aged mice that either retains flexibility in effector function or is committed to the secretion of IgM antibody...
  40. pmc Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects
    Hirotake Tsukamoto
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 185:4535-44. 2010
    ..We suggest that the reduction of Bim levels with age in naive CD4 T cell is the initiating step that leads to increased cellular lifespan and development of age-associated functional defects...
  41. ncbi request reprint SAP is required for Th cell function and for immunity to influenza
    Cris Kamperschroer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 177:5317-27. 2006
    ..Overall, our results demonstrate that SAP is required in CD4 T cells for their ability to help B cell responses and promote influenza-specific immunity...
  42. pmc SAP enables T cells to help B cells by a mechanism distinct from Th cell programming or CD40 ligand regulation
    Cris Kamperschroer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 181:3994-4003. 2008
    ..Instead, SAP is necessary for very late stages of differentiation or, most likely, for allowing Th cells to communicate during cognate T:B interactions...
  43. pmc Impact of post-thymic cellular longevity on the development of age-associated CD4+ T cell defects
    Stephen C Jones
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 180:4465-75. 2008
    ..These data support a correlation between the requirement for increased post-thymic longevity and the development of the most severe naive CD4(+) T cell-aging defects...
  44. ncbi request reprint Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice
    Karen Clise-Dwyer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 178:1321-31. 2007
    ....
  45. ncbi request reprint Why aging T cells fail: implications for vaccination
    Laura Haynes
    Trudeau Institute, Inc, Saranac Lake, New York 12983, USA
    Immunity 24:663-6. 2006
    ..In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly...
  46. ncbi request reprint SAP deficiency results in a striking alteration of the protein profile in activated CD4 T cells
    Cris Kamperschroer
    Trudeau Institute, Saranac Lake, New York, USA
    J Proteome Res 5:1785-91. 2006
    ..Our results reveal protein species whose abundances are profoundly altered by SAP. Our work therefore identifies candidate cellular mediators of SAP-dependent T cell help...
  47. ncbi request reprint IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  48. ncbi request reprint Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response
    Dawn M Jelley-Gibbs
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    J Immunol 178:7563-70. 2007
    ....
  49. ncbi request reprint IL-7: maintaining T-cell memory and achieving homeostasis
    Linda M Bradley
    Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA
    Trends Immunol 26:172-6. 2005
    ..In this Review, we discuss the role of IL-7 in the survival and homeostasis of naive and memory T cells and how that role is regulated by other factors...
  50. pmc Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 104:7175-80. 2007
    ..Thus, the accumulation of NFATc1 and NFATc2 in memory CD4+ T cells represents a previously uncharacterized regulatory mechanism for the induction of early gene expression after antigen stimulation...
  51. ncbi request reprint Aging and immune function. Summary of a workshop held at Trudeau Institute, Saranac Lake, NY
    Laura Haynes
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Mech Ageing Dev 126:822-5. 2005
  52. ncbi request reprint Induction of CD4 T cell changes in murine AIDS is dependent on costimulation and involves a dysregulation of homeostasis
    Michael H Yen
    Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 169:722-31. 2002
    ..Thus, a combination of up-regulation of costimulatory ligands and disruption of homeostatic control may be responsible for CD4 lymphoproliferation in MAIDS...
  53. pmc Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen
    Laura Haynes
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Exp Med 201:845-51. 2005
    ..Our results suggest that age-related defects in response to antigenic stimulation, in part, are caused by the age of the CD4 T cells...
  54. ncbi request reprint Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells
    Paula Y Arnold
    Department of Immunology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    J Immunol Methods 271:137-51. 2002
    ..Furthermore, we have successfully used these reagents to stain T cells generated following viral infection. Thus, MHC class II:gamma2aFc multimers are robust and reliable reagents for the analysis of MHC class II-restricted T cells...