Henri H Versteeg

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Emerging insights in tissue factor-dependent signaling events
    Henri H Versteeg
    Department of Immunology, The Scripps Institute, La Jolla, CA 92037, USA
    Semin Thromb Hemost 32:24-32. 2006
  2. pmc Inhibition of tissue factor signaling suppresses tumor growth
    Henri H Versteeg
    Department of Immunology, SP258, Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:190-9. 2008
  3. pmc Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice
    Henri H Versteeg
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cancer Res 68:7219-27. 2008
  4. ncbi request reprint Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity
    Henri H Versteeg
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 282:25416-24. 2007
  5. pmc Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development
    Florence Schaffner
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 116:6106-13. 2010
  6. pmc Disulfide isomerization switches tissue factor from coagulation to cell signaling
    Jasimuddin Ahamed
    Department of Immunology, The Scripps Research Institute, SP258, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:13932-7. 2006
  7. ncbi request reprint FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, G2 131, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 94:1032-40. 2004
  8. pmc Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1106 AZ Amsterdam, The Netherlands
    Mol Med 10:6-11. 2004
  9. ncbi request reprint Tissue factor as an evolutionary conserved cytokine receptor: Implications for inflammation and signal transduction
    Henri H Versteeg
    Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands
    Semin Hematol 41:168-72. 2004
  10. ncbi request reprint Tissue factor signal transduction in angiogenesis
    Henri H Versteeg
    Laboratory for Experimental Internal Medicine, G2 130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Carcinogenesis 24:1009-13. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Emerging insights in tissue factor-dependent signaling events
    Henri H Versteeg
    Department of Immunology, The Scripps Institute, La Jolla, CA 92037, USA
    Semin Thromb Hemost 32:24-32. 2006
    ..In this review, we relate our current understanding of direct TF signaling pathways to the emerging roles of TF in (patho)physiology...
  2. pmc Inhibition of tissue factor signaling suppresses tumor growth
    Henri H Versteeg
    Department of Immunology, SP258, Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:190-9. 2008
    ..These results show that tumor cell TF-PAR2 signaling is crucial for tumor growth and suggest that anti-TF strategies can be applied in cancer therapy with minor impairment of TF-dependent hemostatic pathways...
  3. pmc Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice
    Henri H Versteeg
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cancer Res 68:7219-27. 2008
    ..This study establishes that protease signaling contributes to mammary tumor development and that PAR2, rather than the thrombin receptor PAR1, plays a crucial role in the angiogenic switch...
  4. ncbi request reprint Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity
    Henri H Versteeg
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 282:25416-24. 2007
    ..PDI enhanced TF coagulant activity on microvesicles shed from cells, suggesting that PDI plays a role as an activating chaperone for circulating cryptic TF...
  5. pmc Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development
    Florence Schaffner
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 116:6106-13. 2010
    ....
  6. pmc Disulfide isomerization switches tissue factor from coagulation to cell signaling
    Jasimuddin Ahamed
    Department of Immunology, The Scripps Research Institute, SP258, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:13932-7. 2006
    ..These experiments delineate an upstream regulatory mechanism that controls TF function, and they provide initial evidence that TF.VIIa signaling can be specifically inhibited with minimal effects on coagulation...
  7. ncbi request reprint FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, G2 131, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Circ Res 94:1032-40. 2004
    ..Finally, we demonstrated for the first time that TF/FVIIa-signal transduction is dependent on G12/G13 class G proteins...
  8. pmc Tissue factor and cancer metastasis: the role of intracellular and extracellular signaling pathways
    Henri H Versteeg
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, 1106 AZ Amsterdam, The Netherlands
    Mol Med 10:6-11. 2004
    ..In this review, we will discuss these phenomena in more detail and hypothesize on their role in TF-driven metastasis...
  9. ncbi request reprint Tissue factor as an evolutionary conserved cytokine receptor: Implications for inflammation and signal transduction
    Henri H Versteeg
    Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands
    Semin Hematol 41:168-72. 2004
    ..This review discusses the role of TF and its ligand FVIIa in inflammation, sepsis, and signal transduction, and describes the way in which these processes interact...
  10. ncbi request reprint Tissue factor signal transduction in angiogenesis
    Henri H Versteeg
    Laboratory for Experimental Internal Medicine, G2 130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Carcinogenesis 24:1009-13. 2003
    ..The recent evidence for this emerging insight will be the subject of this review...
  11. ncbi request reprint In silico tissue factor analysis: a bit-to-bit comparison
    Maikel P Peppelenbosch
    Thromb Haemost 89:592-3. 2003
  12. doi request reprint High factor VIIa levels do not promote tumor metastasis
    Lois W Br├╝ggemann
    Thromb Haemost 99:787-8. 2008
  13. ncbi request reprint Validity of bioluminescence measurements for noninvasive in vivo imaging of tumor load in small animals
    Clara P W Klerk
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biotechniques 43:7-13, 30. 2007
    ....
  14. ncbi request reprint Activation of the canonical beta-catenin pathway by histamine
    Sander H Diks
    Laboratory for Experimental Internal Medicine, Academic Medical Center, Meibergdreef 9, The Netherlands
    J Biol Chem 278:52491-6. 2003
    ..The observation that inflammatory molecules, like histamine, activate the beta-catenin pathway may provide a molecular explanation for a possible link between inflammation and cancer...
  15. ncbi request reprint Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation
    Keren S Borensztajn
    Center for Experimental and Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    Exp Cell Res 313:2622-33. 2007
    ..We thus provide evidence that beyond its role in blood coagulation, FXa plays a key role in cellular processes in which Bim is the central player in determining cell survival...
  16. ncbi request reprint Evidence for activation of tissue factor by an allosteric disulfide bond
    Vivien M Chen
    Centre for Vascular Research, University of New South Wales, Sydney, NSW 2052, Australia
    Biochemistry 45:12020-8. 2006
    ..It is likely that formation of this disulfide bond changes the conformation of the domain that facilitates productive binding of factors IX and X...
  17. ncbi request reprint Coagulation factors VIIa and Xa inhibit apoptosis and anoikis
    Henri H Versteeg
    Laboratory for Experimental Internal Medicine, G2 105, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Oncogene 23:410-7. 2004
    ..Finally, TF:FVIIa-induced FXa generation dramatically increased cell survival. We propose that FVIIa-induced cell survival may explain why overexpression of TF is associated with successful metastasis...
  18. ncbi request reprint VIIa/tissue factor interaction results in a tissue factor cytoplasmic domain-independent activation of protein synthesis, p70, and p90 S6 kinase phosphorylation
    Henri H Versteeg
    Laboratory for Experimental Internal Medicine and the Department of Oncology, Academic Medical Center, Meibergdreef 9, AZ Amsterdam NL 1105, The Netherlands
    J Biol Chem 277:27065-72. 2002
    ..We propose that a TF cytoplasmic domain-independent stimulation of protein synthesis via activation of S6 kinase contributes to FVIIa effects in pathophysiology...