Andrea Cooper

Summary

Affiliation: Trudeau Institute
Country: USA

Publications

  1. ncbi request reprint Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection
    Andrea Cruz
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
    J Immunol 177:1416-20. 2006
  2. pmc Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
    Shabaana A Khader
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 203:1805-15. 2006
  3. pmc Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration
    Richard T Robinson
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 207:591-605. 2010
  4. pmc Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse
    Egidio Torrado
    Trudeau Institute Inc, Saranac Lake, New York, United States of America
    PLoS ONE 8:e61681. 2013
  5. pmc Protection versus pathology in tuberculosis: recent insights
    Andrea M Cooper
    The Trudeau Institute, Inc 154 Algonquin Ave, Saranac Lake, NY 12983, United States
    Curr Opin Immunol 24:431-7. 2012
  6. pmc Role of innate cytokines in mycobacterial infection
    A M Cooper
    Trudeau Institute, Saranac Lake, New York, USA
    Mucosal Immunol 4:252-60. 2011
  7. ncbi request reprint IL-12p40: an inherently agonistic cytokine
    Andrea M Cooper
    Trudeau Institute Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Immunol 28:33-8. 2007
  8. pmc Interleukin-12 and tuberculosis: an old story revisited
    Andrea M Cooper
    The Trudeau Institute, Inc 154 Algonquin Ave Saranac Lake, NY 12983, USA
    Curr Opin Immunol 19:441-7. 2007
  9. ncbi request reprint IL-23 and IL-17 have a multi-faceted largely negative role in fungal infection
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Eur J Immunol 37:2680-2. 2007
  10. pmc The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 226:191-204. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection
    Andrea Cruz
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
    J Immunol 177:1416-20. 2006
    ..This counterregulation pathway may be an important factor in limiting mycobacterially associated immune-mediated pathology...
  2. pmc Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
    Shabaana A Khader
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 203:1805-15. 2006
    ..These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs...
  3. pmc Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration
    Richard T Robinson
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Exp Med 207:591-605. 2010
    ..tuberculosis-specific T cell activation. IL-12Rbeta1DeltaTM thus represents a novel positive-regulator of IL12Rbeta1-dependent DC function and of the immune response to M. tuberculosis...
  4. pmc Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse
    Egidio Torrado
    Trudeau Institute Inc, Saranac Lake, New York, United States of America
    PLoS ONE 8:e61681. 2013
    ..These data support the hypothesis that B cells can modulate immunity to Mtb in an organ specific manner via the modulation of cytokine production and macrophage activation...
  5. pmc Protection versus pathology in tuberculosis: recent insights
    Andrea M Cooper
    The Trudeau Institute, Inc 154 Algonquin Ave, Saranac Lake, NY 12983, United States
    Curr Opin Immunol 24:431-7. 2012
    ..The phenotype of protective T cells is also being re-examined. These developments provide promise for improved vaccine design and highlight the complexity of this disease...
  6. pmc Role of innate cytokines in mycobacterial infection
    A M Cooper
    Trudeau Institute, Saranac Lake, New York, USA
    Mucosal Immunol 4:252-60. 2011
    ....
  7. ncbi request reprint IL-12p40: an inherently agonistic cytokine
    Andrea M Cooper
    Trudeau Institute Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Immunol 28:33-8. 2007
    ..An appreciation of the independent function of IL-12p40 is important for improving our understanding of both protective and pathogenic immune responses...
  8. pmc Interleukin-12 and tuberculosis: an old story revisited
    Andrea M Cooper
    The Trudeau Institute, Inc 154 Algonquin Ave Saranac Lake, NY 12983, USA
    Curr Opin Immunol 19:441-7. 2007
    ..Understanding the balance between IL-12, IL-23 and IL-27 is crucial to the development of immune intervention in tuberculosis...
  9. ncbi request reprint IL-23 and IL-17 have a multi-faceted largely negative role in fungal infection
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Eur J Immunol 37:2680-2. 2007
    ..In the fungal model it appears that IL-23 and IL-17 are counter-productive for protection...
  10. pmc The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunol Rev 226:191-204. 2008
    ..Finally, IL-27 limits protective immunity in the lung, but it is also required for long-term survival. These cytokines are therefore key players in the immune response to TB...
  11. pmc IL-17 and anti-bacterial immunity: protection versus tissue damage
    Andrea M Cooper
    Trudeau Institute, NY 12983, USA
    Eur J Immunol 39:649-52. 2009
    ..Dissecting its essential protective role from its immunopathologic role will allow for improved intervention in both acute and chronic disease...
  12. pmc T cells in mycobacterial infection and disease
    Andrea M Cooper
    The Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    Curr Opin Immunol 21:378-84. 2009
    ..The integration of the T cell functional data with the consequences of infection should improve rational vaccine design...
  13. pmc Cell-mediated immune responses in tuberculosis
    Andrea M Cooper
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Annu Rev Immunol 27:393-422. 2009
    ..We must also determine how to induce both known and novel immunoprotective responses without inducing immunopathologic consequences...
  14. ncbi request reprint Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present
    Andrea M Cooper
    Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 168:1322-7. 2002
    ..This cytokine is composed of the IL-12 p40 subunit and a p19 subunit. In support of a role for this cytokine in protective responses to M. tuberculosis, we determined that the p19 subunit is induced in the lungs of infected mice...
  15. ncbi request reprint IFN-gamma and NO in mycobacterial disease: new jobs for old hands
    Andrea M Cooper
    The Trudeau Institute, PO Box 59, 100 Algonquin Ave, Saranac Lake, NY 12983, USA
    Trends Microbiol 10:221-6. 2002
    ..avium infection, even leads to reduced bacterial growth...
  16. ncbi request reprint IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available
    Shabaana A Khader
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    J Immunol 175:788-95. 2005
    ....
  17. ncbi request reprint IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  18. ncbi request reprint IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice
    John E Pearl
    Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
    J Immunol 173:7490-6. 2004
    ..Because IFN-gamma is detrimental to the survival of effector T cells, we hypothesize that the reduced IFN-gamma within the IL-27R(-/-) lung is responsible for the increased accumulation of lymphocytes within the mycobacterial granuloma...
  19. ncbi request reprint In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice
    Joanne Turner
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins 80523, USA
    J Immunol 169:6343-51. 2002
    ..These data support the hypothesis that IL-10 plays a pivotal role during the chronic/latent stage of pulmonary tuberculosis, with increased production playing a potentially central role in promoting reactivation tuberculosis...
  20. ncbi request reprint CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis
    Bernadette M Saunders
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Cell Immunol 216:65-72. 2002
    ..Early control of M. tuberculosis growth is therefore independent of CD4+ cells but such cells are required to ensure recruitment of mononuclear cells to the lung and thus ensure long-term survival...
  21. pmc In a murine tuberculosis model, the absence of homeostatic chemokines delays granuloma formation and protective immunity
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 183:8004-14. 2009
    ..These results demonstrate that homeostatic chemokines perform distinct functions that cooperate to mediate effective expression of immunity against Mtb infection...
  22. pmc Role of chemokine ligand 2 in the protective response to early murine pulmonary tuberculosis
    Andre Kipnis
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    Immunology 109:547-51. 2003
    ....
  23. ncbi request reprint Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages
    Hubert M Tse
    Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    J Immunol 168:825-33. 2002
    ..Therefore, the data suggest that induction of the MAPK pathway during uptake of bacteria is instrumental in determining the eventual fate of the bacteria...
  24. pmc A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival
    Joanne Turner
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Infect Immun 72:3759-68. 2004
    ..tuberculosis. This study identifies this lipoprotein as an important and potent inducer of protective T cells within the lungs of mice infected with M. tuberculosis and therefore as a possible target for vaccination...
  25. pmc Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge
    Hiromasa Hamada
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 182:3469-81. 2009
    ....
  26. pmc IL-23 and IL-17 in tuberculosis
    Shabaana A Khader
    Trudeau Institute, Inc, 154 Algonquin Ave, Saranac Lake, NY 12983, USA
    Cytokine 41:79-83. 2008
    ..Th1 and Th17 responses cross-regulate each other during mycobacterial infection and this may be important for immunopathologic consequences not only in tuberculosis but also other mycobacterial infections...
  27. pmc Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration
    Richard T Robinson
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 181:5560-7. 2008
    ..pestis-26 degrees. The data demonstrate the molecular pathway by which Y. pestis evades induction of early DC activation as measured by migration and IL-12(p40)(2) production...
  28. pmc ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes
    William W Reiley
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
    Proc Natl Acad Sci U S A 105:10961-6. 2008
    ..These data define a key period in the adaptive immune response to Mtb infection...
  29. ncbi request reprint Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection
    Mercedes Gonzalez-Juarrero
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, 80523, USA
    J Leukoc Biol 77:914-22. 2005
    ..tuberculosis bacterial growth...
  30. ncbi request reprint Cutting edge: T-bet and IL-27R are critical for in vivo IFN-gamma production by CD8 T cells during infection
    Katrin D Mayer
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 180:693-7. 2008
    ..Whereas IFN-gammaR signals are dispensable for the T-bet-dependent IFN-gamma production, direct IL-27Ralpha signals are critical...
  31. ncbi request reprint Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way
    Jeffrey S Schorey
    University of Notre Dame, Department of Biology and Center of Tropical Disease Research and Training, 130 Galvin Life Science Center, Notre Dame, IN 46556, USA
    Cell Microbiol 5:133-42. 2003
    ..Therefore, the ability of pathogenic mycobacteria to limit MAPK activity is likely an important virulence mechanism and may be a potential therapeutic target...
  32. ncbi request reprint The cytolytic activity of natural killer cells is not involved in the restriction of Mycobacterium avium growth
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Int Immunol 15:895-901. 2003
    ..Our data show that resistance to M. avium mediated by NK cells is independent of their cytolytic activity, and that there is a marked phenotypic and functional heterogeneity of the NK cell lineage in vivo during infection...
  33. pmc Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2
    Wayne W Hancock
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:3005-10. 2004
    ..gondii infection and allograft rejection. Together, our findings suggest that Fgl2, although highly conserved and IFN gamma-inducible, is not a critical mediator of either type 1 immunity or immune-associated coagulant activity...
  34. pmc Immunological basis of the development of necrotic lesions following Mycobacterium avium infection
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Portugal
    Immunology 106:590-601. 2002
    ..Our results show that the immunological mediators involved in the induction of protective immunity are also major players in the immunopathology associated with mycobacteriosis...
  35. ncbi request reprint The study of Mycobacterium leprae infection in interferon-gamma gene--disrupted mice as a model to explore the immunopathologic spectrum of leprosy
    Linda B Adams
    National Hansen s Disease Programs, Laboratory Research Branch, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    J Infect Dis 185:S1-8. 2002
    ..Thus, although deficient in an important Th1 cytokine, GKO mice possess compensatory mechanisms to control M. leprae growth and feature elements resembling mid-borderline leprosy in humans...
  36. pmc Gamma interferon-induced T-cell loss in virulent Mycobacterium avium infection
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Infect Immun 73:3577-86. 2005
    ....
  37. pmc An oily, sustained counter-regulatory response to TB
    Christopher L Karp
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Invest 115:1473-6. 2005
    ..tuberculosis, the study raises the possibility that pharmacological inhibition of lipoxin synthesis may provide a method of augmenting inefficient immune responses in TB and other important chronic infectious diseases...

Research Grants3

  1. IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASE
    Andrea Cooper; Fiscal Year: 2001
    ..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
  2. Impact of chronic infection in the aged on the response to vaccination
    Andrea Cooper; Fiscal Year: 2007
    ..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. [unreadable] [unreadable] [unreadable] [unreadable]..
  3. The role of IL-12p40 in the response of pulmonary dendritic cells to tuberculosis
    Andrea M Cooper; Fiscal Year: 2010
    ..This increased understanding will allow targeted and novel interventions that will improve our ability to control disease. ..