Caroline M Tanner
Affiliation: The Parkinson's Institute
- Effect of non-steroidal anti-inflammatory medications on the risk of amyotrophic lateral sclerosisRita A Popat
Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, CA 94305 5405, USA
Amyotroph Lateral Scler 8:157-63. 2007..This study did not find any evidence to suggest that NSAID use reduces the risk of ALS. The observed sex differences with non-aspirin NSAID use could be due to chance or an unmeasured confounder...
- Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007Jeff Bronstein
UCLA School of Medicine, Los Angeles, California, USA
Environ Health Perspect 117:117-21. 2009..People with PD, their families, scientists, health care providers, and the general public are increasingly interested in identifying environmental contributors to PD risk...
- Occupation and risk of parkinsonism: a multicenter case-control studyCaroline M Tanner
Department of Clinical Research, The Parkinson s Institute, Sunnyvale, California 94085, USA
Arch Neurol 66:1106-13. 2009..We examined risk of parkinsonism in occupations (agriculture, education, health care, welding, and mining) and toxicant exposures (solvents and pesticides) putatively associated with parkinsonism...
- Genetic modification of the association of paraquat and Parkinson's diseaseSamuel M Goldman
The Parkinson s Institute, Sunnyvale, California 94085, USA
Mov Disord 27:1652-8. 2012..GSTT1*0 is common and could potentially identify a large subpopulation at high risk of PD from oxidative stressors such as paraquat...
- Solvent exposures and Parkinson disease risk in twinsSamuel M Goldman
The Parkinson s Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
Ann Neurol 71:776-84. 2012..We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design...
- Head injury, α-synuclein Rep1, and Parkinson's diseaseSamuel M Goldman
The Parkinson s Institute, Sunnyvale, CA 94085, USA
Ann Neurol 71:40-8. 2012..To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk...
- Peptidoglycan recognition protein genes and risk of Parkinson's diseaseSamuel M Goldman
San Francisco Veterans Affairs Medical Center, San Francisco, California, USA University of California, San Francisco, San Francisco, California, USA The Parkinson s Institute, Sunnyvale, California, USA
Mov Disord 29:1171-80. 2014..These results require replication, but they are consistent with hypotheses of a causative role for the gut microbiota and gastrointestinal immune response in PD...
- Rotenone, paraquat, and Parkinson's diseaseCaroline M Tanner
The Parkinson s Institute, Sunnyvale, California 94085, USA
Environ Health Perspect 119:866-72. 2011..Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans...
- Smell identification ability in twin pairs discordant for Parkinson's diseaseConnie Marras
The Parkinson s Institute, Sunnyvale, California, USA
Mov Disord 20:687-93. 2005..Smell identification ability may not be a sensitive indicator of future PD 7 or more years before the development of motor signs, even in a theoretically at-risk population...
- Head injury and Parkinson's disease risk in twinsSamuel M Goldman
The Parkinson s Institute, Sunnyvale, CA 94089, USA
Ann Neurol 60:65-72. 2006..Twin studies circumvent some of these problems, because twins are genetically and environmentally much more similar than typical cases and control subjects...
- Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's diseaseRuksana Azhu Valappil
Clinical Research Department, The Parkinson s Institute and Clinical Center, Sunnyvale, California, USA
Mov Disord 25:2296-303. 2010..Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD...
- Clinical features in early Parkinson disease and survivalRaymond Y Lo
The Parkinson s Institute and Clinical Center, Sunnyvale, CA 94085, USA
Arch Neurol 66:1353-8. 2009..To examine the association between demographic and clinical features in early Parkinson disease (PD) and length of survival in a multiethnic population...
- Advances in environmental epidemiologyCaroline M Tanner
Clinical Research, The Parkinson s Institute, Sunnyvale, California 94085, USA
Mov Disord 25:S58-62. 2010..The pathogenesis of PD may begin decades before motor symptoms. PD may have shared determinants with other neurodegenerative disorders involving abnormal protein aggregation...
- Familial aggregation of Parkinson's disease in a multiethnic community-based case-control studyMichael Y Shino
Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, California, USA
Mov Disord 25:2587-94. 2010..4, 95% CI 1.8-16.0) than among parents (RR = 2.7, 95% CI 1.3-5.2). The incidence and familial aggregation of PD is highest among Hispanics, warranting further studies of genetic and environmental risk factors in the Hispanic population...
- A practical approach to remote longitudinal follow-up of Parkinson's disease: the FOUND studyCaroline M Tanner
Clinical Research, The Parkinson s Institute, Sunnyvale, California, USA Department of Health Research and Policy, Stanford University, Palo Alto, California, USA
Mov Disord 29:743-9. 2014....
- Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutationLouis C Tan
The Parkinson s Institute, Sunnyvale, California 84089, USA
Mov Disord 18:758-63. 2003..Clinicians should be aware that patients carrying a parkin gene mutation may present with dystonia-parkinsonism or very subtle parkinsonism with a markedly varied age of onset...
- Nicotine and Parkinson's disease: implications for therapyMaryka Quik
The Parkinson s Institute, Sunnyvale, California, USA
Mov Disord 23:1641-52. 2008....
- Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infectionsHarvey S Singer
Division of Pediatric Neurology, Johns Hopkins Hospital, Rubenstein Child Health Building, Suite 2158, 200 N Wolfe St, Baltimore, MD 21287, USA
Pediatrics 121:1198-205. 2008....
- Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trialConnie Marras
Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
Mov Disord 23:653-9; quiz 776. 2008..Our focus in clinical care needs to be broadened beyond assessing and treating Parkinsonism, recognizing the impact of mood, cognition and function on HRQOL...
- Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studiesCaroline M Tanner
Parkinson s Institute, Sunnyvale, California, USA
Adv Neurol 91:133-42. 2003
- Incidence of Parkinson's disease: variation by age, gender, and race/ethnicityStephen K Van Den Eeden
Division of Research, Kaiser Permanente, Oakland, CA 94612, USA
Am J Epidemiol 157:1015-22. 2003..0, 21.3), followed by non-Hispanic Whites (13.6, 95% CI: 11.5, 15.7), Asians (11.3, 95% CI: 7.2, 15.3), and Blacks (10.2, 95% CI: 6.4, 14.0). These data suggest that the incidence of Parkinson's disease varies by race/ethnicity...
- PD or not PD? That is the questionCaroline M Tanner
Neurology 61:5-6. 2003
- Parkinsonian signs and substantia nigra neuron density in decendents elders without PDG Webster Ross
Honolulu Department of Veteran s Affairs, Honolulu, HI, USA
Ann Neurol 56:532-9. 2004..There was a significant association of increasing number of signs present with decreasing neuron density in both quadrants (p = 0.001 for trend). Low SN neuron density may be the basis for parkinsonian signs in the elderly without PD...
- A responsive outcome for Parkinson's disease neuroprotection futility studiesJordan J Elm
Department of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA
Ann Neurol 57:197-203. 2005....
- Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years laterTerry Reed
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Twin Res Hum Genet 8:362-7. 2005....
- Non-linearity of Parkinson's disease progression: implications for sample size calculations in clinical trialsPaulo Guimaraes
Dept of Biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina, 135 Cannon St Suite 303, Charleston, SC 29425, USA
Clin Trials 2:509-18. 2005..Models can help better understand behavior of the UPDRS after initiation of symptomatic therapy when scores will improve and eventually start deteriorating again...
- Effect of reproductive factors and postmenopausal hormone use on the risk of amyotrophic lateral sclerosisRita A Popat
Department of Health Research and Policy, Division of Epidemiology, Stanford University School of Medicine, Stanford, Calif, USA
Neuroepidemiology 27:117-21. 2006..To examine the associations of reproductive factors and postmenopausal hormone use with the risk of amyotrophic lateral sclerosis (ALS) among women...
- Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international studyAlexis Elbaz
INSERM, Unit 708, Paris, France
Lancet Neurol 5:917-23. 2006..Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain...
- Association of olfactory dysfunction with risk for future Parkinson's diseaseG Webster Ross
Veterans Affairs Pacific Islands Health Care System, University of Hawaii John A Burns School of Medicine, Honolulu, HI 96819, USA
Ann Neurol 63:167-73. 2008..This study examines the association of olfactory dysfunction with future development of PD in Honolulu-Asia Aging Study cohort members..
- Plantation work and risk of Parkinson disease in a population-based longitudinal studyHelen Petrovitch
Department of Medicine, University of Hawaii John A Burns School of Medicine, USA
Arch Neurol 59:1787-92. 2002..Retrospective studies in humans demonstrate a link between exposure to agricultural lifestyle factors and PD...
- Skin Pigmentation and Parkinson's Disease RiskCaroline Tanner; Fiscal Year: 2003..This could be an enormous breakthrough in our understanding of factors that influence the risk (and perhaps even the cause) of Parkinson's disease, and could lead to new strategies for disease prevention. ..
- PESTICIDES AND RISK IN THE AGRICUTURAL HEALTH STUDYCaroline Tanner; Fiscal Year: 2004..The investigators believe that this work could provide a critical and dramatic next step in furthering our knowledge of environmental determinants of PD, and thereby take us closer to our goal of finding its cause(s). ..
- TWINS AND RISK OF PD: A CLINICAL AND IMAGING STUDYCaroline Tanner; Fiscal Year: 2004..This in turn could help set the research agenda on the cause of Parkinson's disease for years to come. ..
- Epidemiology of Dystonia in a Multi-Ethnic PopulationCaroline Tanner; Fiscal Year: 2009..In addition, this cohort will provide a rich resource for future investigations including family studies, genetic analyses and further investigations of environmental risk factors. ..
- Diagnostic Error in DystoniaCaroline M Tanner; Fiscal Year: 2010..If successful, this approach could be applied in other medical care settings, as well as for other rare disorders, to improve medical care and efficiency, and reduce suffering. ..