Robert J Thoma
- Fluctuating asymmetry and the human brainRobert J Thoma
University of New Mexico and New Mexico VA Health Care System, Albuquerque 87108, USA
Laterality 7:45-58. 2002....
- Lateralization of auditory sensory gating and neuropsychological dysfunction in schizophreniaRobert J Thoma
Psychiatry Service, Department of Radiology, New Mexico VA Health Care System, VAMC 116A, 1501 San Pedro SE, Albuquerque, NM 87108, USA
Am J Psychiatry 160:1595-605. 2003....
- M50 sensory gating predicts negative symptoms in schizophreniaRobert J Thoma
Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, United States
Schizophr Res 73:311-8. 2005..This finding is compatible with information processing theories of negative symptoms and with more recent findings of fronto-temporal abnormality in patients with predominantly negative symptoms...
- Impaired secondary somatosensory gating in patients with schizophreniaRobert J Thoma
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
Psychiatry Res 151:189-99. 2007..Patients demonstrated no impairment in SI gating, but a robust gating deficit in SII, supporting the presence of cross modal gating deficits in schizophrenia...
- Cognitive abilities and 50- and 100-msec paired-click processes in schizophreniaAshley K Smith
Center for Functional Brain Imaging, New Mexico VA Health Care System, 1501 San Pedro Drive S E, Albuquerque, NM 87108, USA
Am J Psychiatry 167:1264-75. 2010..In addition, the functional implications remain unclear. In the present study, EEG and magnetoencephalography (MEG) were used to examine paired-click measures and cognitive correlates of paired-click activity...
- A specific test of hippocampal deficit in schizophreniaFaith M Hanlon
Department of Psychiatry, New Mexico Veterans Affairs Health Care System, University of New Mexico, Albuquerque, NM 87131, USA
Behav Neurosci 119:863-75. 2005..Patients' abnormal hippocampal lateralization may play a role in the hippocampal-dependent behavioral deficit...
- Schizophrenia diagnosis and anterior hippocampal volume make separate contributions to sensory gatingRobert J Thoma
Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
Psychophysiology 45:926-35. 2008..Schizophrenia diagnosis predicted M50 gating independent of hippocampal volume. These results are consistent with the finding that hippocampus is a critical part of a fronto-temporal circuit involved in auditory gating...
- Neurometabolite concentration and clinical features of chronic alcohol use: a proton magnetic resonance spectroscopy studyRonald A Yeo
Department of Psychology, University of New Mexico, Albuquerque, NM, USA
Psychiatry Res 211:141-7. 2013..These results suggest that the nature of neurometabolite abnormalities in chronic heavy drinkers may vary as a function of duration of abuse...
- Impairment on the hippocampal-dependent virtual Morris water task in schizophreniaFaith M Hanlon
The Mental Illness and Neuroscience Discovery MIND Institute, 1101 Yale Blvd NE, Albuquerque, New Mexico 87106, USA
Schizophr Res 87:67-80. 2006..There was no deficit in the visible-platform condition. These findings identify a behavioral impairment on a hippocampal-dependent task in schizophrenia and support using the MWT in testing animal models of schizophrenia...
- Bilateral hippocampal dysfunction in schizophreniaFaith M Hanlon
The MIND Research Network, Pete and Nancy Domenici Hall, 1101 Yale Blvd NE, Albuquerque, NM 87106, USA
Neuroimage 58:1158-68. 2011..These data demonstrate the capacity to assess lateralized hippocampal function and suggest a bilateral hippocampal behavioral and activation deficit in schizophrenia...
- Neuropsychological and sensory gating deficits related to remote alcohol abuse history in schizophreniaRobert J Thoma
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
J Int Neuropsychol Soc 12:34-44. 2006....
- Distinct M50 and M100 auditory gating deficits in schizophreniaFaith M Hanlon
Center for Functional Brain Imaging, New Mexico VA Health Care System, Albuquerque, New Mexico 87108, USA
Psychophysiology 42:417-27. 2005..In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating...
- Efficacy of olanzapine and risperidone in schizophrenia: a randomized double-blind crossover designJose M Canive
Psychiatry Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA
Psychopharmacol Bull 39:105-16. 2006..Despite the small number of subjects, this study shows the potential of a within-subject design to elucidate differences in efficacy...
- A non-invasive method for observing hippocampal functionFaith M Hanlon
New Mexico VA Health Care System, 1501 San Pedro Drive, SE Albuquerque, NM 87108, USA
Neuroreport 14:1957-60. 2003..Patients with unilateral hippocampal damage showed activation in undamaged hippocampus. MEG during transverse patterning performance is a promising, non-invasive tool for assessing hippocampal function...
- The impact of developmental instability on Voxel-Based Morphometry analyses of neuroanatomical abnormalities in schizophreniaMatthew Euler
Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA
Schizophr Res 115:1-7. 2009..These results support the DI approach and suggest that the unique etiologic factors associated with schizophrenia lead to widespread gray matter volume reductions...
- A parietal-frontal network studied by somatosensory oddball MEG responses, and its cross-modal consistencyMing Xiong Huang
Department of Radiology, University of California, San Diego, 92103 8756, USA
Neuroimage 28:99-114. 2005....
- Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: preliminary resultsMichael Hunter
New Mexico VA Healthcare System Clinical Neuroscience Research Program, Albuquerque, NM, USA
Psychiatry Res 191:138-44. 2011..These findings suggest that the structural integrity of right hemisphere STG cortices play an important role in auditory sensory gating deficits in PTSD...
- Adolescent substance abuse: the effects of alcohol and marijuana on neuropsychological performanceRobert J Thoma
Department of Psychiatry, University of New Mexico, Albuquerque, 87131, USA
Alcohol Clin Exp Res 35:39-46. 2011....
- The impact of copy number deletions on general cognitive ability and ventricle size in patients with schizophrenia and healthy control subjectsRonald A Yeo
Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA
Biol Psychiatry 73:540-5. 2013..Individual variation in a specific type of mutation, uncommon genetic deletions, has recently been linked with both general cognitive ability and risk for schizophrenia...
- Visual processing of facial affectStephen Lewis
Department of Psychiatry, University of New Mexico, School of Medicine, Albuquerque, NM 87131, USA
Neuroreport 14:1841-5. 2003..These findings are considered in the context of a specialized neural face-dependent information system...
- Diffusion tensor imaging of white matter networks in individuals with current and remitted alcohol use disorders and comorbid conditionsMollie A Monnig
Department of Psychology, University of New Mexico, Albuquerque, NM87131, USA
Psychol Addict Behav 27:455-65. 2013....
- Hippocampus volume and episodic memory in schizophreniaRobert J Thoma
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, USA
J Int Neuropsychol Soc 15:182-95. 2009..In this sample of adults with schizophrenia, atypical relationships between regional hippocampus volumes and episodic memory ability were found, as was an atypical negative association between hippocampus volume and age...
- Dynamic neural activity recorded from human amygdala during fear conditioning using magnetoencephalographySandra N Moses
Department of Psychology, University of New Mexico, Albuquerque, NM 87109, USA
Brain Res Bull 71:452-60. 2007..The amygdala also shows stimulus omission-related activation that could potentially provide feedback about experienced stimulus contingencies to modify future responding during learning and extinction...
- Resting state and task-induced deactivation: A methodological comparison in patients with schizophrenia and healthy controlsMaggie V Mannell
The MIND Research Network, Albuquerque, New Mexico, USA
Hum Brain Mapp 31:424-37. 2010..The increased posterior and reduced anterior connectivity may partially explain some of the cognitive dysfunction and clinical symptoms that are frequently associated with schizophrenia...
- Developmental instability and the neural dynamics of the speed-intelligence relationshipRobert J Thoma
Center for Neuropsychological Services, Department of Psychiatry, 915 Vassar NE, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
Neuroimage 32:1456-64. 2006..These observations suggest that fluid intelligence is primarily related to speed during processing associated with decision time, while fluctuating asymmetry predicted slower processing across all stages of information processing...
- Functional MRI Evaluation of Multiple Neural Networks Underlying Auditory Verbal Hallucinations in Schizophrenia Spectrum DisordersRobert J Thoma
Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA The Mind Research Network and the Lovelace Family of Companies, Albuquerque, NM, USA
Front Psychiatry 7:39. 2016..Overall, the data suggest that AVH generation requires specific and selective activation of auditory cortical and posterior language regions, perhaps coupled to a release of indirect influence by occipital and medial frontal structures. ..
- Rare copy number deletions predict individual variation in human brain metabolite concentrations in individuals with alcohol use disordersRonald A Yeo
Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA
Biol Psychiatry 70:537-44. 2011..The current study investigated the importance of a specific type of genetic mutation, copy number variation (CNV), for neurometabolite concentrations in a bilateral anterior cingulate voxel...
- Magnetoencephalographic and functional MRI connectomics in schizophrenia via intra- and inter-network connectivityJon M Houck
Center on Alcoholism, Substance Abuse, and Addictions, University of New Mexico, Albuquerque, New Mexico, United States Mind Research Network, Albuquerque, New Mexico, United States Electronic address
Neuroimage . 2016..Results suggest that combining these two neuroimaging modalities reveals additional disease-relevant patterns of connectivity that were not detectable with fMRI or MEG alone...
- White matter volume in alcohol use disorders: a meta-analysisMollie A Monnig
Center on Alcoholism, Substance Abuse, and Addictions, University of New Mexico, 2650 Yale Boulevard SE, Albuquerque, NM 87106, USA
Addict Biol 18:581-92. 2013..These results are suggestive of WM recovery with sustained abstinence and point to the need for further investigation of factors related to treatment-seeking status...
- Abnormal stimulus-response intensity functions in posttraumatic stress disorder: an electrophysiological investigationJeffrey David Lewine
Departments of Psychology and Psychiatry, University of New Mexico, Albuquerque, NM, USA
Am J Psychiatry 159:1689-95. 2002....
- Diminished auditory sensory gating during active auditory verbal hallucinationsRobert J Thoma
Department of Psychiatry, 1 University of New Mexico, MSC 09 5030, Albuquerque, NM 87131, USA The Mind Research Network and the Lovelace Family of Companies, 1101 Yale NE, Albuquerque, NM 87131, USA Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA Electronic address
Schizophr Res . 2017..These findings link onset of AVH with a failure of an empirically-defined auditory inhibition system, auditory sensory gating, and pave the way for a sensory gating model of AVH...
- Cross-modal generality of the gating deficitJ Christopher Edgar
Department of Psychology and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, IL 61820, USA
Psychophysiology 42:318-27. 2005..Patients showed abnormal auditory M50 gating but normal somatosensory M20 gating. Results argue against a cross-modal gating deficit in primary somatosensory cortex...
- Superior temporal gyrus spectral abnormalities in schizophreniaJ Christopher Edgar
Department of Psychology, Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Psychophysiology 45:812-24. 2008..Compared to controls, patients with schizophrenia showed more low-frequency phase variability, and the decreased 100-ms S1 evoked response observed in patients was best predicted by the STG phase-locking measure...