Clemencia Pinilla

Summary

Affiliation: Torrey Pines Institute for Molecular Studies
Country: USA

Publications

  1. ncbi request reprint Findings on T cell specificity revealed by synthetic combinatorial libraries
    Eva Borras
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    J Immunol Methods 267:79-97. 2002
  2. pmc Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries
    Clemencia Pinilla
    Torrey Pines Institute for Molecular Studies, San Diego, California, USA
    Mol Pharmacol 84:314-24. 2013
  3. pmc Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctions
    Dev K Ranjit
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182 4614, USA
    Bioorg Med Chem Lett 20:4531-4. 2010
  4. pmc Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches
    Jose L Medina-Franco
    Torrey Pines Institute for Molecular Studies, Port St Lucie, Florida 34987, USA
    J Chem Inf Model 53:1475-85. 2013
  5. ncbi request reprint Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV-1 CTL epitope Gag77-85
    Cesar Boggiano
    Torrey Pines Institute for Molecular Studies, San Diego, USA
    Eur J Immunol 35:1428-37. 2005
  6. ncbi request reprint A powerful combination: the use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes
    J Javier Nino-Vasquez
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Mol Immunol 40:1063-74. 2004
  7. pmc New peptide inhibitors of type IB topoisomerases: similarities and differences vis-a-vis inhibitors of tyrosine recombinases
    David F Fujimoto
    Department of Biology, Center for Microbial Sciences and Molecular Biology Institute, San Diego State University, San Diego, CA 92182 4614, USA
    J Mol Biol 363:891-907. 2006
  8. pmc Improvement of IFNg ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis
    Radleigh Santos
    Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway Port St Lucie, FL 34987, USA
    Cells 4:1-18. 2014
  9. pmc The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors
    Radleigh G Santos
    Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St Lucie, FL 34987, USA
    Molecules 18:6408-24. 2013
  10. doi request reprint Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes
    Marc C Rideout
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182, USA
    Mol Divers 15:989-1005. 2011

Detail Information

Publications56

  1. ncbi request reprint Findings on T cell specificity revealed by synthetic combinatorial libraries
    Eva Borras
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    J Immunol Methods 267:79-97. 2002
    ..Also, important issues like the immunogenicity of such T cell ligands will be discussed...
  2. pmc Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries
    Clemencia Pinilla
    Torrey Pines Institute for Molecular Studies, San Diego, California, USA
    Mol Pharmacol 84:314-24. 2013
    ..Comparative analyses of other previous screening approaches clearly illustrate the efficiency of identifying receptor selective, individual compounds from mixture-based combinatorial libraries...
  3. pmc Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctions
    Dev K Ranjit
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182 4614, USA
    Bioorg Med Chem Lett 20:4531-4. 2010
    ....
  4. pmc Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches
    Jose L Medina-Franco
    Torrey Pines Institute for Molecular Studies, Port St Lucie, Florida 34987, USA
    J Chem Inf Model 53:1475-85. 2013
    ..To illustrate the approach, we discuss the SAR of 106 pyrrolidine bis-diketopiperazines tested against two formylpeptide receptors obtained from positional scanning deconvolution methods of mixture-based libraries. ..
  5. ncbi request reprint Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV-1 CTL epitope Gag77-85
    Cesar Boggiano
    Torrey Pines Institute for Molecular Studies, San Diego, USA
    Eur J Immunol 35:1428-37. 2005
    ..This approach may lead to vaccine candidates with higher in vivo immunogenicity and increased potential for cross-recognition of naturally occurring SL9 variants...
  6. ncbi request reprint A powerful combination: the use of positional scanning libraries and biometrical analysis to identify cross-reactive T cell epitopes
    J Javier Nino-Vasquez
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Mol Immunol 40:1063-74. 2004
    ..We review here the application of PS-SCLs and biometrical analysis to identify cross-reactive T cell epitopes, as well as the current efforts to refine this strategy...
  7. pmc New peptide inhibitors of type IB topoisomerases: similarities and differences vis-a-vis inhibitors of tyrosine recombinases
    David F Fujimoto
    Department of Biology, Center for Microbial Sciences and Molecular Biology Institute, San Diego State University, San Diego, CA 92182 4614, USA
    J Mol Biol 363:891-907. 2006
    ..Our results suggest that the newly identified WYCRCK and peptide WRWYCR interact with a distorted DNA intermediate arising during vTopo-mediated catalysis, or interfere with specific interactions between vTopo and DNA...
  8. pmc Improvement of IFNg ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis
    Radleigh Santos
    Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway Port St Lucie, FL 34987, USA
    Cells 4:1-18. 2014
    ..In addition, a comparison of the results with a 13-day preculture of PBMC with the peptides before testing demonstrates that ON resting is sufficient for the efficient evaluation of immune functioning. ..
  9. pmc The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors
    Radleigh G Santos
    Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St Lucie, FL 34987, USA
    Molecules 18:6408-24. 2013
    ..The flexibility demonstrated in the differently formatted mixture-based libraries allows for their screening in a wide range of assays...
  10. doi request reprint Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes
    Marc C Rideout
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, CA 92182, USA
    Mol Divers 15:989-1005. 2011
    ....
  11. ncbi request reprint Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes
    Valeria Judkowski
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Clin Immunol 113:29-37. 2004
    ..5 T cells results in protection from disease. These results suggest that high affinity peptide analogues of autoimmune epitopes might be useful as therapeutic modulators in active autoimmune disease...
  12. doi request reprint Integrating computational and mixture-based screening of combinatorial libraries
    Austin B Yongye
    Torrey Pines Institute for Molecular Studies, Port St Lucie, FL 34987, USA
    J Mol Model 17:1473-82. 2011
    ..The strategy presented in this work is general and is envisioned as a general-purpose approach that can be applied to other MB-SCLs...
  13. pmc Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis
    Karina Martínez-Mayorga
    Torrey Pines Institute for Molecular Studies, 5775 Old Dixie Highway, Fort Pierce, FL 34946, USA
    Bioorg Med Chem 16:5932-8. 2008
    ..Comparison of our model with known opiates suggest a similar binding mode showing that the bicyclic guanidines presented in this work are suitable scaffolds for further development of new opioid receptors ligands...
  14. pmc Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository
    Narender Singh
    Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St Lucie, Florida 34987, USA
    J Chem Inf Model 49:1010-24. 2009
    ..However, the R-NN analysis also showed that there are a significant number of molecules in several combinatorial libraries that are located in sparse regions of the drug space...
  15. pmc Identification of B cell and T cell epitopes using synthetic peptide combinatorial libraries
    Clemencia Pinilla
    Torrey Pines Institute for Molecular Studies, San Diego, CA, USA
    Curr Protoc Immunol . 2012
    ..Support protocols cover optimization of the assay conditions for each MAb or T cell, to achieve the best level of sensitivity and reproducibility, and preparation of a hexapeptide library, along with deconvolution approaches...
  16. ncbi request reprint Strong attraction may be dangerous: parameters for the development of long term commitment
    Valeria Judkowski
    Torrey Pines Institute for Molecular Studies, C O Darcy Wilson, 3550 General Atomics Centre, San Diego, CA 92121, USA
    Mol Immunol 40:1109-12. 2004
  17. doi request reprint Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs
    Jose L Medina-Franco
    Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port St Lucie, Florida 34987, USA
    J Chem Inf Model 49:477-91. 2009
    ..The protocol presented here can be applied to other data sets to develop a consensus model of the activity landscape...
  18. ncbi request reprint Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods
    Richard A Houghten
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA
    J Comb Chem 10:3-19. 2008
  19. ncbi request reprint Peptides from common viral and bacterial pathogens can efficiently activate diabetogenic T-cells
    Valeria A Judkowski
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Ct, San Diego, CA 92121, USA
    Diabetes 53:2301-9. 2004
    ..5 T-cell is directed at numerous mouse peptides. Our results provide evidence for their possible role as T-cell ligands involved in the activation of diabetogenic T-cells...
  20. pmc Identification of novel human leukocyte antigen-A*0201-restricted, cytotoxic T lymphocyte epitopes on CD133 for cancer stem cell immunotherapy
    Jianfei Ji
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA Torrey Pines Institute for Molecular Studies, San Diego, California, USA ImmunoCellular Therapeutics, Ltd, Calabasas, Calfornia, USA
    Stem Cells Transl Med 3:356-64. 2014
    ..The results presented in this study support the use of CD133-specific epitope vaccines to target CSCs in glioblastoma and other cancers...
  21. ncbi request reprint Advances in the use of synthetic combinatorial chemistry: mixture-based libraries
    Clemencia Pinilla
    Torrey Pines Institute for Molecular Studies, San Diego, California, USA
    Nat Med 9:118-22. 2003
  22. ncbi request reprint Identification of cross-reactive peptides using combinatorial libraries circumvents tolerance against Her-2/neu-immunodominant epitope
    Joseph Lustgarten
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    J Immunol 176:1796-805. 2006
    ..These results have demonstrated that it was possible to circumvent tolerance with the identification of CPs and that these peptides could be of significant clinical value...
  23. ncbi request reprint Synthetic combinatorial libraries as an alternative strategy for the development of novel treatments for infectious diseases
    Sylvie E Blondelle
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA
    Methods Enzymol 369:322-44. 2003
  24. pmc GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination
    Valeria Judkowski
    Torrey Pines Institute for Molecular Studies, San Diego, California, United States of America
    PLoS ONE 6:e24091. 2011
    ....
  25. ncbi request reprint Synthesis of platinum(II) chiral tetraamine coordination complexes
    Adel Nefzi
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA
    J Comb Chem 8:780-3. 2006
    ..The use of both solid-phase synthesis and solution phase follow-on approaches were found to best afford the title compounds...
  26. pmc Correction: Santos, R.S., et al. Improvement of IFNγ ELISPOT Performance Following Overnight Resting of Frozen PBMC Samples Confirmed Through Rigorous Statistical Analysis. Cells 2015, 4, 1-18
    Radleigh Santos
    Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway Port St Lucie, FL 34987, USA
    Cells 4:133-4. 2015
    ..The authors wish to make the following corrections to this paper [1]: [...]. ..
  27. ncbi request reprint A time-resolved fluorescence immunoassay (DELFIA) increases the sensitivity of antigen-driven cytokine detection
    Gina Allicotti
    Torrey Pines Institute for Molecular Studies, San Diego, California 92121, USA
    J Immunoassay Immunochem 24:345-58. 2003
    ..This sensitive, nonisotopic alternative to other cytokine detection methods will be useful for those researchers wanting to quantitate low levels of antigen-driven cytokine production...
  28. ncbi request reprint Specificity and degeneracy of T cells
    Darcy B Wilson
    Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA
    Mol Immunol 40:1047-55. 2004
    ....
  29. pmc Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis
    Arnon P Kater
    Moores Cancer Center at the University of California, San Diego, School of Medicine, University of California, San Diego, CA 92093, USA
    Blood 106:1742-8. 2005
    ....
  30. ncbi request reprint Reversible inhibitors of lambda integrase-mediated recombination efficiently trap Holliday junction intermediates and form the basis of a novel assay for junction resolution
    Jeffrey L Boldt
    Department of Biology and Center for Microbial Sciences, San Diego State University, San Diego, California 92182 4614, USA
    J Biol Chem 279:3472-83. 2004
    ..This assay is particularly useful for determining junction resolution rates in cases where complexes directly assembled on junction substrates undergo little or no catalysis...
  31. ncbi request reprint Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery
    Christa Hamashin
    Mixture Sciences, Inc, 3550 General Atomics Court, San Diego, CA 92121, USA
    Bioorg Med Chem 11:4991-7. 2003
    ..Synthetic multivalent polygalloyl constructs effectively competed with Ulex europaeus agglutinin I (UEA1) for binding to intestinal Caco-2 cell membranes...
  32. ncbi request reprint Successful identification of novel agents to control infectious diseases from screening mixture-based peptide combinatorial libraries in complex cell-based bioassays
    Cesar Boggiano
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Biopolymers 71:103-16. 2003
    ..Furthermore, the use of positional scanning (PS) SCL-based biometrical analyses for the identification of native optimal epitopes specific to HIV-1 proteins is also presented...
  33. pmc Polyspecificity of T cell and B cell receptor recognition
    Kai W Wucherpfennig
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Semin Immunol 19:216-24. 2007
    ..This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes...
  34. ncbi request reprint Use of combinatorial peptide libraries for T-cell epitope mapping
    Mireia Sospedra
    Neuroimmunology Branch, NINDS, National Institutes of Health, 10 Center Drive, MSC 1400, Bethesda, MD 20892 1400, USA
    Methods 29:236-47. 2003
    ..The practical steps that are involved in the latter method are described in this article...
  35. ncbi request reprint Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL
    Verena Rubio-Godoy
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, Lausanne Branch, University Hospital, Lausanne, Switzerland
    J Immunol 169:5696-707. 2002
    ..Together, these results underline the high predictive value of PS-SCL for the identification of sequences cross-recognized by Ag-specific T cells...
  36. ncbi request reprint Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity
    Verena Rubio-Godoy
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, University Hospital CHUV, Lausanne, Switzerland
    Eur J Immunol 32:2292-9. 2002
    ..These results underline the high predictive value of positional scanning synthetic combinatorial peptide library analysis and encourage its use for the identification of CTL ligands...
  37. pmc Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis
    Jan D Lunemann
    Neuroimmunology Branch, Cellular Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 75:243-51. 2007
    ..burgdorferi-specific T cells is not restricted to chronic and treatment-resistant manifestations...
  38. ncbi request reprint Identification of peptides from human pathogens able to cross-activate an HIV-1-gag-specific CD4+ T cell clone
    Sara Venturini
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Immunol 36:27-36. 2006
    ....
  39. ncbi request reprint Toward synthetic combinatorial peptide libraries in positional scanning format (PS-SCL)-based identification of CD8+ Tumor-reactive T-Cell Ligands: a comparative analysis of PS-SCL recognition by a single tumor-reactive CD8+ cytolytic T-lymphocyte clone
    Verena Rubio-Godoy
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, University Hospital CHUV, 1011 Lausanne, Switzerland
    Cancer Res 62:2058-63. 2002
    ..Altogether these results provide insight into the potential of PS-SCL for the identification of CTL-defined tumor-derived antigenic sequences and may significantly implement our ability to interpret the results of these analyses...
  40. ncbi request reprint High level of cross-reactivity in influenza virus hemagglutinin-specific CD4+ T-cell response: implications for the initiation of autoimmune response in multiple sclerosis
    Silva Markovic-Plese
    Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Neuroimmunol 169:31-8. 2005
    ..The results have implications for vaccine design and for antigen-specific treatment strategies for autoimmune diseases...
  41. ncbi request reprint How the T cell repertoire becomes peptide and MHC specific
    Eric S Huseby
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Cell 122:247-60. 2005
    ..Our results also suggest that germline-encoded TCR variable elements have an inherent predisposition to react with features shared by all MHC proteins...
  42. ncbi request reprint Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides
    Sylvaine You
    Division of Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    J Immunol 170:4011-20. 2003
    ..Therefore, we have generated Ag-specific tetramers that could detect a heterogeneous population of T cells, and a very small number of NOD mouse T cells may represent BDC2.5-like cells...
  43. ncbi request reprint Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
    Aaron D Schimmer
    The Burnham Institute, La Jolla, CA 92037, USA
    Cancer Cell 5:25-35. 2004
    ..Active compounds also suppressed growth of established tumors in xenograft models in mice, while displaying little toxicity to normal tissues. These findings validate IAPs as targets for cancer drug discovery...
  44. pmc Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans
    Valerie Dutoit
    Division of Clinical Onco Immunology, Ludwig Institute for Cancer Research, University Hospital CHUV, 1011 Lausanne, Switzerland
    J Exp Med 196:207-16. 2002
    ..Altogether these results indicate that the high frequency of Melan-A multimer(+) T cells can be explained by the existence of largely cross-reactive subsets of naive CD8(+) T cells displaying multiple specificities...
  45. ncbi request reprint Toward targeted oral vaccine delivery systems: selection of lectin mimetics from combinatorial libraries
    Imelda Lambkin
    Elan Drug Delivery, Biotechnology Building, Trinity College, Dublin 2, Ireland
    Pharm Res 20:1258-66. 2003
    ..In this study we characterized compounds identified from mixture-based positional scanning synthetic combinatorial libraries, which mimic UEA1 and, thus, may have properties applicable to targeted drug delivery...
  46. ncbi request reprint Application of support vector machines for T-cell epitopes prediction
    Yingdong Zhao
    Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Bioinformatics 19:1978-84. 2003
    ..Recent data also indicate that it is highly flexible, and one receptor may recognize thousands of different peptides. Deciphering the patterns of peptides that elicit a MHC restricted T-cell response is critical for vaccine development...
  47. pmc Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype
    Mireia Sospedra
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA
    J Immunol 176:1951-61. 2006
    ..A T cell signaling machinery tuned for efficient responses to weak ligands together with structural features of the TCR-HLA/peptide complex result in this promiscuous HLA class II restriction...
  48. ncbi request reprint Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide
    Victor Appay
    Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland
    Eur J Immunol 36:1805-14. 2006
    ..Importantly, these cells are tumor-reactive...
  49. pmc Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity
    Mireia Sospedra
    Cellular Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 1:e41. 2005
    ..Our data suggest that repeated infections with common pathogenic and even nonpathogenic viruses could expand T cells specific for conserved protein domains that are able to cross-react with tissue-derived and ubiquitous autoantigens...
  50. ncbi request reprint Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools
    Jason A Greenbaum
    Immune Epitope Database and Analysis Resource IEDB, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    J Mol Recognit 20:75-82. 2007
    ..By developing common datasets, standardized data formats, and the means with which to consolidate information, we hope to greatly enhance the development of B-cell epitope prediction tools...
  51. pmc Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
    Collins A Karikari
    The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, CRB2 Room 345, 1550 Orleans Street, Baltimore, MD 21231, USA
    Mol Cancer Ther 6:957-66. 2007
    ..These preclinical results suggest that targeting of the apoptotic machinery in pancreatic cancers with XAntags is a promising therapeutic option that warrants further evaluation...
  52. ncbi request reprint Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library
    John Sidney
    La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Immunogenetics 59:745-51. 2007
    ....
  53. ncbi request reprint A similarity-based data-fusion approach to the visual characterization and comparison of compound databases
    Jose L Medina-Franco
    College of Pharmacy and BIO5 Institute, University of Arizona, Tucson, AZ 85721, USA
    Chem Biol Drug Des 70:393-412. 2007
    ....
  54. doi request reprint Degenerate TCR recognition and dual DR2 restriction of autoreactive T cells: implications for the initiation of the autoimmune response in multiple sclerosis
    Xin Zhang
    Department of Neurology, University of North Carolina, Chapel Hill, NC 27599, USA
    Eur J Immunol 38:1297-309. 2008
    ..The DR2-APM-reactive cells' IL-17 secretion, together with cross-reactivity against myelin peptides, may contribute to their role in the development of autoimmune response in MS...
  55. pmc Monkeypox virus evades antiviral CD4+ and CD8+ T cell responses by suppressing cognate T cell activation
    Erika Hammarlund
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 105:14567-72. 2008
    ....
  56. ncbi request reprint Targeting approaches to oral drug delivery
    Imelda Lambkin
    Elan Biotechnology Research, Biotechnology Building, Trinity College, Dublin 2, Ireland
    Expert Opin Biol Ther 2:67-73. 2002
    ..Particular reference is made to advances associated with targeted delivery of vaccines to M-cells or antigen-presenting cells in gut-associated lymphoid tissues...