Brendan M Walker

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol 42:91-7. 2008
  2. pmc The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 31:11-8. 2007
  3. pmc Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence
    Brendan M Walker
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:643-52. 2008
  4. pmc Dissociable effects of ethanol consumption during the light and dark phase in adolescent and adult Wistar rats
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol 42:83-9. 2008
  5. pmc Appetitive motivational experience during adolescence results in enhanced alcohol consumption during adulthood
    Brendan M Walker
    Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Behav Neurosci 123:926-35. 2009
  6. doi request reprint Electrophysiological effects of dizocilpine (MK-801) in adult rats exposed to ethanol during adolescence
    Jose R Criado
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 32:1752-62. 2008
  7. pmc Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
    Brendan M Walker
    The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol 16:116-9. 2011
  8. pmc Milk consumption during adolescence decreases alcohol drinking in adulthood
    Jerry P Pian
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 1501, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 94:179-85. 2009
  9. pmc The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, United States
    Pharmacol Biochem Behav 91:295-302. 2009
  10. pmc Age-related differences in the blood alcohol levels of Wistar rats
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, United States
    Pharmacol Biochem Behav 91:560-5. 2009

Detail Information

Publications17

  1. pmc alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol 42:91-7. 2008
    ..None of the doses tested reliably affected concurrent water self-administration. These results suggest the involvement of the noradrenergic system in the excessive alcohol drinking seen during acute withdrawal in ethanol-dependent rats...
  2. pmc The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol Clin Exp Res 31:11-8. 2007
    ..However, little work has focused on the effects of GABA(B) receptor agonists on self-administration of ethanol in dependent animals...
  3. pmc Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence
    Brendan M Walker
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:643-52. 2008
    ....
  4. pmc Dissociable effects of ethanol consumption during the light and dark phase in adolescent and adult Wistar rats
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Alcohol 42:83-9. 2008
    ..Knowledge of these parameters should be useful for future experiments attempting to evaluate the effects of self-administered ethanol exposure in adult and adolescent rats...
  5. pmc Appetitive motivational experience during adolescence results in enhanced alcohol consumption during adulthood
    Brendan M Walker
    Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Behav Neurosci 123:926-35. 2009
    ..This model should prove useful in delineating appetitive motivation-related factors that contribute to excessive ethanol consumption...
  6. doi request reprint Electrophysiological effects of dizocilpine (MK-801) in adult rats exposed to ethanol during adolescence
    Jose R Criado
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 32:1752-62. 2008
    ....
  7. pmc Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
    Brendan M Walker
    The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol 16:116-9. 2011
    ..Nor-BNI decreased ethanol self-administration in ethanol-dependent animals, with no effect in nondependent animals. Thus, the κ-opioid/dynorphin system is a viable pharmacotherapeutic target for the treatment of alcoholism...
  8. pmc Milk consumption during adolescence decreases alcohol drinking in adulthood
    Jerry P Pian
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 1501, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 94:179-85. 2009
    ..Our findings suggest adolescent exposure to sucrose increases, whereas, exposure to milk reduces ethanol consumption in adult rats. Our results may provide a new theoretical approach to the early prevention of alcoholism...
  9. pmc The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
    Thomas N Greenwell
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, United States
    Pharmacol Biochem Behav 91:295-302. 2009
    ..The data suggest that the alpha1 adrenergic system may contribute to mechanisms that promote dependence in rats with extended access...
  10. pmc Age-related differences in the blood alcohol levels of Wistar rats
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, United States
    Pharmacol Biochem Behav 91:560-5. 2009
    ....
  11. pmc Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats
    Jerry P Pian
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Rd, SP30 1501, La Jolla, CA 92037, USA
    Brain Res 1194:28-36. 2008
    ..Our results provide additional evidence of age-related differences in the effects of acute alcohol on cortical EEG, sedation and tolerance...
  12. pmc Effects of adolescent ethanol exposure on sleep in adult rats
    Jose R Criado
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 1501, La Jolla, CA 92037, USA
    Alcohol 42:631-9. 2008
    ..Although the cellular and molecular mechanisms mediating the consequences of EtOH exposure on the aging process are not known, the similarities between adolescent EtOH exposure and aging merits further investigation...
  13. ncbi request reprint Increased alcohol drinking in isolate-housed alcohol-preferring rats
    Cindy L Ehlers
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Behav Neurosci 121:111-9. 2007
    ..Selective enhancement of limited access ethanol drinking in P rats may represent a model whereby genetic liability to excessive drinking is enhanced by specific environmental exposures...
  14. pmc Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains
    Brendan M Walker
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Alcohol 44:487-93. 2010
    ..Thus, extended ethanol vapor exposure produced long-lasting changes in FST behavior and NPY levels in the brain...
  15. ncbi request reprint Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats
    Brendan M Walker
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USA
    Behav Neurosci 121:401-10. 2007
    ..In summary, rats form reliable learned preferences for EtOH-paired locations (CPPs) that are potentiated by iv heroin and whose acquisition and expression rely on intact DA functionality within the nucleus accumbens...
  16. doi request reprint Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake"
    Brendan M Walker
    FASEB J 22:2113; author reply 2113-4. 2008
  17. ncbi request reprint The effects of alprazolam on conditioned place preferences produced by intravenous heroin
    Brendan M Walker
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USA
    Pharmacol Biochem Behav 75:75-80. 2003
    ..125 mg/kg) and intravenous heroin can interact to produce reliable place preferences. The data thereby support prior work from our laboratory regarding the synergistic actions of BDZs and opiates...