David Abraham

Summary

Affiliation: Thomas Jefferson University
Country: USA

Publications

  1. pmc Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus
    D Abraham
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 69:262-70. 2001
  2. ncbi request reprint Immunity to Onchocerca spp. in animal hosts
    David Abraham
    Dept of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Trends Parasitol 18:164-71. 2002
  3. ncbi request reprint Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 189:1282-90. 2004
  4. pmc Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice
    Udaikumar M Padigel
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    J Infect Dis 196:1844-51. 2007
  5. ncbi request reprint Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Microbes Infect 9:28-34. 2007
  6. pmc Specificity and mechanism of immunoglobulin M (IgM)- and IgG-dependent protective immunity to larval Strongyloides stercoralis in mice
    Jessica A Ligas
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 71:6835-43. 2003
  7. pmc DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Infect Immun 73:2298-305. 2005
  8. pmc Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice
    Ann Marie Galioto
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th St, BLSB 530, Philadelphia, PA 19107, USA
    Infect Immun 74:5730-8. 2006
  9. pmc Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice
    Amy E O'Connell
    1Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 79:2770-8. 2011
  10. pmc Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis
    Sandra Bonne-Annee
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Infect Immun 81:3346-55. 2013

Collaborators

Detail Information

Publications35

  1. pmc Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus
    D Abraham
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 69:262-70. 2001
    ..volvulus. Furthermore, since the antigens functioned with alum as the adjuvant, this vaccine could potentially be used clinically to prevent river blindness in humans...
  2. ncbi request reprint Immunity to Onchocerca spp. in animal hosts
    David Abraham
    Dept of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Trends Parasitol 18:164-71. 2002
    ..Immune mechanisms controlling these infections are described and initial success using recombinant antigen vaccines in these models is reviewed...
  3. ncbi request reprint Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Infect Dis 189:1282-90. 2004
    ....
  4. pmc Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice
    Udaikumar M Padigel
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    J Infect Dis 196:1844-51. 2007
    ..These experiments demonstrate that eosinophils function as antigen-presenting cells for the induction of the primary and the expansion of the secondary Th2 immune responses to S. stercoralis in mice...
  5. ncbi request reprint Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Microbes Infect 9:28-34. 2007
    ..It was therefore concluded that the inability of TLR4-mutant mice to kill larval S. stercoralis during the adaptive immune response is due to a defect in the effector cells recruited to the microenvironment of the larvae...
  6. pmc Specificity and mechanism of immunoglobulin M (IgM)- and IgG-dependent protective immunity to larval Strongyloides stercoralis in mice
    Jessica A Ligas
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 71:6835-43. 2003
    ..It was therefore concluded that while IgM and IgG antibodies are both protective against larval S. stercoralis, they recognize different antigens and utilize different killing mechanisms...
  7. pmc DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Infect Immun 73:2298-305. 2005
    ..Therefore, DNA immunization with Na+-K+ ATPase induces protective immunity in mice, and it is the first identified vaccine candidate against infection with larval S. stercoralis...
  8. pmc Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice
    Ann Marie Galioto
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th St, BLSB 530, Philadelphia, PA 19107, USA
    Infect Immun 74:5730-8. 2006
    ..stercoralis in mice...
  9. pmc Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice
    Amy E O'Connell
    1Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 79:2770-8. 2011
    ..Eosinophils are not required for the development or function of secondary immunity, but MPO from neutrophils is required for protective secondary immunity...
  10. pmc Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis
    Sandra Bonne-Annee
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Infect Immun 81:3346-55. 2013
    ..This study adds macrophages to the armamentarium of immune components that function in elimination of parasitic helminths and demonstrate a novel function by which AAM control large extracellular parasites. ..
  11. pmc Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis
    Louis H Stein
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Innate Immun 1:618-30. 2009
    ..Parasite extract stimulates multiple receptors on the eosinophil surface, which ensures a robust innate immune response to the parasite...
  12. pmc Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis
    Udaikumar M Padigel
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Infect Immun 74:3232-8. 2006
    ..This study highlights the potential of eosinophils to actively induce immune responses against infection by amplifying antigen-specific Th2-cell responses...
  13. pmc Signaling through Galphai2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice
    Udaikumar M Padigel
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    J Leukoc Biol 81:1120-6. 2007
    ..stercoralis; however, Galphai2 is essential for the recruitment of neutrophils required for host-dependent killing of larvae...
  14. ncbi request reprint Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice
    De Broski R Herbert
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Exp Parasitol 100:112-20. 2002
    ..This study demonstrates that IgG-isolated proteins are candidate antigens for a vaccine against larval S. stercoralis...
  15. pmc Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae
    David Abraham
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 72:810-7. 2004
    ..Finally, protective immunity was abolished in mice treated to eliminate IgE from the blood. We therefore concluded that IgE and eosinophils are required for adaptive protective immunity to larval O. volvulus in mice...
  16. pmc Immunization with the recombinant antigen Ss-IR induces protective immunity to infection with Strongyloides stercoralis in mice
    David Abraham
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Vaccine 29:8134-40. 2011
    ....
  17. pmc Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th St, BLSB 530, Philadelphia, PA 19107, USA
    Infect Immun 73:8291-7. 2005
    ..volvulus in TLR4-mutant mice is not due to loss of Th2 immunity or the response to Wolbachia but is due to an unidentified TLR4-dependent larval killing mechanism...
  18. ncbi request reprint Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice
    Laura A Kerepesi
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 176:4315-22. 2006
    ..Therefore, C3 was not required for the development of adaptive immunity, but was required for the larval killing process during both protective innate and adaptive immune responses in mice against larval S. stercoralis...
  19. doi request reprint Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model
    Sandra Bonne-Annee
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Immunol Res 51:205-14. 2011
    ....
  20. ncbi request reprint Strongyloides stercoralis: high worm population density leads to autoinfection in the jird (Meriones unguiculatus)
    Thomas J Nolan
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce St, Philadelphia, PA 19104 6050, USA
    Exp Parasitol 100:173-8. 2002
    ....
  21. pmc The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice
    Jessica A Hess
    Department of Microbiology and Immunology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS Negl Trop Dis 10:e0004797. 2016
    ....
  22. pmc Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis
    Sandra Bonne-Annee
    Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Microbes Infect 16:502-11. 2014
    ..stercoralis larvae and were present in the microenvironment of worms being killed in vivo. These findings demonstrate that NETs ensnare the parasite facilitating larval killing by cells of the immune system...
  23. pmc Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment
    Amy E O'Connell
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Microbes Infect 13:536-44. 2011
    ..Finally, neutrophil stimulation with S. stercoralis soluble extract induced release of the CXCR2 ligands MIP-2 and KC from neutrophils, thereby potentially enhancing neutrophil recruitment...
  24. ncbi request reprint A novel class of peptides that induce apoptosis and abrogate tumorigenesis in vivo
    M Resnicoff
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biochem Biophys Res Commun 240:208-12. 1997
    ..Aspecific toxicity of the synthetic peptides was ruled out by the demonstration that single amino acid substitutions (in at least 4 peptides) completely abrogated the pro-apoptotic effect, even at a concentration of 10(-5) M (10 microM)...
  25. ncbi request reprint The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts
    M Resnicoff
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 273:10376-80. 1998
    ..The possibility that these two properties could be separated was confirmed by demonstrating that R508 cells expressing another anti-apoptotic protein, Bcl-2, could not form tumors in nude mice...
  26. pmc Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model
    Jessica A Hess
    Department of Microbiology and Immunology, Jefferson Medical College, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Int J Parasitol 44:637-46. 2014
    ..Although there was no increase in the level of protective immunity induced by combining the antigens into one vaccine, these antigens remain strong candidates for inclusion in a vaccine to control onchocerciasis in humans. ..
  27. doi request reprint B cell multitasking is required to control nematode infection
    Kishore R Alugupalli
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Immunity 30:317-9. 2009
    ..2009) demonstrate that in addition to producing antibodies, B cells play pivotal roles in specific-antigen presentation and cytokine production for optimal T helper 2 responses required for protection against Heligmosomoides polygyrus...
  28. doi request reprint B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact
    Matthew J Colombo
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, Room 726, Philadelphia, PA 19107, USA
    Immunol Res 51:249-56. 2011
    ..These results demonstrate that IgM-mediated clearance of B. hermsii does not require opsonophagocytosis and indicate that a mechanism for in vivo B1b cell-mediated protection is through the generation of bactericidal IgM...
  29. ncbi request reprint Activity of azithromycin against Leishmania major in vitro and in vivo
    Alejandro Krolewiecki
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Trop Med Hyg 67:273-7. 2002
    ..major in vitro and in vivo. Given the severity of the disease and the limitations of the available therapeutic agents, azithromycin may have a significant role in the treatment of this group of diseases...
  30. ncbi request reprint Immunity to larval Brugia malayi in BALB/c mice: protective immunity and inhibition of larval development
    D Abraham
    Thomas Jefferson University, Philadelphia, Pennsylvania
    Am J Trop Med Hyg 40:598-604. 1989
    ..Sera recovered after challenge of control mice reacted with internal, but not surface, antigens of L-3 and L-4. Alternatively, sera from immunized mice reacted with both internal and external antigens of both L-3 and L-4...
  31. ncbi request reprint The role of B cells in immunity against larval Strongyloides stercoralis in mice
    De Broski R Herbert
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Parasite Immunol 24:95-101. 2002
    ..B-1 cells are required for the secondary immune response and their role appears to be the production of IgM and not as a source of immunoregulatory molecules...
  32. doi request reprint IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages
    A E O'Connell
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Parasite Immunol 31:741-9. 2009
    ..Thus, lethality during M. corti infection of IL-4(-/-) mice is associated with decreased Th2 cytokines, increased Th1 cytokines and impairment of alternatively activated macrophages...
  33. pmc Onchocerca volvulus glycolytic enzyme fructose-1,6-bisphosphate aldolase as a target for a protective immune response in humans
    James S McCarthy
    University of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Western Australia, Australia
    Infect Immun 70:851-8. 2002
    ..50% was seen. This observation provides support for the further study of this parasite enzyme as a vaccine candidate in larger animal models...
  34. ncbi request reprint CD4+-dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions
    Sara Lustigman
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Int J Parasitol 33:1161-71. 2003
    ..volvulus L3 protective immunity in both humans and mice could be applicable to the development of vaccines against other nematode infections...
  35. ncbi request reprint Towards a recombinant antigen vaccine against Onchocerca volvulus
    Sara Lustigman
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Trends Parasitol 18:135-41. 2002
    ..The approaches used to clone potential protective antigens and the successful vaccination of animals with some of the antigens are summarized here...