Leonard G Gomella

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. doi request reprint The current role and limitations of surrogate endpoints in advanced prostate cancer
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University Philadelphia, PA Electronic address
    Urol Oncol 32:28.e1-9. 2014
  2. doi request reprint Current prostate cancer treatments: effect on quality of life
    Leonard G Gomella
    Department of Urology, Jefferson Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 73:S28-35. 2009
  3. ncbi request reprint Contemporary use of hormonal therapy in prostate cancer: managing complications and addressing quality-of-life issues
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    BJU Int 99:25-9; discussion 30. 2007
  4. pmc Proepithelin is an autocrine growth factor for bladder cancer
    Francesca Lovat
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Carcinogenesis 30:861-8. 2009
  5. ncbi request reprint Long-term outcome of patients with prostate cancer and pathologic seminal vesicle invasion (pT3b): effect of adjuvant radiotherapy
    Heather M Lee
    Department of Radiation Oncology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Urology 64:84-9. 2004
  6. pmc Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells
    Matteo Fassan
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e19771. 2011
  7. doi request reprint Patterns of care for elderly men diagnosed with favorable-risk prostate cancer from 2004 to 2008: a population-based analysis
    Mark V Mishra
    Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College Department of Urology, Thomas Jefferson University, Philadelphia, PA
    Am J Clin Oncol 36:606-11. 2013
  8. ncbi request reprint Minimally invasive radical prostatectomy: transition from pure laparoscopic to robotic-assisted radical prostatectomy
    Edouard J Trabulsi
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Esp Urol 64:823-9. 2011
  9. ncbi request reprint Perioperative morbidity of laparoscopic radical prostatectomy compared with open radical retropubic prostatectomy
    James A Brown
    Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 22:102-6. 2004
  10. ncbi request reprint Prostate: high-frequency Doppler US imaging for cancer detection
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107 5244, USA
    Radiology 225:71-7. 2002

Detail Information

Publications94

  1. doi request reprint The current role and limitations of surrogate endpoints in advanced prostate cancer
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University Philadelphia, PA Electronic address
    Urol Oncol 32:28.e1-9. 2014
    ..The ability to discern patient benefit in the absence of patient death or other complications would facilitate both drug development and more appropriate patient care...
  2. doi request reprint Current prostate cancer treatments: effect on quality of life
    Leonard G Gomella
    Department of Urology, Jefferson Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 73:S28-35. 2009
    ..As a part of a risk reduction strategy, effective screening programs, along with possible therapeutic agents, could have a positive effect on QOL and offer a preemptive benefit to patients at increased risk of PCa...
  3. ncbi request reprint Contemporary use of hormonal therapy in prostate cancer: managing complications and addressing quality-of-life issues
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    BJU Int 99:25-9; discussion 30. 2007
    ..Many new therapies are currently under investigation which aim to maximize the clinical effects of ADT while reducing the adverse effects...
  4. pmc Proepithelin is an autocrine growth factor for bladder cancer
    Francesca Lovat
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Carcinogenesis 30:861-8. 2009
    ....
  5. ncbi request reprint Long-term outcome of patients with prostate cancer and pathologic seminal vesicle invasion (pT3b): effect of adjuvant radiotherapy
    Heather M Lee
    Department of Radiation Oncology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Urology 64:84-9. 2004
    ..To evaluate the long-term outcome of patients with prostate cancer who have pathologic seminal vesicle invasion without lymph node metastasis (pT3bN0M0) and compare management strategies...
  6. pmc Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells
    Matteo Fassan
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e19771. 2011
    ....
  7. doi request reprint Patterns of care for elderly men diagnosed with favorable-risk prostate cancer from 2004 to 2008: a population-based analysis
    Mark V Mishra
    Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College Department of Urology, Thomas Jefferson University, Philadelphia, PA
    Am J Clin Oncol 36:606-11. 2013
    ..We performed a population-based analysis to assess patterns of initial treatment (IT) for a contemporary cohort of elderly men diagnosed with a favorable-risk PC in the United States...
  8. ncbi request reprint Minimally invasive radical prostatectomy: transition from pure laparoscopic to robotic-assisted radical prostatectomy
    Edouard J Trabulsi
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Arch Esp Urol 64:823-9. 2011
    ..Validated questionnaires, including the International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF), were utilized in the assessment of urinary and sexual parameters...
  9. ncbi request reprint Perioperative morbidity of laparoscopic radical prostatectomy compared with open radical retropubic prostatectomy
    James A Brown
    Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 22:102-6. 2004
    ..The types of complications differed between the LRP and RRP cohorts...
  10. ncbi request reprint Prostate: high-frequency Doppler US imaging for cancer detection
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107 5244, USA
    Radiology 225:71-7. 2002
    ....
  11. pmc Physician beliefs and practices for adjuvant and salvage radiation therapy after prostatectomy
    Timothy N Showalter
    Department of Radiation Oncology, Jefferson Medical College, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 82:e233-8. 2012
    ..This survey was conducted to evaluate the beliefs and practices of radiation oncologists (RO) and urologists (U) regarding RT after RP...
  12. doi request reprint MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets
    Raffaele Baffa
    Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    J Pathol 219:214-21. 2009
    ..Our results suggest that specific miRNAs may be directly involved in cancer metastasis and that they may represent a novel diagnostic tool in the characterization of metastatic cancer gene targets...
  13. pmc A novel role for drebrin in regulating progranulin bioactivity in bladder cancer
    Shi Qiong Xu
    Department of Urology and Biology of Prostate Cancer Program, Thomas Jefferson University, Philadelphia, PA, USA
    Oncotarget 6:10825-39. 2015
    ..In addition, drebrin may serve as novel biomarker for bladder cancer. ..
  14. pmc Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling
    Renato V Iozzo
    Department Pathology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 286:34712-21. 2011
    ..Thus, decorin loss may contribute to increased IGF-IR activity in the progression of bladder cancer and perhaps other forms of cancer where IGF-IR plays a role...
  15. pmc Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth
    Giada Monami
    Department of Urology, Thomas Jefferson University, 233 South 10th St, BLSB Room 620, Philadelphia, PA 19107, USA
    Am J Pathol 174:1037-47. 2009
    ..Furthermore, proepithelin may prove to be a useful clinical marker for the diagnosis of prostate tumors...
  16. doi request reprint Fez1/Lzts1-deficient mice are more susceptible to N-butyl-N-(4-hydroxybutil) nitrosamine (BBN) carcinogenesis
    Raffaele Baffa
    Department of Urology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Carcinogenesis 29:846-8. 2008
    ..Therefore, LZTS1 may become an excellent target for gene therapy in advanced bladder carcinoma...
  17. doi request reprint Comparison of lymph node yield in robot-assisted laparoscopic prostatectomy with that in open radical retropubic prostatectomy
    Costas D Lallas
    Department of Urology and Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    BJU Int 107:1136-40. 2011
    ....
  18. pmc Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin
    Simone Buraschi
    Department of Pathology, Anatomy and Cell Biology and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Oncotarget 7:39980-39995. 2016
    ..Our data indicate that progranulin may constitute a novel target for therapeutic intervention in bladder tumors. In addition, progranulin may serve as a novel biomarker for bladder cancer...
  19. pmc Transperitoneal robotic-assisted laparoscopic prostatectomy after prosthetic mesh herniorrhaphy
    Costas D Lallas
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    JSLS 13:142-7. 2009
    ....
  20. pmc Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells
    Marco Genua
    Endocrine Mechanisms and Hormone Action Program, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    PLoS ONE 7:e40148. 2012
    ..In addition, Pyk2 and the IGF-IR may serve as novel biomarkers with diagnostic and prognostic significance in bladder cancer...
  21. doi request reprint Enhanced transrectal ultrasound modalities in the diagnosis of prostate cancer
    Edouard J Trabulsi
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 76:1025-33. 2010
    ..EUM, detect prostate cancer more efficiently than standard ultrasound guided biopsies. These emerging technologies may potentially augment standard prostate biopsy in clinical practice...
  22. ncbi request reprint Uropharmacology in primary care: 2010 update
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Can J Urol 17:35-51. 2010
    ..This article will update some of the most commonly used urologic medications to optimize patient management strategies by the primary care provider or in coordination with the urologist...
  23. ncbi request reprint Importance of margin extent as a predictor of outcome after adjuvant radiotherapy for Gleason score 7 pT3N0 prostate cancer
    Richard K Valicenti
    Department of Radiation Oncology, Jefferson Medical College and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 58:1093-7. 2004
    ....
  24. pmc Hematologic Toxicity of Concurrent Administration of Radium-223 and Next-generation Antiandrogen Therapies
    Tu D Dan
    Departments of Radiation Oncology Medical Oncology Urology, Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA
    Am J Clin Oncol . 2015
    ..Here, we report on hematologic toxicity findings from our institution in patients receiving concurrent Radium-223 and next-generation antiandrogen therapies with either enzalutamide or abiraterone...
  25. doi request reprint Adjuvant versus salvage radiation therapy for prostate cancer patients with adverse pathologic features: comparative analysis of long-term outcomes
    Mark V Mishra
    Department of Radiation Oncology Robert Wood Johnson School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ Department of Pharmacology and Experimental Therapeutics, Division of Biostatistics Department of Urology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA
    Am J Clin Oncol 38:55-60. 2015
    ..To compare long-term outcomes of men with adverse pathologic features after adjuvant radiation therapy (ART) versus salvage radiation therapy (SRT) after radical prostatectomy at our institution...
  26. doi request reprint Contrast enhanced transrectal ultrasound for the detection of prostate cancer: a randomized, double-blind trial of dutasteride pretreatment
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5244, USA
    J Urol 188:1739-45. 2012
    ..This study was designed to quantify prostate cancer detection with contrast enhanced ultrasound with or without short-term pretreatment with dutasteride...
  27. ncbi request reprint Detection of prostate carcinoma with contrast-enhanced sonography using intermittent harmonic imaging
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5244, USA
    Cancer 104:2373-83. 2005
    ..The purpose of this study was to assess prostate carcinoma detection and discrimination of benign from malignant prostate tissue with contrast-enhanced ultrasonography...
  28. ncbi request reprint Use of neoadjuvant and adjuvant therapy to prevent or delay recurrence of prostate cancer in patients undergoing surgical treatment for prostate cancer
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 62:46-54. 2003
    ..This article reviews the potential multimodality approaches to prevent or delay recurrence of prostate cancer in patients undergoing surgical treatment for prostate cancer...
  29. ncbi request reprint Directed biopsy during contrast-enhanced sonography of the prostate
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107 5244, USA
    AJR Am J Roentgenol 178:915-9. 2002
    ..We evaluated the value of directed biopsy for the detection of prostate cancer during contrast-enhanced endorectal sonography...
  30. doi request reprint Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor
    Domenico D'Arca
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 28:189-94. 2010
    ....
  31. ncbi request reprint Inactivation of the FHIT gene favors bladder cancer development
    Andrea Vecchione
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 10:7607-12. 2004
    ..c. tumor growth in nude mice. These findings suggest the important role of Fhit in bladder cancer development and support the effort to additionally investigate a FHIT-based gene therapy...
  32. pmc The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin
    David Metalli
    Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Pathol 176:2997-3006. 2010
    ..Thus, the IGF-IR may also serve as a novel biomarker for bladder cancer...
  33. ncbi request reprint The addition of robotic surgery to an established laparoscopic radical prostatectomy program: effect on positive surgical margins
    Edouard J Trabulsi
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Can J Urol 15:3994-9. 2008
    ....
  34. pmc Is there an optimal management for localized prostate cancer?
    Jaspreet Singh
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Interv Aging 5:187-97. 2010
    ....
  35. ncbi request reprint Contrast enhanced ultrasound flash replenishment method for directed prostate biopsies
    Robert A Linden
    Department of Urology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Urol 178:2354-8. 2007
    ..We evaluated prostate cancer detection with contrast enhanced ultrasound of the prostate using MicroFlow Imaging (Toshiba America Medical Systems, Tustin, California) compared to systematic biopsy...
  36. ncbi request reprint Quantitative computed tomography perfusion of prostate cancer: correlation with whole-mount pathology
    Elizabeth P Ives
    Department of Radiation Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Prostate Cancer 4:109-12. 2005
    ..Microvessel density within the prostate is associated with presence of cancer, disease stage, and disease-specific survival. We evaluated multidetector computed tomography (CT) to estimate prostate perfusion and localize prostate cancer...
  37. pmc Genomic prostate cancer classifier predicts biochemical failure and metastases in patients after postoperative radiation therapy
    Robert B Den
    Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania Electronic address
    Int J Radiat Oncol Biol Phys 89:1038-46. 2014
    ..To test the hypothesis that a genomic classifier (GC) would predict biochemical failure (BF) and distant metastasis (DM) in men receiving radiation therapy (RT) after radical prostatectomy (RP)...
  38. ncbi request reprint Pathologic comparison of laparoscopic versus open radical retropubic prostatectomy specimens
    James A Brown
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Urology 62:481-6. 2003
    ..To compare the pathologic evaluation of 60 sequential laparoscopic radical prostatectomy (LRP) specimens with 60 sequential and 60 stage and grade-matched open radical retropubic prostatectomy (RRP) cohort specimens...
  39. ncbi request reprint Correlation of pathology with tumor size of renal masses
    Deborah Glassman
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Can J Urol 14:3616-20. 2007
    ..Mass size has been traditionally described as a parameter to predict the malignant potential. We compiled our experience with surgically treated renal masses and correlated lesion size with final pathology...
  40. doi request reprint Preemptive multimodal pain regimen reduces opioid analgesia for patients undergoing robotic-assisted laparoscopic radical prostatectomy
    Edouard J Trabulsi
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 76:1122-4. 2010
    ..Despite this, most patients require opioid analgesia, which can have significant side effects and toxicity. We report the first urologic study using multimodal analgesia with pregabalin, a gabapentinoid...
  41. doi request reprint Effect of percentage of positive prostate biopsy cores on biochemical outcome in low-risk PCa treated with brachytherapy or 3D-CRT
    Mark L Pe
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 73:1328-34. 2009
    ....
  42. doi request reprint Transition from pure laparoscopic to robotic-assisted radical prostatectomy: a single surgeon institutional evolution
    Edouard J Trabulsi
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 28:81-5. 2010
    ..To review a single surgeon experience of transitioning to a robotic-assisted laparoscopic prostatectomy program (RALP) with prior pure laparoscopic radical prostatectomy (LRP) experience...
  43. pmc Novel actions of next-generation taxanes benefit advanced stages of prostate cancer
    Renée de Leeuw
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania
    Clin Cancer Res 21:795-807. 2015
    ..These studies compared the novel taxane cabazitaxel with the previous generation docetaxel, and aimed to determine which tumors are most likely to respond...
  44. pmc Risk factors for biochemical recurrence after robotic assisted radical prostatectomy: a single surgeon experience
    Ryuta Tanimoto
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut St Suite 1112, Philadelphia, PA, 19107, USA
    BMC Urol 15:27. 2015
    ..We therefore wanted to investigate the prognostic significance of positive surgical margin (PSM) and other pathological factors on BCR in patients treated with RARP by a single surgeon...
  45. ncbi request reprint Predictors of positive surgical margins after radical prostatectomy at a single institution: preoperative and pathologic factors, and the impact of surgeon variability and technique on incidence and location
    Costas D Lallas
    Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    Can J Urol 21:7479-86. 2014
    ..To identify and assess predictive factors for positive surgical margins (PSM) in patients undergoing radical prostatectomy (RP)...
  46. doi request reprint Post-prostatectomy image-guided radiation therapy: evaluation of toxicity and inter-fraction variation using online cone-beam CT
    Harriet B Eldredge
    Department of Radiation Oncology Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Med Imaging Radiat Oncol 55:507-15. 2011
    ....
  47. doi request reprint Evolution of advanced technologies in prostate cancer radiotherapy
    Nicholas G Zaorsky
    Department of Radiation Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Nat Rev Urol 10:565-79. 2013
    ....
  48. doi request reprint Prognostic factors and outcomes after definitive treatment of female urethral cancer: a population-based analysis
    Colin E Champ
    Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urology 80:374-81. 2012
    ..To evaluate the prognostic factors and outcomes for a large observational cohort of female patients with urethral cancer in the Surveillance, Epidemiology, and End Results database...
  49. doi request reprint The effect of ethnicity and sexual preference on prostate-cancer-related quality of life
    Nir Kleinmann
    Department of Urology, Thomas Jefferson University Hospital, 833 Chestnut Street, Suite 703, Philadelphia, PA 19107, USA
    Nat Rev Urol 9:258-65. 2012
    ..These parameters are often poorly documented and addressed by medical practitioners. Greater attention is needed to identify patients who are at increased risk of QOL reduction as a result of these factors...
  50. ncbi request reprint Targeted biopsy of the prostate: the impact of color Doppler imaging and elastography on prostate cancer detection and Gleason score
    Eric D Nelson
    Kimmel Cancer Center, Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 70:1136-40. 2007
    ..To compare detection of prostate cancer and distribution of Gleason scores with gray-scale, color Doppler, and elastographic imaging...
  51. ncbi request reprint Hand-assisted laparoscopic nephroureterectomy: analysis of distal ureterectomy technique, margin status, and surgical outcomes
    James A Brown
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Urology 66:1192-6. 2005
    ....
  52. ncbi request reprint Outcomes of hand-assisted laparoscopic nephrectomy in technically challenging cases
    Pankaj Kalra
    Department of Urology, Thomas Jefferson University, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Urology 67:45-9. 2006
    ..To evaluate the outcomes of hand-assisted laparoscopic nephrectomy in patients with significant complicating clinical factors...
  53. doi request reprint Technique of outpatient placement of intraprostatic fiducial markers before external beam radiotherapy
    Robert A Linden
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 73:881-6. 2009
    ..To describe our technique and preliminary toxicity profile for ultrasound-guided outpatient placement of intraprostatic fiducial markers before intensity-modulated radiotherapy (IMRT) for prostate cancer...
  54. ncbi request reprint Pharmacology for common urologic diseases: 2011 review for the primary care physician
    Xiaolong S Liu
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Can J Urol 18:24-38. 2011
    ..We provide a 2011 update of the available medications for treatment of several common urologic diseases...
  55. doi request reprint Prevalence and Characteristics of Patients with Suspected Inherited Renal Cell Cancer: Application of the ACMG/NSGC Genetic Referral Guidelines to Patient Cohorts
    Hong Truong
    Department of Urology, Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA, USA
    J Genet Couns . 2017
    ..This study supports efforts to increase awareness of referral of patients with RCC for genetic counseling particularly among urologic providers...
  56. ncbi request reprint Decision Support and Shared Decision Making About Active Surveillance Versus Active Treatment Among Men Diagnosed with Low-Risk Prostate Cancer: a Pilot Study
    Ronald E Myers
    Division of Population Science, Department of Medical Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA
    J Cancer Educ . 2016
    ..Increased family and clinician support predicted this choice (p < 0.001). DSI/SDM prepared patients to make an informed decision. Perceived support of the decision facilitated patient choice of AS...
  57. doi request reprint The quality-of-life impact of prostate cancer treatments
    Jaspreet Singh
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 1112, Philadelphia, PA, 19107, USA
    Curr Urol Rep 11:139-46. 2010
    ..This review defines the concept of HRQOL, discusses what is currently known about the impact of various treatments on HRQOL, and summarizes the recent literature in this area relating to the management of localized prostate cancer...
  58. ncbi request reprint Pseudomass of the bladder neck after prostatectomy: report of two cases
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107 5244, USA
    Radiology 226:833-5. 2003
    ..A review of the surgical technique led the authors to conclude that a pseudomass at the vesicourethral anastomosis may result from focal infolding of normal bladder mucosa...
  59. doi request reprint Retropubic, laparoscopic, or robotic radical prostatectomy: is there any real difference?
    Kelly A Healy
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University Philadelphia, PA, USA
    Semin Oncol 40:286-96. 2013
    ..Future prospective studies of perioperative outcomes should aim to use rigorous methodology and established criteria for standardized reporting. ..
  60. pmc Optimization of initial prostate biopsy in clinical practice: sampling, labeling and specimen processing
    Marc A Bjurlin
    Division of Urologic Oncology, Department of Urology, New York University Langone Medical Center, New York, New York 10016, USA
    J Urol 189:2039-46. 2013
    ....
  61. ncbi request reprint Screening for prostate cancer: the current evidence and guidelines controversy
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Can J Urol 18:5875-83. 2011
    ..While screening with prostate specific antigen (PSA) has led to more men diagnosed with prostate cancer than in previous years, the potential for negative effects from over-diagnosis and treatment cannot be ignored...
  62. pmc Enhancing prostate cancer care through the multidisciplinary clinic approach: a 15-year experience
    Leonard G Gomella
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
    J Oncol Pract 6:e5-e10. 2010
    ..To our knowledge, our multidisciplinary genitourinary cancer clinic is the longest continuously operating center of its kind at an NCI Cancer Center in the United States...
  63. doi request reprint Androgen suppression strategies for prostate cancer: is there an ideal approach?
    Mohamed Ismail
    Department of Urology, Wilmington VA Medical Center, 1601 Kirkwood Highway, Wilmington, DE 19805, USA
    Curr Urol Rep 12:188-96. 2011
    ..Attempts to reduce AST adverse effects include intermittent hormonal therapy and methods to reduce amount of intracellular androgens without reducing the circulating testosterone levels...
  64. ncbi request reprint Hand assisted laparoscopic partial nephrectomy for peripheral and central lesions: a review of 30 consecutive cases
    James A Brown
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19317, USA
    J Urol 171:1443-6. 2004
    ..We reviewed our first 30 hand assisted laparoscopic partial nephrectomies and compared the results of 8 centrally located vs 22 peripherally located tumors...
  65. ncbi request reprint New approaches to the minimally invasive treatment of kidney tumors
    Edouard J Trabulsi
    Department of Urology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer J 11:57-63. 2005
    ..The available data regarding laparoscopic nephrectomy, laparoscopic partial nephrectomy, and tissue ablative techniques, such as renal cryoablation, radiofrequency ablation, and high-intensity focused ultrasound are reviewed...
  66. pmc Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report
    Hyun Kim
    Sidney Kimmel Cancer Center, Thomas Jefferson University, PA, USA
    Urol Case Rep 9:51-54. 2016
    ..We suggest that this information help selecting patients for advanced imaging, chemotherapies, or clinical trial...
  67. pmc Sortilin regulates progranulin action in castration-resistant prostate cancer cells
    Ryuta Tanimoto
    Departments of Urology R T, A Morc, M T, S Q X, M S, K G L, D H B, L G G, A Morr, Biology of Prostate Cancer Program L G G, A Morr, and Pathology, Anatomy, and Cell Biology S B, R V I and Cancer Cell Biology and Signaling Program R V I, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 Department of Health Sciences A Morc, M S, A B, Endocrinology, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy and CRS Development of Biomolecular Therapies M T, K S, Experimental Oncology Laboratory, Rizzoli Orthopedic Institute, 40136 Bologna, Italy
    Endocrinology 156:58-70. 2015
    ..Collectively, these results point out a critical role for sortilin in regulating progranulin action in castration-resistant prostate cancer cells, suggesting that sortilin loss may contribute to prostate cancer progression...
  68. ncbi request reprint Effect of dutasteride therapy on Doppler US evaluation of prostate: preliminary results
    Elizabeth P Ives
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107 5244, USA
    Radiology 237:197-201. 2005
    ....
  69. ncbi request reprint Radiation therapy after radical prostatectomy: a review of the issues and options
    Richard K Valicenti
    Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA
    Semin Radiat Oncol 13:130-40. 2003
    ..This review summarizes published retrospective and prospective data to guide decision making in selecting appropriate candidates for postprostatectomy radiation therapy...
  70. doi request reprint Transrectal prostate biopsy
    Mohamed T Ismail
    Department of Urology, VA Medical Center, 1601 Kirkwood Highway, Wilmington, DE 19805, USA Department of Urology, Thomas Jefferson University, 1025 Walnut Street, 1102, Philadelphia, PA 19107, USA
    Urol Clin North Am 40:457-72. 2013
    ..Careful patient evaluation and preparation are essential to maximize the results and minimize the complications of the biopsy procedure. ..
  71. doi request reprint Face, content, and construct validation of the da Vinci Skills Simulator
    Douglas C Kelly
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Urology 79:1068-72. 2012
    ..To report on assessments of face, content, and construct validity for the commercially available da Vinci Skills Simulator (dVSS)...
  72. pmc Targeted therapies in the management of metastatic bladder cancer
    Matteo Fassan
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Biologics 1:393-406. 2007
    ..A review of literature published on the targeted therapy for metastatic bladder cancer is presented, focusing on the molecular pathways shut down by the new therapeutic agents...
  73. ncbi request reprint Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex
    Giada Monami
    Department of Urology, Anatomy and Cell Biology and Cellular Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 66:7103-10. 2006
    ....
  74. ncbi request reprint Global update on the use of hormonal therapy for the management of high-risk prostate cancer: introduction
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    BJU Int 99:1. 2007
  75. ncbi request reprint Micro-RNA profiling in kidney and bladder cancers
    Fedra Gottardo
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 25:387-92. 2007
    ..To study the role of the micro-RNAs in human kidney and bladder cancer, we analyzed the expression profile of 245 micro-RNAs in kidney and bladder primary tumors...
  76. ncbi request reprint High-frequency Doppler US of the prostate: effect of patient position
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107 5244, USA
    Radiology 222:634-9. 2002
    ..To evaluate cancer detection with directed biopsy of the prostate on the basis of high-frequency Doppler ultrasonographic (US) findings, and to determine the effect of patient position on the observed flow pattern...
  77. ncbi request reprint Uropharmacology for the primary care physician
    Paul R Gittens
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA 19107, USA
    Can J Urol 15:78-91; discussion 91. 2008
    ....
  78. ncbi request reprint Percutaneous cryoablation for recurrent low grade renal cell carcinoma after failed nephron-sparing surgery
    Matthew A Morgan
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Can J Urol 20:6933-7. 2013
    ..Partial nephrectomy has a 3%-4% incidence of local treatment failure. This study is to present a series of percutaneous cryoablation for locally recurrent renal cell carcinoma after partial nephrectomy...
  79. pmc Dual roles of PARP-1 promote cancer growth and progression
    Matthew J Schiewer
    Departments of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Discov 2:1134-49. 2012
    ....
  80. pmc Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases
    Andrea Vecchione
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Philadelphia, PA, 19107, USA
    BMC Urol 4:11. 2004
    ..In order to gain an insight into the biology of this tumor we evaluated the expression of five genes involved in the development of renal cancer (FEZ1/LZTS1, FHIT, TP53, P27kip1, and BCL2)...
  81. ncbi request reprint New treatment options for castrate-resistant prostate cancer: a urology perspective
    Leonard G Gomella
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Can J Urol 18:5767-77. 2011
    ..However, two phase III trials in 2004 showed improved survival with docetaxel compared with mitoxantrone in patients with metastatic CRPC. Docetaxel remains the current standard chemotherapy for CRPC...
  82. pmc Hormone therapy in the management of prostate cancer: evidence-based approaches
    Leonard G Gomella
    Chairman, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 1025 Walnut Street, Suite 1112, Philadelphia, PA 19107, USA
    Ther Adv Urol 2:171-81. 2010
    ..In this article we review the basic concepts in hormonal ablation for prostate cancer and review the evidence-based studies that support the use of hormonal therapy in early stage prostate cancer...
  83. pmc Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer
    Clay E S Comstock
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Clin Cancer Res 15:5338-49. 2009
    ..Here, the frequency, tumor relevance, and mechanisms controlling cyclin D1b were challenged...
  84. ncbi request reprint Multi-institutional survey of laparoscopic ureterolysis for retroperitoneal fibrosis
    David A Duchene
    Department of Urology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Urology 69:1017-21. 2007
    ..Preoperative and postoperative adjuvant medical therapy and the timing of surgical intervention are not well-established. We surveyed centers of laparoscopic excellence to determine the current practices in the treatment of RPF...
  85. ncbi request reprint New imaging techniques in prostate cancer
    Edouard J Trabulsi
    Department of Urology, Thomas Jefferson University, 1015 Walnut Street, Suite 1102, Philadelphia, PA 19107, USA
    Curr Urol Rep 7:175-80. 2006
    ..Although intriguing, the available data for positron-emission tomography in prostate cancer remains too shallow to advocate routine use...
  86. ncbi request reprint Chemoprevention using dutasteride: the REDUCE trial
    Leonard G Gomella
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Opin Urol 15:29-32. 2005
    ....
  87. ncbi request reprint Contrast-enhanced US of the prostate with Sonazoid: comparison with whole-mount prostatectomy specimens in 12 patients
    Ethan J Halpern
    Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S 10th St, Philadelphia, PA 19107 5244, USA
    Radiology 222:361-6. 2002
    ..To compare areas of contrast material enhancement in the prostate at ultrasonography (US) with whole-mount radical prostatectomy specimens to determine if the use of contrast material improves the detection rate of prostate cancer...
  88. ncbi request reprint Blue light cystoscopy for detection and treatment of non-muscle invasive bladder cancer
    J Ryan Mark
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Can J Urol 19:6227-31. 2012
    ..In this paper we describe the technique and practical aspects of hexaminolevulinate (HAL) fluorescence cystoscopy, also known as "blue light cystoscopy"...
  89. ncbi request reprint Circulating tumor cells predict survival in patients with metastatic prostate cancer
    Jose G Moreno
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Urology 65:713-8. 2005
    ..To determine whether circulating tumor cells (CTCs) predict for survival in patients with metastatic prostate cancer (PCa) and to compare its prognostic abilities with other clinical factors...
  90. ncbi request reprint Totally endoscopic management of upper tract transitional-cell carcinoma
    David Lee
    Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Endourol 16:37-41. 2002
    ..We reviewed our experience with endourologic treatment and propose an algorithm for the management of upper tract TCC...
  91. ncbi request reprint When prostate cancer markers become unreliable: the PCPT dilemma
    Leonard G Gomella
    Urol Oncol 22:260-1. 2004
  92. ncbi request reprint Delay in the progression of low-risk prostate cancer: rationale and design of the Reduction by Dutasteride of Clinical Progression Events in Expectant Management (REDEEM) trial
    Neil Fleshner
    University Health Network, Princess Margaret Hospital, Toronto, ON, Canada
    Contemp Clin Trials 28:763-9. 2007
    ..Dutasteride, a dual 5alpha-reductase inhibitor (5ARI), may delay prostate cancer progression or extend the time to initiation of more aggressive therapy...
  93. ncbi request reprint Multigene reverse transcription-PCR profiling of circulating tumor cells in hormone-refractory prostate cancer
    S Mark O'Hara
    Immunicon Corporation, Huntingdon Valley, PA 19006, USA
    Clin Chem 50:826-35. 2004
    ..To improve characterization of CTCs we further investigated whether in vitro transcription-based multigene reverse transcription-PCR expression profiles could be obtained from CTCs in HRPC...
  94. ncbi request reprint Attitudes and use of complementary medicine in men with prostate cancer
    Simon Wilkinson
    Department of Health Studies and Weiss Memorial Hospital, University of Chicago, Illinois, USA
    J Urol 168:2505-9. 2002
    ..Patients with cancer are increasingly incorporating complementary therapies into the overall treatment. We determine the prevalence and patterns of use of complementary therapies among patients with prostate cancer...