Marie Ange Thelu
- Prevalence and impact of occult hepatitis B infection in chronic hepatitis C patients treated with pegylated interferon and ribavirinMarion Levast
Laboratory of Virology, Grenoble University Hospital, Grenoble, France
J Med Virol 82:747-54. 2010..This, just as anti-HBC status, had no clinical impact in a large cohort of hepatitis C patients. It therefore does not appear useful to screen for occult hepatitis B in these patients with this test before beginning HCV treatment...
- Lack of clinical significance of variability in the internal ribosome entry site of hepatitis C virusMarie Ange Thelu
Département d Hépato Gastroentérologie, Hopital Albert Michallon, Grenoble, France
J Med Virol 72:396-405. 2004..Variations observed in the IRES are not a parameter of response to antiviral therapy, but the integrity of this region is a necessary condition to maintain its activity...
- Functions of liver natural killer cells are dependent on the severity of liver inflammation and fibrosis in chronic hepatitis CEmilie Fugier
INSERM, U823, Grenoble, France Université Joseph Fourier, UMR S823, Grenoble, France
PLoS ONE 9:e95614. 2014..Thus, we conclude that critical roles of IH-NK cells have to be taken into account in the course of the liver pathogenesis associated to chronic HCV infection. ..
- Hepatitis C virus whole genome sequencing: Current methods/issues and future challengesPauline Trémeaux
a Laboratoire de Virologie, Institut de Biologie et Pathologie, CHU Grenoble Alpes, Grenoble, France
Crit Rev Clin Lab Sci 53:341-51. 2016..The progress brought by new and future technologies will also be discussed, as well as the remaining difficulties, largely due to the genomic variability. ..
- Characterization and role of intra-hepatic regulatory T cells in chronic hepatitis C pathogenesisNathalie Sturm
INSERM, Unité 823, Grenoble, France
J Hepatol 53:25-35. 2010..In vitro data point out that regulatory T cells (Treg) are able to suppress HCV-specific lymphocyte proliferation and cytokine secretion but their implication in this pathology is still debated...